Correlation between Vitamin A Deficiency and the Severity of Mycoplasma Pneumoniae Pneumonia in Children

2021 ◽  
Vol 7 (5) ◽  
pp. 3364-3373
Author(s):  
Teng Wang ◽  
Ping Zheng ◽  
Qian Jiang ◽  
Qianqian Sun
Keyword(s):  
Vitamin A ◽  
Mycoplasma Pneumoniae ◽  
Detection Rate ◽  
Vitamin A Deficiency ◽  
Hospitalized Children ◽  
Immunoglobulin Level ◽  
Normal Ratio ◽  
The Relationship ◽  
Immunoglobulin Levels ◽  
Mycoplasma Pneumoniae Pneumonia

Mycoplasma pneumoniae pneumonia is a problem that has attracted the attention of children’s respiratory department in recent years. The relationship between vitamin A deficiency (VA) and the severity of Mycoplasma disease (MPP) in children was studied. In this paper, the hospitalized children with Mycoplasma pneumoniae pneumonia (MPP) in our hospital were selected as the research objects, and they were divided into common type and refractory type (RMPP) for comparative experiment. The VA and immunoglobulin levels of the two groups were compared. Attention should be paid to the normal ratio of VA deficiency (CVAD) and sub deficiency (svad) in the two groups. In this paper, the relationship between infection, immunoglobulin level and VA level was analyzed. The results showed that CVAD was 27.27% in MPP group and 63.75% in RMPP group. Comparison of immunoglobulin levels between the two groups: the levels of IgM, IgA and IgG in the normal MPP group were significantly lower than those in the RMPP group. On the other hand, the detection rate of CVAD was 81.48% in RMPP with infection and 54.72% in RMPP without infection. The detection rate of CVAD in patients with infection was significantly higher than that in patients without infection. There was a correlation between VA Deficiency and MPP classification.

scholarly journals Vitamin A deficiency is associated with severe Mycoplasma pneumoniae pneumonia in children

2020 ◽  
Vol 8 (4) ◽  
pp. 120-120 ◽  
Author(s):  
Yan Xing ◽  
Kai Sheng ◽  
Xiumei Xiao ◽  
Jiawei Li ◽  
Hongling Wei ◽  
...  
Keyword(s):  
Vitamin A ◽  
Mycoplasma Pneumoniae ◽  
Vitamin A Deficiency ◽  
Mycoplasma Pneumoniae Pneumonia

scholarly journals The effect of vitamin A deficiency on hepatic, renal and pulmonary glutathione S-transferase activities in the rat

1980 ◽  
Vol 188 (3) ◽  
pp. 889-893 ◽  
Author(s):  
Z H Siddik ◽  
E G Mimnaugh ◽  
M A Trush ◽  
T E Gram
Keyword(s):  
Vitamin A ◽  
Vitamin A Deficiency ◽  
Nutritional State ◽  
Glutathione S Transferase ◽  
Chemical Carcinogens ◽  
Deficient Diet ◽  
Liver Cytosol ◽  
Weanling Rats ◽  
Glutathione S Transferases ◽  
The Relationship

Feeding male weanling rats on a vitamin A-deficient diet for 6 weeks resulted in significant increases (44-57%) in glutathione S-aryl-, S-aralkyl- S-alkyl- and S-epoxidetransferase activities in the liver cytosol. Only the S-aralkyl- (27%) and S-alkyltransferase (14%) activities were significantly increased in the kidney as a result of deficiency. There was no effect on any of the pulmonary glutathione S-transferase activities. The increases in hepatic transferase activities were due primarily to increases (25-96%) in the apparent Vmax. There were no changes in the apparant Km of any of the four drug substrates employed. With 3,4-dichloronitrobenzene as the second substrate, the apparent Km for glutathione was increased by over 2-fold in vitamin A-deficient livers as compared with controls. The relationship between these results and enhanced susceptibility to chemical carcinogens in vitamin A deficiency is briefly discussed, and comparison is made between the effects of this nutritional state and pretreatment with drug inducers on the glutathione S-transferases.

scholarly journals Correlation between chest radiographic findings and clinical features in hospitalized children with Mycoplasma pneumoniae pneumonia

PLoS ONE ◽  
2019 ◽  
Vol 14 (8) ◽  
pp. e0219463 ◽  
Author(s):  
Yeon Jin Cho ◽  
Mi Seon Han ◽  
Woo Sun Kim ◽  
Eun Hwa Choi ◽  
Young Hun Choi ◽  
...  
Keyword(s):  
Clinical Features ◽  
Mycoplasma Pneumoniae ◽  
Hospitalized Children ◽  
Radiographic Findings ◽  
Mycoplasma Pneumoniae Pneumonia

scholarly journals The clinical significance of IL-6s and IL-27s in Bronchoalveolar lavage fluids from children with mycoplasma pneumoniae pneumonia

2020 ◽  
Author(s):  
Jie Zhao ◽  
Yuyun Li ◽  
Wen Zhang
Keyword(s):  
Bronchoalveolar Lavage ◽  
Mycoplasma Pneumoniae ◽  
Mixed Infection ◽  
Single Infection ◽  
Infection Group ◽  
Patient Groups ◽  
Infection Types ◽  
And Control ◽  
The Relationship ◽  
Mycoplasma Pneumoniae Pneumonia

Abstract Backgrounds: IL-6 is associated with the severity of mycoplasma pneumoniae pneumonia (MPP). But the relationship between IL-27 and MPP was unknown. Methods: 98 patients with MPP who were under 14 years old, were enrolled in this study and divided into mild cases and severe cases, Mycoplasma pneumoniae (MP) single infection group and MP mixed infection group, and low MP DNA loads group and high MP DNA loads group, by severity, infection types and DNA loads respectively. 15 children with foreign bodies for bronchus were also enrolled as control. IL-6s and IL-27s in bronchoalveolar lavage fluids (BALFs) from these children were measured by ELISA. Results: There were significant differences in IL-6s of BALFs from patients between mild cases and severe cases, MP single infection group and MP mixed infection group, and low MP DNA loads group and high MP DNA loads group, respectively (P﹤0.05). Compared with IL-6s of BALFs from control, IL-6 in BALFs from the 5 patient groups were significantly higher (P﹤0.05) except that from low MP DNA loads group. IL-27s in BALFs from MP mixed infection group were significantly lower than those from MP single infection group and control (P﹤0.05) respectively. Conclusion: IL-6 was firmly associated with MPP and had potential application in clinical practice while IL-27 was not related to MP infection.

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