Dynamic change of Mycoplasma pneumoniae pneumonia in hospitalized children in a general hospital: a 3-year retrospective analysis

Mycoplasma pneumoniae pneumonia is a problem that has attracted the attention of children’s respiratory department in recent years. The relationship between vitamin A deficiency (VA) and the severity of Mycoplasma disease (MPP) in children was studied. In this paper, the hospitalized children with Mycoplasma pneumoniae pneumonia (MPP) in our hospital were selected as the research objects, and they were divided into common type and refractory type (RMPP) for comparative experiment. The VA and immunoglobulin levels of the two groups were compared. Attention should be paid to the normal ratio of VA deficiency (CVAD) and sub deficiency (svad) in the two groups. In this paper, the relationship between infection, immunoglobulin level and VA level was analyzed. The results showed that CVAD was 27.27% in MPP group and 63.75% in RMPP group. Comparison of immunoglobulin levels between the two groups: the levels of IgM, IgA and IgG in the normal MPP group were significantly lower than those in the RMPP group. On the other hand, the detection rate of CVAD was 81.48% in RMPP with infection and 54.72% in RMPP without infection. The detection rate of CVAD in patients with infection was significantly higher than that in patients without infection. There was a correlation between VA Deficiency and MPP classification.

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Bacterial co-infection in hospitalized children with Mycoplasma pneumoniae pneumonia

Indian Pediatrics ◽

10.1007/s13312-016-0951-8 ◽

2016 ◽

Vol 53 (10) ◽

pp. 879-882 ◽

Cited By ~ 7

Author(s):

Qing Song ◽

Bao-Ping Xu ◽

Kun-Ling Shen

Keyword(s):

Mycoplasma Pneumoniae ◽

Hospitalized Children ◽

Mycoplasma Pneumoniae Pneumonia

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Mycoplasma pneumoniae pneumonia. Massive pulmonary involvement and pleural effusion

JAMA ◽

10.1001/jama.194.9.1010 ◽

1965 ◽

Vol 194 (9) ◽

pp. 1010-1011 ◽

Cited By ~ 1

Author(s):

H. G. Decancq

Keyword(s):

Pleural Effusion ◽

Mycoplasma Pneumoniae ◽

Pulmonary Involvement ◽

Mycoplasma Pneumoniae Pneumonia

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A Diagnostic Dilemma: PCR or Serology to Detect Mycoplasma Pneumoniae Pneumonia in Children

10.1542/peds.140.1_meetingabstract.39 ◽

2017 ◽

Author(s):

Cristina E. Figallo ◽

Liz Bayes ◽

Mariana Lanata ◽

Veronica Etinger

Keyword(s):

Mycoplasma Pneumoniae ◽

Diagnostic Dilemma ◽

Mycoplasma Pneumoniae Pneumonia

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Clinical, radiographic and hematological characteristics of Mycoplasma pneumoniae pneumonia

Jornal de Pediatria ◽

10.2223/jped.2044 ◽

2010 ◽

Vol 0 (0) ◽

Cited By ~ 1

Author(s):

Letícia Alves Vervloet ◽

Paulo Augusto Moreira Camargos ◽

Damião Ranulfo Fernandes Soares ◽

Gabriel Antônio de Oliveira ◽

Janúncio Nunes de Oliveira

Keyword(s):

Mycoplasma Pneumoniae ◽

Mycoplasma Pneumoniae Pneumonia

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Macrolide-Resistant and Macrolide-Sensitive Mycoplasma pneumoniae Pneumonia in Children Treated Using Early Corticosteroids

Journal of Clinical Medicine ◽

10.3390/jcm10061309 ◽

2021 ◽

Vol 10 (6) ◽

pp. 1309

Author(s):

Hye Young Han ◽

Ki Cheol Park ◽

Eun-Ae Yang ◽

Kyung-Yil Lee

Keyword(s):

Mycoplasma Pneumoniae ◽

Serological Test ◽

Corticosteroid Treatment ◽

23S Rrna ◽

Laboratory Parameters ◽

The Mean ◽

Domain V ◽

Positive Results ◽

Mycoplasma Pneumoniae Pneumonia

We have found that early corticosteroid therapy was effective for reducing morbidity during five Korea-wide epidemics. We evaluated the clinical and laboratory parameters of 56 children who received early corticosteroid treatment for pneumonia that was caused by macrolide-resistant Mycoplasma pneumoniae (M. pneumoniae) or macrolide-sensitive M. pneumoniae between July 2019 and February 2020. All subjects had dual positive results from a PCR assay and serological test, and received corticosteroids within 24–36 h after admission. Point mutation of residues 2063, 2064, and 2067 was identified in domain V of 23S rRNA. The mean age was 6.8 years and the male:female ratio was 1.2:1 (31:25 patients). Most of the subjects had macrolide-resistant M. pneumoniae (73%), and all mutated strains had the A2063G transition. No significant differences in clinical and laboratory parameters were observed between macrolide-resistant and macrolide-sensitive M. pneumoniae groups that were treated with early dose-adjusted corticosteroids. Higher-dose steroid treatment may be needed for patients who have fever that persists for >48 h or increased biomarkers such as lactate dehydrogenase concentration at follow-up despite a usual dose of steroid therapy.

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