scholarly journals Correlation between maternal thyroid stimulating hormone and birth weight of neonate

2021 ◽  
Vol 11 (1) ◽  
pp. 55
Author(s):  
Nishita Shettian ◽  
Hema Venkata Naga Sai Sudha Pavuluri
Keyword(s):  
Birth Weight ◽  
Low Birth Weight ◽  
First Trimester ◽  
Thyroid Stimulating Hormone ◽  
Research Centre ◽  
Healthy Pregnancy ◽  
Maternal Thyroid ◽  
Altered Thyroid ◽  
Study Participants ◽  
Stimulating Hormone

Background: The aim of this study is to determine the pregnancy outcomes in women with thyroid disorders.Methods: This is a retrospective observational study conducted in the department of obstetrics and gynaecology of AJ institute of medical sciences and research centre from the month of March to September 2021. The first trimester thyroid stimulating hormone (TSH) level and birth weight of new born is collected from hospital records, study participants included all the pregnant mothers who were admitted and delivered in the labour ward of AJ institute of medical sciencesResults: According to our study low birth weight in neonates in euthyroid, hypothyroid, hyperthyroid participants were 21.4%, 61.5%, and 100% respectively.Conclusions: This study indicates that there is an association between maternal thyroid levels and neonatal birth weight. A higher TSH concentration during first trimester of pregnancy is associated with low birth weight. Based on these findings, it is recommended that maternal thyroid levels be monitored closely in the first trimester and initiate timely treatment in case of altered thyroid levels during pregnancy in order to have a healthy pregnancy and healthy baby with no compromise in the fetal weight. 

scholarly journals Initial and delayed thyroid-stimulating hormone elevation in extremely low-birth-weight infants

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Shin Ae Yoon ◽  
Yun Sil Chang ◽  
So Yoon Ahn ◽  
Se In Sung ◽  
Won Soon Park
Keyword(s):  
Birth Weight ◽  
Low Birth Weight ◽  
Perinatal Asphyxia ◽  
Thyroid Stimulating Hormone ◽  
Extremely Low Birth Weight ◽  
Free T4 ◽  
Low Birth Weight Infants ◽  
Neurodevelopmental Outcomes ◽  
Levothyroxine Replacement ◽  
Stimulating Hormone

Abstract Background To determine the incidence, etiology, and outcomes of thyroid-stimulating hormone (TSH) elevation in extremely low-birth-weight infants (ELBWIs). Methods Newborn thyroid screening data of 584 ELBWIs (birth weight, < 1000 g; gestational age, ≥ 23 weeks) were retrospectively analyzed to identify initial (≤ 2 postnatal weeks) and delayed (> 2 weeks) TSH elevations. Growth and neurodevelopmental outcomes at 2 years’ corrected age (CA) were assessed according to levothyroxine replacement. Results Initial and delayed TSH elevations were detected at CAs of 27 and 30 weeks, respectively, with incidence rates of 0.9 and 7.2%, respectively. All infants with initial TSH elevations had perinatal asphyxia, and 95% of those with delayed TSH elevation were exposed to various stressors, including respiratory support, drugs, and surgery within 2 weeks before diagnosis of TSH elevation. Free thyroxine (T4) levels were simultaneously reduced in 80 and 57% of infants with initial and delayed TSH elevations, respectively. Both initial and delayed TSH elevations were transient, regardless of levothyroxine replacement. Infants receiving levothyroxine replacement therapy had significantly higher TSH elevations, significantly lower free T4 levels, and significantly reduced mortality, compared to untreated infants. However, levothyroxine replacement had no significant effect on long-term growth and neurodevelopmental outcomes. Conclusions The timing of insult superimposition on hypothalamic–pituitary–thyroid axis maturation is a major determinant of initial or delayed TSH elevation in ELBWIs. Levothyroxine replacement did not affect growth or neurodevelopmental outcomes in this population.

EPIDEMIOLOGIC CHARACTERISTICS AND RISK FACTORS FOR CONGENITAL HYPOTHYROIDISM FROM 2009 TO 2018 IN XIAMEN, CHINA

2020 ◽  
Vol 26 (6) ◽  
pp. 585-594 ◽  
Author(s):  
Jing Chen ◽  
Shaowu Lin ◽  
Guozhang Zeng ◽  
Weixing Wang ◽  
Zhenqiu Lin ◽  
...  
Keyword(s):  
Birth Weight ◽  
Low Birth Weight ◽  
Newborn Screening ◽  
Congenital Hypothyroidism ◽  
Urban Areas ◽  
Thyroid Stimulating Hormone ◽  
Diagnosis And Treatment ◽  
Low Birth Weight Infants ◽  
Transient Congenital Hypothyroidism ◽  
Stimulating Hormone

Objective: Early diagnosis and treatment of children with congenital hypothyroidism (CH) through newborn screening can effectively prevent delayed development. This study was designed to investigate the pathogenesis and factors that influence CH in urban areas of China between 2009 and 2018. Methods: A retrospective analysis of newborn screening data and diagnosis and treatment information for CH diagnosed in the information database of the neonatal disease screening center in one of China's five special economic zones from 2009 to 2018. Results: Of the 947,258 newborns screened between 2009 and 2018, 829 (406 girls) were diagnosed with CH at birth (1 diagnosis/1,136 births). Among the 608 cases of CH diagnosed at birth and re-evaluated at the age of 3 years, 487 were permanent congenital hypothyroidism (PCH, 1/1,429), and 121 were transient congenital hypothyroidism (TCH, 1/5,882). A total of 83.2% of infants with PCH (405/487) underwent thyroid imaging in the neonatal period, of which thyroid dysgenesis accounted for 28.64% (116/405) and functional defects accounted for 71.36% (289/405). The incidence of CH changed significantly in infants with initial serum thyroid-stimulating hormone concentrations of 41 to 100 mIU/L and ≥100 mIU/L, whereas the incidence of mild CH showed a slight increase. The incidence of CH was significantly higher in postterm infants (1/63) and low-birth-weight infants (1/370). Conclusion: In the past decade, the incidence of CH has increased, mainly due to the increase in the incidence of PCH and TCH. The incidence of mild CH has increased slightly. Postterm birth and low birth weight are important factors affecting the incidence of CH. Abbreviations: CH = congenital hypothyroidism; FT4 = free thyroxine; L-T4 = levothyroxine sodium; PCH = permanent congenital hypothyroidism; TCH = transient congenital hypothyroidism; TSH = thyroid-stimulating hormone; TT4 = total thyroxine

The role of maternal prenatal thyroid function on offspring depression: Findings from the ALSPAC cohort

2019 ◽  
Vol 32 (1) ◽  
pp. 189-196 ◽  
Author(s):  
Dagnachew Muluye Fetene ◽  
Kim S. Betts ◽  
Rosa Alati
Keyword(s):  
Thyroid Function ◽  
First Trimester ◽  
Thyroid Stimulating Hormone ◽  
Thyroid Peroxidase ◽  
Child Depression ◽  
Depression And Anxiety ◽  
Thyroid Peroxidase Antibodies ◽  
First Trimester Of Pregnancy ◽  
Maternal Thyroid ◽  
Stimulating Hormone

AbstractMaternal thyroid dysfunction during pregnancy may contribute to offspring neurobehavioral disorders. In this paper, we investigate the relationship between maternal thyroid function during pregnancy and offspring depression and anxiety. Data were taken from the Avon Longitudinal Study of Parents and Children. A total of 2,920 mother-child pairs were included. Thyroid-stimulating hormone levels, free thyroxine (FT4), and thyroid peroxidase antibodies were assessed during the first trimester of pregnancy because maternal supply is the only source of thyroid hormone for the fetus during the first 12 weeks of gestation. Child symptoms of depression and anxiety were assessed using the Development and Well-Being Assessment at ages 7.5 and 15 years. The odds of presenting with depression and anxiety were estimated using the generalized estimating equation. The level of FT4 during the first trimester of pregnancy was associated with child depression combined at ages 7.5 and 15 (odds ratio = 1.21, 95% confidence interval [1.00, 1.14]. An increase of 1 standard deviation of FT4 during pregnancy increased the odds of child depression by 28% after adjustment made for potential confounders. No association was found among maternal levels of thyroid-stimulating hormone, FT4, and thyroid peroxidase antibodies and childhood anxiety. In conclusion, increased levels of FT4 during the first trimester of pregnancy appear be linked to greater risk of offspring depression.

MATERNAL THYROID-STIMULATING HORMONE LEVEL IN THE FIRST TRIMESTER AND SEX RATIO AT BIRTH

2019 ◽  
Vol 25 (4) ◽  
pp. 315-319
Author(s):  
Xiao Wang ◽  
Xiaoting Sun ◽  
Lili Yang ◽  
Rong Tang ◽  
Jing Zhou ◽  
...  
Keyword(s):  
Sex Ratio ◽  
Hormone Level ◽  
First Trimester ◽  
Thyroid Stimulating Hormone ◽  
Sex Ratio At Birth ◽  
Maternal Thyroid ◽  
Stimulating Hormone
Sign in / Sign up

Export Citation Format

Share Document