scholarly journals Association of serum hormone profile and semen quality of infertile males in and around Chennai

Author(s):  
K. Palani ◽  
A. Abdul Jabbar ◽  
N. Jagannathan ◽  
T. Babu Thangadurai

Background: The infertility rate in India has also increased gradually along with population growth. Based on the geographic, the prevalence of male infertility varies. It is noticed that around the world 60–80 million couples with infertility problem every year. The aim of the study was to assess the correlation between the serum hormones and semen quality in infertile males.Methods: This research study was conducted in 60 infertile males aged from 20–50 years who reported at the Department of Andrology, Kanmani Fertility Centre (Pvt. Ltd.), Chennai, Tamil Nadu, India. The semen and hormone analysis was done in all study participants and its correlation was studied using SPSS (statistical product and service solutions) software.Results: The results demonstrate that among the study participants, 15.0% of them were normozoospermia, asthenozoospermia (26.6%), asthenoteratozoospermia (21.6%), oligoasthenozoospermia (16.6%) and oligoasthenoteratozoospermia (20.0) respectively. The results of Pearson correlation revealed that TSH, FSH, LH and PRL show a negative correlation but TST level shows a positive correlation with semen parameters.Conclusions: This study concludes that the serum hormones concentration was observed abnormal in infertile males which show negative correlation with semen parameters of the study participants.

2020 ◽  
Vol 32 (2) ◽  
pp. 137
Author(s):  
Y. Pirosanto ◽  
M. Valera ◽  
A. Molina ◽  
J. Dorado ◽  
S. Demyda-Peyrás

Inbreeding depression, a genetic condition produced by the mating of close-related individuals, has been associated with a reduction of fertility in several species. However, a loss in sperm quality was also associated with age. In horses, the few existing reports have described a tendency of both parameters to produce a negative effect on sperm quality. However, those reports were performed using a subjective evaluation of sperm motility. In the present study, a total of 692 ejaculates from 86 Pure Spanish stallions (PRE), aged between 3 and 22 years, were evaluated using a computer-assisted methodology to determine the effect of inbreeding in four semen parameters: free-gel volume (V), sperm concentration (C, by haemocytometer), and total (TM) and progressive (PM) sperm motility (by Spermvision sperm class analyser; Minitube). The inbreeding coefficient (F) was estimated using 300 000 PRE pedigree records approximately (minimum pedigree depth, eight equivalent complete generations; range, between 1 and 30.1%). Stallion, age, ejaculate, and season of semen collection were the variables included in the statistical model (general linear model), with ejaculate and season being the variables with a major effect (by variance components analysis). Our results showed that sperm concentration (r=−0.18; P<0.0001) and volume (to a lesser extent) were reduced with advancing age, both showing a major decline after 15 years of age. To the contrary, sperm motility was not affected by age of the stallion. We also found a negative correlation between the inbreeding coefficient and ejaculate volume (r=−0.14; P<0.001), with a marked decrease seen when F was between 7 and 20%. Also, a negative correlation was observed in PM (r=−0.08; P<0.05), although to a lower extent. Conversely, C and TM were not affected by inbreeding depression (P>0.05). In conclusion, our results demonstrated that high levels of inbreeding can compromise severely the sperm quality of the PRE stallion, which, subsequently, may have a negative influence on fertility. Ongoing studies using genomic data will help to detect genetic variants associated with stallion semen quality and how it is influenced by inbreeding in specific genomic regions.


2013 ◽  
Vol 61 (2) ◽  
pp. 209-219 ◽  
Author(s):  
Janko Mrkun ◽  
Marjan Kosec ◽  
Petra Zrimšek

The aim of this study was to address the question whether changes in boar semen quality after short-term storage could be predicted on the basis of standard semen parameters and TNF-α level determined on the day of semen collection under commercial conditions. Progressive motility showed the highest positive correlation with morphology on day 0 of collection, and progressive motility on day 3 (P < 0.05) showed a negative correlation with acrosome abnormalities (P < 0.05). According to the area under receiver operating characteristics (ROC) curves (AUCs), progressive motility could also be used in predicting semen quality after 3 days of storage (AUC > 0.5; P < 0.05). TNF-α in seminal plasma is the only parameter measured on day 0 to show a significant correlation with the percentage of viable spermatozoa after 3 days of semen storage (r = 0.495, P < 0.05). ROC analysis shows that TNF-α level is helpful in discriminating viability outcome after semen storage (AUC = 0.94, P < 0.001). We can predict with 92.35% certainty that fresh semen samples with more than 150 pg/ml of TNF-α in the seminal plasma will retain more than 85% of viable spermatozoa after 3 days of storage. Thus, TNF-α can contribute to predicting the quality of short-term stored semen.


2021 ◽  
Vol 48 (1) ◽  
pp. 47-54
Author(s):  
I. A. Omodewu ◽  
T. Olorungbohunmi ◽  
B. A. Boladuro ◽  
J. O. Abiona ◽  
C. P. Njoku

Moringa oleifera leaf extract (MLE) contains antibacterial properties; this study evaluated the effect of including MLE, breed and storage time on semen quality of boars extended with Beltsville thawing solution (BTS). Semen samples were collected weekly from twelve boars (Four Duroc, four Large White and four Landrace). Samples were extended with 0, 0.25, 0.50, 0.75 and 1.00g MLE inclusions. Parameters; volume and concentration were taken immediately after collection while pH, mass activity (%MA), progressive motility (%PM), liveability (%LA) and abnormality (%ABN) were taken at 0, 24, 48 and 72 hours. Data obtained were subjected to analysis of variance. All parameters considered except %ABN were significant (p<0.05). MA ranged between 3.31 (1.00gMLE) and 4.00 (0gMLE). Highest PM was 60.93% in 0.25gMLE, pH differed with 6.98 (0gMLE) and 6.90 (1.00gMLE), 0gMLE (89.64%) had higher LA compared to 0.25gMLE (86.40%), ABN ranged between3.94 to 4.60%. As storage time increased viability of all semen parameters reduced, between 48 and 72 hours parameters reduced below normal limits. Breed effect differed (p<0.05) for MA, Volume and Conc., Duroc (3.78) had higher MA compared to Large White (3.64) and Landrace (3.60). Semen volume (p<0.05) for Landrace (255.20g) was highest while Duroc (170.80g) was lowest. Large white concentration (201.8million spermatozoa/ml) was higher (p<0.05) than Landrace (187.4 million spermatozoa/ml) and Duroc (123.8million spermatozoa/ml). %LA ranged between 88.06% and 88.72% for Duroc and landrace respectively while %ABN was between 3.97-4.41% for Large White and Landrace. This study concluded that 0.75-1.00gMLE could replace synthetic antibiotic in BTS for 24 hours.     L'extrait de feuille de Moringa oleifera (le 'MLE') contient des propriétés antibactériennes ; Cette étude a évalué l'effet de l'inclusion de 'MLE', de la race et du temps de stockage sur la qualité du sperme de verrats exotiques additionnés de solution de décongélation de Beltsville (le 'BTS'). Des échantillons de sperme ont été prises chaque semaine de douze verrats (quatre Duroc, quatre Large White et quatre Landrace). Les échantillons ont été étendus avec des inclusions de 0, 0,25, 0,50, 0,75 et 1,00 g de 'MLE'. Paramètres ; le volume et la concentration ont été prélevés immédiatement après le prélèvement tandis que le pH, l'activité massique (% 'MA'), la motilité progressive (% 'PM'), l'habitabilité (% LA) et l'anomalie (% ABN) ont été pris à 0, 24, 48 et 72 heures. Les données obtenues ont été soumises à une analyse de variance. Tous les paramètres considérés à l'exception du% ABN étaient significatifs (p <0,05). Le MA variait entre 3,31 (1,00 g MLE) et 4,00 (0 gMLE). La'PM la plus élevée était de 60,93% dans 0,25 gMLE, le pH différait de 6,98 (0 gMLE) et 6,90 (1,00 gMLE), 0 gMLE (89,64%) avait un LA plus élevé par rapport à 0,25 gMLE (86,40%), l''ABN' variait entre 3,94 et 4,60%. À mesure que la durée de stockage augmentait la viabilité de tous les paramètres du sperme, entre 48 et 72 heures, les paramètres étaient réduits en dessous des limites normales. L'effet de la race était différent (p <0,05) pour la MA, le volume et la concentration. Duroc (3,78) avait une MA plus élevée que le Large White (3,64) et le Landrace (3,60). Le volume de sperme (p <0,05) pour Landrace (255,20 g) était le plus élevé, tandis que Duroc (170,80 g) était le plus faible. La grande concentration de blanc (201,8 millions de spermatozoïdes / ml) était plus élevée (p <0,05) que Landrace (187,4 millions de spermatozoïdes / ml) et Duroc (123,8 millions de spermatozoïdes / ml). % LA variait entre 88,06% et 88,72% pour Duroc et landrace respectivement tandis que% ABN était entre 3,97-4,41% pour Large White et Landrace. Cette étude a conclu que 0,75-1,00 gMLE pouvait remplacer l'antibiotique synthétique dans le BTS pendant 24 heures.


2021 ◽  
Author(s):  
Samuel Opoku Asiedu ◽  
Alexander Kwarteng ◽  
Emmanuel Kobla Atsu Amewu ◽  
Priscilla Kini ◽  
Bill Clinton Aglomasa ◽  
...  

Abstract BackgroundHuman lymphatic filarial pathology is the leading cause of disability and poverty among people living with the infection. The second goal of the Global Programme to Eliminate Lymphatic Filariasis (GPELF) is to manage the disease's morbidity to improve patients' quality of life. Consequently, the current study assessed the overall quality of life of lymphatic filariasis (LF) pathology patients in some selected endemic communities in rural Ghana. MethodIn the present study, the Lymphatic Filariasis Quality of Life Questionnaire (LFSQQ) was used to evaluate the effect of lymphatic filariasis on the quality of life of people, with the disease in nine (9) communities in the Ahanta West District of the Western Region of Ghana where mass drug administration is being implemented for the past twenty years. Pearson’s correlation, linear regression, and one-way analysis of variance (ANOVA) analyses were used to assess the associations between the LFSQQ instrument domains.ResultsOf the 155 study participants recruited, 115 (74.19%) were females, and 40 (25.81%) males. A greater proportion of the study participants (40, 25.8%) were presented with stage two (2) lymphoedema, while only two patients had stage seven (7) lymphoedema. The average of the overall quality of life scores of study participants was 68.24. There was a negative Pearson correlation (r = -0.504, p-value < 0.001) between the stage of lymphoedema (severity of the disease) and the quality of life of the LF patients. In addition, a clear pattern of positive correlation (r = 0.71, p-value < 0.001) was observed between the disease burden and pain/discomfort domains of the study participants. Whereas the highest domain-specific score (85.03) was observed in the domain of self-care, we noted that the environmental domain, which consists of the financial status, was the lowest (45.94) among the study participants. ConclusionOur findings support previous works on the reduced quality of life among lymphatic filariasis patients with pathology. In this study, our results reveal a depressing financial condition among people presenting with late stages of LF pathologies, which eventually reduces their well-being.


2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Samuel Opoku Asiedu ◽  
Alexander Kwarteng ◽  
Emmanuel Kobla Atsu Amewu ◽  
Priscilla Kini ◽  
Bill Clinton Aglomasa ◽  
...  

Abstract Background Human lymphatic filarial pathology is the leading cause of disability and poverty among people living with the infection. The second goal of the Global Programme to Eliminate Lymphatic Filariasis (GPELF) is to manage the disease’s morbidity to improve patients’ quality of life. Consequently, the current study assessed the overall quality of life of lymphatic filariasis (LF) pathology patients in some selected endemic communities in rural Ghana. Method In the present study, the Lymphatic Filariasis Quality of Life Questionnaire (LFSQQ) was used to evaluate the effect of lymphatic filariasis on the quality of life of people, with the disease in nine (9) communities in the Ahanta West District of the Western Region of Ghana where mass drug administration is being implemented for the past twenty years. Pearson’s correlation, linear regression, and one-way analysis of variance (ANOVA) analyses were used to assess the associations between the LFSQQ instrument domains. Results Of the 155 study participants recruited, 115 (74.19%) were females, and 40 (25.81%) males. A greater proportion of the study participants (40, 25.8%) were presented with stage two (2) lymphoedema, while only two patients had stage seven (7) lymphoedema. The average of the overall quality of life scores of study participants was 68.24. There was a negative Pearson correlation (r = − 0.504, p-value < 0.001) between the stage of lymphoedema (severity of the disease) and the quality of life of the LF patients. In addition, a clear pattern of positive correlation (r = 0.71, p-value < 0.001) was observed between the disease burden and pain/discomfort domains of the study participants. Whereas the highest domain-specific score (85.03) was observed in the domain of self-care, we noted that the environmental domain, which consists of the financial status, was the lowest (45.94) among the study participants. Conclusion Our findings support previous works on the reduced quality of life among lymphatic filariasis patients with pathology. In this study, our results reveal a depressing financial condition among people presenting with late stages of LF pathologies, which eventually reduces their well-being.


2017 ◽  
Vol 4 (4) ◽  
Author(s):  
Dr. M. Sridhar ◽  
Dr. Syed Ummar I ◽  
Dr. Sushith Sugathan Chennatte

Objective: To study the correlation between severity of depression and the quality of sleep disturbances in patients with non psychotic depression. Method: A cross-sectional study of a cohort of 30 outpatient sample with non psychotic depression were recruited for the study. Controls were the accompanying relatives of the patients. Study was conducted at a government hospital in Tamil Nadu, South India. Inclusion criteria in the study group required fulfillment of ICD 10 criteria for major depressive disorder. Patients who were 18yrs of age and above and both male and female genders were included in the study. Both study and control groups were administered the Pittsburg Sleep Quality Index (PSQI) and the Epworth sleepiness scale to measure the quality of sleep disturbances in the sample. Correlation between HAMD depression severity and the PSQI sleep quality scores and the Epworth sleepiness scale scores in the depressive patients and the correlation between nocturnal sleep disturbances and day-time sleepiness among depressed patients were analyzed using Pearson correlation coefficient. Results: Analysis revealed significant inverse correlation between the severity of depression and components of quality of sleep such as subjective sleep quality, total sleep duration and habitual sleep efficiency and positive correlation with sleep latency. Conclusions: Study shows that as the severity of depression increases the severity of sleep disturbances also increases which also was significant when compared with the various components of sleep quality on the PSQI scale.


2020 ◽  
Author(s):  
Samuel Opoku Asiedu ◽  
Emmanuel Kobla Atsu Amewu ◽  
Priscilla Kini ◽  
Bill Clinton Aglomasa ◽  
John Boulard Forkuor ◽  
...  

Abstract BackgroundHuman lymphatic filarial pathology is the main cause of disability and poverty among people living with the infection. The second goal of the Global Programme to Eliminate Lymphatic Filariasis (GPELF) is to manage the morbidity associated with the disease with the purpose of improving the quality of life of the patients. Consequently, the current study assessed the overall quality of life of lymphatic filariasis (LF) pathology patients in some selected endemic communities in rural Ghana.MethodIn the present study, the Lymphatic Filariasis Quality of Life Questionnaires (LFSQQ) was used to evaluate the effect of lymphatic filariasis on the quality of life of people with the disease in ten (10) communities in the Ahanta West District of the Western Region of Ghana where, mass drug administration is being implemented for the past twenty years.ResultsOf the 155 study participants recruited, 115 (74.19%) were females and 40 (25.81%) males. A greater proportion of the study participants (40, 25.8%) were presented with stage two (2) lymphedema while only 2 patients had stage seven (7) lymphedema. The average of the overall quality of life scores of study participants was 68.24. There was a negative Pearson correlation (r = -0.504, p-value < 0.0001) between the stage of lymphedema (severity of the disease) and the quality of life of the LF patients. In addition, a clear pattern of positive correlation (r = 0.71, p-value < 0.001) was observed between the disease burden and pain/discomfort domains of the study participants. Whereas, the highest domain specific score (85.03) was observed in the domain of self-care, we noted that the environmental domain, which consist of the financial status was the lowest (45.94) among the study participants.ConclusionOur findings support previous works on the reduced quality of life among lymphatic filariasis patients with pathology. In this study, our results reveal a depressing financial condition among people presenting with late stages of LF pathologies, which eventually reduces their wellbeing.


2020 ◽  
Author(s):  
Samuel Opoku Asiedu ◽  
Alexander Kwarteng ◽  
Emmanuel Kobla Atsu Amewu ◽  
Priscilla Kini ◽  
Bill Clinton Aglomasa ◽  
...  

Abstract Background Human lymphatic filarial pathology is the main cause of disability and poverty among people living with the infection. The second goal of the Global Programme to Eliminate Lymphatic Filariasis (GPELF) is to manage the morbidity associated with the disease with the purpose of improving the quality of life of the patients. Consequently, the current study assessed the overall quality of life of lymphatic filariasis (LF) pathology patients in some selected endemic communities in rural Ghana. Method In the present study, the Lymphatic Filariasis Quality of Life Questionnaire (LFSQQ) was used to evaluate the effect of lymphatic filariasis on the quality of life of people, with the disease in nine (9) communities in the Ahanta West District of the Western Region of Ghana where mass drug administration is being implemented for the past twenty years. Pearson’s correlation, linear regression and one-way analysis of variance (ANOVA) analyses were used to assess the associations between the domains of LFSQQ instrument. Results Of the 155 study participants recruited, 115 (74.19%) were females and 40 (25.81%) males. A greater proportion of the study participants (40, 25.8%) were presented with stage two (2) lymphedema while only 2 patients had stage seven (7) lymphedema. The average of the overall quality of life scores of study participants was 68.24. There was a negative Pearson correlation (r = -0.504, p-value < 0.001) between the stage of lymphedema (severity of the disease) and the quality of life of the LF patients. In addition, a clear pattern of positive correlation (r = 0.71, p-value < 0.001) was observed between the disease burden and pain/discomfort domains of the study participants. Whereas the highest domain specific score (85.03) was observed in the domain of self-care, we noted that the environmental domain, which consists of the financial status was the lowest (45.94) among the study participants. Conclusion Our findings support previous works on the reduced quality of life among lymphatic filariasis patients with pathology. In this study, our results reveal a depressing financial condition among people presenting with late stages of LF pathologies, which eventually reduces their wellbeing.


2005 ◽  
Vol 21 (1-2) ◽  
pp. 55-63 ◽  
Author(s):  
Elena Kistanova ◽  
H. Zlatev ◽  
V. Karcheva ◽  
A. Kolev

Tribulus terrestris extract was added to the forage of 8 rams of Pleven Blackhead and Abaci breed once daily in dose l,5g per head for a period of 40 days. Semen parameters and sexual behavior during semen collection were evaluated. It was found that Tribulus terrestris extract improves semen quality of rams: the count of spermatozoids, time of viability and motility of sperms increase. The great number of born lambs after the use of treated rams for insemination confirms high fertility of their semen. All experimental rams manifested a good libido and active sexual behavior.


2018 ◽  
Vol 30 (1) ◽  
pp. 186
Author(s):  
C. C. Goblet ◽  
A. E. Newell-Fugate ◽  
G. West ◽  
J. M. Campos-Krauer

Priority conservation actions for the endangered Chacoan peccary (Catagonus wagneri) include improvement of captive breeding initiatives. Eleven captive male peccaries housed in mixed-sex groups of 17 to 35 animals at the Centro Chaqueño para la Conservación e Investigación in Paraguay were immobilised with intramuscular tiletamine/zolazepam (30 mg; Zoletil® 50, Virbac, Forth Worth, TX, USA), azaperone (10 mg; 50 mg mL−1; ZooPharm, Windsor, CO, USA), and medetomidine (1 mg;10 mg mL−1; ZooPharm). Animals were administered supplemental intranasal oxygen (1-2 L min−1) and reversed with atipamazole (5 mg; 25 mg mL−1; ZooPharm). Testis length, width, and firmness (1-3 scale; 1 = hard, 2 = normal, 3 = flaccid) were recorded. The preputial sheath was clipped, cleaned, and flushed with sterile saline using a Foley catheter. A lubricated 13-mm-diameter electroejaculator probe (Beltron Instruments, Longmont, CO, USA) was inserted into the rectum to a depth of 5 cm. The electroejaculation protocol consisted of 4 cycles of 10 stimuli each (1-4 V/cycle). Collection tubes were changed frequently during electroejaculation to avoid urine or gel fraction contamination of the sperm-rich fraction. Collected semen was evaluated for volume, color/appearance, and pH. Percent motility was determined as the average motility of spermatozoa from 10 fields (40×). Progressive motility of spermatozoa was scored on a scale of 0-5 (0 = dead sperm; 5 = rapid forward progression). Semen samples were assessed for total spermatozoa. Percent of live spermatozoa and spermatozoa morphology were evaluated with Eosin-Negrosin smears. The mean ± standard error of the mean of each parameter is presented. A Pearson correlation coefficient between age and semen parameters was calculated. Males assessed in this study were 10.5 ± 1.2 years old. The mean testis volume was 1005.7 ± 50.9 cm3 and mean testis firmness was 2.1 ± 0.1. The mean ejaculate volume was 2.9 ± 0.7 mL and pH was 7.7 ± 0.3. Few males had motile spermatozoa (n = 5/9), which yielded a mean percent motility of 18.3 ± 8.5 (range: 0-50%) and a mean progressive motility of 0.6 ± 0.3 (range: 0-2). The mean percentage of live spermatozoa was 25.1 ± 5.6 (range: 4-44%). Male Chacoan peccaries in this population had a low percentage of normal spermatozoa (12.4 ± 2.5%; range: 2.8-24.0%). The mean total count of spermatozoa per ejaculate was 1.58 ± 1.01 million (range: 0.09-8.28 million). Spermatozoa defects were predominantly primary (67.1%), with the most common defects being tapered head (15.4 ± 6.2%), diadem/crater (14.8 ± 2.6%), and excess residual cytoplasm (8.5 ± 2.7%). There was no correlation between age and semen parameters (percent live: r = –0.19; motility percentage: r = 0.01; percent normal spermatozoa: r = 0.38; total count: r = 0.29; P > 0.05). This is the first report of semen parameters in the Chacoan peccary. It is unknown whether the poor semen quality is inherent to the species or this population. Reproductive assessment of males from other captive populations and of wild male Chacoan peccaries is warranted.


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