Modern Tendencies of Synovial Fluid Substituting Drugs Based on Bound Hyaluronic Acid Use in Treatment of Patients with Loco-Motor System Pathology and Injuries

2013 ◽  
Vol 20 (4) ◽  
pp. 85-91
Author(s):  
M. A Strakhov ◽  
A. V Skoroglyadov
Keyword(s):  
Molecular Weight ◽  
Hyaluronic Acid ◽  
Synovial Fluid ◽  
Production Technology ◽  
Motor System ◽  
Pain Syndrome ◽  
Complex Treatment ◽  
High Efficacy

Analysis of literature on hyaluronic acid role and properties as well as on the use of synovial fluid substituting drugs based on bound hyaluronic acid (HA) shows the significance of this type of therapy for the arrest of articular and periarticular pain syndrome, and high efficacy in complex treatment of osteoarthritis. Recent data enabled to understand better the mechanisms of HA metabolism and to determine the advantages HA drugs use depending on the production technology, molecular weight and other pharmacodynamics properties.

A decrease in the molecular weight of hyaluronic acid in synovial fluid from patients with temporomandibular disorders

2004 ◽  
Vol 33 (4) ◽  
pp. 224-229 ◽  
Author(s):  
Tetsu Takahashi ◽  
Kazuhiro Tominaga ◽  
Hiroshi Takano ◽  
Wataru Ariyoshi ◽  
Manabu Habu ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Hyaluronic Acid ◽  
Synovial Fluid ◽  
Temporomandibular Disorders

scholarly journals Features of Hyaluronic Acid Solutions for Intra-articular Introduction and Recent Trends in Their Development (Review)

2020 ◽  
Vol 9 (2) ◽  
pp. 45-54
Author(s):  
Y. Y. Zagorulko ◽  
E. Y. Zagorulko
Keyword(s):  
Molecular Weight ◽  
Hyaluronic Acid ◽  
Synovial Fluid ◽  
Viscoelastic Properties ◽  
Sodium Succinate ◽  
Acid Solutions ◽  
Molecular Weight Range ◽  
Polymer Complexes ◽  
Promising Area ◽  
The Creation

Introduction. The most common way to maintain the viscoelastic properties of synovial fluid is intra-articular administration of hyaluronic acid solutions. Such forms have several features due to the method of administration, the characteristics of the substance, as well as their composition, technology, and packaging. The aim of the work to analyze the features of hyaluronic acid solutions for intra-articular administration, as well as to consider resent trends to their pharmaceutical development.Text. Currently, in Russia, most of these forms are registered as medical devices. Each drug has its characteristics, including the source of the substance, the main molecular weight and the molecular weight range of hyaluronic acid, the structure of the molecule (linear or cross-linked), the method of its chemical modification, concentration, solution volume, dosage, etc. As excipients most often use sodium chloride, water for injection, and phosphate-buffered saline to maintain pH values close to the synovial fluid. Some prostheses contain mannitol as an antioxidant. Combinations of hyaluronic acid with active chondroprotective substances (chondroitin sulfate, sodium succinate) are known. The main type of primary packaging is glass prefilled syringes. The choice of sterilization methods is determined by the chemical structure of hyaluronic acid, aseptic production is used for most prostheses.Conclusion. Currently, research solutions to create thermostable and enzyme-resistant compositions with hyaluronic acid for intra-articular administration are being successfully applied. Modern developments are aimed at creating polymer complexes of hyaluronic acid with substances that improve the lubricity of solutions, the development of nanosystems (liposomes, nanoparticles, nano micelles, etc.) with chondroprotective, as well as the creation of inert biocompatible prostheses with viscoelastic properties. The creation of forms of hyaluronic acid and alternative drugs that can support the rheological properties of synovial fluid is currently a promising area of research.

scholarly journals The Role of Different Hyaluronic Acids in the Articular Cartilage of Rabbit

2010 ◽  
Vol 4 (1) ◽  
pp. 44-47 ◽  
Author(s):  
Jaime Antonio Sánchez Lázaro ◽  
Pilar Coronel Granado ◽  
Mercedes Gimeno del Sol ◽  
Ana González Medina ◽  
Luis Díaz Gállego ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Hyaluronic Acid ◽  
Synovial Fluid ◽  
Cruciate Ligament ◽  
Rheological Behaviour ◽  
Study Groups ◽  
Similar Molecular Weight ◽  
Physico Chemical ◽  
Hyaluronic Acids

Purpose: To elucidate if the differences found in the physico-chemical and rheological behaviour of Hyaluronic Acids result in different in vivo activity. For this purpose two Hyaluronic Acids (HA), HA-1 and HA-2, with similar molecular weight but different percentage of concentration variation, were compared through an osteoarthritis model. Methods and Materials: Osteoarthritis was induced in white New Zealand rabbits by anterior cruciate ligament section. After the induction period, the animals were allocated to receive HA-1 or HA-2 intra-articularly in one knee whereas the contralateral knee was used as Operated Control. An additional group of non-operated animals was used as Healthy Controls. Samples of cartilage were taken for different measures: apoptosis, nitric oxide (nitrites) and hyaluronic acid in synovial fluid. Results: The administration of HA-1 had a significant inhibitor effect on apoptosis of the chondrocytes compared to operated untreated animals (p = 0.0089), whereas this difference was not observed in the HA-2 knees. Levels of nitrites determined by HPLC in the HA-1 knees were similar to those in the Healthy group (p = 0.6551) whereas they were significantly higher in Operated Control and HA-2 groups (p = 0.0001). The comparison between HA-1 and HA-2 also revealed significantly lower levels of nitrites in the HA-1 knees (p = 0.0001). Values of hyaluronic acid in synovial fluid did not show statistical differences between the different study groups. Conclusions: HA-1 and HA-2 showed different physico-chemical characteristics and these differences have resulted in different in vivo behaviour. As a consequence, not all the HA with similar molecular weight can be considered as equivalent.

scholarly journals Analge­tic and Anti-Inflammatory Therapy in Early Postoperative Period in Patients with Injuries and Diseases of Loco-Motor System

2005 ◽  
Vol 12 (1) ◽  
pp. 46
Author(s):  
L. L Silin ◽  
A. V Garkavi ◽  
A. E Pikhlak ◽  
S. M Mezhidov
Keyword(s):  
Drug Therapy ◽  
Motor System ◽  
Pain Syndrome ◽  
Early Postoperative Period ◽  
Control Group ◽  
Complex Treatment ◽  
Local Inflammatory Reaction ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Inflammatory Action

A protocol for gradual use of nonsteroid anti-inflammatory drugs with mainly analgetic action (Ketorol) and mainly anti-inflammatory action (Nise) are suggested for complex treatment after operations on loco-motor system. It is shown that the protocol (applied in 38 patients) allows to cup off both pain syndrome and local inflammatory reaction in the operation zone more effective as compared with the routine drug therapy (40 patients — control group).

On the interaction of hyaluronic acid with synovial fluid lipid membranes

2019 ◽  
Vol 21 (19) ◽  
pp. 9845-9857 ◽  
Author(s):  
Paul Smith ◽  
Robert M. Ziolek ◽  
Elena Gazzarrini ◽  
Dylan M. Owen ◽  
Christian D. Lorenz
Keyword(s):  
Molecular Dynamics ◽  
Molecular Weight ◽  
Hyaluronic Acid ◽  
Synovial Fluid ◽  
Molecular Dynamics Simulations ◽  
Lipid Membranes ◽  
Low Molecular Weight ◽  
Dynamics Simulations

All-atom molecular dynamics simulations have been used to investigate the adsorption of low molecular weight hyaluronic acid to lipid membranes.

Arterial Embolization in Patients with Tumors and Tumor-Like Diseases of Loco-Motor System

2004 ◽  
Vol 11 (3) ◽  
pp. 40
Author(s):  
S. P Mironov ◽  
A. V Balberkin ◽  
A. K Morozov ◽  
Z. G Natsvlishvili ◽  
A. F Kolondaev ◽  
...  
Keyword(s):  
Marked Reduction ◽  
Motor System ◽  
Palliative Treatment ◽  
Malignant Tumors ◽  
Arterial Embolization ◽  
Pain Syndrome ◽  
Tissue Structure ◽  
High Efficacy ◽  
Pelvic Bones ◽  
Reduction Of Pain

Reendovascular occlusion of pathologic vessels responsible for the blood supply of highly vascu­larized tumors of the femur, large pelvic bones, spine and tumor-like foci was used in 20 patients. High efficacy of the method was demonstrated. Marked reduction of the pathologic blood flow resulted in the decreased blood loss during organ saving operations for malignant tumors. Improvement of bone tissue structure in aneurismal cyst and pelvic bones hemangioma was accompanied by manifest positive clinical dynamics. At palliative treatment of patients with inoperable and metastatic tumors rapid and significant reduction of pain syndrome was noted.

The rationale for the combined use of osteopathic methods of correction and reflexology in the complex treatment of patients with dorsopathy at the cervico-thoracic level

2020 ◽  
pp. 82-94 ◽  
Author(s):  
V. O. Belash ◽  
L. R. Urazgalieva ◽  
R. I. Fayzullina ◽  
L. G. Agasarov
Keyword(s):  
Drug Therapy ◽  
Drug Treatment ◽  
Pain Syndrome ◽  
Clinical Effectiveness ◽  
Complex Treatment ◽  
Standard Drug ◽  
Treatment Methods ◽  
Thoracic Level ◽  
Combined Use ◽  
Complex Therapy

Introduction. Degenerative-dystrophic changes in the spine are the most common chronic human diseases. Pronounced clinical manifestations of vertebrogenic diseases are observed during active labor activity and represent one of the most frequent causes of temporary disability. It is also known that any pain syndromes are accompanied by the development of psychovegetative disorders, which reduces the effectiveness of treatment. In recent years, there has been a reasonable increase in the interest of the medical community to the non-drug treatment methods. It is caused by the polypharmacotherapy side effects, an increased numbers of allergic reactions, problems with polypragmasia, and a low level of compliance. At the same time, the question of the possibility of various non-drug treatment methods combining is quite acute.The goal of research is to substantiate the clinical effectiveness of the combined application of osteopathic correction and reflexotherapy in the complex treatment of patients with dorsopathy at the cervical-thoracic level.Materials and methods. A prospective controlled randomized study was conducted on the basis of the medical clinics of LLC «Family Health» (Kazan) and ANO «Center for SEB assistance» (Kazan) from April 2018 to May 2019. The study involved 52 people with dorsopathy at the cervical-thoracic level, aged from 25 to 45 years. In accordance with the exclusion criteria, 7 people dropped out of the study. The remaining patients (45 people), depending on the used treatment method, were divided by a simple randomization method using a random number generator into three groups of 15 people. The first group (main group) received osteopathic correction and reflexotherapyon the background of standard drug therapy; the second and the third groups (control groups) received only osteopathic correction orreflexotherapy, respectively, on the background of standard drug therapy. The osteopathic examination was performed for all patients regardless of the group, before and after the course of therapy, with the formation of an osteopathic conclusion.Also there was the estimation of the degree of pain syndrome severity,the asthenia, and the degree of accumulated emotional and energy charge that does not get out in a person.Results. It was found in the course of the study that the inclusion of osteopathic correction and reflexotherapy in the complex therapy of patients with dorsopathy at the cervical-thoracic level is clinically more effective than the isolated use of these methods. Such complex therapy allows to achieve a more significant reduction in the severity of the pain syndrome by VAS (p<0,05), relief of internal emotional tension (p<0,05), and increase the effectiveness of correction of dominant somatic dysfunction. Based on the obtained data, it could be assumed that reflexotherapy potentiates the effects of osteopathic correction.Conclusion. Based on the study, it can be concluded that the combination of osteopathic correction and reflexotherapy in the treatment of patients with dorsopathy at the cervical-thoracic level increases the clinical effectiveness of the standard drug therapy. At the same time, it is worth noting the potentiating effect of the combined use of two non-medicinal methods. The question of combining of various non-drug treatment methods is quite acute today, so this study will be continued. 

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