The level of free radical oxidation products in heart and blood plasma by diabetes mellitus with chronic alcohol intoxication

2010 ◽  
Vol 56 (2) ◽  
pp. 257-265
Author(s):  
A.V. Indutny ◽  
D.E. Bykov ◽  
V.E. Vysokogorsky
Keyword(s):  
Diabetes Mellitus ◽  
Free Radical ◽  
Blood Plasma ◽  
Alcohol Intoxication ◽  
Free Radical Oxidation ◽  
Oxidation Products ◽  
Chronic Alcohol ◽  
Chronic Alcohol Consumption ◽  
Radical Oxidation ◽  
Chronic Alcohol Intoxication

The research results of level glycemia, contents of free radical oxidation products (thiobarbiturate-reactive substances, oxidized-modified proteins) in blood plasma and heart of diabetes mellitus rats with chronic alcohol intoxication are presented. It is shown, that at presence of a diabetes mellitus the chronic alcohol consumption does not change blood plasma levels of the oxidized-modified proteins, thiobarbiturate-reactive substances and glucose. However the contents of thiobarbiturate-reactive substances and oxidizing modification of proteins products in animals heart is more considerably increased at combination of the diabetes with chronic alcohol consumption, in comparison with changes at the diabetes mellitus outside of alcoholization and with changes at the isolated chronic alcohol influence. Found out alcohol-induced free radical processes hyperactivation in heart at the diabetes is capable to render additional injuring influence.

Alcohol-induced damage to skeletal muscles in women with chronic alcohol intoxication

2021 ◽  
Vol 26 (4) ◽  
pp. 23-30
Author(s):  
N. S. Shcheglova ◽  
E. O. Zinovyeva ◽  
B. S. Shenkman
Keyword(s):  
Skeletal Muscle ◽  
Blood Plasma ◽  
Skeletal Muscles ◽  
Alcohol Intoxication ◽  
Femoral Nerve ◽  
Chronic Alcohol ◽  
Chronic Alcoholic ◽  
Chronic Alcohol Intoxication ◽  
Alcoholic Myopathy ◽  
In Blood Plasma

In Russia, there is a high level of alcohol consumption among women in doses that represent a high risk of developing alcoholic diseases, manifested, in particular, by damage to skeletal muscles.The purpose of the study. Analysis of clinical, biochemical, neurophysiological, as well as morphometric and immunohistochemical features of alcoholic skeletal muscle damage in women with chronic alcohol intoxication.Material and methods. A clinical and laboratory examination of 30 women aged 20 to 60 years with chronic alcohol intoxication was performed, which included the determination of creatine phosphokinase (CPK) and insulin-like growth factor I (IGF-I) in blood plasma, stimulation and needle electromyography (EMG), as well as morphological and immunohistochemical examination of biopsies of the quadriceps femoris.Results. Myopathic syndrome in the form of proximal para-or tetraparesis was observed in 73.3% of the examined women in combination with a decrease in IGF-1 at normal values of CPK in blood plasma. The EMG results indicated the absence of changes in the parameters of the potentials of motor units, characteristic of primary muscular lesions, and of conduction disturbances along the femoral nerve. Morphometric and immunohistochemical studies of skeletal muscle biopsies showed a decrease in the cross-sectional area of muscle fibers of types I and II without signs of muscle tissue necrosis.Conclusion. Chronic alcoholic myopathy is a common manifestation of alcoholic disease in women with long-term alcohol intoxication. The severity of the atrophic process in the skeletal muscle is comparable to the degree of proximal paresis. Violations of systemic protein synthesis and acceleration of apoptosis are considered as pathogenetic mechanisms of the atrophic process in the muscles in chronic alcoholic myopathy in women.

scholarly journals CHARACTERISTIC OF FREE-RADICAL DAMAGE AND ANTIOXIDANT PROTECTION STATE IN PATIENTS WITH CHRONIC KIDNEY DISEASE AGAINST A BACKGROUND OF MALABSORPTION SYNDROME

2021 ◽  
Vol 20 (3) ◽  
Author(s):  
А.Е. Shkarutyak
Keyword(s):  
Chronic Kidney Disease ◽  
Free Radical ◽  
Kidney Disease ◽  
Free Radical Oxidation ◽  
Oxidation Products ◽  
Essential Factor ◽  
Free Radical Damage ◽  
Radical Oxidation ◽  
Oxidation Processes ◽  
Radical Damage

Oxidation processes play an important role in damage of the renal structures, especiallyagainst a background of other serious pathologies, in particular, malabsorptionsyndrome.The study of the mechanisms of mutual aggravation and progression of kidneydamage against a background of malabsorption is a very urgent problem of the presenttime.Purpose - to investigate the state of free radical oxidation of lipids, proteins andantioxidant defense in patients with chronic kidney disease of different ages withoxaluria against a background of malabsorption syndrome.Material and methods. 98 patients with chronic kidney disease of the I-II stages(pyelonephritis) with the presence of oxaluria against a background of malabsorptionsyndrome of different age were examined.The age of the patients under examination was32 - 64. All patients underwent a study of the system of free radical oxidation of lipidsand proteins.Results. chronic kidney disease with the presence of oxaluria is accompanied by asignificant increase in the blood content of free radical oxidation products, namelyaldehyde and ketone dinitrophenylhydrazones, especially of a neutral nature,malondialdehyde, as well as a significant decrease in the indicators of the antioxidantdefense system, which manifested itself to a greater extent in patients with older age.groups.Conclusion. An essential factor in the development and progression of chronic kidneydisease with the presence of oxaluria against a background of malabsorption syndromeis an increase in the intensity of free radical oxidation of lipids and proteins (mainly dueto aldehyde and ketondinitrophenylhydrazones of a neutral nature).

scholarly journals ACETAMINOPHEN EFFECT ON FREE RADICAL OXIDATION INDICES IN RATS WITH TYPE 2 DIABETES MELLITUS

2017 ◽  
Author(s):  
O. B. Furka ◽  
I. B. Ivanusa ◽  
M. M. Mykhalkiv ◽  
I. M. Klishch
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Free Radical ◽  
Liver Homogenate ◽  
Free Radical Oxidation ◽  
Maximum Increase ◽  
Radical Oxidation ◽  
Age Related

Background. Acetaminophen is a drug used to relieve pain syndrome. It is used both independently and in composition of combined drugs. Type 2 diabetes is an age-related disease that is associated with a violation of insulin synthesis by pancreas.Objective. The aim of the research was to study the effect of acetaminophen on major free radical oxidation indices of rats with type 2 diabetes mellitus in time dynamics.Methods. We conducted two series of experiments. The first series comprised rats with type 2 diabetes mellitus and acute acetaminophen toxic lesions. The second series involved rats with type 2 diabetes mellitus and acetaminophen administration at a dose of 55 mg/kg for the period of 7 days.Results. Administration of acetaminophen for rats with type 2 diabetes mellitus caused the increase in the content of malondialdehyde, diene and triene conjugates and Schiff bases in blood plasma and malondialdehyde, diene and triene conjugates in liver homogenate. The maximum increase in these indices was observed on the first day of the experiment. Gradually these indices decreased on the 3rd, 5th and 7th days of the experiment.Conclusions. Free radical oxidation increased in both series of the experiment. This process developed in rats with type 2 diabetes mellitus and acute acetaminophen toxic lesions more intensively, than in rats with type 2 diabetes mellitus and administration of acetaminophen at the highest therapeutic dose during 7 days.

scholarly journals THE CONTENT OF SULFUR-CONTAINING AMINO ACIDS AND RELATED COMPOUNDS IN THE BLOOD PLASMA OF RATS WITH DIFFERENT TYPES OF ALCOHOL INTOXICATION

2021 ◽  
Vol 19 (2) ◽  
pp. 170-175
Author(s):  
A. K. Semenchuk ◽  
◽  
V. V. Lelevich ◽  
Keyword(s):  
Amino Acids ◽  
Blood Plasma ◽  
Free Amino ◽  
Alcohol Intoxication ◽  
Chronic Alcohol ◽  
Rat Blood ◽  
Chronic Alcohol Intoxication ◽  
Different Types ◽  
Related Compounds ◽  
Sulfur Containing

Background. Change of the content of sulfur-containing amino acids and their metabolites is one of the pathochemical mechanisms of alcohol intoxication. Purpose of the study. To study the effect of chronic and intermittent alcohol intoxication on the content of sulfurcontaining amino acids and related compounds in the rat blood plasma. Material and methods. Thirty white outbred rats weighing 180-220 g. The content of free amino acids and biogenic amines was determined by HPLC. Results. A 14-day chronic alcohol intoxication was accompanied by a significant decrease in the level of methionine and an increase in the level of homocysteine in the blood plasma. The concentration of glutathione increased by 5%. In the intermittent alcohol intoxication IAI-4 group, the homocysteine content also increased, as did the level of homoserine and cystathionine in the IAI-1 group. Conclusions. Сhronic and intermittent alcohol intoxications cause similar violations of the level of sulfur-containing amino acids and their metabolites in the rat blood plasma.

scholarly journals Free-Radical Oxidation (Peroxidation) Products in Plasma in Normal and Abnormal Pregnancy

1981 ◽  
Vol 18 (3) ◽  
pp. 158-162 ◽  
Author(s):  
D Wickens ◽  
M H Wilkins ◽  
J Lunec ◽  
G Ball ◽  
T L Dormandy
Keyword(s):  
Blood Pressure ◽  
Free Radical ◽  
Radical Reaction ◽  
Free Radical Oxidation ◽  
Oxidation Products ◽  
Control Group ◽  
Free Radical Reaction ◽  
Reaction Products ◽  
Third Trimester ◽  
Radical Oxidation

Using recently developed methods for measuring free-radical oxidation products in biological material, plasma extracts were studied in 24 women in the first two trimesters of pregnancy, in 124 women in the third trimester of pregnancy, in 20 women with pre-eclamptic toxaemia (PET), and in a control group. There was a significant progressive rise of two groups of free-radical oxidation products throughout pregnancy and a significantly greater rise in PET. In women whose diastolic blood pressure rose to above 70 mmHg there was a highly significant relation between two groups of free-radical reaction products and blood pressure.

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