To X-ray diagnostics of malignant neoplasms in patients with operated stomach

The decisive method for the treatment of malignant neoplasms of the stomach is surgical intervention. The successes achieved in this direction are limited mainly to surgery for primary cancer of the stomach. Patients with recurrent tumors in the stomach stump, as well as with secondary malignant neoplasms in this area after surgery for peptic ulcer, polyps and other diseases, were considered doomed and hopeless until recently.

Antichelicobacter therapy in the context of increasing bacterial resistance

A modern strategy for the treatment of diseases associated with Helicobacter pylori is the mandatory inclusion in the scheme of treatment of antibiotics, as well as considering the level of bacterial resistance to the main components of therapy. In Ukraine, Helicobacter pylori infection in some areas can reach about 80%, so the prevalence of peptic ulcer, atrophic gastritis and other diseases of the gastrointestinal tract is extremely high in all sections of the population. Topical for our country is the use of standard triple antyhelicobacter therapy, which includes: proton pump inhibitor in combination with clarithromycin + amoxicillin. Such therapy lasting 10 or 14 days allows to completely free the gastrointestinal tract from Helicobacter pylori, and to prevent the further development of pathological process on the mucous membrane. This tactic can successfully prevent the growth of incidence of gastric lymphoma, cancer of the stomach, as well as reduce the likelihood of complications in peptic ulcers.

A study of In vitro antioxidant and apoptotic effect of citrus medica Linn. leaves (Naarthai) against human gastric adenocarcinoma cell line (ags)

Carcinoma or cancer of the stomach is one of the common malignancies of older men. Numerous methods of treatment options, including herbal and plant products, have been described for its management. The leaves of citrus medica or the naarthai leaves as it has been named traditionally do possess activities in the gastric mucosa. Hence, we decided to extract the phytochemicals from the leaves and find out the antioxidant, cytotoxic potential of the same. After confirmation of the leaves from appropriate authorities, petroleum ether, ethanolic and aqueous extracts of the leaves were made. The IC 50 was found to 200 micrograms and tested for cytotoxicity and apoptotic abilities in the AGS human gastric cell lines. The ethanolic extract showed maximal phytoconstituents. The aqueous extract showed 76.15% of scavenging effect, whereas the ethanolic extract showed 85.33% scavenging activity. Regarding the cytotoxicity effect of C. medica extract on the AGS cell line, it was observed that the percentage of cells was reduced to 50% in the treatment group when compared to the control group. The cells treated with ethanolic leaf extract of C. medica were arrested in G0-G1. Late apoptosis was significantly increased in the treated group when compared to the control group. The ethanolic leaf extracts of citrus medica possessed antioxidant and anti-cancer properties in gastric mucosal lines. This option can be considered for further production of drugs from such plants.

Helicobacter pylori infection and fatty liver

Helicobacter pylori infection is widespread worldwide. It plays a signifi cant role in the pathogenesis of many diseases of the gastrointestinal tract, such as peptic ulcer, atrophic gastritis, and cancer of the stomach. Recently, a large number of works have appeared that indicate the association of Helicobacter pylori infection with extragastric diseases. Liver diseases, and especially fatty liver disease, are also widespread and actively studied. The association between Helicobacter pylori infection and non-alcoholic fatty liver disease has been the subject of many studies, but there is still insufficient evidence to make it clear.

Double synchronous primary gastric and thyroid cancer

Second or multiple primary malignancies is very rare and the number of patients diagnosed with multiple primary cancers has recently been increasing due to the improved diagnostic techniques. Herein we report a very rare case of synchronous double primary cancer of the stomach and thyroid gland for the 39 years old lady who presented with a short period of abdominal pain were diagnosed to have an invasive adenocarcinoma with signet ring differentiation of the stomach by gastroscopy and biopsy. Computed tomography and positron emission tomography scan showed high fludeoxyglucose uptake of the thyroid gland were biopsied to confirm the malignancy. underwent initially for radical distal gastrectomy followed by adjuvant chemotherapy and interval total thyroidectomy. Although Synchronous tumors are defined as ≥2 primary tumors occurring within 6 months of diagnosis of the first primary tumor, our case was discovered concomitantly at the first presentation of the patient. The prognosis of patients with multiple primary cancers can be determined independently by the stage of each cancer.

Carcinoma gástrico e disfagia: uma revisão sistemática

Introdução: O carcinoma gástrico, também conhecido como câncer de estômago é um dos tipos de câncer com grande incidência no Brasil, segundo dados do INCA. As formas de tratamento para carcinomas gástricos estão relacionadas ao estágio em que a doença se encontra, podem variar de cirurgias, ressecções a gastrectomias e linfadenectomias, podendo ser necessária a presença de quimioterapia. Sabe-se que alguns dos muitos tipos de cânceres podem levar à apresentação de algum quadro de disfagia, caracterizada pelas alterações no processo de deglutição. Objetivo: verificar qual o impacto do câncer gástrico na disfagia. Material e Método: Buscas de artigos nas bases de dados Medline (Pubmed), Cochrane Library, SciELO, LILACS e MEDLINE sem restrição de localização ou idiomas, publicados no período de janeiro de 2010 até agosto de 2018. A pesquisa foi realizada na base de dados com os descritores (“Deglutition Disorders” or “Dysphagia” or “Esophageal Dysphagia” or “Oropharyngeal Dysphagia” or “Swallowing Disorders”) and (“Stomach Neoplasms” or “Cancer of Stomach” or “Cancer of the Stomach” or “Gastric Cancer” or “Gastric Cancer, Familial Diffuse” or “Gastric Neoplasms” or “Neoplasms, Gastric or Neoplasms”, “Stomach” or “Stomach Cancer”). Resultados: A relação entre o câncer gástrico e a disfagia é abordada como uma importante consequência dos tipos de tratamentos. Foram encontrados cinco estudos que responderam a pergunta norteadora. Três dos cinco estudos selecionados tratam da qualidade de vida dos pacientes posteriormente ao tratamento. Conclusão: Foi verificado que a disfagia é observada como uma possível consequência do carcinoma gástrico e seu tratamento.

Endoscopic and histological evaluation of the mucous membrane of the stomach in relatives of people suffering from cancer of the stomach

The condition of gastric mucosa was assessed in relatives of patients with gastric cancer (RPGC). The study included 108 RPGC (main group) and 102 patients with no family history of gastric cancer who were screened for dyspepsia. All study participants were subjected to clinical examination, questioning and esophagogastroduodenoscopy (EGDS) with a biopsy, in which the gastric mucosa state was assessed according to the modified Sydney system, the OLGA and OLGIM systems, and the definition of Helicobacter pylori (H. pylori) infection. It was established that the prevalence of H. pylori infection in the main group was 58.3 % (95 % CI 48.8–67.7), in the control group – 56.0 % (95 % CI 46.1–65.6). At RPGC, atrophy of any localization (46.3 % (95 % CI 39.4–53.2) versus 26.5 % (95 % CI 20.4–32.6), respectively, was found more often than in the control group, respectively, p = 0.002), antral atrophic gastritis (41.6 % (95 % CI 34.8–48.4) versus 26.5 % (95 % CI 20.4–32.6), respectively, p = 0.020), and isolated atrophy in the stomach body (4.6 % (95 % CI 1.7–7.4) versus 0 % ( p = 0.03). In RPGC, atrophy developed at a younger age (48.0 years (95 % CI 44.0–52.0) versus 53.0 years in the control group (95 % CI 48.3–57.8) p = 0.000). There were no significant differences between the groups in the incidence of metaplasia and dysplasia. The following risk factors for development of atrophy were identified in the factor analysis: age over 6f0 years (odd ratio (OR) 53.0; 95 % CI 12.2–390.1; p < 0.001), age over 40 years (OR 4.0; 95 % CI 2.0–8.2; p < 0.001), heredity burdened by gastric cancer (OR 2.7; 95 % CI 1.4–5.7; p = 0.006) and the use of strong alcoholic beverages (OR 5.5; 95 % CI 1.6–21.6; p = 0.009). The frequency of the atrophy development of the gastric mucosa is increased in RPGC, and atrophic gastritis develops at a younger age in comparison with individuals without a burdened hereditary history. In addition to the hereditary factor, the risk of atrophy is associated with age and alcohol use.

Malignant Neoplasms as the Most Priority Medical and Social Issue of the Healthcare System

The article provides literature data on the trends of malignant neoplasms not only in the world but also in the Kyrgyz Republic. Malignant neoplasms are a global problem in public health, occupy a leading place for the causes of mortality. In 2018, more than 18 million new cases of cancer were diagnosed worldwide, more than 9.6 million people died, and the total number of patients increased to 43 million. According to forecasts, by 2030, the number of new cases of cancer will increase to 26.4 million per year, and the number of deaths — up to 17 million. The epidemiological situation of cancer remains unfavorable, both in Russia and around the world. In the Russian Federation, there is an increase in cancer incidence from 363.0 in 2010 to 425.3 in 2018 per 100,000 population. Moreover, the growth trend is observed in all regions of the country. In the Kyrgyz Republic, the incidence of malignant neoplasms increased from 83.1 in 2010 to 90.3 per 100,000 of the population in 2018. This indicator is growing in Chui, Naryn and Batken regions, as well as in Osh, and in other regions, there is a slight decrease in the indicator. In the structure of oncological morbidity, the first place is occupied by breast cancer (206‱), the second place — cancer of the cervix (153‱), and the third place — cancer of the stomach (117‱). It should be noted that in Russia for every 100 patients who died from malignant neoplasms, 10.7 were not registered. The mortality rate in the Kyrgyz Republic has somewhat stabilized, both in the republic as a whole and in individual regions, and in 2018 amounted to 56.3 per 100,000 of the population (56.4 in 2017). In the female population, 1st place is occupied by breast cancer — 605‱, 2nd place — by the cervix (153‱), 3rd place — by the stomach (71‱). One of the most common forms of malignant neoplasms of the organs of the reproductive system is cervical cancer, which takes 2nd place in frequency and 3rd place in mortality from cancer in women. The analysis of morbidity and mortality from malignant neoplasms in various countries showed that screening and early detection, as well as timely and effective treatment, are necessary to reduce mortality.