scholarly journals Double synchronous primary gastric and thyroid cancer

2020 ◽  
Vol 7 (8) ◽  
pp. 2728
Author(s):  
Abdulhakeem Almasood ◽  
Mohammed Hussain ◽  
Mohammed Aljabali ◽  
Bandar Idrees Ali
Keyword(s):  
Thyroid Gland ◽  
Diagnostic Techniques ◽  
Multiple Primary Cancers ◽  
Invasive Adenocarcinoma ◽  
Primary Tumors ◽  
Cancer Of The Stomach ◽  
Multiple Primary Malignancies ◽  
Number Of Patients ◽  
Short Period ◽  
Multiple Primary

Second or multiple primary malignancies is very rare and the number of patients diagnosed with multiple primary cancers has recently been increasing due to the improved diagnostic techniques. Herein we report a very rare case of synchronous double primary cancer of the stomach and thyroid gland for the 39 years old lady who presented with a short period of abdominal pain were diagnosed to have an invasive adenocarcinoma with signet ring differentiation of the stomach by gastroscopy and biopsy. Computed tomography and positron emission tomography scan showed high fludeoxyglucose uptake of the thyroid gland were biopsied to confirm the malignancy. underwent initially for radical distal gastrectomy followed by adjuvant chemotherapy and interval total thyroidectomy. Although Synchronous tumors are defined as ≥2 primary tumors occurring within 6 months of diagnosis of the first primary tumor, our case was discovered concomitantly at the first presentation of the patient. The prognosis of patients with multiple primary cancers can be determined independently by the stage of each cancer.

scholarly journals Multiple primary cancers: An enigma

2016 ◽  
Vol 05 (01) ◽  
pp. 29-32 ◽  
Author(s):  
Amitabh Jena ◽  
Rashmi Patnayak ◽  
Amancharla Yadagiri Lakshmi ◽  
Banoth Manilal ◽  
Mandyam Kumaraswamy Reddy
Keyword(s):  
Cancer Patients ◽  
Surgical Oncology ◽  
Diagnostic Techniques ◽  
Multiple Primary Cancers ◽  
Primary Malignancy ◽  
Term Survival ◽  
Multiple Primary Malignancies ◽  
Multiple Primary ◽  
Synchronous Malignancies ◽  
Age Range

Abstract Background: Incidence of multiple primary cancers though uncommon, is being frequently reported now-a-days owing to better diagnostic techniques, the prolonged life span and the increased incidence of long-term survival of cancer patients. Materials and Methods: This is a retrospective study. Cases of multiple malignancies diagnosed histopathologically were retrieved from the archives of department of surgical oncology. Clinical data were obtained from the medical records. They were categorized as synchronous malignancies if the interval between them was less or equal to 6 months and metachronous, if the interval was more than 6 months. Results: A total of 13 cases were encountered in the 5 year study period. Out of them two were in the metachronous category and the rest were synchronous as the 2nd malignancy was detected mostly during clinical evaluation of the patients for the primary malignancy. There was female predominance with age range being 43-68 years. Majority of the cases were in the 7th decade. The most common organ involved was breast, followed by cervix. Apart from bilateral breast malignancies, there were combinations like breast with uterine endometrial carcinoma, cervical carcinoma and even papillary thyroid carcinoma. Conclusion: Detection of multiple primary malignancies is becoming increasingly common in day-to-day practice. Greater awareness of this is required among both cancer patients and their treating clinicians.

Multiple primary tumors in patients with carcinosarcoma of bladder: A coincidence or an etiological association? A study of 221 carcinosarcoma of bladder cases

2009 ◽  
Vol 27 (15_suppl) ◽  
pp. e16138-e16138
Author(s):  
J. Wang ◽  
F. Wang
Keyword(s):  
Prognostic Factors ◽  
Natural History ◽  
Tumor Stage ◽  
Population Based ◽  
Primary Tumors ◽  
Multiple Primary Tumors ◽  
Number Of Patients ◽  
Multiple Primary ◽  
Primary Bladder ◽  
Patient’S Outcome

e16138 Background: Carcinosarcoma of the bladder are rare; As a result, few studies of carcinosarcoma of the bladder have included sufficient number of patients to define their natural history and to determine the factors that impact survival. The objective of this study was to examine the epidemiology, natural history, and prognostic factors that affect the survival for carcinosarcoma of the bladder by using population-based registries. Methods: The Surveillance, Epidemiology, and End Results (SEER) Program database (1973–2004) was used to identify cases of carcinosarcoma of the bladder by tumor site and histology codes. The association between clinical and demographic characteristics and survival of carcinosarcoma of the bladder was examined. Results: A total of 221 cases of histology confirmed carcinosarcoma of the bladder were identified, this account for approximately 0.11% of primary bladder tumors during same period. By using linked population files, we calculated the incidence of carcinosarcoma of the bladder as a rate 0.22 per 100,000 per year, age-adjusted to year 2000 U.S. standard population. Median age of all patients were 75 years (range 41–96). In about 40% of study population, more than one or multiple primary were also indentified. Majority of (212, 95.9 %) patients received cancer directed surgery. For survival analyses, we excluded the cases that were identified at autopsy or on the basis of death certificates only and the patients have more than one primary. Total 132 patients were included in survival analysis. The median overall survival for all cases was 9 months (range 6–12 months). In multivariate analysis, only tumor stage was found to be significant prognostic factors for disease-specific survival. Conclusions: Carcinosarcoma of the bladder are rare tumors that are challenging, the survival is poor even in patients underwent surgical resection. Better therapy is needed to improve patient's outcome. A significant fraction of carcinosarcoma patients are actually affected by multiple primary tumors, the potential association between carcinosarcoma and other neoplasms remain to be investigated. No significant financial relationships to disclose.

Multiple Primary Cancers of the Esophagus and Thyroid Gland

1999 ◽  
Vol 29 (7) ◽  
pp. 349-352 ◽  
Author(s):  
Y. Naomoto ◽  
M. Haisa ◽  
T. Yamatsuji ◽  
Y. Shirakawa ◽  
T. Muramatsu ◽  
...  
Keyword(s):  
Thyroid Gland ◽  
Multiple Primary Cancers ◽  
Multiple Primary

scholarly journals MULTIPLE PRIMARY TUMORS IN CHRONIC LEUKEMIA AND GENERALIZED LYMPHOMAS

2018 ◽  
Vol 23 (2) ◽  
pp. 79-81
Author(s):  
E. I Buevich ◽  
Elena F. Kotovshchikova ◽  
A. F Lazarev ◽  
D. I Ganov
Keyword(s):  
Hematological Malignancies ◽  
Bowel Cancer ◽  
Chronic Myelomonocytic Leukemia ◽  
Multiple Primary Cancers ◽  
Case Histories ◽  
Primary Tumors ◽  
Chronic Leukemia ◽  
Multiple Primary Tumors ◽  
Multiple Primary ◽  
Myelomonocytic Leukemia

There are presented results of the analysis of case histories of 418 patients with generalized lymphomas and chronic leukemia, among whom 49 patients had information about multiple primary cancers. Among these patients, 37 were diagnosed as generalized lymphoma, 8 - multiple myeloma and 4 - chronic myelomonocytic leukemia. Most often hemoblastosis combined with skin cancer (17 patients), bowel cancer (11 patients) and lung cancer (9 patients). 3 patients had hemoblastosis combination with prostate, as well as kidney, stomach, and thyroid malignant diseases. Among all cases, 44 patients had two multiple primary tumors, 4 patients had three tumors. In this work, the analysis of patients is given according to the age-gender structure, time of the onset of the development of tumors. As an example, the short information about 4 patients with hematological malignancies in combination with other tumors is given.

Multiple primary malignancies among patients with advanced melanoma.

2021 ◽  
Vol 39 (15_suppl) ◽  
pp. e22531-e22531
Author(s):  
Matthew Isaiah Ebia ◽  
Gino Kim In
Keyword(s):  
Median Time ◽  
Immune Suppression ◽  
Advanced Melanoma ◽  
Second Primary ◽  
Primary Cancer ◽  
Second Primary Cancer ◽  
Synchronous Tumor ◽  
Primary Tumors ◽  
Multiple Primary Malignancies ◽  
Multiple Primary

e22531 Background: Multiple primary malignancies (MPMs) describe two or more primary tumors arising in a synchronous or metachronous manner in the same individual. Patients with a primary cutaneous melanoma are at high risk of developing MPMs. While melanoma and other tumors are highly immunogenic and may cause immune suppression at the individual level, the molecular underpinnings of immune suppression among patients with MPMs remains to be elucidated. Here, we attempt to describe this rare, but unique group of patients who have both advanced melanoma and at least one other primary malignancy. Methods: Patients with advanced melanoma (stage III-IV disease) and at least one other non-melanoma cancer were identified. Synchronous tumors were defined as those occurring within 6 months of the first primary cancer. Metachronous tumors were defined as those occurring at least 6 months after the first primary cancer. Patients who had melanoma first, before a second cancer, and those who had a prior other cancer first, followed by melanoma were included. Overall survival (OS) describes the time from diagnosis of the first primary cancer to death due to any cause. Two-sample t-tests were used to compare OS among these groups with statistical significance if p < 0.05. Results: Eleven patients with MPMs including advanced melanoma were identified. Advanced melanoma was the first primary tumor in 5 patients and the second primary in 6 patients. A synchronous second primary was observed in 4 patients, whereas a metachronous second primary was observed in 7 patients. The median time between the diagnosis of the first primary cancer to the second primary was 21 months and the median time between the diagnosis of a second primary to a third primary was also 21 months. The median OS for all patients was 73 months. The median OS for synchronous MPMs and metachronous MPMs were 64.5 months and 82 months, respectively (p = 0.013). For patients with melanoma as the first primary cancer, the median OS was 73 months, compared to 87 months when melanoma was the second primary cancer (p = 0.785). Among all 11 patients, two are deceased, while the remaining patients are under surveillance. Among the remaining 9 patients, 100% have no evidence of disease with respect to melanoma. Conclusions: Despite the favorable outcomes from early detection and the advanced treatments available such as immunotherapy, a robust treatment plan should be in place when advanced melanoma is diagnosed as a synchronous tumor or second primary cancer. Further research is warranted since there are no guidelines available for the treatment of MPMs.

Rare heterochronous liver and pancreatic multiple primary cancers: a case report and literature review

2020 ◽  
Vol 58 (11) ◽  
pp. 1094-1098
Author(s):  
Wangjun Zhang ◽  
Fan Xiao ◽  
Jie Li ◽  
Xiaoyu Guo ◽  
Zhitao Lin ◽  
...  
Keyword(s):  
Diagnostic Techniques ◽  
Multiple Primary Cancers ◽  
Second Primary ◽  
Second Primary Malignancy ◽  
Primary Malignancy ◽  
Liver Malignancy ◽  
Term Survival ◽  
Pancreatic Cancers ◽  
Multiple Primary ◽  
Medical Diagnostic

AbstractIn recent years, with the continuous improvement of medical diagnostic techniques, the incidence of multiple primary carcinoma (MPC) has increased gradually. Elderly patients are at high risk of MPC. However, the risk of developing a second primary malignancy is 1 % for primary liver malignancy 1. The risk of pancreatic cancers as secondary malignancies with primary liver malignancy is very rare. Here, we report a rare case of heterochronous liver and pancreatic MPCs and review the related literature. We report this case to raise the clinician’s attention to the disease because the long-term survival rate can be effectively improved by timely diagnosis and appropriate treatment. For patients with HCV-positive primary cancers, active antiviral therapy should be simultaneously provided with antitumor therapy, thereby effectively reducing the incidence of MPC.

scholarly journals Polygenic Panels Predicting the Susceptibility of Multiple Upper Aerodigestive Tract Cancer in Oral Cancer Patients

2021 ◽  
Vol 11 (5) ◽  
pp. 425
Author(s):  
Huei-Tzu Chien ◽  
Chi-Chin Yeh ◽  
Chi-Kuang Young ◽  
Tzu-Ping Chen ◽  
Chun-Ta Liao ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Cancer Patients ◽  
Neck Cancer ◽  
Alcohol Drinking ◽  
Aerodigestive Tract ◽  
Multiple Primary Cancers ◽  
Upper Aerodigestive Tract ◽  
Primary Tumors ◽  
Multiple Primary

Head and neck cancer was closely related with habitual use of cigarette and alcohol. Those cancer patients are susceptible to develop multiple primary tumors (MPTs). In this study, we utilized the single nucleotide polymorphisms (SNPs) array (Affymetrix Axion Genome-Wide TWB 2.0 Array Plate) to investigate patients’ risks of developing multiple primary cancers. We recruited 712 male head and neck cancer patients between Mar 1996 and Feb 2017. Two hundred and eighty-six patients (40.2%) had MPTs and 426 (59.8%) had single cancer. Four hundred and twelve normal controls were also recruited. A list of seventeen factors was extracted and ten factors were demonstrated to increase the risks of multiple primary cancers (alcohol drinking, rs118169127, rs149089400, rs76367287, rs61401220, rs141057871, rs7129229, older age, rs3760265, rs9554264; all were p value < 0.05). Polygenic scoring model was built and the area under curve to predict the risk developing MPTs is 0.906. Alcohol drinking, among the seventeen factors, was the most important risk factor to develop MPT in upper aerodigestive tract (OR: 7.071, 95% C.I.: 2.134–23.434). For those with high score in polygenic model, routine screening of upper digestive tract including laryngoscope and esophagoscope is suggested to detect new primaries early.

scholarly journals Genetic analysis of multiple primary cancers: A case report

2020 ◽  
Vol 73 (5-6) ◽  
pp. 170-174
Author(s):  
Marko Jevric ◽  
Emilija Filipovic ◽  
Ana Krivokuca
Keyword(s):  
Breast Cancer ◽  
Case Report ◽  
Previous Treatment ◽  
Primary Treatment ◽  
Left Breast ◽  
Multiple Primary Cancers ◽  
Malignant Neoplasms ◽  
Multiple Cancer ◽  
Primary Tumors ◽  
Multiple Primary

Introduction. The occurrence of more than one primary cancer in the same patient is not very common. Multiple cancer prevalence is about 7.9% and the percentage is lower as the number of multiple primary cancers is higher. The incidence of four or more primary cancers in one patient is very rare and its prevalence is around 0.07%. Case Report. We report a rare case of a female with four histopathologically confirmed primary malignant neoplasms. The first tumor was endometrial carcinoma diagnosed at the age of 52. Three additional metachronous tumors were diagnosed as follows: left breast cancer, melanoma, and contralateral breast cancer. Extensive genetic testing was performed and 19 genes were sequenced using the next generation sequencing (BRCA1, BRCA2, ATM, BRIP1, CDH1, CHEK2, MSH2, MLH1, MSH6, PMS2, EPCAM, NBN, NF1, PALB2, PTEN, RAD51C, RAD51D, STK11 and TP53). Even with the existing indicators of genetic etiology, this case showed no pathogenic mutations in any of these genes. This indicates the existence of other underlying mechanisms such as hormonal factors, previous treatment of the primary and subsequent tumors, environmental factors, gene-gene and gene-environment interactions, as well as immunosuppression that could increase the risk for the second and subsequent malignancies. Conclusion. Detailed information on the biology of multiple primary tumors is important for both clinicians and cancer patients during medical management following primary treatment. In addition, genetic information is very important because it has future implications for both patients and their family members.

scholarly journals Colon Carcinoma Presenting with a Synchronous Oesophageal Carcinoma and Basal Cell Carcinoma of the Skin

ISRN Oncology ◽  
2011 ◽  
Vol 2011 ◽  
pp. 1-3
Author(s):  
Nidhi Gupta ◽  
Rakesh Kapoor ◽  
Suresh C. Sharma
Keyword(s):  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Colon Carcinoma ◽  
Basal Cell ◽  
Oesophageal Carcinoma ◽  
Diagnostic Techniques ◽  
Treatment Modalities ◽  
Multiple Primary Malignancies ◽  
Number Of Patients ◽  
Colonic Primary

With advances in diagnostic techniques and treatment modalities, the number of patients identified with colorectal carcinoma who develop multiple primary malignancies during long-term followup has been increasing. We report a patient who developed three histologically distinct malignancies. Primary colon carcinoma treated radically followed by an 8-year disease-free period. The patient then presented with progressive dysphagia and was investigated and diagnosed to have a synchronous multicentric squamous cell carcinoma of the oesophagus and basal cell carcinoma of the skin. There was a simultaneous multicentric recurrence in the colon. This case is worth mentioning because the clustering of three primary malignancies (synchronous and metachronous) is of rare occurrence in a single patient, and, to our knowledge, this is the first report of this combination occurring in the same individual. In addition, the report emphasizes the importance of evaluating patients with known colonic primary neoplasms for synchronous colonic and extracolonic tumors.

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