Kimura’s disease: a rare cause of facial mass in a caucasian male patient

Kimura’s disease is an uncommon inflammatory disorder of unclear aetiology, mainly affecting young Asian descent males among their second and fourth decades of life. The disease typically emerges as a long-standing and painless subcutaneous mass lesion in the head and neck region, frequently associated with swelling of major salivary glands, particularly the parotid gland, and regional lymphadenopathy. Peripheral eosinophilia and high serum immunoglobulin E are also characteristic findings. We report a case and describe the imaging and pathological features of the disease in a 19-year-old Caucasian male, with review of the literature.

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Kimura’s disease: a diagnostic and therapeutic enigma

International Journal of Research in Medical Sciences ◽

10.18203/2320-6012.ijrms20182310 ◽

2018 ◽

Vol 6 (6) ◽

pp. 2176

Author(s):

Vinay Bharat ◽

Abhishek Gupta ◽

Rani Bansal ◽

Priya Gupta ◽

Mamta Gupta

Keyword(s):

Lymph Nodes ◽

Elevated Serum ◽

Neck Region ◽

Kimura’S Disease ◽

Inflammatory Disorder ◽

Neck Swelling ◽

Peripheral Eosinophilia ◽

Head And Neck Region ◽

Chronic Inflammatory Disorder ◽

Reactive Hyperplasia

Kimura’s disease is a rare chronic inflammatory disorder present in 2nd and 3rd decade. It has a predilection for head and neck region presenting as a slowly growing painless swelling. It is usually accompanied by peripheral eosinophilia and elevated serum IgE and hence it was initially thought to be of allergic origin. Histologically the lesions are characterized by reactive hyperplasia of lymph nodes, eosinophilic infiltration and increase in postcapillary venules. Authors have reported a male patient with a slowly growing right sided neck swelling which is recurring even after course of steroids and excision done twice at an interval of 6 months. Kimura’s disease although a benign Lymphoid disorder but the incidence of recurrence despite taking treatment is a cause of much concern for the patient.

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Eosinophilic chronic rhinosinusitis and concurrent Kimura’s disease treated with mepolizumab

BMJ Case Reports ◽

10.1136/bcr-2019-232627 ◽

2021 ◽

Vol 14 (1) ◽

pp. e232627

Author(s):

Jacqueline Ho ◽

Sophie Walter ◽

Richard J Harvey

Keyword(s):

English Language ◽

Cervical Lymphadenopathy ◽

Upper Airway ◽

Neck Region ◽

Kimura’S Disease ◽

Inflammatory Disorder ◽

Head And Neck Region ◽

Chronic Inflammatory Disorder ◽

First Case ◽

Eosinophilic Chronic Rhinosinusitis

Kimura’s disease is a rare, benign, chronic inflammatory disorder characterised by its eosinophilic infiltrate. Patients often present with one or more progressively enlarging subcutaneous lymph nodes in the head and neck region or enlarging salivary glands. We describe the case of a 26-year-old man presenting with severe peripheral eosinophilia and upper airway inflammatory symptoms, who later developed cervical lymphadenopathy and formally diagnosed with Kimura’s disease. Based on our English-language MEDLINE literature search, to our knowledge this is the first case report describing treatment of Kimura’s disease with mepolizumab.

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Kimura's Disease: A Case Report

Ear Nose & Throat Journal ◽

10.1177/014556130007900314 ◽

2000 ◽

Vol 79 (3) ◽

pp. 195-199 ◽

Cited By ~ 5

Author(s):

Sebastian J. Karavattathayyil ◽

John R. Krause

Keyword(s):

Case Report ◽

Soft Tissue ◽

Lymph Nodes ◽

Head And Neck ◽

Salivary Glands ◽

Immunoglobulin E ◽

Elevated Serum ◽

Neck Region ◽

Kimura’S Disease ◽

Head And Neck Region

Kimura's disease is a rare, idiopathic condition that usually affects young men of Asian descent. The disease is characterized by swelling and lesions in the head and neck region, with involvement of the subcutaneous soft tissue, major salivary glands, and lymph nodes. Patients almost always have eosinophilia and elevated serum immunoglobulin E levels. The diagnosis is established by biopsy. Kimura's disease is usually self-limiting. Its etiology is unknown but is thought to be a manifestation of an aberrant allergic response. In this paper, we describe the case of a 30-year-old patient who was diagnosed with Kimura's disease at our institution.

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Kimura's disease: case report and brief review of the literature

The Journal of Laryngology & Otology ◽

10.1017/s0022215100128750 ◽

1994 ◽

Vol 108 (11) ◽

pp. 1005-1007 ◽

Cited By ~ 22

Author(s):

Mette Nyrop

Keyword(s):

Neck Region ◽

Malignant Tumour ◽

Chronic Inflammatory Disease ◽

Surgical Removal ◽

Kimura’S Disease ◽

Review Of The Literature ◽

Fine Needle Aspirate ◽

Japanese People ◽

Head And Neck Region ◽

Disease Case

AbstractKimura's disease is a chronic inflammatory disease which often presents as a tumour-like swelling in the head and neck region with or without lymphadenopathy. Most cases have been described predominantly in Chinese and Japanese people. The lesion is benign, but it may easily be mistaken for a malignant tumour. Kimura's disease has been confused with angiolymphoid hyperplasia with eosinophilia (ALHE), from which it probably should be distinguished as a separate entity. The diagnosis may be suggested by a fine needle aspirate, but is established by a biopsy. The treatment of choice is surgical removal.A case of Kimura's disease in a Caucasian male of 12 years' duration is presented together with a brief review of the literature.

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Unusual presentation of Kimura’s disease: a case series

International Journal of Research in Dermatology ◽

10.18203/issn.2455-4529.intjresdermatol20175378 ◽

2017 ◽

Vol 3 (4) ◽

pp. 535

Author(s):

Aarti S. Salunke ◽

Ravindranath B. Chavan ◽

Vasudha A. Belgaumkar ◽

Neelam Bhatt

Keyword(s):

Case Series ◽

Neck Region ◽

Chronic Inflammatory Disease ◽

Good Prognosis ◽

Unknown Etiology ◽

Kimura’S Disease ◽

Peripheral Eosinophilia ◽

Unusual Site ◽

Head And Neck Region ◽

Subcutaneous Nodules

<p style="margin-bottom: 0in; line-height: 100%;" align="JUSTIFY">Kimura’s disease is a rare chronic inflammatory disease of unknown etiology, presenting as painless subcutaneous nodules with lymphadenopathy and peripheral eosinophilia, mainly disturbing the head and neck region. It mainly affects Asian males in their 2nd to 4th decade of life. Kimura’s disease, although difficult to diagnose clinically, should be considered in the differential diagnosis of patients who have a primary lymphadenopathy with eosinophilia with or without subcutaneous nodules. It should be investigated accordingly as the disease has an indolent course and good prognosis. Herein we report two cases of Kimura’s disease, of which one had unusual site of involvement. </p>

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Oropharyngeal Kimura’s disease: a diagnostic dilemma and therapeutic challenge

BMJ Case Reports ◽

10.1136/bcr-2020-236366 ◽

2020 ◽

Vol 13 (10) ◽

pp. e236366

Author(s):

Prasanna Kumar Saravanam ◽

Aishwarya Gajendran ◽

Nethra Dinakaran ◽

Dhaarani Jayaraman

Keyword(s):

Histopathological Examination ◽

Subcutaneous Tissue ◽

Neck Region ◽

Treatment Modalities ◽

Kimura’S Disease ◽

Inflammatory Disorder ◽

First Line ◽

Diagnostic Dilemma ◽

Head And Neck Region ◽

Chronic Inflammatory Disorder

Kimura’s disease is a chronic inflammatory disorder involving subcutaneous tissue and locoregional lymph nodes of head and neck region, characterised by angiolymphoid proliferation. It is typically associated with peripheral eosinophilia, increased serum IgE and lymphadenopathy. Diagnosis is usually based on histopathological examination. Though various treatment modalities have been put forward, surgical management remains the first line of treatment, followed by systemic steroids application. This case report discusses the diagnostic dilemma and therapeutic management of a rare clinical presentation and management of oropharyngeal Kimura’s disease in a young immunocompetent woman.

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Kimura’s Disease in a Female Patient: Case Report and Review of the Literature

Journal of Clinical Review & Case Reports ◽

10.33140/jcrc/03/08/00001 ◽

2018 ◽

Vol 3 (8) ◽

Keyword(s):

Female Patient ◽

Immunoglobulin E ◽

Subcutaneous Tissue ◽

Neck Region ◽

Excisional Biopsy ◽

Serum Levels ◽

Chronic Inflammatory Disease ◽

Kimura’S Disease ◽

Patient Case ◽

Head And Neck Region

Kimura’s disease is a rare chronic inflammatory disease of uncertain cause, manifesting commonly as a painless swelling of the subcutaneous tissue in the head and neck region with predilection for peri auricular areas. A significant increase in serum levels of immunoglobulin E and eosinophilia in the peripheral blood and in tissues has been associated with this disorder. Many cases of nephropathy in patients with Kimura’s Disease had been reported in the literature. Excisional biopsy for histopathological evaluation is the only way to confirm the diagnosis of Kimura’s Disease. We report a case of Kimura’s disease in a 26-year- old female patient who presented to our clinic with painless right retro-auricular swellings.

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Kimura’s disease as an uncommon cause of post auricular swelling

International Journal of Otorhinolaryngology and Head and Neck Surgery ◽

10.18203/issn.2454-5929.ijohns20203585 ◽

2020 ◽

Vol 6 (9) ◽

pp. 1737

Author(s):

Chandre Gowda Bendiganahalli Venkate Gowda ◽

Madhuri Gandham

Keyword(s):

Immunoglobulin E ◽

Neck Region ◽

Unknown Etiology ◽

Kimura’S Disease ◽

Histopathological Diagnosis ◽

Inflammatory Disorder ◽

Chronic Inflammatory Disorder ◽

Tissue Eosinophilia ◽

Common Causes ◽

Rule Out

<p>Kimura’s disease (KD) is a rare chronic inflammatory disorder of unknown etiology, primarily seen in young Asian males. In India, only 200 cases have been reported worldwide since its histopathological diagnosis. The disease is characterized by painless subcutaneous swelling in head & neck region, blood and tissue eosinophilia and raised Immunoglobulin E (IgE) levels. A systematic multidisciplinary approach is mandatory to rule out the other common causes of post auricular lymphadenopathy. The diagnosis of KD can be difficult and misleading and patients with this disease are often evaluated using avoidable procedures by just not being aware of KD. Here, we present a case of a 20 year old male who presented with nodular swellings in the bilateral post auricular region. The diagnosis of KD was done based on characteristic histopathologic finding in conjunction with peripheral eosinophilia.</p>

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Rituximab Treatment in a Patient with Kimura Disease and Membranous Nephropathy: Case Report

Case Reports in Nephrology and Dialysis ◽

10.1159/000515644 ◽

2021 ◽

pp. 116-123

Author(s):

Roald Vissing-Uhre ◽

Alastair Hansen ◽

Susanne Frevert ◽

Ditte Hansen

Keyword(s):

Case Report ◽

Membranous Nephropathy ◽

Neck Region ◽

Renal Diseases ◽

Kimura’S Disease ◽

Inflammatory Disorder ◽

Kimura Disease ◽

Chronic Inflammatory Disorder ◽

Eosinophil Granulocytes ◽

Anti Cd20

Kimura disease (KD) is a chronic, inflammatory disorder with slowly developing subcutaneous tumor-like swellings, often occurring in the head and neck region. KD is diagnosed based on histology, elevated levels of immunoglobulin type E, and increased peripheral eosinophil granulocytes. KD may coexist with glomerular renal diseases, and this case report is based on a patient with KD-associated membranous nephropathy. Patients with membranous nephropathy without KD have demonstrated responsiveness to treatment with monoclonal anti-CD20 antibodies. This case report is the first to investigate the effect of rituximab treatment in a patient with KD-associated membranous nephropathy. A 30-year-old Italian man living in Denmark was diagnosed with Kimura’s disease based on subcutaneous nodules with eosinophil angiolymphoid hyperplasia. The patient was admitted to the hospital due to nephrotic syndrome. Serology showed eosinophil granulocytosis and negative PLA2-receptor antibody. Renal biopsy showed membranous nephropathy, and the patient was treated with systemic methylprednisolone followed by cyclosporin and then cyclophosphamide with only partial remission. Ultimately, treatment with intravenous rituximab was initiated, which resulted in overall remission and no nephrotic relapses at 30 months of follow-up. Thus, intravenous rituximab effectively decreased proteinuria and prevented nephrotic relapses in a patient with treatment-refractory membranous nephropathy due to KD.

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