scholarly journals The smart phone study: assessing the reliability and accuracy of neonatal jaundice measurement using smart phone application

2018 ◽  
Vol 5 (2) ◽  
pp. 285 ◽  
Author(s):  
Srujana Swarna ◽  
Sekar Pasupathy ◽  
Balaji Chinnasami ◽  
Nirmala Manasa D. ◽  
Balaji Ramraj
Keyword(s):  
Gold Standard ◽  
Neonatal Jaundice ◽  
Serum Bilirubin ◽  
Smart Phone ◽  
Medical Application ◽  
Background Current ◽  
Blood Samples ◽  
Smart Phone Application ◽  
Transcutaneous Bilirubinometer ◽  
Better Than

Background: Current gold standard for bilirubin estimation in newborns is invasive while transcutaneous bilirubinometer which is a noninvasive option is costly. Smart phone applications can be used as an alternative to measure bilirubin. We did the study to evaluate “Biliscan” medical application for screening of neonatal jaundice.Methods: During the first seven days, neonates with suspected jaundice were taken blood samples for serum bilirubin. Within two hours photographs were taken using Biliscan app by placing a colour calibration card over the chest. Bilirubin estimate obtained after colour balancing, feature extraction and machine learning regression were compared with blood values.Results: There is a good correlation (0.6) between Biliscan bilirubin estimation and serum bilirubin levels (p <0.0001) in the present study on 35 neonates. Biliscan thorax values correlated better than abdomen values (0.6 versus 0.551) with serum values. Hence chest is the preferred area for Biliscan measurement. Conclusions: Biliscan app appears to be a good cheap option to screen for jaundice in newborns noninvasively.

scholarly journals Clinical utility of hand held, non invasive transcutaneous bilirubinometer in neonatal jaundice: a prospective observational study

2021 ◽  
Author(s):  
Bibhudatta Mishra ◽  
Bishwajit Mishra ◽  
Guruveera Jeyasingh Malini ◽  
Arjit Mohapatra ◽  
Prafulla Kumar Biswal ◽  
...  
Keyword(s):  
Clinical Utility ◽  
Neonatal Jaundice ◽  
Prospective Observational Study ◽  
Screening Tool ◽  
Serum Bilirubin ◽  
Blood Sampling ◽  
Viable Option ◽  
Transcutaneous Bilirubin ◽  
Non Invasive ◽  
Transcutaneous Bilirubinometer

Background: Neonatal Jaundice is the most common morbidity in the first week of life, occurring in 60% of term and 80% of preterm newborn. However, visual inspection, being subjective, usually inaccurate and unreliable and will result in a number of unnecessary blood sampling. Taking all these in to considerations, transcutaneous bilirubinometer (TCB) may provide a solution which is an objective, noninvasive, fast and painless method of bilirubin estimation.Methods: Transcutaneous bilirubinometer levels were measured at forehead and sternum and blood samples for TSB were collected by venepuncture within 30 minutes and sent to biochemistry lab. After getting serum bilirubin reports, TCB and TSB values were compared by using Bhutani’s hour specific nomogram. Results: The correlation between serum bilirubin and transcutaneous bilirubin measured at forehead and sternum is very good at serum bilirubin <15 mg/dl, r value (Karl Pearson’s Correlation co-efficient) is 0.93 and 0.94 respectively.Conclusions: The findings of the present study indicate that the TCB is a reliable screening tool for hyperbilirubinemia in newborns >35 weeks of gestation, especially with bilirubin levels ≤15 mg/dl in 2-7 days of life. TCB can be a viable option for universal screening. Incorporating the use of TCB devices in clinical practice, can reduce the need for blood sampling for the management of neonatal jaundice.

scholarly journals The Impact of Phototherapy on the Accuracy of Transcutaneous Bilirubin Measurements in Neonates: Optimal Measurement Site and Timing

Diagnostics ◽  
2021 ◽  
Vol 11 (9) ◽  
pp. 1729
Author(s):  
Shau-Ru Ho ◽  
Yu-Chen Lin ◽  
Chi-Nien Chen
Keyword(s):  
Neonatal Jaundice ◽  
Serum Bilirubin ◽  
Pearson Correlation ◽  
Neonatal Hyperbilirubinemia ◽  
Total Serum ◽  
Transcutaneous Bilirubin ◽  
Optimal Measurement ◽  
The Impact ◽  
Transcutaneous Bilirubinometer ◽  
Time Point

Transcutaneous bilirubinometer devices are widely applied to assess neonatal hyperbilirubinemia. However, the optimal skin site and timing of transcutaneous bilirubin (TCB) measurements for the strongest correlation with total serum bilirubin (TSB) levels after phototherapy are still unclear. We conducted a retrospective observational study evaluating the correlation of TCB and TSB levels in neonates postphototherapy. The TCB measurements on the forehead and mid-sternum at 0 and 30 min postphototherapy were assessed by using a JM-103 bilirubinometer. Paired TCB and TSB measurements were assessed by Pearson correlation and Bland–Altman plots. We analyzed 40 neonates with 96 TSB and 384 TCB measurements. The TSB level correlated moderately with the forehead TCB level at 30 min postphototherapy (r = 0.65) and less strongly with the midsternum TCB level at 0 min postphototherapy (r = 0.52). The forehead at 30 min after cessation of phototherapy was the best time point and location of TCB measurement for the assessment of neonatal jaundice status. The reliability of TCB measurements varied across skin sites and durations after phototherapy. The effectiveness of TCB measurement to assess neonatal hyperbilirubinemia is much better on covered skin areas (foreheads) 30 min postphototherapy. The appropriate application of transcutaneous bilirubinometers could aid in clinical practice and avoid unnecessary management.

scholarly journals Evaluation of four different HPLC devices for hemoglobinopathy screening

2020 ◽  
Vol 0 (0) ◽  
Author(s):  
Müjgan Ercan Karadağ ◽  
Emiş Deniz Akbulut ◽  
Esin Avcı ◽  
Esra Fırat Oğuz ◽  
Saadet Kader ◽  
...  
Keyword(s):  
Gold Standard ◽  
High Performance ◽  
Public Health Problem ◽  
Reference Value ◽  
Comparison Study ◽  
Gold Standard Method ◽  
Blood Samples ◽  
Systematic Biases ◽  
Hemoglobin Variants ◽  
Thalassemia Screening

AbstractObjectiveHemoglobinopathies are a common public health problem in Turkey. In the screening of these disorders in population, cation-exchange high performance liquid chromatography (HPLC) is accepted as the gold standard method. In this study, the aim was to assess four different HPLC devices used in hemoglobinopathy screening.Materials and methodsA total of 58 blood samples were analyzed with four different HPLC methods (Bio-Rad variant II, Agilent 1100, Tosoh G8 and Trinity Ultra2 trademarks).ResultsThe comparison study demonstrated a good correlation between the results of each HPLC analyzer and the reference value obtained by averaging all the HbA2 results belonging to the methods tested in the study [ (Tosoh G8 (r=0.988), Bio-Rad variant II (r=0.993), Agilent 1100 (r=0.98) and Trinity Ultra2 (r=0.992) ]. HbA2 determination in the presence of HbE was interfered in both Bio-Rad variant II and Tosoh G8.ConclusionThe analyzers were found to have compatible HbA2 results but with accompanying different degrees of proportional and systematic biases. HPLC analyzers may be affected by different hemoglobin variants at different HbA2 concentrations, which is an important point to take into consideration during the evaluation of HbA2 results in thalassemia screening.

scholarly journals Performance of Seven Consumer Sleep-Tracking Devices Compared with Polysomnography

SLEEP ◽  
2020 ◽  
Author(s):  
Evan D Chinoy ◽  
Joseph A Cuellar ◽  
Kirbie E Huwa ◽  
Jason T Jameson ◽  
Catherine H Watson ◽  
...  
Keyword(s):  
Performance Measures ◽  
Gold Standard ◽  
High Performance ◽  
Sleep Stage ◽  
Sleep Laboratory ◽  
Sleep Assessment ◽  
Sleep Condition ◽  
Different Populations ◽  
Tracking Devices ◽  
Better Than

Abstract Study Objectives Consumer sleep-tracking devices are widely used and becoming more technologically advanced, creating strong interest from researchers and clinicians for their possible use as alternatives to standard actigraphy. We therefore tested the performance of many of the latest consumer sleep-tracking devices, alongside actigraphy, versus the gold-standard sleep assessment technique, polysomnography (PSG). Methods In total, 34 healthy young adults (22 women; 28.1 ± 3.9 years, mean ± SD) were tested on three consecutive nights (including a disrupted sleep condition) in a sleep laboratory with PSG, along with actigraphy (Philips Respironics Actiwatch 2) and a subset of consumer sleep-tracking devices. Altogether, four wearable (Fatigue Science Readiband, Fitbit Alta HR, Garmin Fenix 5S, Garmin Vivosmart 3) and three non-wearable (EarlySense Live, ResMed S+, SleepScore Max) devices were tested. Sleep/wake summary and epoch-by-epoch agreement measures were compared with PSG. Results Most devices (Fatigue Science Readiband, Fitbit Alta HR, EarlySense Live, ResMed S+, SleepScore Max) performed as well as or better than actigraphy on sleep/wake performance measures, while the Garmin devices performed worse. Overall, epoch-by-epoch sensitivity was high (all ≥0.93), specificity was low-to-medium (0.18-0.54), sleep stage comparisons were mixed, and devices tended to perform worse on nights with poorer/disrupted sleep. Conclusions Consumer sleep-tracking devices exhibited high performance in detecting sleep, and most performed equivalent to (or better than) actigraphy in detecting wake. Device sleep stage assessments were inconsistent. Findings indicate that many newer sleep-tracking devices demonstrate promising performance for tracking sleep and wake. Devices should be tested in different populations and settings to further examine their wider validity and utility.

scholarly journals Transcutaneous billirubinometry to estimate total serum bilirubin in neonatal jaundice

2017 ◽  
Vol 57 (1) ◽  
pp. 8 ◽  
Author(s):  
Andra Kurnianto ◽  
Herman Bermawi ◽  
Afifa Darmawanti ◽  
Erial Bahar
Keyword(s):  
Neonatal Jaundice ◽  
Serum Bilirubin ◽  
Subcutaneous Tissue ◽  
Correlation Coefficients ◽  
Total Serum Bilirubin ◽  
Blood Sampling ◽  
Total Serum ◽  
Transcutaneous Bilirubin ◽  
Non Invasive ◽  
Transcutaneous Bilirubinometry

Background The gold standard for diagnosis of neonatal jaundice is total serum bilirubin (TSB) measurement. This method, however, is invasive, painful, and costly in terms of workload, time, and money. Moreover, repeated blood sampling may lead to significant blood loss, which is of particular concern in preterm infants. To overcome these drawbacks, non-invasive methods of bilirubin measurement have been proposed. Transcutaneous bilirubinometry (TcB) determines the yellowness of the subcutaneous tissue of a newborn infant by measuring the difference between optical densities for light in the blue and green wavelength regions.Objective To evaluate the accuracy of transcutaneous bilirubinometry for estimating TSB levels in neonatal jaundice.Methods Subjects were infants aged < 28 days with jaundice who had never been treated with phototherapy or exchange transfusion. The study was done from February to July 2016 in Mohammad Hoesin Hospital. Subjects underwent transcutaneous bilirubin (TcB) and TSB assays, with a maximum interval of 15 minutes between tests.Results One hundred fifty patients were included in this study. The TcB values > 5 mg/dL were correlated to TSB > 5 mg/dL, with 100% sensitivity and 83.3% specificity. This cut-off point was obtained from a receiver-operator characteristic (ROC) curve with AUC 99.3% (95%CI 97.9 to 100%; P< 0.001).The correlation coefficients (r) for TSB and TcB measurements on the forehead were 0.897 (P<0.001).Conclusion Transcutaneous bilirubinometry can be used to accurately estimate TSB levels in neonatal jaundice, and may be useful in clinical practice as a non-invasive method to reduce blood sampling.

scholarly journals Neonatal wearable device for colorimetry-based real-time detection of jaundice with simultaneous sensing of vitals

2021 ◽  
Vol 7 (10) ◽  
pp. eabe3793
Author(s):  
Go Inamori ◽  
Umihiro Kamoto ◽  
Fumika Nakamura ◽  
Yutaka Isoda ◽  
Azusa Uozumi ◽  
...  
Keyword(s):  
Heart Rate ◽  
Oxygen Saturation ◽  
Neonatal Jaundice ◽  
Treatment Approach ◽  
Combined Treatment ◽  
Simultaneous Detection ◽  
Clinical Experiments ◽  
Simultaneous Sensing ◽  
Severe Hyperbilirubinemia ◽  
Transcutaneous Bilirubinometer

Neonatal jaundice occurs in >80% of newborns in the first week of life owing to physiological hyperbilirubinemia. Severe hyperbilirubinemia could cause brain damage owing to its neurotoxicity, a state commonly known as kernicterus. Therefore, periodic bilirubin monitoring is essential to identify infants at-risk and to initiate treatment including phototherapy. However, devices for continuous measurements of bilirubin have not been developed yet. Here, we established a wearable transcutaneous bilirubinometer that also has oxygen saturation (SpO2) and heart rate (HR) sensing functionalities. Clinical experiments with neonates demonstrated the possibility of simultaneous detection of bilirubin, SpO2, and HR. Moreover, our device could consistently measure bilirubin during phototherapy. These results demonstrate the potential for development of a combined treatment approach with an automatic link via the wearable bilirubinometer and phototherapy device for optimization of the treatment of neonatal jaundice.

Implementation of Smart Home System Based on Internet of Things

2013 ◽  
Vol 475-476 ◽  
pp. 1150-1153 ◽  
Author(s):  
Yan Zeng Gao ◽  
Ling Yan Wei
Keyword(s):  
Internet Of Things ◽  
Embedded System ◽  
Smart Home ◽  
Smart Phone ◽  
Cloud Service ◽  
Control Center ◽  
Cloud Server ◽  
Novel Method ◽  
Smart Phone Application

Smart home can apply new internet of things concepts along cloud service technologies. This paper introduces a novel method for smart home system building. The system is driven by use case and it is composed of home control center, zigbee end devices, smart phone applications and cloud server. The home control center is based on arm-linux embedded system, it is the relay of cloud server and home devices. Wireless network of smart home devices was designed according to zigbee. A smart phone application was developed as the role of the user interface.

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