Application Value of Combined Detection of Serum IGF-I and IGFBP-3 in the Diagnosis of Bladder Cancer

Objective. To investigate the application value of the combined detection of serum IGF-I and IGFBP-3 in the diagnosis of bladder cancer (BC). Methods.Sixty BC patients in our hospital (January 2019-January 2020) were chosen as group A, while sixty healthy people during the same period were chosen as group B. The serum IGF-I and IGFBP-3 levels of the subjects were detected to explore the relationship between the two levels (serum IGF-I and IGFBP-3) and BC.Results.Compared with group B, the two levelsof group A were lower while IGF-l/IGFBP-3 was higher. Compared with low-grade BC group, non-muscle invasive BC (NMIBC) group and non-lymph node metastasis group, the two levels were lower in high-grade BC group, muscle-invasive BC (MIBC) group and lymph node metastasis group (P<0.05). No notable difference in IGF-l/IGFBP-3 was found among patients with high-grade or low-grade BC, with or without lymph node metastasis, andwith or without muscular invasion (P>0.05). Conclusion. The serum IGF-I and IGFBP-3 levels of BC patients are obviously different compared with healthy people, and vary in patients with different types of BC, indicating the two factors can be applied in clinical diagnosic of BC.

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Sentinel node theory helps tracking of primary lesions of cancers of unknown primary

10.21203/rs.2.23792/v1 ◽

2020 ◽

Author(s):

Yilin Shao ◽

Xin Liu ◽

Silong Hu ◽

Yingjian Zhang ◽

Wentao Li ◽

...

Keyword(s):

Lymph Node ◽

Lymph Node Metastasis ◽

Sentinel Node ◽

Lesion Group ◽

Unknown Primary ◽

Suspicious Lesion ◽

Node Metastasis ◽

Group A ◽

Group B ◽

Fdg Pet Ct

Abstract Background: Sentinel lymph node is the first stop of lymphatic spreading of cancer with known primary. The lymph node metastasis pattern of cancer of unknown primary (CUP) is unclear and has been presumed to follow the same pathway. To test this hypothesis, data of all 716 patients clinically diagnosed as CUP in our center were collected.Methods: Diagnoses of lymph node metastasis were established by 18F-FDG PET-CT and/or biopsy pathology. Three hundred and forty-seven cases meeting the criteria were divided into three groups: pathology-confirmed primary with invasive biopsy or surgery of the suspicious lesion (group A, n=64), primary still unknown even with invasive biopsy or surgery of the suspicious lesion (group B, n=204), and others with no suspicious lesion or lesions who had not been sampled due to medical or other reasons (group C, n=79). We assessed the clinicopathological features between these groups, and the relationship between lymph node metastasis pattern and confirmed primary site. Results: In group A, the primary sites of 61 cases were compatible with sentinel node theory, resulting in a positive predictive value of 95%. No significant differences in age, sex, bone metastasis, or visceral metastasis observed between group A and group B, except that group A had a higher ratio of differentiated carcinoma (94% vs. 77%, P=0.003). Conclusion: To our knowledge, this is the first evidence indicating that the majority of clinical CUP cases follow the sentinel node theory to spread in lymph nodes, which helps tracking the primary, especially for differentiated carcinoma.

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A Prediction Model of Endometrial Cancer Lesion Metastasis under Region of Interest Target Detection Algorithm

Scientific Programming ◽

10.1155/2021/9928842 ◽

2021 ◽

Vol 2021 ◽

pp. 1-7

Author(s):

Yuquan Xu ◽

Renfeng Zhao

Keyword(s):

Endometrial Cancer ◽

Lymph Node ◽

Lymph Node Metastasis ◽

Prediction Model ◽

Target Detection ◽

Region Of Interest ◽

Detection Algorithm ◽

Node Metastasis ◽

Group A ◽

Group B

The predictive values of region of interest (ROI) target detection algorithm-based radiomics for endometrial cancer (EC) lymph node metastasis was investigate in this work. 143 patients with EC admitted by hospital were selected as the research objects and divided randomly into a training group (group A) and a test group (group B). They received preoperative pelvic-enhanced magnetic resonance imaging (MRI) scanning. The ROI algorithm was applied to extract features to construct an EC lymph node radiomics model that was compared with a comprehensive prediction model of EC lymph node. The receiver operating characteristic (ROC) curve was employed to evaluate the diagnostic efficiency of the radiomic model and comprehensive predictive model. Results showed that both the radiomics model (area under the curve (AUC) of group A = 0.875 and AUC of group B = 0.882) and comprehensive prediction model (AUC of group A = 0.917 and AUC of group B = 0.893) had good predictive effects, and effect of the latter was markedly better than that of the former. It indicated that radiomics parameters of ROI target detection algorithm were effective markers for preoperative prediction of EC lymph node metastasis, and its comprehensive prediction model could play a guiding role in clinical decision-making.

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Highlights of 15th Biennial Congress of the Asian Association of Endocrine Surgeons, April 2016

World Journal of Endocrine Surgery ◽

10.5005/wjoes-8-1-128 ◽

2016 ◽

Vol 8 (1) ◽

pp. 128-131

Author(s):

Inhye Park ◽

Nayoon Her ◽

Jun-Ho Choe ◽

Jung-Han Kim ◽

Jee Soo Kim

Keyword(s):

Lymph Node ◽

Lymph Node Metastasis ◽

Central Neck Dissection ◽

Central Neck ◽

Clinicopathologic Characteristics ◽

Node Metastasis ◽

Prophylactic Central Neck Dissection ◽

Group A ◽

Group B

ABSTRACT BACKGROUND AND AIMS The efficacy of prophylactic central neck dissection (pCND) in patients with papillary thyroid carcinoma (PTC) is still unclear. The aim of this prospective randomized controlled study was to evaluate the clinical strengths and weaknesses of pCND. METHODS Between May 2009 and September 2015, a total of 1,134 patients with clinical N0 PTC were randomly assigned to two groups. Group A was treated with thyroidectomy alone and group B was treated with thyroidectomy + pCND. When the surgeon detected extrathyroidal extension or suspicious lymph nodes during the operation, frozen biopsy was performed to confirm the metastasis and the patients were excluded. We analyzed the clinicopathologic characteristics, postoperative complications, and recurrence. RESULTS Of the 1,134 patients, 110 were excluded because they had evidence of either capsular invasion or lymph node metastasis proven by frozen biopsy during the operation (rate of dropout: 9.7%). A total of 1,024 patients were included, 504 patients in group A and 520 patients in group B. In group B, 67 patients had ipsilateral central lymph node metastasis in frozen biopsy that were converted to total thyroidectomy. Clinicopathologic characteristics of the two groups were not significantly different. The median follow-up period was 20 months (1–77 months). Recurrence was detected in three patients (0.3%) in the lateral lymph node. Disease-free survival was not statistically significantly different between the two groups (p = 0.561). However, the incidence of temporary hypoparathyroidism in group B was significantly higher than that in group A (group A: 13.1%, group B: 20.8%, p = 0.001), while the permanent hypoparathyroidism, vocal cord palsy, chyle leakage, bleeding, and wound infection were similar between groups A and B. CONCLUSION Prophylactic central neck dissection did not reduce locoregional recurrence in clinical N0 PTC, but it significantly increased the incidence of transient hypoparathyroidism. But the assessment of effectiveness of pCND in reducing recurrence and mortality requires a long-term follow-up.

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Case Report: Rare Pulmonary Sclerosing Pneumocytoma: Large, Multiple, Metastatic, and Fatal

Frontiers in Medicine ◽

10.3389/fmed.2021.661032 ◽

2021 ◽

Vol 8 ◽

Author(s):

Weidong Zhang ◽

Yuanyuan Liu ◽

Yamei Chai ◽

Kefeng Shi ◽

Jialing Chen ◽

...

Keyword(s):

Case Report ◽

Lymph Node ◽

Lymph Node Metastasis ◽

Malignant Tumor ◽

Abdominal Cavity ◽

Low Grade ◽

Node Metastasis ◽

Multiple Lesions ◽

Extra Pulmonary ◽

First Time

Pulmonary sclerosing pneumocytoma (PSP) is a rare benign or low-grade malignant tumor, but it has the potential to present with multiple lesions, lymph node metastasis, extra-pulmonary metastasis, recurrence and even cause death. Herein, a case of PSP that was huge, presented with multiple lesions and had lymph node as well as extrapulmonary metastases (liver, abdominal cavity, bones) is reported for the first time. This patient was also the first one to die of respiratory and circulatory failure caused by the PSP tumor and its metastases which compressed the mediastinal tissue.

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