scholarly journals Colon Carcinoma Presenting with a Synchronous Oesophageal Carcinoma and Basal Cell Carcinoma of the Skin

ISRN Oncology ◽  
2011 ◽  
Vol 2011 ◽  
pp. 1-3
Author(s):  
Nidhi Gupta ◽  
Rakesh Kapoor ◽  
Suresh C. Sharma
Keyword(s):  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Colon Carcinoma ◽  
Basal Cell ◽  
Oesophageal Carcinoma ◽  
Diagnostic Techniques ◽  
Treatment Modalities ◽  
Multiple Primary Malignancies ◽  
Number Of Patients ◽  
Colonic Primary

With advances in diagnostic techniques and treatment modalities, the number of patients identified with colorectal carcinoma who develop multiple primary malignancies during long-term followup has been increasing. We report a patient who developed three histologically distinct malignancies. Primary colon carcinoma treated radically followed by an 8-year disease-free period. The patient then presented with progressive dysphagia and was investigated and diagnosed to have a synchronous multicentric squamous cell carcinoma of the oesophagus and basal cell carcinoma of the skin. There was a simultaneous multicentric recurrence in the colon. This case is worth mentioning because the clustering of three primary malignancies (synchronous and metachronous) is of rare occurrence in a single patient, and, to our knowledge, this is the first report of this combination occurring in the same individual. In addition, the report emphasizes the importance of evaluating patients with known colonic primary neoplasms for synchronous colonic and extracolonic tumors.

scholarly journals Basal Cell Carcinoma: A Frequent Challenge / Bazocelularni karcinom: čest izazov

2012 ◽  
Vol 4 (1) ◽  
pp. 5-32
Author(s):  
Tatjana Roš ◽  
Branislava Gajić ◽  
Milana Ivkov-Simić ◽  
Zorica Gajinov
Keyword(s):  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
Hedgehog Signaling ◽  
Prognostic Significance ◽  
Surgical Excision ◽  
Diagnostic Techniques ◽  
Treatment Modalities ◽  
Main Role ◽  
Invasive Treatment

Abstract Basal cell carcinoma is a slow-growing, malignant epidermal tumor predominantly affecting sun exposed areas in Caucasians, accounting for up to 80% of all diagnosed skin cancers, with a rising incidence. Chronic UV radiation, in association with constitutional factors, plays the main role in its etiology. Inappropriate activation of the hedgehog signaling pathway seems to be a key pathogenesis mechanism. Basal cell carcinoma metastases are extremely rare, but it is a locally invasive tumor that can cause significant destruction of the surrounding tissues, with their functional and esthetic impairment. There are four main clinical types of basal cell carcinoma, although clinical classification is of poor prognostic significance. Preselection of suspicious lesions and treatment planning include noninvasive diagnostic techniques: dermoscopy, confocal microscopy and ultrasoud imaging, yet histopathology remains the “gold standard” of basal cell carcinoma diagnosis. In terms of the histological growth pattern, which is essential for the prognosis, basal cell carcinoma may be divided into circumscribed or diffuse types. Surgical excision is considered to be a first line treatment option, but there are numerous less invasive treatment modalities for low-risk basal cell carcinoma. Prevention strategies are focused on behavioral modifications, regular follow up and use of chemopreventive agents in high-risk patients.

scholarly journals Basal Cell Carcinoma: A Retrospective Clinicopathological Analysis of 100 Cases Derived from the Histopathological Registry of the Institute of Pathology in Niš / Bazocelularni karcinom: retrospektivna kliničko-histološka analiza 100 slučajeva na osnovu Histopatološkog registra Instituta za patologiju u Nišu

2012 ◽  
Vol 4 (1) ◽  
pp. 18-30
Author(s):  
Khair Fadel Merei Al Junidi ◽  
Mirjana Paravina ◽  
Vuka Katić ◽  
Pasxalina Mitsa
Keyword(s):  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
Age Distribution ◽  
Histopathological Analysis ◽  
X Rays ◽  
Important Place ◽  
Age Related ◽  
Number Of Patients ◽  
The Face

Abstract Basal cell carcinoma (BCC) is the most common malignant tumor of the skin. This study was conducted to analyze patients with BCC, their age and sex distribution, occupation, site distribution of tumors, clinical types, and histopathological characteristics of lesions. Based on the data obtained from the Histopathological Registry, a clinical and histopathological analysis of the surgically excised BCCs was performed. The study included 100 randomly selected patients out of 263 consecutive patients with histopathologically diagnosed BCC at the Institute of Pathology of the Clinical Center in Niš in the period of 15 months. The sex ratio was 1.4:1 in favor of men (p<0.05). Two thirds of patients were over the age of 60 (p<0.0001). The average age of patients was 66.6 ± 12.2 years (range 23 - 90). In agreement with the age distribution, 53 patients were retired (mostly retired farmers), 12 were workers, 14 farmers, 12 without permanent employment, 5 were housewives, and 4 clerks. A substantial majority of 61% of examinees lived in the country (p<0.001). The employment status was related to the age of examinees, but also with the altered demographic structure in the country: many workers lived in the country, or returned to the country after retirement. BCC was commonly found on the face (77%), and rarely on the trunk (11%) and extremities (2%). There were no data about exposition to X-rays or chemicals (except for pesticides and insecticides), scars resulting from burns or genodermatoses. In 87% of cases, BCC was significantly most often found at sites continually exposed to the sun (head including face and scalp, and neck). The most commonly diagnosed was the nodular type (57%), then the superficial (7%), ulcerative (5%), ulcero-sclerotic (4%), pigmented (1%), and morpheaform (1%). In 27% of cases, there were no data about the histopathological type of BCC in the Histopathological Registry, based on which accurate histological type of BCC could have been established. Based on histopathological analysis, apart from the nodular (40%), other types were rarely diagnosed, like the adenoid (12%) (p<0.0001), mixed types (nodular-adenoid, nodular-adenoid-fibroblastic and mixed) (9%), superficial (7%), fibroblastic (2%), infiltrative (1%), pigmented (1%), and morpheaform (1%). Surgical excision is the gold standard in the treatment of BCC: conventional, conducted in our patients, and Mohs micrographic surgery, which takes an important place in the treatment of high-risk BCCs. In 6% of cases, the tumor process was found in the margins of the excision. In conclusion: Basal cell carcinoma was more common in males than in females. Significantly more patients with excised basal cell carcinoma lived in the country. An age-related increase in the number of patients with BCC has been established, and most patients with excised basal cell carcinomas belonged to the age group of 61 to 81 years of age. In most patients the tumor site was on the face, whereas clinically and histopathologically, nodular type was the most common.

Basal Cell Carcinoma: Epidemiology, Risk Factors, and Treatment Options

2017 ◽  
Author(s):  
Jeffrey M Farma ◽  
Elena P Lamb
Keyword(s):  
Risk Factors ◽  
Photodynamic Therapy ◽  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
Treatment Options ◽  
Sun Exposure ◽  
Hedgehog Pathway ◽  
Treatment Modalities ◽  
Genetic Syndromes

Ultraviolent (UV) solar radiation is considered to be the dominant risk factor for development of basal cell carcinoma (BCC). The development of BCC is thought to arise from intense, intermittent sun exposure leading to burns. Identifying patients with high-risk factors for developing BCC includes chronic immunosuppression, exposure to ionizing radiation, and certain genetic syndromes. Primary treatment goals of BCC include cure of tumor with maximal preservation of function. Although rarely metastatic, BCC can produce substantial local destruction. Treatment modalities can be divided into surgical and nonsurgical therapies, although surgical therapy is the mainstay of treatment. Superficial therapies, such as topical imiquimod or 5-fluorouracil, photodynamic therapy, or cryotherapy, may be effective for anatomically challenging locations where surgery or radiation is contraindicated, but the cure rates of these approaches are lower compared with surgery. Recent FDA-approved hedgehog pathway inhibitors include vismodegib and sonidegib for patients who have exhausted surgical and radiation options for treating advanced BCC. This review contains 4 figures, 5 tables, and 25 references. Key words: cryosurgery, cutaneous basal cell carcinoma, hedgehog pathway inhibitors, Mohs micrographic surgery, pathologic risk factors, photodynamic therapy, radiation therapy, surgical margins, topical therapies 

scholarly journals Epidemiology of Basal Cell Carcinoma – Observations of One Department

2020 ◽  
Vol 71 (2) ◽  
pp. 55-66
Author(s):  
Agnieszka Borzęcka-Sapko ◽  
Piotr Siermontowski ◽  
Mateusz Mleczko ◽  
Andrzej Borzęcki
Keyword(s):  
Skin Cancer ◽  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
Epidemiological Data ◽  
Place Of Residence ◽  
Temporal Area ◽  
Number Of Patients ◽  
Urban Rural ◽  
Almost All

Abstract Introduction. Basal cell carcinoma is the most common malignant skin cancer. It is one of the so-called nonmelanoma skin cancers, the incidence of which has increased rapidly worldwide in recent years. Unfortunately, the National Cancer Registry in Poland does not classify basal cell skin cancer separately. Therefore, the precise data on the incidence in the population remain unknown. Work objective. Retrospective analysis of the incidence of basal cell carcinoma in NZOZ Med-Laser in Lublin in the years 2005 – 2015 depending on gender, age group, place of residence (urban-rural) and clinical form of the disease. Material and methodology. The data of NZOZ Med-Laser from the years 2005 - 2015 were used in the study. The data concern all patients with histopathologically diagnosed basal cell carcinoma, who during the period covered by the study were consulted either as outpatients or hospitalised in an institution providing dermatological services under contract with the National Health Fund (NFZ). Patients were divided into several groups depending on gender, age and place of residence. All groups were compared quantitatively and the results are shown in the figures below. Results. The data collected indicate that between 2005 and 2015 a total of 922 patients with basal cell carcinoma received dermatological treatment. Over the years, there has been a clear increase in the number of patients with basal cell carcinoma. The disease occurred mainly in people over 59 years of age, with the majority of women living in cities. The most common locations of the cancer are nose, cheeks, forehead and temporal area. Histopathologically, solidum, superficiale, exulceratum and pseudoadenoides were the most frequently diagnosed forms. Conclusions. Basal cell carcinoma of the skin is frequent in our society. Its incidence has been increasing in recent years. Therefore, action should be taken to create consistent international registries to gather reliable epidemiological data that would show the scale of the problem, which we are dealing with almost all over the world.

Basal Cell Carcinoma: Epidemiology, Risk Factors, and Treatment Options

2017 ◽  
Author(s):  
Jeffrey M Farma ◽  
Elena P Lamb
Keyword(s):  
Risk Factors ◽  
Photodynamic Therapy ◽  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
Treatment Options ◽  
Sun Exposure ◽  
Hedgehog Pathway ◽  
Treatment Modalities ◽  
Genetic Syndromes

Ultraviolent (UV) solar radiation is considered to be the dominant risk factor for development of basal cell carcinoma (BCC). The development of BCC is thought to arise from intense, intermittent sun exposure leading to burns. Identifying patients with high-risk factors for developing BCC includes chronic immunosuppression, exposure to ionizing radiation, and certain genetic syndromes. Primary treatment goals of BCC include cure of tumor with maximal preservation of function. Although rarely metastatic, BCC can produce substantial local destruction. Treatment modalities can be divided into surgical and nonsurgical therapies, although surgical therapy is the mainstay of treatment. Superficial therapies, such as topical imiquimod or 5-fluorouracil, photodynamic therapy, or cryotherapy, may be effective for anatomically challenging locations where surgery or radiation is contraindicated, but the cure rates of these approaches are lower compared with surgery. Recent FDA-approved hedgehog pathway inhibitors include vismodegib and sonidegib for patients who have exhausted surgical and radiation options for treating advanced BCC. This review contains 4 figures, 5 tables, and 25 references. Key words: cryosurgery, cutaneous basal cell carcinoma, hedgehog pathway inhibitors, Mohs micrographic surgery, pathologic risk factors, photodynamic therapy, radiation therapy, surgical margins, topical therapies 

Nevoid Basal Cell Carcinoma Syndrome Presenting as Chronic Maxillary Sinusitis

1994 ◽  
Vol 8 (4) ◽  
pp. 181-184
Author(s):  
Richard F. Busch
Keyword(s):  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
Maxillary Sinusitis ◽  
Rare Condition ◽  
Treatment Modalities ◽  
Jaw Cysts ◽  
Skeletal Abnormalities ◽  
Rare Syndrome ◽  
Chronic Maxillary Sinusitis

Nevoid basal cell carcinoma syndrome is a very rare condition consisting of nevoid basal cell epitheliomas, jaw cysts, and skeletal abnormalities. This article describes the first reported presentation of this syndrome as maxillary sinusitis. The multiple and varied features of this rare syndrome are discussed together with management and treatment modalities.

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