Synthesis and Characterization of Biologically Potent Chalcone Bearing 1,3,4-Oxadiazole Linkage
2015 ◽
Vol 61
◽
pp. 77-83
Keyword(s):
H Nmr
◽
In this article, we have described to design and synthesized a series of substituted chalcone based 1,3,4-oxadiazole derivatives. Titled compounds (E)-S-(-5-phenyl-1,3,4-oxadiazol-2-yl) 2-(4-(3-(5-methyl-3oxo-2(p-tolyl)-2,3-dihydro-1H-pyrazol-4-yl)-3-oxoprop-1-en-1-yl) phenoxy) etanethioate (III1-6) were synthesized using of derivatives of S-(-5-phenyl-1,3,4 oxadiazole-2-yl)2-chloroethaethioate (I1-6) were reacted with (E)-4-(3-(4-hydroxyphenyl) acryloyl)-5-methyl-2(p-tolyl)-1H-pyrazol-3(2H)-one (II) in presence of K2CO3 in DMF as a solvent. The synthesized compounds were evaluated for their antimicrobial activity. The newly synthesized compounds were characterized by analytical and spectral (IR, 1H NMR, and LC-MS) Methods.
2011 ◽
Vol 161
(9-10)
◽
pp. 869-880
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Keyword(s):
2014 ◽
Vol 39
◽
pp. 129-135
2009 ◽
Vol 509
(1)
◽
pp. 274/[1016]-282/[1024]
2013 ◽
Vol 2013
◽
pp. 1-7
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