scholarly journals Retrospective audit of sinonasal inverted papilloma at a tertiary care centre

2017 ◽  
Vol 3 (3) ◽  
pp. 517
Author(s):  
Somu L. ◽  
Prasanna Kumar S. ◽  
Urvashi Singh
Keyword(s):  
Malignant Transformation ◽  
Tertiary Care ◽  
Concurrent Chemotherapy ◽  
Inverted Papilloma ◽  
Sinonasal Tract ◽  
Female Ratio ◽  
Sinonasal Inverted Papilloma ◽  
Retrospective Audit ◽  
Total Maxillectomy

<p class="abstract"><strong>Background:</strong> <span lang="EN-IN">Inverted Papilloma of the sinonasal tract is a benign neoplasm with unique locally destructive capacity, tendency to recur and a propensity for malignant change. Despite varied studies, there seems to be a lack in consensus with regards to its etiology, predictors of recurrence and malignant transformation. The aim of our study is to analyse the clinical profile, management and outcome of histopathologically proven Inverted Papilloma of the nose and paranasal sinus at our institute. </span></p><p class="abstract"><strong>Methods:</strong> <span lang="EN-IN">Retrospective chart review of 17 patients of histologically proven Sinonasal Inverted Papilloma over a period of 2 years from May 2013 to May 2015. </span></p><p class="abstract"><strong>Results:</strong> <span lang="EN-IN">The majority were in their 5th and 6th decade of life (47%) with a male to female ratio of 15:2. All had been managed surgically with 10 patients undergoing endoscopic assisted polypectomy, 6 requiring partial maxillectomy &amp; 1 requiring total maxillectomy for complete surgical clearance. All patients had been followed up for a minimum duration of 1 year and recurrence was found in 41%. 2 patients had been diagnosed with malignant transformation during follow-up, out of which 1 underwent right partial maxillectomy along with concurrent chemotherapy and other patient underwent left total maxillectomy with concurrent chemotherapy and intensity modulated radiation therapy. </span></p><p class="abstract"><strong>Conclusions:</strong> <span lang="EN-IN">Inverted Papilloma of the sinonasal tract is a locally aggressive disease requiring careful endoscopic and radiological assessment. Adequate surgical management can ensure complete clearance of disease. A strict long term follow-up protocol will facilitate identifying recurrence and malignant transformation.</span></p><p> </p>

Clinical Implications of Carcinoma In Situ in Sinonasal Inverted Papilloma

2019 ◽  
Vol 161 (6) ◽  
pp. 1036-1042 ◽  
Author(s):  
Ivy W. Maina ◽  
Charles C. L. Tong ◽  
Esther Baranov ◽  
Neil N. Patel ◽  
Vasiliki Triantafillou ◽  
...  
Keyword(s):  
Malignant Transformation ◽  
Recurrence Rate ◽  
Carcinoma In Situ ◽  
Inverted Papilloma ◽  
Sinonasal Inverted Papilloma ◽  
Definitive Surgery ◽  
Severe Degree ◽  
Multiple Recurrences

Objective Sinonasal inverted papilloma (IP) is a typically benign sinonasal tumor with a tendency to recur and the potential for malignant transformation. Varying degrees of dysplasia may be present, of which carcinoma in situ (CIS) is most advanced. We hereby describe the biological and clinical behavior of IP with CIS (IPwCIS). Study Design Retrospective cohort. Setting Tertiary academic referral center. Subjects and Methods Patients who underwent surgical resection for IP between 2002 and 2017. Pertinent clinical data were obtained, and all IPwCIS cases were histologically confirmed. Results In total, 37 of 215 cases (17.2%) were identified with IPwCIS. Mean age was 57 years and 86.5% of patients were male. Median follow-up was 82 months, and the recurrence rate was 27%. The maxillary sinus was the most common primary site (37.8%) and 14 tumors (37.8%) demonstrated multifocal attachment, which was associated with recurrence (odds ratio [OR], 9.7; 95% confidence interval [CI], 1.4-112.8; P = .028). IPwCIS was also associated with multiple recurrences (OR, 2.71; 95% CI, 1.246-5.814; P = .021). Most patients were treated with surgery alone (89.1%) and 4 patients received adjuvant radiotherapy (8.1%). Only 1 patient (2.7%) demonstrated malignant transformation after definitive surgery. Conclusions IPwCIS represents the most severe degree of dysplasia prior to malignant transformation and is associated with higher recurrence rate and multifocal involvement but low rate of conversion to invasive carcinoma. The need for adjuvant therapy remains controversial, and further research into the etiology of the disease is warranted.

Malignant transformation of sinonasal inverted papilloma and related genetic alterations: a systematic review

2017 ◽  
Vol 274 (8) ◽  
pp. 2991-3000 ◽  
Author(s):  
M. Re ◽  
F. M. Gioacchini ◽  
A. Bajraktari ◽  
M. Tomasetti ◽  
S. Kaleci ◽  
...  
Keyword(s):  
Systematic Review ◽  
Malignant Transformation ◽  
Genetic Alterations ◽  
Inverted Papilloma ◽  
Sinonasal Inverted Papilloma

scholarly journals Risk Factors of Recurrence and Malignant Transformation of Sinonasal Inverted Papilloma

2017 ◽  
Vol 2017 ◽  
pp. 1-7 ◽  
Author(s):  
Marta Gamrot-Wrzoł ◽  
Paweł Sowa ◽  
Grażyna Lisowska ◽  
Wojciech Ścierski ◽  
Maciej Misiołek
Keyword(s):  
Malignant Transformation ◽  
Clinical Medicine ◽  
Surgical Techniques ◽  
Diagnostic Techniques ◽  
Postoperative Management ◽  
Inverted Papilloma ◽  
Surgical Approaches ◽  
Ki 67 ◽  
Wnt Proteins ◽  
Sinonasal Inverted Papilloma

Sinonasal inverted papilloma is a relatively rare disease; however, it is prevalent enough for every ENT practitioner to encounter it several times throughout medical routines. Despite the developments in experimental and clinical medicine as well as surgical techniques, our knowledge of this disease is still inadequate. With improved imaging and better diagnostic techniques, proper diagnosis and qualification for surgical approaches leave no doubt. Although the endoscopic approach seems to be the gold standard for such condition, some cases may additionally require an external approach. Regardless of the type of surgery, postoperative management is crucial for both healing and long-term follow-up. Unfortunately, the procedures are still lacking in explicit and standardized postoperative management guidelines. Moreover, an important issue is still the need for a biomarker indicative of inverted papilloma and its malignant transformation. Several particles, within the spotlight of the researchers, have been SCCA, Ki-67, Bcl-2, Wnt proteins, and many more. Nevertheless, the topic requires further investigations.

scholarly journals Sinonasal Inverted Papilloma and the Dilemma of Treatments

2013 ◽  
Vol 6 (2) ◽  
pp. 61-63
Author(s):  
Bandar Al Qahtani ◽  
Mariam S Al-Amro
Keyword(s):  
Malignant Transformation ◽  
Recent Literature ◽  
Inverted Papilloma ◽  
Sinonasal Inverted Papilloma

ABSTRACT This is a review of most recent literature to find the best methods for management of sinonasal inverted papilloma and if there is any standardized modality/modalities. Also there is concern about the advancement in the management of sinonasal inverted papilloma based on recent literature revision. Inverted papilloma has to be managed aggressively from the beginning putting in mind its ability to recur and malignant transformation. Until now days there is no single verified modality of treatment and the choice of the best approach is tailored to every case. How to cite this article Al-Qahtani BM, Al-Amro MS. Sinonasal Inverted Papilloma and the Dilemma of Treatments. Clin Rhinol An Int J 2013;6(2):61-63.

Primary temporal inverted papilloma with premalignant change

2010 ◽  
Vol 125 (2) ◽  
pp. 206-209 ◽  
Author(s):  
H Zhou ◽  
Z Chen ◽  
H Li ◽  
G Xing
Keyword(s):  
Recurrence Rate ◽  
Radical Resection ◽  
Therapeutic Strategies ◽  
Inverted Papilloma ◽  
Sinonasal Inverted Papilloma ◽  
Sinonasal Papilloma

AbstractObjectives:To explore the pathology, diagnosis, therapeutic strategies and prognosis of primary temporal inverted papilloma.Methods:We present one of the first reported cases of primary temporal inverted papilloma with premalignant change. The available data are reviewed.Results:To the best of our knowledge, only 10 evaluable cases of this tumour have been reported. The recurrence rate is higher for this tumour than for sinonasal inverted papilloma.Conclusion:Primary temporal inverted papilloma is extremely rare, and its diagnosis should be made only following clinical exclusion of sinonasal papilloma. Therapy mainly comprises radical resection of the lesion, and long-term post-operative follow up is mandatory.

Comparison of Current Staging Systems for Sinonasal Inverted Papilloma

2020 ◽  
Vol 35 (1) ◽  
pp. 64-71
Author(s):  
Tsuguhisa Nakayama ◽  
Yasuhiro Tsunemi ◽  
Takashi Kashiwagi ◽  
Akihito Kuboki ◽  
Shuchi Yamakawa ◽  
...  
Keyword(s):  
Disease Free Survival ◽  
Staging System ◽  
Inverted Papilloma ◽  
Machine Learning Algorithms ◽  
Recurrence Rates ◽  
Cox Proportional Hazard ◽  
Sinonasal Inverted Papilloma ◽  
Staging Systems ◽  
Cox Proportional Hazard Models

Background A staging system is essential for determining the optimal surgical approach and predicting postoperative outcomes for inverted papilloma (IP). Although staging systems based on the extent to which the location is occupied by an IP have been widely used, an origin site-based classification of IP using unsupervised machine learning algorithms has recently been reported. Objective To determine the most appropriate of five staging systems for sinonasal IP by comparing recurrence rates for each stage according to each of those systems. Methods Eighty-seven patients with sinonasal IP were enrolled in the study. Their tumors were retrospectively categorized according to the Krouse, Oikawa, Cannady, and Han staging systems, which are based on the extent of IP, and the Meng system, which is based on the site of origin. The rates of recurrence for each stage of the five systems were compared. Results Seven of the 87 patients (8.0%) had recurrences during an average 45.5 months (12–138 months) of follow-up. There were significant differences in disease-free survival between the stages specified by Han and Meng (p = 0.027 and p < 0.001, respectively), but not between the stages specified by Krouse, Oikawa, and Cannady (p = 0.236, 0.062, and 0.130, respectively). Cox proportional hazard models revealed that Meng system (adjusted hazard ratio [aHR] 4.32, 95% confidence interval [CI] 1.10–17.04) and presence of dysplasia (aHR 7.42, 95% CI 1.15–47.85) were significantly associated with recurrence. Conclusion The staging systems proposed by Han and Meng were found to be accurate in terms of tumor recurrence. We recommend use of the Han staging system before surgery and the Meng system after intraoperative identification of the origin of the tumor.

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