A study of the association of premature androgenetic alopecia with metabolic syndrome and coronary artery disease

Background: Androgenetic alopecia (AGA) is a common form of patterned hair loss characterized by transformation of terminal hair of the scalp to vellous hair mediated mainly by androgens. Premature androgenetic alopecia can be defined as androgenetic alopecia developing before 35 years of age and presenting with at least stage 2 of Norwood-Hamilton classification. Premature AGA not only adds to psychological stress but is also reported as a risk factor for cardiovascular diseases, metabolic syndrome and carcinoma prostrate. In many subsequent studies, AGA has been shown to be associated with several diseases such as insulin resistance (IR), abnormal serum lipid profiles and obesity.Methods: Various parameters of metabolic syndrome were measured in 75 male patients of AGA in the department of dermatology, Safdarjung hospital from June 2015 to April 2016. ECG and echocardiography was done in all patients to look for any evidence of premature coronary artery disease.Results: In our study grade III and IV of AGA were the most common types (32% each). We found the prevalence of metabolic syndrome to be 8% in our patients with premature androgenetic alopecia in accordance with the NCEP ATP III guidelines. There was a significant positive correlation between grade of androgenetic alopecia and metabolic syndorme in our patients (p=0.049). Conclusions: The prevalence of metabolic syndrome was not increased as compared to general population.

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Serum Interleukin-6 and Lipid Atherogenic Index Risk Ratios as Interpreters of Cardiac Disease in Obese and Non Obese Male Patients of Coronary Artery Disease

10.53350/pjmhs211561203 ◽

2021 ◽

Vol 15 (6) ◽

pp. 1203-1205

Author(s):

S. Naz ◽

M. Raza ◽

A. Akbar ◽

A. N. Zaidi ◽

S. Khaliq ◽

...

Keyword(s):

Coronary Artery Disease ◽

Coronary Artery ◽

Lipid Profile ◽

Interleukin 6 ◽

Significant Positive Correlation ◽

Atherogenic Index ◽

Positive Correlation ◽

Male Patients ◽

Artery Disease ◽

Obese Male

Aim: To evaluate serum Interleukin-6, and lipids as predictors of cardiovascular diseases (CVD) in obese and non obese male patients of coronary artery disease (CAD). Methodology: It was cross-sectional comparative study. Serum Interleukin-6 and lipid profile was determined in non diabetic, non smoker and non hypertensive age matched obese and non obese male patients of CAD and healthy subjects. Sixty male subjects were divided equally into groups. Group 1, healthy controls (n=20), group 2, non obese male patients with CAD (n=20) and group 3 included Obese male patients with CAD (n=20). The serum was assayed for lipid profile and interleukin-6 . Results: Age matched healthy and patients were non diabetics, non hypertensive and non smoker with altered lipid profile in obese and non obese male patients with coronary artery disease. Patients have high serum cholesterol, low density cholesterol(LDL-C), Triglyceride(TG,) very low density lipoprotein(VLDL) and interleukin-6. The High density lipoprotein was lowered in both obese and non obese male patients with CAD. Significant positive correlation was observed in CAD group of IL-6 with TC (rho= 0.405, p= 0.009*) , with TG (rho= 0.639, p= 0.000*) ,with LDL (rho= 0.398, p= 0.002*), with VLDL (rho= 0.315, p= 0.014*). Significant negative correlation was observed in CAD group of IL-6 with HDL (rho= -0.565, p= 0.000*) Significant positive correlation was observed in CAD group of IL-6 .Significant positive correlation of IL-6 was observed with AI (rho= 0.602, p= 0.000*). Conclusion: Dyslipidemia, Raised interleukin-6 and strong positive correlation of Atherogenic index with IL-6 are independent risk factors for CVD; using Atherogenic risk ratios as a screening tool for the estimation of CVD risk is useful in patients with CAD. Keywords: Lipid profile, serum interleukin-6,Atherogenic index,coronary artery disease.

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Association between androgenetic alopecia and coronary artery disease in young male patients

International Journal of Trichology ◽

10.4103/0974-7753.136747 ◽

2014 ◽

Vol 6 (1) ◽

pp. 5 ◽

Cited By ~ 13

Author(s):

KamalH Sharma ◽

Anchal Jindal

Keyword(s):

Coronary Artery Disease ◽

Coronary Artery ◽

Young Male ◽

Androgenetic Alopecia ◽

Male Patients ◽

Artery Disease

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Prevalence of metabolic syndrome in patients with premature coronary artery disease proven by coronary angiogram

International Journal of Research in Medical Sciences ◽

10.18203/2320-6012.ijrms20174963 ◽

2017 ◽

Vol 5 (11) ◽

pp. 5021 ◽

Cited By ~ 1

Author(s):

Varun Sundaramoorthy ◽

Anith Kumar Mambatta ◽

Yoganathan Chidambaram ◽

Rajendiran Gopalan ◽

Sujaya Menon

Keyword(s):

Coronary Artery Disease ◽

Metabolic Syndrome ◽

Coronary Artery ◽

Young Patients ◽

International Diabetes Federation ◽

Premature Coronary Artery Disease ◽

Coronary Angiogram ◽

Coronary Syndrome ◽

Significant Difference ◽

Artery Disease

Background: Metabolic syndrome (MS) is associated with premature coronary artery disease (CAD). The aim of this study was to evaluate the prevalence of MS and its association with severity of CAD proven by coronary angiogram (CAG) in young patients.Methods: We included patients, aged 45 years or less, admitted with acute coronary syndrome (ACS), who had CAD confirmed by coronary angiography. They were divided into two groups according to the presence or absence of MS based on International Diabetes Federation (IDF) criteria. CAD was classified into single, double and triple vessel disease (TVD). The prevalence of MS and its individual parameters was calculated.Results: Among 90 young patients who presented with ACS, MS was present in 67 patients (74.44%). Among those with MS, the prevalence of each individual criterion was statistically significant in MS group (P <0.05). Prevalence of pre-existing hypertension and diabetes was significantly higher in MS group (p <0.01). Smoking, alcohol consumption and family history of CAD were not statistically significant in patients with and without MS. Fifteen out of 90 patients (14 in MS group) who presented with ACS had TVD in CAG, but this was not statistically significant (p 0.06).Conclusions: This study confirms a very high prevalence of MS in young Indian patients with premature CAD. MS was more prevalent than the conventional risk factor smoking in young CAD patients. We could not find significant difference in severity of CAD based on CAG between MS and non-MS group.

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A8200 Clinical Significance and Determinants of Arterial Stiffness in Male Patients with Premature Coronary Artery Disease

Journal of Hypertension ◽

10.1097/01.hjh.0000548656.41201.e4 ◽

2018 ◽

Vol 36 ◽

pp. e161-e162

Author(s):

Nan Cheng

Keyword(s):

Coronary Artery Disease ◽

Coronary Artery ◽

Arterial Stiffness ◽

Clinical Significance ◽

Premature Coronary Artery Disease ◽

Male Patients ◽

Artery Disease

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Abstract P261: Rheumatoid Arthritis And Coronary Artery Disease: Are We Considering The Real Risk?

Circulation ◽

10.1161/circ.141.suppl_1.p261 ◽

2020 ◽

Vol 141 (Suppl_1) ◽

Author(s):

Rania Al Asmar ◽

Sudha Penumala ◽

Kanaan Mansoor ◽

Emilia Leigh ◽

Bisher Mustafa ◽

...

Keyword(s):

Rheumatoid Arthritis ◽

Coronary Artery Disease ◽

Metabolic Syndrome ◽

Coronary Artery ◽

Primary Prevention ◽

Patient Population ◽

Premature Coronary Artery Disease ◽

Atherosclerotic Cardiovascular Disease ◽

Inflammatory Conditions ◽

Artery Disease

Background: Rheumatoid arthritis (RA) is one of the most common inflammatory conditions linked to premature coronary artery disease (CAD). West Virginia (WV) has abundance of population that has metabolic syndrome and RA. We aimed to study the demographics of the RA in patient population of WV. Primary end points included the incidence of coexisting metabolic syndrome and RA, secondary end point was whether these patients were prescribed Aspirin and Statins for primary prevention of CAD. Methods: In our observational, retrospective study, we reviewed electronic medical records of patients diagnosed with RA and CAD. Charts were collected based on ICD-10 codes of the diagnoses; RA (M05.79, M06.09, M06.9), and CAD (I25.10, I21.9). SPSS version 20 was used for statistical analysis. Results: Out of 2275 patients with RA, 233 patients had coexisting diagnosis of CAD and RA. 20 patients were excluded due to incomplete charts. Mean BMI of the patients was 29.6 kg/m2. Sixty four percent were smokers, and 66% had family history of CAD. Coexisting comorbidities were prevalent; there were 37% diabetic, 88% hypertensive, 80% dyslipidemic, and while 33% had other autoimmune disease. Of note, primary prevention of CAD was only provided to 5% of patients by using a statin, and 5% of patients by using low dose aspirin, and 37% using both. Conclusion: Rheumatoid arthritis remains one of the important risk factors for premature coronary artery disease, especially in the predisposed patient population. More studies are needed to assess the exact risk of premature CAD in RA patients with metabolic syndrome, and perhaps consider RA as one additional determinant of the Atherosclerotic Cardiovascular Disease (ASCVD) risk.

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