Regeneration of Knee Joint Cartilage under the Effect of Low-Molecular Fraction of Cord Blood (up to 5 kDa)

2011 ◽  
Vol 18 (3) ◽  
pp. 69-74
Author(s):  
A K Gulevskiy ◽  
Evgeniy Gennadievich Ivanov ◽  
A K Gulevsky ◽  
Ye G Ivanov
Keyword(s):  
Knee Joint ◽  
Motor Activity ◽  
Cord Blood ◽  
Intramuscular Injection ◽  
Cartilage Regeneration ◽  
Structural Proteins ◽  
Joint Cartilage ◽  
Injured Limb ◽  
Molecular Fraction ◽  
Positive Effect

The effect of the cattle cord blood low-molecular fraction (up to 5 kDa) (FCB) on regeneration of knee joint cartilage following mechanical injury was studied in rats using biochemical, histological and roentgenological methods. It was shown that intramuscular injection of FCB significantly stimulated the accumulation of the basic components of matrix, the most important structural proteins in cartilage regeneration as well as provided the positive effect on morphologic state of cartilage and surrounding tissues. That positive effect was noted during both stage of granulation and stage of chondrocyte development. It was shown that injection of FCB promoted normalization of motor activity in injured limb.

Systemic hypoxia alters gene expression levels of structural proteins and growth factors in knee joint cartilage

2005 ◽  
Vol 330 (2) ◽  
pp. 386-394 ◽  
Author(s):  
Jochen G. Hofstaetter ◽  
Livius Wunderlich ◽  
Raymond E. Samuel ◽  
Fawzy A. Saad ◽  
Yeong-Hoon Choi ◽  
...  
Keyword(s):  
Gene Expression ◽  
Growth Factors ◽  
Knee Joint ◽  
Structural Proteins ◽  
Joint Cartilage ◽  
Expression Levels ◽  
Systemic Hypoxia ◽  
Gene Expression Levels

scholarly journals Treatment of Degenerative-Dystrophic Diseases of the Knee Joint Based on the use of Mesenchymal Stem Cells of the Synovial Membrane

2020 ◽  
Vol 2 (52) ◽  
pp. 18-23
Author(s):  
Nurlan Batpenov ◽  
◽  
Yerik Raimagambetov ◽  
Gulzhanat Korganbekova ◽  
Madina Sarsenova ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Knee Joint ◽  
Effective Number ◽  
Joint Cartilage ◽  
Autologous Mesenchymal Stem Cells ◽  
Arthroscopic Knee ◽  
Positive Effect ◽  
Number Of Cells ◽  
Joint Evaluation

Using autologous mesenchymal stem cells, 12 patients with pathology of the knee joint cartilage were successfully treated. At the first stage, all patients underwent traditional arthroscopic knee debridement, during which a sample of the synovium was taken, after which the sample was transferred to the National Center for Biotechnology for the cultivation of mesenchymal stem cells. After culturing a therapeutically effective number of cells, the material was punctured into the cavity of the affected joint. Evaluation of the results demonstrated a positive effect of the method on the course of the disease.

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