scholarly journals Maternofetal outcome in early versus late detected asymptomatic bacteriuria of pregnancy

2017 ◽  
Vol 7 (1) ◽  
pp. 80
Author(s):  
Indira Guntoory ◽  
Poornima Penmetsa ◽  
Sarath B. Rayapu ◽  
Nambaru R. Nambaru
Keyword(s):  
Urinary Tract Infection ◽  
Urinary Tract ◽  
Tract Infection ◽  
Pregnant Women ◽  
Asymptomatic Bacteriuria ◽  
P Value ◽  
Negative Group ◽  
Symptomatic Urinary Tract Infection ◽  
Foetal Outcome ◽  
In Pregnancy

Background: Urinary tract infection in pregnancy is a problem of global significance. Untreated asymptomatic bacteriuria in pregnancy is known to be associated with maternal and foetal outcome in the form of symptomatic urinary tract infection (UTI), acute pyelonephritis, anaemia, pregnancy induced hypertension (PIH), preterm labour (PTL), low birth weight (LBW), intrauterine growth restriction (IUGR) and prematurity. This study is aimed to compare the maternal and foetal outcome of pregnant women with bacteriuria with that of women without bacteriuria and also to see if screening later in pregnancy at 28-37 weeks of gestation is as effective as screening at less than 20 weeks of pregnancy in terms of maternofoetal outcome.Methods: 165 pregnant women attending the antenatal clinic at MIMS, Nellimerla, Vizianagaram district, Andhra Pradesh, India were screened for asymptomatic bacteriuria by urine culture and sensitivity. They were grouped into asymptomatic bacteriuria negative and culture positive groups. Culture positives were further grouped as early detected and late detected group based on the gestational age at sampling. They were followed up till delivery. The maternofoetal outcome was compared between different groups by computing Odd’s ratio and P value of less than 0.05 was taken as significant.Results: There was no statistically significant increase in adverse maternofoetal outcome between early detected and bacteriuria negative group. The women of late detected group had greater odds of developing symptomatic UTI, PIH, PTL, LBW, IUGR and neonatal intensive care unit admissions when compared to early detected and bacteriuria negative group which was statistically significant.Conclusions: Screening for asymptomatic bacteriuria early in pregnancy at less than 20 weeks is more effective in reducing the adverse maternofoetal outcome.

scholarly journals Infeksi Saluran Kemih pada Kehamilan: Prevalensi dan Faktor-Faktor yang Memengaruhinya

2018 ◽  
Vol 11 (1) ◽  
pp. 19
Author(s):  
Edy Fakhrizal
Keyword(s):  
Risk Factors ◽  
Urinary Tract Infection ◽  
Urinary Tract ◽  
Tract Infection ◽  
Pregnant Women ◽  
Asymptomatic Bacteriuria ◽  
Total Water ◽  
In Pregnancy

To obtain a prevalence of urinary tract infection in pregnancy andits influential risk factors.This is a cross sectionalstudy. The subjects were all pregnant women who came to Obstetric & Gynecology clinic of Arifin Achmad Pekanbaru– Riau Hospital, between June 1st and October 31st 2016. Subjects with appropriate inclusion and exclusion criteriaand agreed to join this study were asked to fill out questionnaire and urinalysis test was done.The data was analyzedwith Stata 12. The distribution of data was analyzed with descriptive univariate and presented in (n) and(%). Bivariateanalysis was done to see any influential risk factors to urinary tract infection in pregnancy. From recruited 74 subjects,27subjects (36,5%) were with urinary tract infection and 4 subject of its (14,8%) was asymptomatic bacteriuria. Theprevalence of urinary tract infection in pregnancy in this study was 36,5% and the influential risk factors wereeducation, occupation, total water consumpted a day, and cleaning vagina before coitus.

scholarly journals Prevalence and Bacteriology of Symptomatic Urinary Tract Infection among Pregnant women at Mbarara Regional Referral Hospital, South-western Uganda

2020 ◽  
Author(s):  
Johnson Bahati ◽  
Bawakanya Mayanja Stephen ◽  
Ngonzi Joseph ◽  
Owaraganise Asiphas ◽  
Kayondo Musa ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Drug Resistance ◽  
Urinary Tract Infection ◽  
Urinary Tract ◽  
Tract Infection ◽  
Pregnant Women ◽  
Regional Referral Hospital ◽  
Symptomatic Urinary Tract Infection ◽  
Culture Positive ◽  
In Pregnancy

Abstract Background: Urinary tract infections (UTIs) in pregnant women contribute about 25% of all infections and are among the most frequent clinical bacterial infections. Pregnancy changes in women that include anatomical, physiological and hormonal make them susceptible to develop UTI. Left untreated, UTI in pregnancy is associated with grave complications to the mother and fetus. These complications can be decreased by prompt and proper diagnosis and appropriate treatment that also reduces the emergency of drug resistance. Antimicrobial resistance is a major health problem in the treatment of UTI. We determined the prevalence, bacteriology and antimicrobial susceptibility of symptomatic urinary tract infection among pregnant women at Mbarara Regional Referral Hospital.Methods: We conducted a cross-sectional study from November 2019 to February 2020 involving 400 pregnant women with symptomatic UTI. Patient information was obtained using a structured questionnaire. We collected clean-catch midstream urine specimens for culture and performed antimicrobial susceptibility testing following Clinical and Laboratory Standards Institute standards. Data was entered into RED-cap Version 8.2 software and then exported to Stata Version 14.1 for analysis.Results: The proportion of culture-positive UTI was 140/400 (35%). Gram-negative bacteria were more prevalent (73%): Klebsiella pneumoniae 52(37.41%), Escherichia coli 40(28.78%), Pseudomonas aeruginosa and Proteus mirabilis 7(5.04% each), Citrobacter freundii 1(1%). Staphylococcus aureus 33(23.57%) was the only gram-positive isolate. All the isolates were resistant to ampicillin, amoxicillin, amoxicillin/clavulanic acid and ceftazidime/clavulanic acid (95.7%, 95.0%, 72.9% and 50.7% respectively). Prevalence of extended-spectrum beta-lactamases producing Enterobacteriaceae was 29.0% while that of methicillin-resistant Staphylococcus aureus was 33.3%. Multi-drug resistance (resistance in >2 drugs) was seen in 100% of the isolated bacteria. Majority of the bacterial isolates were sensitive to ciprofloxacin, ceftriaxone, nitrofurantoin, cefotaxime and gentamicin at 82.9%, 81.4%, 79.3%, 78.6%, 66.4% and 65.7% respectivelyConclusions: Klebsiella pneumoniae was the most prevalent isolate followed by E. coli. These two organisms were highly resistant to the commonly used antibiotics. Our study recorded a higher prevalence of culture-positive UTI in pregnancy than all the studies in Uganda. Empirical treatment of UTI should be minimized as sensitivity varies for each organism, for each drug and over time.

scholarly journals Molecular Detection ctx-M, TEM and VIM in ESBL-Producing E. coli Strains Isolated from Pregnant Women in Osogbo

2019 ◽  
pp. 1-8
Author(s):  
O. C. Adekunle ◽  
A. J. Falade-Fatila ◽  
G. Odewale
Keyword(s):  
Urinary Tract Infection ◽  
Urinary Tract ◽  
Tract Infection ◽  
Pregnant Women ◽  
Molecular Detection ◽  
Multiple Drug Resistance ◽  
Previous History ◽  
Diffusion Method ◽  
E Coli ◽  
In Pregnancy

Urinary tract infection (UTI) is a major bacterial infection causing serious health problem in pregnant women. The physiological and anatomical changes in pregnancy facilitate urinary tract infection (UTI) during pregnancy. Asymptomatic bacteriuria in pregnancy is associated with pyelonephritis, preterm labour and low birth weight infants. The study was designed to characterise phenotypically and genetically the major organism associated with UTI among pregnant women in Osun State. A cross-sectional study design was used to collect mid-stream urine samples between March 2018 to September 2018 from 150 pregnant and 50 non-pregnant women which serve as control. Samples were inoculated into Cysteine Lactose Electrolyte Deficient (CLED) medium, subcultured onto MacConkey and Blood agar plates. A standard agar disc diffusion method was used to determine antimicrobial susceptibility pattern of the isolates and the molecular detection of the antibiotic resistant genes were done. Data were subjected to descriptive statistics. The ages of women enrolled in this study ranges from 22 to 43 years (mean ± standard deviation = 25 ± 4.7 years). The predominant bacteria identified were E. coli (34.5%), S. aureus (10.3%), coagulase negative Staphylococci [CoNS] (17.2%), Klebsiella species (6.9%) and Enterobacter species (31.0%). Majority of Gram-negative bacteria isolates were resistant to ampicillin (70%), cefotaxime (62%), while 75–100% of the Gram positive isolates were resistant to ampicillin. Multiple drug resistance was observed, all the E. coli isolates were resistant to Cefotaxime, meropenem and ampicillin. Of E. coli isolates, 4, 3 and 6 were positive for the VIM, ctx-M and TEM genes respectively.Similarly, the risk of UTI was higher in those had previous UTI history (OR = 2.29, 95% CI = 1.15–4.56, P = 0.019) as compared to those who had no previous history of UTI.

scholarly journals Assessment of Rapid Dipstick Test for Diagnosis of Urinary Tract Infection in Asymptomatic Pregnant Female

2016 ◽  
Vol 5 (1) ◽  
pp. 965
Author(s):  
Ashish Khanna ◽  
Menka Khanna
Keyword(s):  
Urinary Tract Infection ◽  
Urinary Tract ◽  
Tract Infection ◽  
Gold Standard ◽  
Urine Culture ◽  
Asymptomatic Bacteriuria ◽  
Culture Method ◽  
Premature Delivery ◽  
Dipstick Test ◽  
In Pregnancy

<strong>Background:</strong>Bacteriuria during pregnancy has been known to cause many complications like low birth weight and premature delivery.<p><strong>Objective</strong>: This study was done to evaluate the diagnostic accuracy of rapid dipstick test to predict urinary tract infection in pregnancy against the gold standard urine culture.</p><p><strong>Material&amp;Methods:</strong> A total of 200 mid stream urine samples were collected from asymptomatic pregnant females. These specimens were cultured in blood agar and MacConkey's agar by using the standard loop technique and incubated aerobically at 37°C overnight. The criterion for clinically significant bacteriuria was either a pure or predominant culture of &gt;10<sup>5</sup> colony forming units (CFU)/ml. All the specimens were also examined microscopically for pyuria and bacteriuria.</p><p><strong>Results:</strong> The prevalence of asymptomatic bacteriuria in pregnancy was 15 % in our study. The sensitivity and the specificity for leucocyte esterase were 85.7% and 74.4% and for nitrites, they were 64.2% and 72%.</p><p><strong>Conclusion:</strong> The study revealed that use of either leukocyte esterase or nitrite for screening of asymptomatic bacteriuria in pregnancy was associated with many false positive and negative results when compared with the gold standard urine culture method. By using their combination maximum negative predictive value of .98 was achieved.</p>

scholarly journals Microscopic Examination of Urine Samples as the Early Detection of Asymptomatic Urinary Tract Infection in Pregnant Women: A Cross-Sectional Study

2019 ◽  
pp. 208-212
Author(s):  
Yeva Rosana ◽  
Dwiana Ocviyanti ◽  
Rahmah Amran
Keyword(s):  
Urinary Tract Infection ◽  
Urinary Tract ◽  
Tract Infection ◽  
Early Diagnosis ◽  
Pregnant Women ◽  
Microscopic Examination ◽  
Urine Culture ◽  
Early Stage ◽  
Urine Samples ◽  
P Value

Abstract Objectives:To investigate the role of microscopic examination of urine sample in supporting early diagnosis of asymptomatic urinary tract infection (UTI) in pregnant women. To compare correspondence between microscopic examination and urine culture result as a gold standard diagnostic modality to support the diagnosis of UTIs and as an evidence-based to start empirical therapy. Methods: Microscopic analysis was conducted in 74 centrifuged and non-centrifuged urine samples from 317 pregnant who came to six healthcare centres in Jakarta, which showed a positive result of nitrite examination.  The results of the microscopic examination of bacteriuria and leukocyturia were compared with a urine culture. Results: Sensitivity of centrifuged bacteriuria was the highest among the other microscopic parameters, which was 74% with the p-value of 0.009. Combination of bacteriuria and leukocyturia≥3/HPF dan≥5/HPF have increased the specificity with the value of 91.5% and 93.6% in non-centrifuged urine. Conclusion: This result showed that the best method of microscopic examination for early diagnosis of asymptomatic urinary tract infection in pregnant women is the detection of bacteriuria in centrifuged urine. Combination of bacteriuriaandleukocyturiatest, as well as leukocyturia≥3/HPF and≥5/HPF,  can be used to rule out the diagnosis of UTI at an early stage. Keywords: asymptomatic urinary tract infection, bacteriuria, leukocyturia,microscopic examination, urine culture.   Abstrak Tujuan: Mengetahui peran pemeriksaan mikroskopis sampel urin dalam mendukung diagnosis dini infeksi saluran kemih asimptomatik (ISK) pada perempuan hamil. Membandingkan kesesuaian antara pemeriksaan mikroskopis dan hasil kultur urin sebagai modalitas diagnostik standar emas untuk mendukung diagnosis ISK dan sebagai dasar bukti untuk memulai terapi empiris. Metode: Penelitian uji mikroskopik dilakukan pada 74 sampel urin disentrifugasi dan tidak sentrifugasi, dari 317 sampel urin perempuan hamil yang berobat ke-enam puskesmas di Jakarta dengan uji nitritpositif. Hasil uji mikroskopik bakteri uria dan leukosit uria dibandingkan dengan hasil kultururin. Hasil: Sensitivitas bakteriuria yang disentrifugasi menunjukan hasil yang paling baik dibandingkan dengan parameter uji mikroskopik lain, yaitu 74% dengan nilai p yang bermakna sebesar 0,009.  Kombinasi bakteri uria dan leukosituria ≥3/LPB dan ≥5/LPB dapat meningkatkan spesifisitas uji dengan nilai 91,5% dan 93,6% pada urin yang  tidak disentrifugasi. Kesimpulan: Hasil menunjukkan bahwa bakteri uria pada urin yang disentrifugasi, merupakan metode yang paling baik untuk membantu diagnosis dini ISK tidak bergejala pada perempuan hamil. Uji kombinasi bakteri uria dan leukosituria, serta uji leukosituria ≥3/LPB dan ≥5/LPB dapat dimanfaatkan untuk membantu secara dini menyingkirkan orang yang tidak mengalami  ISK. Kata kunci: bakteriuria, infeksi saluran kemih tidak bergejala, kultur urin,leukosituria, uji mikroskopik

Bacterial vaginosis and antibacterial susceptibility pattern of asymptomatic urinary tract infection in pregnant women at a tertiary care hospital, Visakhaptn, India

2020 ◽  
Author(s):  
Appikatla Madhu Bhavana ◽  
Pilli Hema Prakash Kumari ◽  
Nitin Mohan ◽  
Vijayalakshmai Chandrasekhar ◽  
Payala Vijayalakshmi ◽  
...  
Keyword(s):  
Urinary Tract Infection ◽  
Urinary Tract ◽  
Tract Infection ◽  
Bacterial Vaginosis ◽  
Pregnant Women ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Asymptomatic Bacteriuria ◽  
Care Hospital ◽  
Posterior Fornix

Background and Objectives: The association between bacterial vaginosis and urinary tract infection (UTI) in pregnant women is at a greater risk comparatively than patients with bacterial vaginosis or UTI. Bacterial vaginosis and asymptomatic UTI both pose risk for  mother and fetus. Early diagnosis and treatment can save the life of both. The present investigation was aimed to find out the magnitude of asymptomatic bacteriuria in pregnant women with noticeable bacterial vaginitis at- tending antenatal outpatient and inpatient of a tertiary care hospital and to identify the organisms causing it. Materials and Methods: A total of 117 antenatal women from different age and parity groups with different gestational ages were included in the study. The samples were subjected to standard microbiological techniques for identification of micro- organisms. While performing Per speculum examination, vaginal secretions were collected from the posterior fornix. Swabs from the posterior fornix were tested for pH using litmus paper. A wet mount and Gram smear was made and examined for the presence of bacteria, polymorphs and clue cells indicating bacterial vaginosis. Amsel’s criteria and Nugent scoring sys- tem were applied for diagnosis of bacterial vaginosis. Antibiotic susceptibility of the isolated bacteria was performed using Kirby-Bauer method. Results: Bacterial vaginosis infection rate (62.3%) was common in the present study followed by asymptomatic UTI (n=60, 51%). It was also observed that asymptomatic urinary tract infection (UTI) with Bacterial vaginosis prevalent rate was 49 (41.8%) in the current study. Conclusion: Bacterial vaginosis was more common than asymptomatic bacteriuria in pregnant women. It is recommended that antenatal health care facilities should incorporate screening of vaginitis among pregnant women to prevent the complica- tions of pregnancy. And those women with Bacterial vaginosis should be screened for UTI. Proper use of antibiotics should be encouraged, abuse of antibiotics should be in check.

Renal disease in pregnancy

2010 ◽  
pp. 2103-2107
Author(s):  
John D. Firth
Keyword(s):  
Urinary Tract Infection ◽  
Birth Weight ◽  
Urinary Tract ◽  
Tract Infection ◽  
Renal Disease ◽  
Asymptomatic Bacteriuria ◽  
Fetal Outcome ◽  
Symptomatic Infection ◽  
Adverse Fetal Outcome ◽  
In Pregnancy

Urinary tract infection—2 to 10% of pregnancies are complicated by asymptomatic bacteriuria, which progresses to symptomatic infection in 40% of cases and is associated with adverse fetal outcome. Antibiotic treatment reduces the chances of developing symptomatic infection and of infants being born with low birth weight....

scholarly journals Prevalence of asymptomatic bacteriuria in pregnant women

2015 ◽  
Vol 9 (2) ◽  
pp. 64-69
Author(s):  
Nishat Jubaida ◽  
Narjis Maliha Kawsar ◽  
Nahid Elora ◽  
Md Rahimgir ◽  
Nahid Reaz Shapla ◽  
...  
Keyword(s):  
Urinary Tract Infection ◽  
Urinary Tract ◽  
Tract Infection ◽  
Pregnant Women ◽  
Asymptomatic Bacteriuria ◽  
Armed Forces ◽  
Antenatal Visit ◽  
Urine Specimen ◽  
Antimicrobial Susceptibility Pattern ◽  
Increased Risk

Introduction: Women with asymptomatic bacteriuria during pregnancy are more likely to deliver premature or low birth weight babies and having a 20 – 40 percent increased risk of developing pyelonephritis during pregnancy compared with women without bacteriuria. Asymptomatic bacteriuria is a microbiological diagnosis based on urine culture from persons without signs or symptoms of urinary tract infection. Objectives: The aim of this study was to determine the prevalence of asymptomatic bacteriuria in pregnant women and also to determine the relationship between the asymptomatic bacteriuria and pyuria to isolate the causative pathogens and to find out the antimicrobial susceptibility pattern of the isolates. Methods: A total of 540 urine specimen were collected from 540 asymptomatic pregnant women for urinary tract infection, over a period 2 years from January 2011 to December 2012 at Border Guard Bangladesh (BGB) Hospital, Pilkhana, Dhaka. All specimens were processed using standard microbiological procedures. All the subjects were evaluated for bacteriuria. Results: The prevalence of asymptomatic bacteriuria was 10.2% . Pyuria was found in 15.9% of cases. Escherichia coli (80%) was the commonest causative agent of asymptomatic bacteriuria followed by Staphylococcus saprophyticus (14.5%) and Pseudomonas spp.(5.5%). Nitrofurantoin was found to be highly sensitive to most of the isolates. 64 JAFMC Bangladesh. Vol 9, No 2 (December) 2013 Conclusion: Screening for bacteriuria in pregnancy and proper treatment of diagnosed cases must be considered as an essential part of antenatal care in our country. To prevent complications of asymptomatic bacteriuria, all pregnant women should be screened at the first antenatal visit. A negative test for pyuria is not a reliable indicator of the absence of asymptomatic bacteriuria in pregnant women. DOI: http://dx.doi.org/10.3329/jafmc.v9i2.21830 Journal of Armed Forces Medical College Bangladesh Vol.9(2) 2013

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