scholarly journals Sentinel node theory helps tracking of primary lesions of cancers of unknown primary

2020 ◽  
Author(s):  
Yilin Shao ◽  
Xin Liu ◽  
Silong Hu ◽  
Yingjian Zhang ◽  
Wentao Li ◽  
...  
Keyword(s):  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Sentinel Node ◽  
Lesion Group ◽  
Unknown Primary ◽  
Suspicious Lesion ◽  
Node Metastasis ◽  
Group A ◽  
Group B ◽  
Fdg Pet Ct

Abstract Background: Sentinel lymph node is the first stop of lymphatic spreading of cancer with known primary. The lymph node metastasis pattern of cancer of unknown primary (CUP) is unclear and has been presumed to follow the same pathway. To test this hypothesis, data of all 716 patients clinically diagnosed as CUP in our center were collected.Methods: Diagnoses of lymph node metastasis were established by 18F-FDG PET-CT and/or biopsy pathology. Three hundred and forty-seven cases meeting the criteria were divided into three groups: pathology-confirmed primary with invasive biopsy or surgery of the suspicious lesion (group A, n=64), primary still unknown even with invasive biopsy or surgery of the suspicious lesion (group B, n=204), and others with no suspicious lesion or lesions who had not been sampled due to medical or other reasons (group C, n=79). We assessed the clinicopathological features between these groups, and the relationship between lymph node metastasis pattern and confirmed primary site. Results: In group A, the primary sites of 61 cases were compatible with sentinel node theory, resulting in a positive predictive value of 95%. No significant differences in age, sex, bone metastasis, or visceral metastasis observed between group A and group B, except that group A had a higher ratio of differentiated carcinoma (94% vs. 77%, P=0.003). Conclusion: To our knowledge, this is the first evidence indicating that the majority of clinical CUP cases follow the sentinel node theory to spread in lymph nodes, which helps tracking the primary, especially for differentiated carcinoma.

Application Value of Combined Detection of Serum IGF-I and IGFBP-3 in the Diagnosis of Bladder Cancer

2021 ◽  
Vol 7 (5) ◽  
pp. 3942-3947
Author(s):  
Xu-Dong Li ◽  
Sen Wei ◽  
Lei Wang
Keyword(s):  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Low Grade ◽  
Node Metastasis ◽  
Igf I ◽  
Group A ◽  
Muscle Invasive ◽  
Group B ◽  
Combined Detection ◽  
Igfbp 3

Objective. To investigate the application value of the combined detection of serum IGF-I and IGFBP-3 in the diagnosis of bladder cancer (BC). Methods.Sixty BC patients in our hospital (January 2019-January 2020) were chosen as group A, while sixty healthy people during the same period were chosen as group B. The serum IGF-I and IGFBP-3 levels of the subjects were detected to explore the relationship between the two levels (serum IGF-I and IGFBP-3) and BC.Results.Compared with group B, the two levelsof group A were lower while IGF-l/IGFBP-3 was higher. Compared with low-grade BC group, non-muscle invasive BC (NMIBC) group and non-lymph node metastasis group, the two levels were lower in high-grade BC group, muscle-invasive BC (MIBC) group and lymph node metastasis group (P<0.05). No notable difference in IGF-l/IGFBP-3 was found among patients with high-grade or low-grade BC, with or without lymph node metastasis, andwith or without muscular invasion (P>0.05). Conclusion. The serum IGF-I and IGFBP-3 levels of BC patients are obviously different compared with healthy people, and vary in patients with different types of BC, indicating the two factors can be applied in clinical diagnosic of BC.

scholarly journals A Prediction Model of Endometrial Cancer Lesion Metastasis under Region of Interest Target Detection Algorithm

2021 ◽  
Vol 2021 ◽  
pp. 1-7
Author(s):  
Yuquan Xu ◽  
Renfeng Zhao
Keyword(s):  
Endometrial Cancer ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Prediction Model ◽  
Target Detection ◽  
Region Of Interest ◽  
Detection Algorithm ◽  
Node Metastasis ◽  
Group A ◽  
Group B

The predictive values of region of interest (ROI) target detection algorithm-based radiomics for endometrial cancer (EC) lymph node metastasis was investigate in this work. 143 patients with EC admitted by hospital were selected as the research objects and divided randomly into a training group (group A) and a test group (group B). They received preoperative pelvic-enhanced magnetic resonance imaging (MRI) scanning. The ROI algorithm was applied to extract features to construct an EC lymph node radiomics model that was compared with a comprehensive prediction model of EC lymph node. The receiver operating characteristic (ROC) curve was employed to evaluate the diagnostic efficiency of the radiomic model and comprehensive predictive model. Results showed that both the radiomics model (area under the curve (AUC) of group A = 0.875 and AUC of group B = 0.882) and comprehensive prediction model (AUC of group A = 0.917 and AUC of group B = 0.893) had good predictive effects, and effect of the latter was markedly better than that of the former. It indicated that radiomics parameters of ROI target detection algorithm were effective markers for preoperative prediction of EC lymph node metastasis, and its comprehensive prediction model could play a guiding role in clinical decision-making.

Highlights of 15th Biennial Congress of the Asian Association of Endocrine Surgeons, April 2016

2016 ◽  
Vol 8 (1) ◽  
pp. 128-131
Author(s):  
Inhye Park ◽  
Nayoon Her ◽  
Jun-Ho Choe ◽  
Jung-Han Kim ◽  
Jee Soo Kim
Keyword(s):  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Central Neck Dissection ◽  
Central Neck ◽  
Clinicopathologic Characteristics ◽  
Node Metastasis ◽  
Prophylactic Central Neck Dissection ◽  
Group A ◽  
Group B

ABSTRACT BACKGROUND AND AIMS The efficacy of prophylactic central neck dissection (pCND) in patients with papillary thyroid carcinoma (PTC) is still unclear. The aim of this prospective randomized controlled study was to evaluate the clinical strengths and weaknesses of pCND. METHODS Between May 2009 and September 2015, a total of 1,134 patients with clinical N0 PTC were randomly assigned to two groups. Group A was treated with thyroidectomy alone and group B was treated with thyroidectomy + pCND. When the surgeon detected extrathyroidal extension or suspicious lymph nodes during the operation, frozen biopsy was performed to confirm the metastasis and the patients were excluded. We analyzed the clinicopathologic characteristics, postoperative complications, and recurrence. RESULTS Of the 1,134 patients, 110 were excluded because they had evidence of either capsular invasion or lymph node metastasis proven by frozen biopsy during the operation (rate of dropout: 9.7%). A total of 1,024 patients were included, 504 patients in group A and 520 patients in group B. In group B, 67 patients had ipsilateral central lymph node metastasis in frozen biopsy that were converted to total thyroidectomy. Clinicopathologic characteristics of the two groups were not significantly different. The median follow-up period was 20 months (1–77 months). Recurrence was detected in three patients (0.3%) in the lateral lymph node. Disease-free survival was not statistically significantly different between the two groups (p = 0.561). However, the incidence of temporary hypoparathyroidism in group B was significantly higher than that in group A (group A: 13.1%, group B: 20.8%, p = 0.001), while the permanent hypoparathyroidism, vocal cord palsy, chyle leakage, bleeding, and wound infection were similar between groups A and B. CONCLUSION Prophylactic central neck dissection did not reduce locoregional recurrence in clinical N0 PTC, but it significantly increased the incidence of transient hypoparathyroidism. But the assessment of effectiveness of pCND in reducing recurrence and mortality requires a long-term follow-up.

scholarly journals The impact of 18F-FDG PET/CT in the clinical management of patients with lymph node metastasis of unknown primary origin

Neoplasma ◽  
2020 ◽  
Author(s):  
Petya Nikolaeva Nikolova ◽  
Valeria Hristova Hadzhiyska ◽  
Kiril Blagoev Mladenov ◽  
Mihaela Georgieva Ilcheva ◽  
Stefani Veneva ◽  
...  
Keyword(s):  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Unknown Primary ◽  
Node Metastasis ◽  
Pet Ct ◽  
Primary Origin ◽  
18F Fdg ◽  
Fdg Pet Ct ◽  
The Impact ◽  
Unknown Primary Origin

Sentinel Node Biopsy: Interpretation and Management of Patients With Immunohistochemistry-Positive Sentinel Nodes and Those With Micrometastases

2008 ◽  
Vol 26 (5) ◽  
pp. 698-702 ◽  
Author(s):  
Emiel J.T. Rutgers
Keyword(s):  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Sentinel Node ◽  
Tumor Cells ◽  
Clinical Decision Making ◽  
Prognostic Significance ◽  
Axillary Lymph ◽  
Isolated Tumor Cells ◽  
Sentinel Nodes ◽  
Node Metastasis

The sentinel node procedure is an adequate tool to identify lymph node metastasis in breast cancer. Sentinel nodes are generally examined with greater attention mainly to exclude, as reliably as possible, lymph node metastasis. To achieve this, many protocols are used, resulting in different rates of micrometastasis or isolated tumor cells encountered. Since the prognostic significance of isolated tumor cells or micrometastasis in the sentinel nodes, and the risk of further axillary lymph node involvement in patients with isolated tumor cells, is uncertain and at most limited, these findings may pose difficulties for clinicians in clinical decision making. Protocols that identify lymph node metastasis, from which the clinical relevance is known, are warranted. Unnecessary lymph node dissections should be avoided.

scholarly journals Erratum to: Advantages of FDG-PET/CT over CT alone in the preoperative assessment of lymph node metastasis in patients with esophageal cancer

Surgery Today ◽  
2015 ◽  
Vol 45 (4) ◽  
pp. 478-478
Author(s):  
Ryuichi Karashima ◽  
Masayuki Watanabe ◽  
Yu Imamura ◽  
Satoshi Ida ◽  
Yoshifumi Baba ◽  
...  
Keyword(s):  
Esophageal Cancer ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Fdg Pet ◽  
Preoperative Assessment ◽  
Node Metastasis ◽  
Pet Ct ◽  
Fdg Pet Ct

scholarly journals Correlation of coagulation markers with axillary lymph node metastasis in breast malignancy: a tertiary care centre study in North India

2020 ◽  
Vol 7 (4) ◽  
pp. 1045
Author(s):  
Vaibhav Srivastava ◽  
Nandan Rai ◽  
Shabi Ahmad ◽  
Vikram Singh ◽  
Shirish Kumar
Keyword(s):  
Breast Cancer ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Factor Viii ◽  
Sentinel Node ◽  
Factor Vii ◽  
Carcinoma Breast ◽  
Node Metastasis ◽  
Node Biopsy ◽  
D Dimer

Background: Breast cancer is the most common female cancer worldwide representing nearly a quarter (25%) of all cancers. Search for a marker which can predict lymph node metastasis in clinically negative axilla has been a matter of research for long. The present study is an attempt to evaluate role of coagulation makers with special reference to D-dimer and factor 7 and 8 in patients of carcinoma breast in predicting lymph node metastasis in carcinoma patients.Methods: The study was a prospective study conducted in 50 diagnosed patients of carcinoma breast in whom D dimer levels and factor 7 and 8 levels were measured at the time of commencement of the treatment and at six weeks after surgery.Results: Most of the patients in the study group were in the age group 41-70 (80%) years. 22% patients were of early Breast cancer. The reduction in D-dimer, factor VII and factor VIII value after 6 weeks of surgery were significant (p value 0.0001 for all three).Conclusions: D-dimer and factor VII were found to be an independent predictive factor for lymph node metastatsis, thus providing as a safe, easy, objective and convenient supplement to sentinel node biopsy in assessing metastatic disease in axilla. Combined- with other biomarkers, it may prove to be an alternative to sentinel node biopsy in assessing metastatic disease in axilla. Significant postoperative decrease in D-dimer, factor VII and factor VIII may provide objective criteria to assess completion of surgery.

scholarly journals Combination of FDG PET/CT and Contrast-Enhanced MSCT in Detecting Lymph Node Metastasis of Esophageal Cancer

2014 ◽  
Vol 15 (18) ◽  
pp. 7719-7724 ◽  
Author(s):  
Ru Tan ◽  
Shu-Zhan Yao ◽  
Zhao-Qin Huang ◽  
Jun Li ◽  
Xin Li ◽  
...  
Keyword(s):  
Esophageal Cancer ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Fdg Pet ◽  
Node Metastasis ◽  
Contrast Enhanced ◽  
Pet Ct ◽  
Fdg Pet Ct
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