scholarly journals Helicobacter pylori risk in type 2 diabetes mellitus: a hospital based case-control study

2017 ◽  
Vol 4 (10) ◽  
pp. 3419 ◽  
Author(s):  
Rajesh S. ◽  
Reshma S. ◽  
Shruthi Kamal V.
Keyword(s):  
Helicobacter Pylori ◽  
Case Control Study ◽  
Case Control ◽  
Diabetic Patients ◽  
Type Ii ◽  
Dyspeptic Symptoms ◽  
H Pylori ◽  
Type 2 Diabetic ◽  
Control Study

Background: The aim of this study is to determine the frequency of Helicobacter pylori (H. pylori) infection in Type 2 diabetic and non-diabetic patients with dyspeptic symptoms and to compare the frequency of H. pylori infection in both groups.Methods: This was a hospital-based case-control study was conducted on 196 subjects in the Department of General Surgery, Saveetha Medical College and Hospital (tertiary care hospital) from March 2016 to November 2016. Patients were divided into two groups i.e. type 2 diabetics with poor glycemic control with dyspeptic symptoms and non-diabetics with dyspeptic symptoms. Each group consisted of 98 patients. All type 2 diabetic patients of ≥35 years of age with poor glycemic control both gender and the known cases with history of dyspepsia, epigastric pain or bloating for more than a month were screened for helicobacter pylori infection. The collected data of both groups was evaluated and separated for analysisResults: Majority of the patients were male with mean age±SD, 50±12. Among the type II diabetic group with dyspeptic symptoms, H. pylori was positive in 70/98 (71.4%), whereas in non-diabetic group with dyspeptic symptoms H. pylori was positive in 51/98 (52%) cases.Conclusion: Type II diabetic patients with dyspeptic symptoms are more prone and at risk to acquire H. pylori infection. Therefore, proper monitoring of blood glucose level and screening for H. pylori infection are effective preventive measures for this chronic infection. 

scholarly journals Helicobacter pylori infection among type 2 diabetics: a case control study

2020 ◽  
Vol 8 (3) ◽  
pp. 1047
Author(s):  
Hafiz Qazi Muhammad Amir ◽  
Omaila Ikram ◽  
Muhammad Tayyab Zia ◽  
Fareha Kashan Theba ◽  
Naila Ikram ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Case Control Study ◽  
Case Control ◽  
Helicobacter Pylori Infection ◽  
P Value ◽  
Type 2 Diabetics ◽  
Dyspeptic Symptoms ◽  
H Pylori ◽  
Control Study

Background: Helicobacter pylori infection has been associated with hyperglycemia among type 2 diabetics. The objective of this study was to compare the H. pylori infection frequency in diabetic and non-diabetic patients.Methods: This case-control study was done at Al-Tibri Medical College and Hospital from May 2019 to August 2019. After written and informed consent, patients between 18-75 years with epigastric burning, dyspepsia, regurgitation were included and with history of eradication therapy, antibiotic or NSAID use in the last 6 months or surgery of upper GI tract months were excluded. Type 2 diabetics were placed in one group and non-diabetic individuals in another. Both groups were compared for presence of H. pylori infection. Data was analysed using SPSS. Demographic variables included age, gender and status of H. pylori infection. Quantitative data was expressed as frequency and percentages. Chi-square test was applied to test for significance keeping p-value of <0.05 statistically significant.Results: From 480 patients, 355 patients showed positive H. pylori, among them 282 were diabetic and 73 non-diabetic (p-value <0.001). Amongst the 355 diabetics, 55% were male Among 73 non-diabetics, 64% were male. All the patients in the study had dyspeptic symptoms and complained of dyspepsia, epigastric burning and regurgitation.Conclusions: A substantial relationship between H. pylori infection among type 2 diabetes mellitus patients was observed compared to non-diabetics. As a result, diabetic patients having active dyspeptic symptoms should undergo further confirmatory tests for diagnosing H. pylori infection.

scholarly journals Urine transferrin as an early endothelial dysfunction marker in type 2 diabetic patients without nephropathy: a case control study.

2021 ◽  
Author(s):  
José Juan Sánchez-Hidalgo ◽  
Juan Antonio SUÁREZ-CUENCA ◽  
José Juan Lozano-Nuevo ◽  
Víctor Hugo García-López ◽  
María Graciela Leal-Gutiérrez ◽  
...  
Keyword(s):  
Diabetic Nephropathy ◽  
Endothelial Dysfunction ◽  
Case Control Study ◽  
Case Control ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Early Diabetic Nephropathy ◽  
Type 2 Diabetic ◽  
Control Study

Abstract Background Albumin, along with other proteins, is abnormally eliminated via the urine during early stages of diabetic nephropathy. Moreover, endothelial dysfunction (ED) accompanying early diabetic nephropathy may develop even before microalbuminuria is detectable. Transferrin has a molecular weight comparable to albumin, and transferrinuria and microalbuminuria in a 24-hour urine sample may comparably reflect early diabetic nephropathy. However, transferrin physiochemical properties may be related with ED, but these have not been elucidated yet. This case-control study was aimed to evaluate relation between ED and urinary transferrin concentration before early diabetic nephropathy is present. Methods Patients were enrolled from two study sites in Mexico City: Ticoman General Hospital to evaluate control patients; and Dr. Manuel Gonzalez Rivera Specialized Clinic for the Management of the Diabetic Patient for case patients. All patients provided written informed consent. The primary endpoint was the correlation between urinary transferrin concentration and endothelial dysfunction measured in type 2 diabetic patients without albuminuria. ED was evaluated by ultrasonographic validated measurements, which included carotid intima-media thickness (CIMT) and flow mediated dilation (FMD). A power calculation, to detect a statistical difference, with a p value of 0.05, mandated a sample of 60 patients. The patients were tested for serum biomarkers such as glycated hemoglobin, creatinine, cholesterol, triglycerides, and urinary dipstick for albuminuria and urinary tract infection; using inclusion, exclusion and elimination criteria as described. Results The group with type 2 diabetes was older and showed higher serum transferrin and lower urinary transferrin values. Likewise, the group with type 2 diabetes showed subclinical atherogenic risk characterized by lower FMD and higher CIMT and ABI values. Risk factors associated to endothelial dysfunction measured by CIMT were time from diagnosis of diabetes, insulin resistance, dyslipidemia, and male sex. Hba1c and time since diabetes diagnosis correlated both for risk associated to FMD and CIMT. CIMT was the only factor correlated with urinary transferrin values. Conclusion Urinary transferrin correlated to subclinical endothelial dysfunction measured by CIMT in type 2 diabetic patients without nephropathy and can be used to test for early nephropathy in patients without albuminuria.

scholarly journals Urine Transferrin as an Early Endothelial Dysfunction Marker in Type 2 Diabetic Patients Without Nephropathy: A Case Control Study.

2021 ◽  
Author(s):  
José Juan Sánchez-Hidalgo ◽  
Juan Antonio SUÁREZ-CUENCA ◽  
José Juan Lozano-Nuevo ◽  
Vìctor Hugo García-López ◽  
María Graciela Leal-Gutierrez ◽  
...  
Keyword(s):  
Diabetic Nephropathy ◽  
Endothelial Dysfunction ◽  
Case Control Study ◽  
Case Control ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Early Diabetic Nephropathy ◽  
Type 2 Diabetic ◽  
Control Study

Abstract Background Albumin, along with other proteins, is abnormally eliminated via the urine during early stages of diabetic nephropathy. Moreover, endothelial dysfunction (ED) accompanying early diabetic nephropathy may develop even before microalbuminuria is detectable. Transferrin has a molecular weight comparable to albumin, and transferrinuria and microalbuminuria in a 24-hour urine sample may comparably reflect early diabetic nephropathy. However, transferrin physiochemical properties may be related with ED, but these have not been elucidated yet. This case-control study was aimed to evaluate relation between ED and urinary transferrin concentration before early diabetic nephropathy is present. Methods Patients were enrolled from two study sites in Mexico City: Ticoman General Hospital to evaluate control patients; and Dr. Manuel Gonzalez Rivera Specialized Clinic for the Management of the Diabetic Patient for case patients. All patients provided written informed consent. The primary endpoint was the correlation between urinary transferrin concentration and endothelial dysfunction measured in type 2 diabetic patients without albuminuria. ED was evaluated by ultrasonographic validated measurements, which included carotid intima-media thickness (CIMT) and flow mediated dilation (FMD). A power calculation, to detect a statistical difference, with a p value of 0.05, mandated a sample of 60 patients. The patients were tested for serum biomarkers such as glycated hemoglobin, creatinine, cholesterol, triglycerides, and urinary dipstick for albuminuria and urinary tract infection; using inclusion, exclusion and elimination criteria as described. Results The group with type 2 diabetes was older and showed higher serum transferrin and lower urinary transferrin values. Likewise, the group with type 2 diabetes showed subclinical atherogenic risk characterized by lower FMD and higher CIMT and ABI values. Risk factors associated to endothelial dysfunction measured by CIMT were time from diagnosis of diabetes, insulin resistance, dyslipidemia, and male sex. Hba1c and time since diabetes diagnosis correlated both for risk associated to FMD and CIMT. CIMT was the only factor correlated with urinary transferrin values. Conclusion Urinary transferrin correlated to subclinical endothelial dysfunction measured by CIMT in type 2 diabetic patients without nephropathy and can be used to test for early nephropathy in patients without albuminuria.

scholarly journals Association of low oleic acid intake with diabetic retinopathy in type 2 diabetic patients: a case–control study

2016 ◽  
Vol 13 (1) ◽  
Author(s):  
Nuria Alcubierre ◽  
Eva M. Navarrete-Muñoz ◽  
Esther Rubinat ◽  
Mireia Falguera ◽  
Joan Valls ◽  
...  
Keyword(s):  
Diabetic Retinopathy ◽  
Oleic Acid ◽  
Case Control Study ◽  
Case Control ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Acid Intake ◽  
Type 2 Diabetic ◽  
Control Study
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