scholarly journals Antimosquito and Antimicrobial Clerodanoids and a Chlorobenzenoid from Tessmannia species

2010 ◽  
Vol 5 (2) ◽  
pp. 1934578X1000500
Author(s):  
Charles Kihampa ◽  
Mayunga H.H. Nkunya ◽  
Cosam C. Joseph ◽  
Stephen M. Magesa ◽  
Ahmed Hassanali ◽  
...  
Keyword(s):  
Spectroscopic Data ◽  
Antibacterial Activities ◽  
Clerodane Diterpenoids

The clerodane diterpenoids trans-kolavenolic acid, 18-oxocleroda-3,13(E)-dien-15-oic acid, ent-(18-hydroxycarbonyl)-cleroda-3,13(E)-dien-15-oate, 2-oxo-ent-cleroda-3,13(Z)-dien-15-oic acid and trans-2-oxo-ent-cleroda-13(Z)-en-15-oic acid, and the chlorobenzenoid O-(3-hydroxy-4-hydroxycarbonyl-5-pentylphenyl)-3-chloro-4-methoxy-6-pentyl-2-oxybenzoic acid were isolated from Tessmannia martiniana var pauloi and T. martiniana var matiniana. Structures were established based on interpretation of spectroscopic data. Some of the compounds exhibited significant antimosquito, antifungal and antibacterial activities.

scholarly journals An Antibacterial Isovaleronitrile Diglycoside From Detarium microcarpum Guill. Perr. (Fabaceae)

2020 ◽  
Vol 15 (7) ◽  
pp. 1934578X2093693
Author(s):  
William F. Feudjou ◽  
Arnaud M. Mbock ◽  
Marlyse B. W. Ouahouo ◽  
Valérie T. Sielinou ◽  
Racéline K. Gounoue ◽  
...  
Keyword(s):  
Spectroscopic Data ◽  
Salmonella Enteritidis ◽  
Methanolic Extract ◽  
Antibacterial Activities ◽  
Salmonella Typhi ◽  
Methyl Gallate ◽  
Extensive Analysis ◽  
Detarium Microcarpum ◽  
Inhibition Concentration ◽  
C Nmr

A new isovaleronitrile diglycoside, named microcarposide (1), together with 6 known compounds: lupeol (2), betulinic acid (3), β-sitosterol glucoside (4), methyl gallate (5), luteolin (6), and epicatechin (7), was isolated from the methanolic extract of the fruits of Detarium microcarpum Guill. Perr. The structures of the compounds were determined by extensive analysis of 1D- and 2D-1H and 13C NMR spectroscopic data in conjunction with mass spectrometry and by comparison with data reported in the literature. Compound 1 was characterized as (2 R)-2-[(6″- O-β-l-rhamnopyranosyl-β-d-glucopyranosyl)oxy]-3-methylbutanenitrile. Some of the isolated compounds were evaluated for their antibacterial activities against several microorganisms; only compound 1 was active against Salmonella typhi, Salmonella enteritidis, and Salmonella typhimurium with minimum inhibition concentration values of 153.4, 76.7, and 76.7 μM, respectively.

scholarly journals Antibacterial Meroterpenoids, Merochlorins G–J from the Marine Bacterium Streptomyces sp.

Marine Drugs ◽  
2021 ◽  
Vol 19 (11) ◽  
pp. 618
Author(s):  
Min-Ji Ryu ◽  
Prima F. Hillman ◽  
Jihye Lee ◽  
Sunghoon Hwang ◽  
Eun-Young Lee ◽  
...  
Keyword(s):  
Spectroscopic Data ◽  
Nuclear Overhauser Effect ◽  
Antibacterial Activities ◽  
Streptomyces Sp ◽  
Overhauser Effect ◽  
Planar Structures ◽  
Value Range ◽  
Bacterium Strain ◽  
Nuclear Overhauser ◽  
And Staphylococcus Aureus

Four new chlorinated meroterpenoids, merochlorins G−J (1−4), and 10, a dihydronaphthalenedione precursor, along with known merochlorins A (5) and C−F (6−9), were obtained from cultivation of the bacterium strain Streptomyces sp. CNH-189, which was isolated from marine sediment. The planar structures of compounds 1−4 and 10 were elucidated by interpretation of MS, UV, and NMR spectroscopic data. The relative configurations of compounds 1−4 were determined via analysis of nuclear Overhauser effect (NOE) spectroscopic data, after which their absolute configurations were established by comparing the experimental electronic circular dichroism (ECD) spectra of compounds 1−4 to those of previously reported possible enantiomer models and DP4 calculations. Compound 3 displayed strong antibacterial activities against Bacillus subtilis, Kocuria rhizophila, and Staphylococcus aureus, with MIC values of 1, 2, and 2 μg/mL, respectively, whereas compound 1 exhibited weak antibacterial effects on these three strains, with a 16−32 μg/mL MIC value range.

scholarly journals Antibacterial Secondary Metabolites from Marine-Derived Fungus Aspergillus sp. IMCASMF180035

Antibiotics ◽  
2021 ◽  
Vol 10 (4) ◽  
pp. 377
Author(s):  
Fuhang Song ◽  
Rui Lin ◽  
Na Yang ◽  
Jia Jia ◽  
Shangzhu Wei ◽  
...  
Keyword(s):  
Secondary Metabolites ◽  
Spectroscopic Data ◽  
Inhibitory Concentration ◽  
Antibacterial Activities ◽  
Ring System ◽  
Ionization Mass ◽  
Inhibitory Effects ◽  
Nmr Techniques ◽  
Aspergillus Sp ◽  
H Pylori

Four new secondary metabolites, including one spiro[anthracenone-xanthene] derivative aspergiloxathene A (1), one penicillide analogue, Δ2′-1′-dehydropenicillide (2), and two new phthalide derivatives, 5-methyl-3-methoxyepicoccone (3) and 7-carboxy-4-hydroxy-6-methoxy-5-methylphthalide (4), together with four known compounds, yicathin C (5), dehydropenicillide (6), 3-methoxyepicoccone (7), 4-hydroxy-6-methoxy-5-methylphthalide (8), were identified from the marine-derived fungus Aspergillus sp. IMCASMF180035. Their structures were determined by spectroscopic data, including high-resolution electrospray ionization mass spectrometry (HRESIMS), 1D and 2D nuclear magnetic resonance (NMR) techniques. Compound 1 was identified as the first jointed molecule by xanthene and anthracenone moieties possessing an unprecedented carbon skeleton with spiro-ring system. All compounds were evaluated activities against Staphylococcus aureus, methicillin resistant S. aureus (MRSA), Escherichia coli, Escherichia faecium, Pseudomonas aeruginosa, and Helicobacter pylori. Compound 1 showed significant inhibitory effects against S. aureus and MRSA, with minimum inhibitory concentration (MIC) values of 5.60 and 22.40 µM. Compounds 2 and 6 exhibited potent antibacterial activities against H. pylori, with MIC values of 21.73 and 21.61 µM, respectively.

scholarly journals Antimicrobial and Antiparasitic Abietane Diterpenoids from the Roots of Clerodendrum eriophyllum

2010 ◽  
Vol 5 (6) ◽  
pp. 1934578X1000500 ◽  
Author(s):  
Francis Machumi ◽  
Volodymyr Samoylenko ◽  
Abiy Yenesew ◽  
Solomon Derese ◽  
Jacob O. Midiwo ◽  
...  
Keyword(s):  
Spectroscopic Data ◽  
Antimalarial Activity ◽  
Antibacterial Activities ◽  
Cd Spectra ◽  
Normal Series ◽  
Abietane Diterpenoids ◽  
Abietane Diterpenes ◽  
First Time ◽  
Absolute Stereochemistry

Chromatographic separation of the roots of a Kenyan medicinal plant, Clerodendrum eriophyllum, led to the isolation of ten abietane diterpenoids (1-10), one of which (1) was isolated for the first time from a natural source. Using spectroscopic data, the structure of 1 was determined to be 12-hydroxy-8,12-abietadiene-3,11,14-trione. Circular dichroism (CD) spectra showed that the stereochemistry of compounds 1, 3, and 6-8 belongs to the normal series of abietane diterpenes, which confirmed the absolute stereochemistry of the isolated compounds. Compounds 1-10 were evaluated for their in vitro antiplasmodial, antileishmanial, antifungal and antibacterial activities. Compounds 3 and 7 exhibited potent antifungal activity (IC50/MIC 0.58/1.25 and 0.96/2.5 μg/mL, respectively) against C. neoformans, whereas 3, 6 and 7 showed strong antibacterial activity against Staphylococcus aureus and methicillin-resistant S. aureus with IC50/MIC values between 1.33-1.75/2.5-5 and 0.96-1.56/2.5 μg/mL, respectively. In addition, compounds 3 and 9 exhibited potent antileishmanial activity (IC50 0.08 and 0.20 μg/mL, respectively) against L. donovani, while 3 and 7 displayed weak antimalarial activity against Plasmodium falciparum, but 9 was inactive.

scholarly journals Production of New Antibacterial 4-Hydroxy-α-Pyrones by a Marine Fungus Aspergillus niger Cultivated in Solid Medium

Marine Drugs ◽  
2019 ◽  
Vol 17 (6) ◽  
pp. 344 ◽  
Author(s):  
Lijian Ding ◽  
Lu Ren ◽  
Shuang Li ◽  
Jingjing Song ◽  
Zhiwen Han ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Aspergillus Niger ◽  
Spectroscopic Data ◽  
Pathogenic Bacteria ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
Inhibitory Concentration ◽  
Solid Medium ◽  
Antibacterial Activities ◽  
Marine Fungus ◽  
Mic Value

Four 4-hydroxy-α-pyrones including three new ones named nipyrones A–C (1–3) together with one known analogue germicidin C (4) were discovered from a marine sponge-derived fungus Aspergillus niger cultivated in a solid rice culture. Their structures and absolute configurations were elucidated through a combination of spectroscopic data and electronic circular dichroism (ECD) calculations as well as comparison with literature data. Compounds 1–4 were evaluated for their antibacterial activities against five pathogenic bacteria (Staphylococcus aureus, Escherichia coli, Bacillus subtilis, methicillin-resistant Staphylococcus aureus, and Mycobacterium tuberculosis). Compound 3 showed promising activity against S. aureus and B. subtilis, with minimum inhibitory concentration (MIC) values of 8 μg/mL and 16 μg/mL, respectively, and displayed weak antitubercular activities against M. tuberculosis, with MIC value of 64 μg/mL, while compounds 1 and 2 exhibited moderate antibacterial efficacy against four pathogenic bacteria with MIC values of 32–64 μg/mL.

scholarly journals STRUCTURE ELUCIDATION OF ANTIBACTERIAL COMPOUND FROM Ficus deltoidea Jack LEAVES

2011 ◽  
Vol 11 (1) ◽  
pp. 67-70 ◽  
Author(s):  
Suryati Suryati ◽  
Hazli Nurdin ◽  
Dachriyanus Dachriyanus ◽  
Md Nordin Hj Lajis
Keyword(s):  
1H Nmr ◽  
13C Nmr ◽  
Spectroscopic Data ◽  
Structure Elucidation ◽  
Antibacterial Activities ◽  
Ficus Deltoidea ◽  
E Coli ◽  
Minimum Inhibition Concentration ◽  
Antibacterial Compound ◽  
Inhibition Concentration

An antibacterial compound has been isolated from Ficus deltoidea Jack leaves. Based on spectroscopic data (IR, 1H-NMR, 13C NMR 1D and 2D and MS), the structure of this compound was identified as 3β-hydroksilup-20(29)-en, (lupeol), C30H50O. This compound showed antibacterial activities against E. coli, B. subtilis and S. aureus. The minimum inhibition concentration (MIC) against E. coli, B. subtilis and S. aureus are 150, 220 and 130 μg/mL respectively.

scholarly journals Three New Polyketides from the Insect-Associated Fungus Letendraea sp. 5XNZ4-2

2021 ◽  
Vol 15 (3) ◽  
pp. 187-193
Author(s):  
Yan Xu ◽  
Nanyan Fu ◽  
Wanjing Ding ◽  
Pinmei Wang ◽  
Jinzhong Xu
Keyword(s):  
Antibacterial Activity ◽  
Single Crystal ◽  
Spectroscopic Data ◽  
Antibacterial Activities ◽  
X Ray Diffraction ◽  
Potato Dextrose Broth ◽  
Etoac Extract ◽  
X Ray ◽  
New Compounds ◽  
Modified Mosher’S Method

Chemical investigation of the EtOAc extract of an insect-associated fungus Letendraea sp. 5XNZ4-2 cultured in Potato Dextrose Broth (1/2 PDB) medium lead to the isolation of three new polyketides, named letendronol D (1), phomopsiketones H-I (2-3). The structures of new compounds were elucidated by the analysis of HRESIMS and NMR spectroscopic data, and the absolute configurations were determined by modified Mosher’s method, ECD calculation and single-crystal X-ray diffraction. Cytotoxicity and antibacterial activities of 1 were assayed and regrettably 1 didn’t display any cytotoxicity and antibacterial activity. 3 was the first phomopsiketone derivative obtaining the lactone.

scholarly journals Clerodane Diterpenoids from Callicarpa hypoleucophylla and Their Anti-Inflammatory Activity

Molecules ◽  
2020 ◽  
Vol 25 (10) ◽  
pp. 2288 ◽  
Author(s):  
Yu-Chi Lin ◽  
Jue-Jun Lin ◽  
Shu-Rong Chen ◽  
Tsong-Long Hwang ◽  
Shu-Yen Fang ◽  
...  
Keyword(s):  
Nuclear Magnetic Resonance ◽  
Superoxide Anion ◽  
Spectroscopic Data ◽  
Structural Diversity ◽  
Inflammatory Activity ◽  
Endemic Plant ◽  
Superoxide Anion Generation ◽  
Phytochemical Investigation ◽  
Clerodane Diterpenoids ◽  
Anti Inflammatory

Plants of the genus Callicarpa are known to possess several medicinal effects. The constituents of the Taiwan endemic plant Callicarpa hypoleucophylla have never been studied. Therefore, C. hypoleucophylla was selected for our phytochemical investigation. Two new clerodane-type diterpenoids, named callihypolins A (1) and B (2), along with seven known compounds were isolated from the leaves and twigs of the Lamiaceae plant C. hypoleucophylla and then characterized. The structures of compounds 1 and 2 were elucidated by spectroscopic data analysis, specifically, two-dimension nuclear magnetic resonance (NMR). The anti-inflammatory activity of compounds 1–9 based on the suppression of superoxide anion generation and elastase release was evaluated. Among the isolates, compounds 2–4 showed anti-inflammatory activity (9.52−32.48% inhibition at the concentration 10 μm) by suppressing superoxide anion generation and elastase release. Our findings not only expand the description of the structural diversity of the compounds present in plants of the genus Callicarpa but also highlight the possibility of developing anti-inflammatory agents from Callicarpa endemic species.

scholarly journals Phenolic constituents from the tree barks of garcinia cf cymosa and their antioxidant and antibacterial activities

2014 ◽  
Vol 9 (3) ◽  
Author(s):  
Yuliar Yuliar ◽  
Yunazar Manjang ◽  
Sanusi Ibrahim ◽  
Sjamsul Arifin Achmad
Keyword(s):  
Spectroscopic Data ◽  
Radical Scavenging Activity ◽  
Radical Scavenging ◽  
Antibacterial Activities ◽  
Free Radical Scavenging ◽  
Tree Barks ◽  
Ic50 Value ◽  
Phenolic Constituents ◽  
In Vitro Antibacterial Activity

Two isoprenylated xanthones, α-mangostin (1) and β-mangostin (2) were isolated from the tree barks of Garcinia cf cymosa, along with the flavanol epicatechin (3). Their structures were elucidated by analysis of spectroscopic data. Compounds 1-3 exhibited moderate in vitro antibacterial activity against Staphylococcus aureus and Bacillus sp, while in the 1,2-diphenyl-picryl-hydrazyl (DPPH) antioxidant assay system only compound 3 showed moderate free radical scavenging activity, with IC50 value of 41.8 ppm.

scholarly journals Eight New Clerodane Diterpenoids from the Bark of Ptychopetalum olacoides

2011 ◽  
Vol 6 (3) ◽  
pp. 1934578X1100600
Author(s):  
Wanxia Tang ◽  
Kenichi Harada ◽  
Miwa Kubo ◽  
Hideaki Hioki ◽  
Yoshiyasu Fukuyama
Keyword(s):  
Medicinal Plant ◽  
Spectroscopic Data ◽  
Meoh Extract ◽  
Nmr Data ◽  
Clerodane Diterpenoids

Eight new clerodane type diterpenoids, named 7-oxo-kolavelool (1), 7α-hydroxykolavelool (2), 6α,7α-dihydroxykolavenol (3), 12-oxo-hardwickiic acid (4), ptycholide I (5), ptycholide II (6), ptycholide III (7), and ptycholide IV (8) were isolated from the MeOH extract of the bark of a Brazilian medicinal plant, Ptychopetalum olacoides. The structures of 1–8 were elucidated by analyzing spectroscopic data and by comparing their NMR data with those of the previously reported compounds kolavelool (1a), kolavenol (3a), hardwickiic acid (4a), and ptychonolide (5a). Compounds 5 and 6 existed as a 1:1 mixture of inseparable epimers at C-15.

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