Association between serum zinc level and simple febrile seizures in children: a hospital-based study

Background: Febrile seizures are the most common cause of convulsions in children and a frequent cause of emergency hospital admissions. There are different hypothesis about neurotransmitters and trace element (such as zinc) changes in cerebrospinal fluid and serum, which can have a role in pathogenesis of febrile convulsions. Hence we want to study this association in our set up. Objectives was to study the association between serum zinc levels and febrile seizures in childern in our set up.Methods: This hospital based, prospective case control study was done in SKIMS Soura Srinagar, Kashmir (J and K), India for one-year period from August 2015 to July 2016. A total of 100 children aged 6 months to 6 years admitted in the hospital presenting with febrile seizures after fulfilling our inclusion and exclusion criteria were enrolled for the study. Informed consent was taken from their attendants and classified into 2 groups of 50 each. Patients with history of simple febrile seizures were taken as cases and those with fever without seizures as controls. A detailed history was taken, and complete physical examination was done on the patients and recorded on a precoded and pretested proforma. Blood was collected within 12 hours of admission and serum zinc levels were estimated. For statistical analysis, SPSS 17 program using t-test was employed. Chi-square test was performed to compare proportion between 2 or more discrete variables. P<0.05 was considered statistically significant.Results: Out of 100 children enrolled, male to female ratio was 1.63:1. Majority of the children were between 6 to 12 months (36%). The clinical presentation comprised of mainly non localized fevers majority of which had clinical evidence to suggest viral etiology (60%), followed by ARI (20%), ASOM (10%), UTI (6%) and bronchiolitis (4%). Mean serum zinc level in cases was 30.96±7.93ugm/dl and in controls it was 35.95±9.25ugm/dl. Serum zinc level was found significantly low in cases of simple febrile seizures as compared to controls (P<0.05).Conclusions: This study reveals that there is positive correlation between low serum zinc levels and febrile convulsions.

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Serum zinc levels in children with simple febrile seizures

International Journal of Contemporary Pediatrics ◽

10.18203/2349-3291.ijcp20192173 ◽

2019 ◽

Vol 6 (4) ◽

pp. 1480

Author(s):

Malavika P. Santappanawar ◽

Habeeb U. Khan ◽

Jaidev M. Devdas ◽

Sujonitha John ◽

Pavan Hegde

Keyword(s):

Serum Zinc ◽

Febrile Seizures ◽

Zinc Level ◽

Nutritional Deficiencies ◽

Control Group ◽

Serum Zinc Level ◽

Chi Square ◽

The Mean ◽

Zinc Levels ◽

Serum Zinc Levels

Background: Febrile seizures are the most common seizures in childhood and are often associated with nutritional deficiencies. The present study was done to find any correlation of serum zinc levels in children with simple febrile seizures.Methods: This study was a hospital based prospective case control study, involving 60 children (30 cases and 30 controls) aged between 6 months to 60 months. Serum zinc level was measured in all subjects by atomic absorption spectrophotometer. Data was analysed by using frequency, percentage and Pearson’s chi square test..Results: Most cases (80%) had serum zinc levels <90 mcg/dl, in comparison with children in the control group where only 30% had serum zinc levels <90 mcg/dl. The mean serum zinc level was 78.9±14.26 mcg/dl in cases with simple febrile seizures and 96.7±12.12 mcg/dl in the control group.Conclusions: The mean serum zinc level was significantly lower in children with simple febrile seizures in comparison with controls.

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A study of serum zinc levels in children with febrile convulsions in comparison with normal and febrile children

International Journal of Contemporary Pediatrics ◽

10.18203/2349-3291.ijcp20200487 ◽

2020 ◽

Vol 7 (3) ◽

pp. 588

Author(s):

Madhubalan T. ◽

Chidambaranathan S. ◽

Ramamoorthy R.

Keyword(s):

Statistical Significance ◽

Serum Zinc ◽

Zinc Level ◽

Serum Zinc Level ◽

Normal Children ◽

Febrile Convulsions ◽

Significant Difference ◽

Zinc Levels ◽

The Brain ◽

Serum Zinc Levels

Background: A seizure is a paroxysmal time-limited change in motor activity and or behavior that results from abnormal electrical activity in the brain. Seizures are common in the pediatric age group and occur in approximately 10% of children. Most seizures in children are provoked by somatic disorders originating outside the brain such as high fever, infection, syncope, head trauma, hypoxia, or toxins. To determine whether children with febrile convulsion have decreased serum zinc level when compared to normal children and children with fever without convulsions.Methods: The study included children admitted with bronchiolitis in between during the period of September 2018 to January 2019 at Department of Pediatrics, Raja Muthiah Medical College and Hospital. It is a case-control study. A sample size of 50 was selected for each group Totally 3 Groups, 1. Children with febrile convulsions,2. Children with fever without convulsions, 3. Normal Children.Results: The mean serum zinc level in children with febrile convulsions was 42.9 mcg/dl. The serum zinc level in children with fever and normal children was 70 mcg/dl and 71 mcg/dl respectively. On comparing the serum zinc level among the three groups statistical significance was obtained between children with febrile convulsions and the other two groups namely normal children and children with fever alone. Thus, decreased serum zinc level is a significant predisposing factor for febrile convulsions. By using Posthoc Multiple comparisons test we came to know that the Fever convulsion group is significantly different from fever and normal group. There is no significant difference between fever and normal group.Conclusions: This study shows that serum zinc levels are decreased in children with febrile convulsions, thus indicating that zinc deprivation plays a significant role in the pathogenesis of febrile convulsions.

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Estimation of serum zinc levels in children with febrile convulsions

International Journal of Contemporary Pediatrics ◽

10.18203/2349-3291.ijcp20182556 ◽

2018 ◽

Vol 5 (4) ◽

pp. 1518 ◽

Cited By ~ 1

Author(s):

Ubaidur Rehman H. ◽

Shamshad Ahmed Khan ◽

Prakash R. Saldanha

Keyword(s):

Serum Zinc ◽

Febrile Seizures ◽

Cross Sectional Study ◽

Zinc Level ◽

Sectional Study ◽

Serum Zinc Level ◽

Cross Sectional ◽

Significant Difference ◽

Zinc Levels ◽

Serum Zinc Levels

Background: Febrile seizures are the most common form of convulsion in children with the aged between 6 months to 6 years. Diﬀerent studies have shown that reduction of zinc leads to the incidence of febrile seizures in children. This study was conducted with the goal of examination of the zinc level in the patients with Febrile Seizures.Methods: This cross sectional study was conducted on 50 children in two equal groups of children with febrile seizures, febrile children without seizures. In order to examine the zinc level blood samples were taken of all subjects and the zinc level of these patients was determined. The data was analyzed using the SPSS-16 statistical software and by descriptive statistical tests.Results: 31 males (47.2%) and 19 female children (52.8%) with the average age of 27.23±15.3 months were examined. The two groups had no signiﬁcant diﬀerence in terms of age and sex. The average of zinc level in the patients with Febrile Seizures was 57.4 µg/dL and it was 116 µg/dL in the febrile children without FS there was a signiﬁcant diﬀerence between the two groups in terms of the zinc level (P=0.01).Conclusions: The low serum zinc level in the group of patients with Febrile Seizures compared with children without febrile seizures indicate the existence of a relationship between the serum zinc level and development of FS in children aged between 6 months and 6 years.

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A study of serum zinc levels among children with seizures in comparison with febrile children without seizures

International Journal of Contemporary Pediatrics ◽

10.18203/2349-3291.ijcp20201023 ◽

2020 ◽

Vol 7 (4) ◽

pp. 876

Author(s):

Pranam G. M. ◽

Usha Hirevenkanagoudar ◽

Sanjeev Chetty

Keyword(s):

Neuronal Excitability ◽

Serum Zinc ◽

Febrile Seizures ◽

Zinc Level ◽

Seizure Threshold ◽

Febrile Convulsions ◽

Pediatric Age Group ◽

High Zinc ◽

Zinc Levels ◽

Serum Zinc Levels

Background: Infants and children are more prone to have seizures than adults. This reflects the greater neuronal excitability at certain ages as the excitatory glutamate system and inhibitory GABA system do not always balance each other. Febrile seizures are the most common type of seizures observed in pediatric age group. Febrile seizures occur in young children at a time in their development when seizure threshold is low. Objective of the study was to determine the levels of zinc in children with febrile seizures when compared to children with fever without seizures.Methods: To determine the levels of zinc in children with febrile seizures when compared to children with fever without seizures. A total of 50 Study subjects were selected into each group. Group 1: Children with Febrile Seizures. Group 2: Children with Fever and Without Febrile Seizures.Results: Among the cases with fever and convulsion Zinc level was found to be low among 72% of the subjects, 22 % of them had normal zinc levels and only 6% had high zinc levels. Among the subjects with Fever and no convulsions nearly 80% of them had normal zinc levels, 16 % had low levels of zinc and 4% had high zinc levels. The association of levels of Zinc between both the groups was found to be statistically significant.Conclusions: This study shows that serum zinc levels are decreased in children with febrile convulsions when compared to children with fever alone without convulsions, thus indicating that zinc deprivation plays significant role in the pathogenesis of febrile convulsions.

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Serum zinc level and prognosis of neonatal sepsis

Paediatrica Indonesiana ◽

10.14238/pi60.2.2020.61-66 ◽

2020 ◽

Vol 60 (2) ◽

pp. 61-66

Author(s):

Chaliza Adnan ◽

I Wayan Dharma Artana ◽

Ketut Suarta ◽

I Gusti Lanang Sidiartha ◽

I Wayan Gustawan ◽

...

Keyword(s):

Neonatal Sepsis ◽

Early Onset ◽

Area Under The Curve ◽

Serum Zinc ◽

Zinc Level ◽

High Serum ◽

Serum Zinc Level ◽

Chi Square ◽

Zinc Levels ◽

Serum Zinc Levels

Background The prognosis of neonatal sepsis can be influenced by various risk factors, one of which is a deficiency of zinc micronutrient substances. Objective To assess for a potential association between serum zinc level and prognosis of infants with early-onset neonatal sepsis (EONS). Methods This prospective cohort study was done in neonates with clinical EONS from September 2017 until December 2018. Serum zinc level was measured on the first day of diagnosis and prognosis was assessed on the fourth day. The association between serum zinc levels and prognosis of EONS was analyzed by Chi-square test and logistic regression with adjustment for confounding variables. Results A total of 70 subjects were divided into two groups based on their serum zinc levels. A cut-off point of 75 ug/dL was used based on area under the curve (sensitivity 91.2% and specificity 93.7%), with accuracy 97.8% (95%CI 0.943 to 1.000; P=0.0001). Subjects with lowzinc level had a 16.8 times greater risk compared to subjects with high serum zinc (RR=16.81; 95% CI 4.35 to 65.02; P <0.0001). Multivariate analysis revealed that subjects with low serum zinc levels had 203.7 times greater risk of worsening than subjects who had a higher serum zinc level (RR 203.72; 95% CI 26.79 to 1549.17; P <0.0001). Covariates such as male sex, low gestational age (<37 weeks), low birth weight (<2,500 grams), asphyxia, Caesarean section delivery, and the presence of comorbidities did not have significant associations with outcomes of EONS (P >0.05). Conclusion Serum zinc level is associated with prognosis of early onset neonatal sepsis, with a cut-off of 75 μg/dL. The high level of serum zinc associates with a better prognosis.

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Serum zinc level and prognosis of neonatal sepsis

Paediatrica Indonesiana ◽

10.14238/pi60.2.2020.37-42 ◽

2020 ◽

Vol 60 (2) ◽

pp. 37-42

Author(s):

Chaliza Adnan ◽

I Wayan Dharma Artana ◽

Ketut Suarta ◽

I Gusti Lanang Sidiartha ◽

I Wayan Gustawan ◽

...

Keyword(s):

Neonatal Sepsis ◽

Early Onset ◽

Area Under The Curve ◽

Serum Zinc ◽

Zinc Level ◽

High Serum ◽

Serum Zinc Level ◽

Chi Square ◽

Zinc Levels ◽

Serum Zinc Levels

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Association between Reduced Serum Zinc and Diastolic Dysfunction in Maintenance Hemodialysis Patients

Nutrients ◽

10.3390/nu13062077 ◽

2021 ◽

Vol 13 (6) ◽

pp. 2077

Author(s):

Jiun-Chi Huang ◽

Ya-Chin Huang ◽

Pei-Yu Wu ◽

Wen-Hsien Lee ◽

Yi-Chun Tsai ◽

...

Keyword(s):

Diastolic Dysfunction ◽

Left Atrial Volume ◽

Serum Zinc ◽

Zinc Level ◽

Volume Index ◽

Serum Zinc Level ◽

Lower Serum ◽

Echocardiographic Parameters ◽

Zinc Levels ◽

Serum Zinc Levels

Diastolic dysfunction is an emerging challenge among hemodialysis (HD) patients, and the associations between serum zinc with echocardiographic parameters and diastolic function remain uncertain. A total of 185 maintenance HD patients were stratified by the tertiles of serum zinc level to compare their clinical characteristics and echocardiography. Correlations of serum zinc levels with echocardiographic parameters were examined using Pearson’s analysis. Univariate and multivariate logistic regression analyses were performed to investigate the determinants of E/e’ ratio >15 and left atrial volume index (LAVI) > 34 mL/m2, both indicators of diastolic dysfunction. Patients belonging to the first tertile of serum zinc level had a significantly higher E/e’ ratio and LAVI. Serum zinc levels were negatively correlated with E (r = −0.204, p = 0.005), E/e’ ratio (r = −0.217, p = 0.003), and LAVI (r = −0.197, p = 0.007). In a multivariate analysis, older age, diabetes, coronary artery disease, and lower serum zinc levels (OR = 0.974, 95% CI = 0.950–0.999, p = 0.039) were significantly associated with E/e’ ratio >15. Furthermore, diabetes and lower serum zinc levels (OR = 0.978, 95% CI = 0.958–0.999, p = 0.041) were significantly associated with LAVI >34 mL/m2. Reduced serum zinc level was significantly associated with diastolic dysfunction among HD patients. Further prospective studies are warranted to investigate whether zinc supplementation can attenuate cardiac dysfunction in maintenance HD patients.

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Serum Zinc Levels and in Vivo Beta-Amyloid Deposition in the Human Brain

10.21203/rs.3.rs-705022/v1 ◽

2021 ◽

Author(s):

Jee Wook Kim ◽

Min Soo Byun ◽

Dahyun Yi ◽

Jun Ho Lee ◽

Min Jung Kim ◽

...

Keyword(s):

Serum Zinc ◽

Beta Amyloid ◽

Zinc Level ◽

Amyloid Deposition ◽

Serum Zinc Level ◽

Positron Emission ◽

Zinc Levels ◽

The Relationship ◽

Serum Zinc Levels

Abstract Background: Despite the known associations between zinc levels and Alzheimer’s disease (AD) dementia and related cognitive impairment, the underlying neuropathological links remain poorly understood. We tested the hypothesis that serum zinc level is associated with cerebral beta-amyloid protein (Ab) deposition. Additionally, we explored associations between serum zinc levels and other AD pathologies [i.e., tau deposition and AD-signature cerebral glucose metabolism (AD-CM)] and white matter hyperintensities (WMHs), which are measures of cerebrovascular injury. Methods: A total of 241 cognitively normal older adults between 55 and 90 years of age were enrolled. All the participants underwent comprehensive clinical assessments, serum zinc level measurement, and multimodal brain imaging, including Pittsburgh compound B-positron emission tomography (PET), AV-1451 PET, fluorodeoxyglucose (FDG)-PET, and magnetic resonance imaging. Zinc levels were stratified into three categories: < 80 µg/dL (low), 80 to 90 µg/dL (medium), and > 90 µg/dL (high). Results: A low serum zinc level was significantly associated with increased Ab retention. In addition, apolipoprotein E ε4 allele (APOE4) status moderated the association: the relationship between low zinc level and Ab retention was significant only in APOE4 carriers. Although a low zinc level appeared to reduce AD-CM, the relationship became insignificant on sensitivity analysis including only individuals with no nutritional deficiency. The serum zinc level was associated with neither tau deposition nor the WMH volume. Conclusions: Our findings suggest that decreased serum zinc levels are associated with elevation of brain amyloid deposition. In terms of AD prevention, more attention needs to be paid to the role of zinc.

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ROLE OF SERUM ZINC LEVEL IN CHILDREN WITH FEBRILE CONVULSIONS

International Journal of Medical and Biomedical Studies ◽

10.32553/ijmbs.v3i9.513 ◽

2019 ◽

Vol 3 (9) ◽

Author(s):

Dr. Laxminarayan Nagal ◽

Dr Jagdish Dabi ◽

Dr. Harish Kumar Mourya

Keyword(s):

Febrile Seizure ◽

Tertiary Care ◽

Serum Zinc ◽

Zinc Level ◽

Control Group ◽

Serum Zinc Level ◽

Tertiary Care Centre ◽

Febrile Convulsions ◽

Zinc Levels ◽

And Control

Background: The aim of the present study was to determine whether there were any changes in serum zinc level in children with febrile seizure in comparison with febrile children without seizure. Methods: A prospective observational study was done on 100 children, admitted in a tertiary care centre. Of these 50 children were diagnosed to have febrile convulsions. The other 50 were febrile children without seizures. Serum zinc levels were measured in all 100 subjects using calorimetric methods. Data was analyzed using SPSS version 22. Results: In present study, we studied 50 children (36 males, 14 females) with febrile seizure and a control group of 50 patients (37 male, 13 female). The mean ages of patients in the febrile seizure and control group were 25.01±14.07 months and 26.07±13.6 months, respectively. Mean zinc level was 69.78±13.13mcg/dl and 80.72±10.21 mcg/dl in study and control groups respectively and this difference was found statistically highly significant (p<0.001). Conclusion: Our findings revealed that serum zinc level was significantly lower in children with febrile seizure in comparison with children without seizure. Keywords: febrile seizure, children, epilepsy.

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Low Serum Zinc Level May be Related to Higher Doses of EPO in Hemodialysis Patients

BANTAO Journal ◽

10.2478/bj-2014-0009 ◽

2015 ◽

Vol 12 (1) ◽

pp. 40-44

Author(s):

Itir Yegenaga ◽

Zeki Aydin

Keyword(s):

Serum Zinc ◽

Zinc Level ◽

Control Group ◽

Inadequate Response ◽

Recombinant Erythropoietin ◽

Serum Zinc Level ◽

Human Recombinant Erythropoietin ◽

Zinc Levels ◽

The Relationship ◽

Serum Zinc Levels

AbstractIntroduction.Anemia is a complication of chronic renal failure observed in patients on hemodialysis (HD) affecting morbidity and mortality of these patients. It is associated with erythropoietin (EPO) deficiency and can be treated by human recombinant erythropoietin (hrEPO). Iron deficiency has been reported as the first line cause for inadequate response to this treatment. Zinc deficiency in hemodialysis (HD) patients was previously reported and the relationship between iron and zinc deficiencies has been known for years. The aim of this study was to find out the relationship between serum zinc level, anemia and rhEPO consuming in HD patients.Methods.A total of 69 HD patients and 34 healthy individuals were included in the study. Serum zinc levels, clinical, hematologic, biochemical parameters and rhEPO doses were evaluated.Results.Serum zinc levels were found to be lower in HD patients in comparison to those in the control group (29.92±12.94, 44.82±27.69μg/dL, respectively) (p<0.001). There was a positive correlation between serum zinc and hemoglobin (Hb) in the control group (R2=0.06). In HD patients who needed less then 8000U/week rhEPO, Hb levels (p<0.05) and serum zinc levels were higher. Serum zinc and Hb levels were found to be higher in patients who were under HD treatment for more than 12 months (10.05±1.06 vs 10.69±1.29; p=0.022 and 26.96±13.29 vs 30.88±12.61; p=0.178).Conclusions.HD patients who needed lower dose of EPO had higher serum zinc levels. Although the difference was not statistically significant, these results provide evidence that serum zinc level should be taken into consideration especially in HD patients resistant to EPO therapy.

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