scholarly journals Glycemic Variability in Type 1 Diabetes—Does It Matter?

2014 ◽  
Vol 10 (01) ◽  
pp. 20 ◽  
Author(s):  
Frank L Schwartz ◽  
Cynthia R Marling ◽  
◽  
Keyword(s):  
Type 1 Diabetes ◽  
Clinical Assessment ◽  
Predictive Power ◽  
Glycosylated Hemoglobin ◽  
Glycemic Variability ◽  
Complications Of Diabetes ◽  
Patients With Diabetes ◽  
Clinical Research Trials

Clinical assessment of glycemic variability (GV) attempts to measure factors that may be contribute to tissue damage and the complications of diabetes that are not measured in glycosylated hemoglobin (HbA1C). Physicians managing patients with diabetes immediately understand the concept of GV; however, how it is assessed in clinical research trials and whether it has any predictive power in patients with type 1 diabetes is controversial and uncertain. This review is intended to help the reader understand the various GV metrics currently being reported in the literature, the potential mechanisms by which GV may contribute to the pathogenesis of the long-term complications of diabetes, and, finally, the evidence that reducing GV is beneficial to patients with type 1 diabetes.

Short and long-term glycemic variability associated with severe hypoglycemia and retinopathy in type 1 diabetes mellitus

2020 ◽  
Author(s):  
Martín Borja Sanz ◽  
Gimeno Sergio Roman ◽  
Peteiro Miranda Carlos Miguel ◽  
Ortez Toro Jose Jorge ◽  
Ana Agudo ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Severe Hypoglycemia ◽  
Glycemic Variability ◽  
Short And Long Term

Assessment of human cartilage glycoprotein 39 (YKL-40), preptin, and nitric oxide in adolescent patients with type 1 diabetes and its relation to cardiorenal affection

2015 ◽  
Vol 0 (0) ◽  
Author(s):  
Soha M. Abd El Dayem ◽  
Ahmed A. Battah ◽  
Amal El Shehaby ◽  
Nagwa Abd Allah
Keyword(s):  
Nitric Oxide ◽  
Type 1 Diabetes ◽  
Diastolic Dysfunction ◽  
Negative Correlation ◽  
Glycosylated Hemoglobin ◽  
Creatinine Ratio ◽  
Human Cartilage ◽  
Albumin Creatinine Ratio ◽  
Patients With Diabetes

AbstractTo evaluate new biomarkers such as YKL-40, preptin, and nitric oxide (NO) in patients with diabetes and to assess its relation to cardiorenal injury.The study included 62 patients with type 1 diabetes and 30 healthy volunteers. Blood sample was taken for assessment of glycosylated hemoglobin, lipid profile, YKL-40, preptin, and NO. Also, urine sample was taken for analysis of albumin/creatinine ratio. Echocardiography was also done.NO was lower, whereas YKL-40, preptin, and albumin/creatinine ratio were significantly higher in patients with diabetes. NO had a significant negative correlation with LVEDD, LVESD, PWT, LV mass, YKL-40, preptin, and albumin/creatinine ratio. YKL-40 had a significant positive correlation with waist/height ratio, preptin and negative correlation with E/A ratio. Stepwise multiple regression revealed that E/A ratio is the only parameter related to YKL-40. On the contrary, NO and systolic blood pressure are related to preptin.A significant reduction of NO and elevation of YKL-40 and preptin was found in patients with diabetes. A decrease in NO is associated with diastolic dysfunction, LV hypertrophy, and renal impairment, whereas YKL-40 is associated with diastolic dysfunction. An increase in preptin level was associated with hypertension.

scholarly journals THE Assesssment of PARAMETERS OF LONG-TERM METABOLIC control in children WITH DIABETES TYPE I using UNDERGOING different types of insulin THerapy and using different means of its introduction

2015 ◽  
pp. 41-45
Author(s):  
N. V. Volkova ◽  
H. G. Mikhno ◽  
A. V. Solntseva
Keyword(s):  
Glycosylated Hemoglobin ◽  
Diabetes Type ◽  
Type I ◽  
Diabetes Type 1 ◽  
Complications Of Diabetes ◽  
Acute Complications ◽  
Different Types ◽  
Diabetes Type I

Objective: to carry out comparative analysis of long-term compensation of carbohydrate metabolism in children with diabetes type 1 undergoing different types of insulin therapy and using different means of its introduction. Material and methods . We analyzed data of 77 medical histories of children with diabetes type 1. The patients were divided into 3 groups depending on the type of insulin and the way of its introduction. We analyzed both initial and current for the moment of the experiment parameters of glycosylated hemoglobin levels, frequency of blood glucose self-testing, presence of acute complications of diabetes mellitus. Results . The children undergoing continuous subcutaneous insulin introduction revealed significant decrease of glycosylated hemoglobin levels and absence of acute complications of diabetes. The group of children using insulin analogues for a long time had significantly lower glycemia variability and revealed no acute complications of diabetes. Conclusions . We revealed long-term compensation of carbohydrate metabolism in the children with diabetes type I who used insulin pump therapy.

scholarly journals Impact of COVID-19 Lockdown on Glycemic Control in Adults with Type 1 Diabetes Mellitus

2020 ◽  
Vol 4 (12) ◽  
Author(s):  
Begoña Pla ◽  
Alfonso Arranz ◽  
Carolina Knott ◽  
Miguel Sampedro ◽  
Sara Jiménez ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Glycemic Control ◽  
Type 1 Diabetes Mellitus ◽  
Glycosylated Hemoglobin ◽  
Glucose Monitoring ◽  
Glycemic Variability ◽  
Glucose Management ◽  
The Impact

Abstract Aim To examine the impact of the lockdown caused by the COVID-19 pandemic on both the glycemic control and the daily habits of a group of patients with type 1 diabetes mellitus (T1DM) using flash continuous glucose monitoring devices (flash CGMs). Methods Retrospective analysis based on all the information gathered in virtual consultations from a cohort of 50 adult patients with T1DM with follow-up at our site. We compared their CGM metrics during lockdown with their own previous data before the pandemic occurred, as well as the potential psychological and therapeutic changes. Results We observed a reduction of average glucose values: 160.26 ± 22.55 mg/dL vs 150 ± 20.96 mg/dL, P = .0009; estimated glycosylated hemoglobin: 7.21 ± 0.78% vs 6.83 ± 0.71%, P = .0005; glucose management indicator 7.15 ± 0.57% vs 6.88 ± 0.49%; P = .0003, and glycemic variability: 40.74 ± 6.66 vs 36.43 ± 6.09 P < .0001. Time in range showed an improvement: 57.46 ± 11.85% vs a 65.76 ± 12.09%, P < .0001, without an increase in percentage of time in hypoglycemia. Conclusions COVID-19 lockdown was associated with an improvement in glycemic control in patients with T1DM using CGMs.

scholarly journals Glycemic control is not related to cerebral small vessel disease in neurologically asymptomatic individuals with type 1 diabetes

2021 ◽  
Author(s):  
Jussi Inkeri ◽  
Krishna Adeshara ◽  
Valma Harjutsalo ◽  
Carol Forsblom ◽  
Ron Liebkind ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Blood Glucose ◽  
Glycemic Control ◽  
Small Vessel Disease ◽  
Glycemic Variability ◽  
Cerebral Small Vessel Disease ◽  
Vessel Disease ◽  
Asymptomatic Individuals

Abstract Aims To determine if medium- and long-term blood glucose control as well as glycemic variability, which are known to be strong predictors of vascular complications, are associated with underlying cerebral small vessel disease (cSVD) in neurologically asymptomatic individuals with type 1 diabetes. Methods A total of 189 individuals (47.1% men; median age 40.0, IQR 33.0–45.2 years) with type 1 diabetes (median diabetes duration of 21.7, IQR 18.3–30.7 years) were enrolled in a cross-sectional retrospective study, as part of the Finnish Diabetic Nephropathy (FinnDiane) Study. Glycated hemoglobin (HbA1c) values were collected over the course of ten years before the visit including a clinical examination, biochemical sampling, and brain magnetic resonance imaging. Markers of glycemic control, measured during the visit, included HbA1c, fructosamine, and glycated albumin. Results Signs of cSVD were present in 66 (34.9%) individuals. Medium- and long-term glucose control and glycemic variability did not differ in individuals with signs of cSVD compared to those without. Further, no difference in any of the blood glucose variables and cSVD stratified for cerebral microbleeds (CMBs) or white matter hyperintensities were detected. Neither were numbers of CMBs associated with the studied glucose variables. Additionally, after dividing the studied variables into quartiles, no association with cSVD was observed. Conclusions We observed no association between glycemic control and cSVD in neurologically asymptomatic individuals with type 1 diabetes. This finding was unexpected considering the large number of signs of cerebrovascular pathology in these people after two decades of chronic hyperglycemia and warrants further studies searching for underlying factors of cSVD.

Evaluation of gastric emptying and neuropathy in short- and long-term type-1 diabetes

2006 ◽  
Vol 44 (05) ◽  
Author(s):  
T Várkonyi ◽  
É Börcsök ◽  
R Takács ◽  
R Róka ◽  
C Lengyel ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Gastric Emptying ◽  
Short And Long Term ◽  
Term Type
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