scholarly journals CHARACTERISTIC OF FREE-RADICAL DAMAGE AND ANTIOXIDANT PROTECTION STATE IN PATIENTS WITH CHRONIC KIDNEY DISEASE AGAINST A BACKGROUND OF MALABSORPTION SYNDROME

2021 ◽  
Vol 20 (3) ◽  
Author(s):  
А.Е. Shkarutyak
Keyword(s):  
Chronic Kidney Disease ◽  
Free Radical ◽  
Kidney Disease ◽  
Free Radical Oxidation ◽  
Oxidation Products ◽  
Essential Factor ◽  
Free Radical Damage ◽  
Radical Oxidation ◽  
Oxidation Processes ◽  
Radical Damage

Oxidation processes play an important role in damage of the renal structures, especiallyagainst a background of other serious pathologies, in particular, malabsorptionsyndrome.The study of the mechanisms of mutual aggravation and progression of kidneydamage against a background of malabsorption is a very urgent problem of the presenttime.Purpose - to investigate the state of free radical oxidation of lipids, proteins andantioxidant defense in patients with chronic kidney disease of different ages withoxaluria against a background of malabsorption syndrome.Material and methods. 98 patients with chronic kidney disease of the I-II stages(pyelonephritis) with the presence of oxaluria against a background of malabsorptionsyndrome of different age were examined.The age of the patients under examination was32 - 64. All patients underwent a study of the system of free radical oxidation of lipidsand proteins.Results. chronic kidney disease with the presence of oxaluria is accompanied by asignificant increase in the blood content of free radical oxidation products, namelyaldehyde and ketone dinitrophenylhydrazones, especially of a neutral nature,malondialdehyde, as well as a significant decrease in the indicators of the antioxidantdefense system, which manifested itself to a greater extent in patients with older age.groups.Conclusion. An essential factor in the development and progression of chronic kidneydisease with the presence of oxaluria against a background of malabsorption syndromeis an increase in the intensity of free radical oxidation of lipids and proteins (mainly dueto aldehyde and ketondinitrophenylhydrazones of a neutral nature).

scholarly journals Efficacy of the N-acetylglucosamine in experimental therapy of chronic kidney disease

Pharmacia ◽  
2020 ◽  
Vol 67 (4) ◽  
pp. 253-259
Author(s):  
Sergii Shebeko ◽  
Igor Zupanets ◽  
Inna Otrishko
Keyword(s):  
Chronic Kidney Disease ◽  
Free Radical ◽  
Kidney Disease ◽  
Experimental Studies ◽  
Free Radical Oxidation ◽  
Thiobarbituric Acid ◽  
Conjugated Dienes ◽  
Experimental Therapy ◽  
Thiobarbituric Acid Reactive Substances ◽  
Radical Oxidation

The efficacy of N-acetylglucosamine in rats with chronic kidney disease is described in this article. The results of the study show that N-acetylglucosamine significantly increased (p<0.05) the excretion of nitrogen compounds (creatinine by 100.4% and urea by 46.6%) and as a result de-creased the level of azotemia. The intensity of free radical oxidation was significantly decreased (p<0.05) (blood conjugated dienes by 32.9%, blood thiobarbituric acid reactive substances – by 14.1%, kidney conjugated dienes – by 40.1% and kidney thiobarbituric acid reactive substances – by 26.3%) and the balance of kidney antioxidant system was restored. N-acetylglucosamine was significantly superior (p<0.05) to comparator quercetin in renal excretory function and nitro-gen metabolism by the most of indicators and was not inferior to the influence on the free radical oxidation and kidney oxidative stress. Thus, N-acetylglucosamine is advisable to further experimental studies at i.m. administration as a chronic kidney disease treatment.

scholarly journals Influence of neuropeptides acth(4-7)-pro-gly-pro and acth(6-9)-pro-gly-pro on the intensity of redox reactions under experimental depression

2020 ◽  
Vol 10 (3) ◽  
pp. 29-32
Author(s):  
Marina Samotrueva ◽  
Anna Yasenyavskaya ◽  
Aleksandra Tsibizova ◽  
Jumazia Erizhepova ◽  
Nikolai Myasoedov ◽  
...  
Keyword(s):  
Free Radical ◽  
Social Stress ◽  
Redox Reactions ◽  
Antioxidant Properties ◽  
Free Radical Oxidation ◽  
Male Rats ◽  
Radical Oxidation ◽  
Oxidation Processes ◽  
Initial Content ◽  
The Brain

The experiment is devoted to the study of the antioxidant properties of neuropeptides from melanocortins ACTH(4-7)-Pro-Gly-Pro (Semax) and ACTH(6-9)-ProGly-Pro under conditions of experimental depression. The study was carried out on white outbred male rats. In the process of modeling experimental depression (social stress) inter-male confrontations were observed as a result of which groups of animals with aggressive and submissive behaviors were formed. The free radical oxidation processes were assessed by determining the activity of catalase, the initial content of malondialdehyde (MDA), the rate of spontaneous and ascorbate-dependent lipid peroxidation (LPO) in the hypothalamic and prefrontal regions of the brain by spectrophotometric method. It was found that under the influence of melanocortins, there is a pronounced suppression of the processes of free radical oxidation in the hypothalamic and prefrontal regions of the brain, which arose against the background of a stressful load which is manifested by a decrease in the indicators of the oxidative process.

scholarly journals Effects of His-Phe-Arg-Trp-Pro-Gly-Pro peptide on free-radical oxidation processes in conditions of chronic restraint stress

2021 ◽  
Author(s):  
AO Vorvul ◽  
II Bobyntsev ◽  
OA Medvedeva ◽  
IuE Azarova ◽  
AE Belykh ◽  
...  
Keyword(s):  
Free Radical ◽  
Restraint Stress ◽  
Free Radical Oxidation ◽  
Regulatory Peptides ◽  
Thiobarbituric Acid ◽  
Synthetic Analog ◽  
Chronic Restraint Stress ◽  
Radical Oxidation ◽  
Oxidation Processes ◽  
Wide Range

Studying the effects of regulatory peptides on the stress-induced shifts in the bodily processes is of great fundamental and applied significance. Currently, a wide range of peptide neurotropic drugs, affecting the stress response development, are used in medicine, and new promising molecules are being studied. The study was aimed to assess the effects of the adrenocorticotropic hormone (ACTH) synthetic analog, ACTH(6-9)-Pro-Gly-Pro, administered at a dose of 5, 50 and 500 μg/kg, on the free-radical oxidation processes in Wistar rats, subjected to chronic restraint stress (CRS) during two weeks. Serum levels of 8-oxo-2'-deoxyguanosine (8-OHdG) and superoxide dismutase 3 (SOD3) were assessed by enzyme immunoassay, and the levels of thiobarbituric acid reactive substances (TBARS) were assessed by fluorimetric method. CRS lead to the significant increase in the 8-OHdG levels by 18.4% (p = 0.01) and the decrease in the SOD3 levels by 14.3% (p = 0.01), however, it had no effect on the levels of TBARS. ACTH(6-9)-Pro-Gly-Pro, administered at a dose of 5 and 50 μg/kg, significantly decreased the levels of 8-OHdG by 19.8% (p = 0.03) and 30% (p = 0.001), respectively. Thus, it was found that CRS resulted in oxidative stress in animals. ACTH(6-9)-Pro-Gly-Pro administration at a dose of 5 and 50 μg/kg inhibits the stress-induced free-radical oxidation processes.

The level of free radical oxidation products in heart and blood plasma by diabetes mellitus with chronic alcohol intoxication

2010 ◽  
Vol 56 (2) ◽  
pp. 257-265
Author(s):  
A.V. Indutny ◽  
D.E. Bykov ◽  
V.E. Vysokogorsky
Keyword(s):  
Diabetes Mellitus ◽  
Free Radical ◽  
Blood Plasma ◽  
Alcohol Intoxication ◽  
Free Radical Oxidation ◽  
Oxidation Products ◽  
Chronic Alcohol ◽  
Chronic Alcohol Consumption ◽  
Radical Oxidation ◽  
Chronic Alcohol Intoxication

The research results of level glycemia, contents of free radical oxidation products (thiobarbiturate-reactive substances, oxidized-modified proteins) in blood plasma and heart of diabetes mellitus rats with chronic alcohol intoxication are presented. It is shown, that at presence of a diabetes mellitus the chronic alcohol consumption does not change blood plasma levels of the oxidized-modified proteins, thiobarbiturate-reactive substances and glucose. However the contents of thiobarbiturate-reactive substances and oxidizing modification of proteins products in animals heart is more considerably increased at combination of the diabetes with chronic alcohol consumption, in comparison with changes at the diabetes mellitus outside of alcoholization and with changes at the isolated chronic alcohol influence. Found out alcohol-induced free radical processes hyperactivation in heart at the diabetes is capable to render additional injuring influence.

scholarly journals Free-Radical Oxidation (Peroxidation) Products in Plasma in Normal and Abnormal Pregnancy

1981 ◽  
Vol 18 (3) ◽  
pp. 158-162 ◽  
Author(s):  
D Wickens ◽  
M H Wilkins ◽  
J Lunec ◽  
G Ball ◽  
T L Dormandy
Keyword(s):  
Blood Pressure ◽  
Free Radical ◽  
Radical Reaction ◽  
Free Radical Oxidation ◽  
Oxidation Products ◽  
Control Group ◽  
Free Radical Reaction ◽  
Reaction Products ◽  
Third Trimester ◽  
Radical Oxidation

Using recently developed methods for measuring free-radical oxidation products in biological material, plasma extracts were studied in 24 women in the first two trimesters of pregnancy, in 124 women in the third trimester of pregnancy, in 20 women with pre-eclamptic toxaemia (PET), and in a control group. There was a significant progressive rise of two groups of free-radical oxidation products throughout pregnancy and a significantly greater rise in PET. In women whose diastolic blood pressure rose to above 70 mmHg there was a highly significant relation between two groups of free-radical reaction products and blood pressure.

scholarly journals Biochemical evaluation of excisional wound healing in rats with diabetes mellitus after using different methods of wound closure

2017 ◽  
Author(s):  
Ye. O. Loza ◽  
M. I. Marushchak
Keyword(s):  
Diabetes Mellitus ◽  
Wound Healing ◽  
Free Radical ◽  
Antioxidant Defense ◽  
Free Radical Oxidation ◽  
Antioxidant Defense System ◽  
Male Rats ◽  
Defense System ◽  
Radical Oxidation ◽  
Oxidation Processes

Introduction. Wound healing according to modern concepts is a coordinated process that passes through certain stages with the participation of different cells and products of its vital functions that regulate the healing process. It is well known that in patients with diabetes there is a violation of the process of wound healing, although until now, all the features of diabetes underlying such an inclination have not been fully understood.The aim of the study – to identify the features of oxidative stress on the background of diabetes mellitus in the rat's homogenate when different methods of closing wounds had been used. Research Methods. The experiment was conducted on 60 male rats weighing 280–320 g, which pre-simulated diabetes mellitus and surgical wounds. To detect the activation of free radical oxidation processes, the content of active forms of oxygen (AFC), lipid hydroperoxides (HPL), diene conjugates (DK) and trienic conjugates (TC) and oxidation modifications of proteins (OMP370 and OMP430). To study the antioxidant defense system, activity of superoxide dismutase was determined. Also, the activity of catalase and sulfhydryl groups (SH-groups) was determined.Results and Discussion. The research conducted by us showed that during the wounded process, on the background of diabetes, the activity of free radical oxidation processes increased. However, in the animal skin homogenates, which are labeled "Dermabond", all indices are significantly lower than in the group of animals that have been sewed over the course of all research periods. In the early stages of scar formation (3 days), an increase in the activity of the antioxidant defense system in both groups was observed. At the same time, in the experimental group of animals, which imposed the nodal seams, the activity of SOD and catalase significantly exceeded the skin index of animals, which applied glue and made (199.81±7.59) UM and (175.02±8.31) cat/kg, respectively.Conclusion. The use of skin glue reduces the intensity of the course of free radical oxidation in the cells of the scar tissue of the postoperative wound in conditions of diabetes mellitus in comparison with the imposition of nodal sutures on it: in the skin of animals, which is applied to the "Dermabond" glue, all indicators are significantly lower than in the group of animals, which imposed seam joints, throughout all research periods. 

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