scholarly journals Correlation between CT and operative findings in pancreatic cancers and role of pre-operative CA19-9 values in predicting metastatic disease

2021 ◽  
Vol 8 (4) ◽  
pp. 1247
Author(s):  
Rajat Prabhakar ◽  
Shyam S. Jaiswal ◽  
Ravi Prakash
Keyword(s):  
Metastatic Disease ◽  
Tertiary Care ◽  
Malignant Ascites ◽  
Tumour Marker ◽  
Staging Laparoscopy ◽  
Radiological Findings ◽  
Tertiary Care Centre ◽  
Pancreatic Cancers ◽  
Operative Findings

Background: Pancreatic cancers carry a poor prognosis with 20-30% of cases found resectable on MDCT (Multi-detector CT). 60-91% of these lesions are actually found resectable during surgery. CA 19-9 is an extensively studied tumour marker in pancreatic cancers and its abnormally high value may point towards metastatic disease.Methods: A study was conducted in a tertiary care centre in which all patients of pancreatic cancers found resectable on imaging were subjected to surgery after staging laparoscopy to find metastatic disease missed on MDCT, the findings were noted and correlated with the radiological findings. Also, pre-operative CA 19-9 levels were analysed to predict metastatic disease in patients with high CA 19-9 values.Results: The study included 34 patients of pancreatic cancers deemed resectable on imaging. Out of these, four (11.7%) patients were found to be unresectable on staging laparoscopy in the form of subcentimetric liver/peritoneal metastasis. It was also found that preoperative CA 19-9 levels were higher in patients found to be metastatic. By using ROC curve, it was found that pre-operative values of CA 19-9 had 100% sensitivity and 80% specificity at the cut off level >106.75 U/ml.Conclusions: MDCT fails to identify some unresectable diseases because of presence of distant metastasis in the form of liver and peritoneal metastatic nodules and malignant ascites. Staging laparoscopy prior to laparotomy is a useful procedure which prevents unwanted laparotomy in some cases of metastatic pancreatic cancer not identified on imaging. Abnormally high values of CA 19-9 may point towards metastatic disease.

scholarly journals Microbiological and Radiological Perspective of Fungal Rhinosinusitis during the COVID-19 Pandemic: A Prospective Observational Study in A Tertiary Care Centre in Northern India

2021 ◽  
Author(s):  
Pavneet Kaur ◽  
Mehak Arora ◽  
Arvinder Singh Sood ◽  
Amandeep Singh
Keyword(s):  
Tertiary Care ◽  
Radiological Findings ◽  
Tertiary Care Centre ◽  
Northern India ◽  
Fungal Rhinosinusitis ◽  
Microbiological Techniques ◽  
Diagnosis And Classification ◽  
Single Method ◽  
Magnetic Resonance Imaging Mri

Radiological investigations are essential for the diagnosis and classification of fungal rhinosinusitis; however, radiological findings might occasionally be misleading. Computed tomography (CT) scan and magnetic resonance imaging (MRI) complement each other, facilitating clinicians to arrive at a diagnosis. Hence, even with the best radiological modalities, correlation between clinical and microbiological findings is crucial for the accurate diagnosis of fungal rhinosinusitis. In addition, the role of traditional methods such as KOH microscopy and culture should be accurately evaluated. To this end, we aimed to diagnose rhinosinusitis with a fungal etiology based on radiological findings and subsequently correlate these findings with those of microbiological techniques, namely culture and KOH microscopy. A total of 57 clinically suspected fungal rhinosinusitis cases were included in the study. Radiological investigations were performed using either CT or MRI. Tissues samples were processed and analyzed using KOH microscopy and culture. The results of the study suggest that using a single method for the diagnosis of fungal rhinosinusitis is inadequate. Rather, the diagnosis should be based on radiological as well as microbiological findings, especially for cases that are clinically ambiguous.

scholarly journals Role of Colposcopy in Evaluation of Abnormal Cytology a Tertiary Care Centre Experience

2020 ◽  
Vol 10 (3) ◽  
pp. 130-134
Author(s):  
Sachan Rekha ◽  
Shukla Ayushi ◽  
Sachan Pushpalata ◽  
Patel ML ◽  
Shankhwar Pushpalata
Keyword(s):  
Tertiary Care ◽  
Care Centre ◽  
Abnormal Cytology ◽  
Tertiary Care Centre

scholarly journals ROLE OF HEMATOLOGICAL PARAMETERS IN EARLY DIAGNOSIS OF COVID-19 IN A TERTIARY CARE CENTRE

2021 ◽  
Vol 5 (6) ◽  
Author(s):  
Angira Saha ◽  
Sakar Saxena ◽  
Romi Srivastava ◽  
Sanjeev Narang
Keyword(s):  
Early Diagnosis ◽  
Hematological Parameters ◽  
Tertiary Care ◽  
Tertiary Care Centre ◽  
College Hospital ◽  
Neutrophil Lymphocyte Ratio ◽  
Lymphocyte Ratio ◽  
Platelet Lymphocyte Ratio ◽  
Significant Difference

Aim: To evaluate the role of biomarkers from blood samples of COVID-19 patients admitted in Index Medical College Hospital & R.C. Material & Methods: Hematological parameters such as Neutrophil lymphocyte ratio (NLR), Platelet lymphocyte ratio (PLR) & Systemic Inflammatory Index (SII) were studied in RT-PCR positive patients to evaluate the utility of these parameters for early diagnosis of COVID-19. Results: The study showed that there was statistically significant difference in test groups in reference to Neutrophil lymphocyte ratio (NLR) & SII values (p<0.05). But no statistically significant difference was observed between test groups in reference to Platelet lymphocyte ratio (PLR) values (p>0.05). Conclusion: Leukocyte, Neutrophil, NLR & SII values can be used in the early diagnosis of COVID-19. Keywords: NLR, SII, Leukocyte, Neutrophil

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