scholarly journals Thionylchloride Catalyzed Aldol Condensation: Synthesis, Spectral Correlation and Antibacterial Activities of some 3,5-Dichloro-2-Hydroxyphenyl Chalcones

2013 ◽  
Vol 4 ◽  
pp. 17-38 ◽  
Author(s):  
R. Arulkumaran ◽  
S. Vijayakumar ◽  
R. Sundararajan ◽  
S.P. Sakthinathan ◽  
D. Kamalakkannan ◽  
...  
Keyword(s):  
Statistical Analysis ◽  
Thionyl Chloride ◽  
Spectroscopic Data ◽  
Aldol Condensation ◽  
Aldol Reaction ◽  
Antibacterial Activities ◽  
Spectral Correlation ◽  
Effect Of Substituents ◽  
Substituent Constants

A series of substituted styryl 3,5-dichloro-2-hydroxyphenyl ketones [1-(3,5-dichloro-2-hydroxy)-3-phenylprop-2-en-1-one] were synthesized using thionyl chloride assisted Crossed-Aldol reaction. The yields of chalcones were more than 80%. The synthesized chalcones were characterized by analytical and spectroscopic data. From the spectroscopic data the group frequencies were correlated with Hammett substituent constants, F and R parameters. From the results of statistical analysis the effect of substituents were discussed. The antibacterial activities of these chalcones have been evaluated using Bauer-Kirby method.

scholarly journals Spectral Correlations in some Substituted Styryl (E)-4-((2-Oxopropyl)Diazenyl) Benzoic Acids

2014 ◽  
Vol 30 ◽  
pp. 33-43
Author(s):  
V. Sathiyendiran ◽  
K.G. Sekar ◽  
Ganesamoorthy Thirunarayanan ◽  
R. Arulkumaran ◽  
R. Sundararajan ◽  
...  
Keyword(s):  
Regression Analysis ◽  
Statistical Analysis ◽  
Linear Regression ◽  
Linear Regression Analysis ◽  
Benzoic Acids ◽  
Effect Of Substituents ◽  
Substituent Constants ◽  
Multi Linear Regression ◽  
Spectral Group

A series of titled compounds were prepared and analyzed their purities by literature method. The infrared and NMR spectral group frequencies of the compounds were assigned and correlated with Hammett substituent constants, F and R constants using single and multi linear regression analysis. From the results of statistical analysis, the effect of substituents on the above spectral frequencies was discussed.

scholarly journals Structure Parameter Correlation of some Quinoxaline Derivatives through IR and 13C NMR Spectra

2014 ◽  
Vol 38 ◽  
pp. 198-207 ◽  
Author(s):  
Ganesamoorthy Thirunarayanan ◽  
I. Muthuvel ◽  
V. Sathiyendiran
Keyword(s):  
Regression Analysis ◽  
Statistical Analysis ◽  
Spectral Data ◽  
Nmr Spectra ◽  
Structure Parameter ◽  
Effect Of Substituents ◽  
Parameter Correlation ◽  
Quinoxaline Derivatives ◽  
Substituent Constants ◽  
C Nmr

A series of 6-substituted quanoxaline derivatives have been synthesized and examined their purities by literature method. The infrared and 13C NMR spectral data of these quinoxalines were correlated with Hammett substituent constants, F and R parameters using single and multi-regression analysis. From the results of statistical analysis, the effect of substituents on the spectral frequencies has been studied.

scholarly journals Spectral QSAR and QPR Study of some (E)-4-(((2-Hydroxy-6-(Substituted Phenyl)-1,6 Dihydropyrimidin-4-yl)Methyl)Diazenyl)Benzoic Acid Derivatives

2014 ◽  
Vol 36 ◽  
pp. 10-20
Author(s):  
Ganesamoorthy Thirunarayanan ◽  
K.G. Sekar
Keyword(s):  
Statistical Analysis ◽  
Benzoic Acid ◽  
Nmr Spectra ◽  
Effect Of Substituents ◽  
Benzoic Acid Derivatives ◽  
Substituent Constants ◽  
Spectral Group

A series of titled compounds were synthesized and recorded the infrared and NMR spectra. The assigned spectral group frequencies were correlated with Hammett substituent constants, F and R parameter. From the statistical analysis results, the effect of substituents on the spectral group frequencies has been studied.

scholarly journals Effect of Substituents on Phenazine Derivatives by Spectral Studies

2015 ◽  
Vol 48 ◽  
pp. 114-122
Author(s):  
G. Thirunarayanan ◽  
I. Muthuvel ◽  
V. Sathiyendiran
Keyword(s):  
Regression Analysis ◽  
Statistical Analysis ◽  
Spectral Data ◽  
Chemical Shifts ◽  
Spectral Studies ◽  
Nmr Chemical Shifts ◽  
Effect Of Substituents ◽  
Substituent Constants ◽  
Infrared Frequencies ◽  
C Nmr

A series of eleven substituted dipyrido[3,2-a; 2′,3′-c]phenazine derivatives have been synthesized and examined their purities by literature method. The infrared and 13C NMR spectral data of prepared phenazines were correlated with Hammett substituent constants, F and R parameters using single and multi-regression analysis. From the results of statistical analysis, the effect of substituents on the infrared frequencies (ν, cm-1) and 13C nmr chemical shifts(δ, ppm) has been studied.

scholarly journals Synthesis and Spectral Studies of some N-[(E)-Phenylmethylidene]benzenesulfonamides

2013 ◽  
Vol 13 ◽  
pp. 249-258
Author(s):  
K.G. Sekar ◽  
Ganesamoorthy Thirunarayanan
Keyword(s):  
Regression Analysis ◽  
Statistical Analysis ◽  
Linear Regression ◽  
Microwave Irradiation ◽  
Spectroscopic Data ◽  
Linear Regression Analysis ◽  
Solvent Free ◽  
Spectral Studies ◽  
Solvent Free Conditions ◽  
Substituent Constants

A series of some N-[(E)-phenylmethylidene]benzenesulfonamide derivatives have been synthesised using solid SiO2-H3PO4 catalyst under solvent free conditions in microwave irradiation. The synthesised E-N-benzene sulfonilimines purities have been verified by their physical constants and spectroscopic data. The spectral frequencies are correlated with Hammett substituent constants, F and R parameters using linear regression analysis. From the results of statistical analysis the effect of substituents on the group frequencies will be discussed.

An efficient click synthesis of chalcones derivatized with two 1-(2-quinolon-4-yl)-1,2,3-triazoles

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Mohammed B. Alshammari ◽  
Ashraf A. Aly ◽  
Alan B. Brown ◽  
Md Afroz Bakht ◽  
Ahmed M. Shawky ◽  
...  
Keyword(s):  
Aldol Condensation ◽  
Aldol Reaction ◽  
Click Synthesis

Abstract Chalcones derivatized with 1-(2-quinolonyl)-1,2,3-triazoles were synthesized by reaction of 4-azido-2-quinolones with 1-phenyl-3-(4-propargyloxyphenyl)prop-2-en-1-one, or by aldol reaction of 4-{[1-(2-oxo-1,2-dihydroquinolin-4-yl)-1H-1,2,3-triazol-4-yl]methoxy}benzaldehydes with acetophenone. Whereas, chalcones bearing two 1-(2-quinolonyl)-1,2,3-triazoles were synthesized by reaction of 1,3-bis(4-propargyloxyphenyl)prop-2-en-1-one with 4-azido-2-quinolones, or by aldol condensation between 4-{4-[(4-acetylphenoxy)methyl]-1H-1,2,3-triazol-1-yl}quinolin-2(1H)-ones and 4-{[1-(2-oxo-1,2-dihydroquinolin-4-yl)-1H-1,2,3-triazol-4-yl]methoxy}benzaldehydes.

scholarly journals Five-membered ring annelation in [2.2]paracyclophanes by aldol condensation

2014 ◽  
Vol 10 ◽  
pp. 2021-2026 ◽  
Author(s):  
Henning Hopf ◽  
Swaminathan Vijay Narayanan ◽  
Peter G Jones
Keyword(s):  
Structural Analysis ◽  
Spectroscopic Data ◽  
Acid Treatment ◽  
Aldol Condensation ◽  
Membered Ring ◽  
X Ray

Under basic conditions 4,5,12,13-tetraacetyl[2.2]paracyclophane (9) cyclizes by a double aldol condensation to provide the two aldols 12 and 15 in a 3:7 ratio. The structures of these compounds were obtained from X-ray structural analysis, spectroscopic data, and mechanistic considerations. On acid treatment 12 is dehydrated to a mixture of the condensed five-membered [2.2]paracyclophane derivatives 18–20, whereas 15 yields a mixture of the isomeric cyclopentadienones 21–23. The structures of these elimination products are also deduced from X-ray and spectroscopic data. The sequence presented here constitutes the simplest route so far to cyclophanes carrying an annelated five-membered ring.

scholarly journals An Antibacterial Isovaleronitrile Diglycoside From Detarium microcarpum Guill. Perr. (Fabaceae)

2020 ◽  
Vol 15 (7) ◽  
pp. 1934578X2093693
Author(s):  
William F. Feudjou ◽  
Arnaud M. Mbock ◽  
Marlyse B. W. Ouahouo ◽  
Valérie T. Sielinou ◽  
Racéline K. Gounoue ◽  
...  
Keyword(s):  
Spectroscopic Data ◽  
Salmonella Enteritidis ◽  
Methanolic Extract ◽  
Antibacterial Activities ◽  
Salmonella Typhi ◽  
Methyl Gallate ◽  
Extensive Analysis ◽  
Detarium Microcarpum ◽  
Inhibition Concentration ◽  
C Nmr

A new isovaleronitrile diglycoside, named microcarposide (1), together with 6 known compounds: lupeol (2), betulinic acid (3), β-sitosterol glucoside (4), methyl gallate (5), luteolin (6), and epicatechin (7), was isolated from the methanolic extract of the fruits of Detarium microcarpum Guill. Perr. The structures of the compounds were determined by extensive analysis of 1D- and 2D-1H and 13C NMR spectroscopic data in conjunction with mass spectrometry and by comparison with data reported in the literature. Compound 1 was characterized as (2 R)-2-[(6″- O-β-l-rhamnopyranosyl-β-d-glucopyranosyl)oxy]-3-methylbutanenitrile. Some of the isolated compounds were evaluated for their antibacterial activities against several microorganisms; only compound 1 was active against Salmonella typhi, Salmonella enteritidis, and Salmonella typhimurium with minimum inhibition concentration values of 153.4, 76.7, and 76.7 μM, respectively.

scholarly journals Antimosquito and Antimicrobial Clerodanoids and a Chlorobenzenoid from Tessmannia species

2010 ◽  
Vol 5 (2) ◽  
pp. 1934578X1000500
Author(s):  
Charles Kihampa ◽  
Mayunga H.H. Nkunya ◽  
Cosam C. Joseph ◽  
Stephen M. Magesa ◽  
Ahmed Hassanali ◽  
...  
Keyword(s):  
Spectroscopic Data ◽  
Antibacterial Activities ◽  
Clerodane Diterpenoids

The clerodane diterpenoids trans-kolavenolic acid, 18-oxocleroda-3,13(E)-dien-15-oic acid, ent-(18-hydroxycarbonyl)-cleroda-3,13(E)-dien-15-oate, 2-oxo-ent-cleroda-3,13(Z)-dien-15-oic acid and trans-2-oxo-ent-cleroda-13(Z)-en-15-oic acid, and the chlorobenzenoid O-(3-hydroxy-4-hydroxycarbonyl-5-pentylphenyl)-3-chloro-4-methoxy-6-pentyl-2-oxybenzoic acid were isolated from Tessmannia martiniana var pauloi and T. martiniana var matiniana. Structures were established based on interpretation of spectroscopic data. Some of the compounds exhibited significant antimosquito, antifungal and antibacterial activities.

The Aldol Condensation of Acetaldehyde: the Equilibrium Constant for the Reaction and the Rate Constant for the Hydroxide Catalyzed RetroAldol Reaction

1974 ◽  
Vol 52 (11) ◽  
pp. 2037-2040 ◽  
Author(s):  
J. Peter Guthrie
Keyword(s):  
Equilibrium Constant ◽  
Rate Constant ◽  
Aldol Condensation ◽  
Aldol Reaction ◽  
Enthalpy Change

An indirect thermochemical estimate of the equilibrium constant for the aldol condensation of acetaldehyde suggested that this reaction was much less irreversible than has been believed. The rate of the hydroxide catalyzed retroaldol reaction has been measured; k21 = 2.8 × 10−3 M−1 s−1 at 25°, so that the equilibrium constant is 4.0 × 102 M−1. The γ value for acetaldehyde as addend is 0.40. The enthalpy change for the aldol reaction is −9.84 kcal/mol.

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