scholarly journals A clinical and epidemiological study on discoid lupus erythematosus

2018 ◽  
Vol 4 (3) ◽  
pp. 396 ◽  
Author(s):  
Geetharani Gopalan ◽  
Sudha R. Gopinath ◽  
Kothandaramasamy R. ◽  
Sathesh Pandian
Keyword(s):  
Lupus Erythematosus ◽  
Severe Disease ◽  
Disease Onset ◽  
Discoid Lupus Erythematosus ◽  
Systemic Involvement ◽  
Male Ratio ◽  
Lupus Panniculitis ◽  
Female Predominance ◽  
Complete Physical Examination ◽  
Cutaneous Lupus

<p class="abstract"><strong>Background:</strong> Discoid lupus erythematosus (DLE) is the commonest form of cutaneous lupus erythematosus.The objective of our study is to analyze the clinical and epidemiological aspects of DLE.</p><p class="abstract"><strong>Methods:</strong> All clinically diagnosed cases of DLE attending the dermatology OPD from October 2010 to September 2012were included in the study. A detailed history, complete physical examination, biopsy for confirmation and other relevant investigations were done in all cases.<strong></strong></p><p class="abstract"><strong>Results:</strong> The incidence was 4.79 per 10000 cases (51 of 106368 dermatology patients) showing female to male ratio of 4.1:1. Localized type was more common than the disseminated type. Few lesions (less than five) in a localized area without head and neck involvement were also classified as localized type in this study. Mucosal, verrucous, tumid and lupus panniculitis were the variants of DLE encountered. The sites involved were face, scalp, trunk, upper and lower limb in descending order of frequency. Antinuclear antibody (ANA) was positive in 22 of 30 cases done (73%). The systemic involvement was seen in 15 patients all of whom were diagnosed as systemic lupus erythematosus (SLE). Squamous cell carcinoma was seen in 2 cases of disseminated DLE.</p><p class="abstract"><strong>Conclusions:</strong> Majority of patients had disease onset at 3<sup>rd</sup> to 5<sup>th</sup> decade showing female predominance. When compared to localized type, disseminated type was found more frequently in males. Early onset and severe disease was noted among offspring born to a patient suffering from disseminated DLE. Serious morbidity like lupus nephritis was observed only in 1 case. The occurrence of DLE over the herpes zoster scar was an interesting observation.</p>

The dynamism of cutaneous lupus erythematosus: mild discoid lupus erythematosus evolving into SLE with SCLE and treatment-resistant lupus panniculitis

2006 ◽  
Vol 26 (7) ◽  
pp. 1176-1179 ◽  
Author(s):  
Anna Wozniacka ◽  
Małgorzata Salamon ◽  
Aleksandra Lesiak ◽  
Daniel Paul McCauliffe ◽  
Anna Sysa-Jedrzejowska
Keyword(s):  
Lupus Erythematosus ◽  
Cutaneous Lupus Erythematosus ◽  
Discoid Lupus Erythematosus ◽  
Treatment Resistant ◽  
Lupus Panniculitis ◽  
Cutaneous Lupus

scholarly journals Molecular Profiling of Cutaneous Lupus Lesions Identifies Subgroups Distinct from Clinical Phenotypes

2019 ◽  
Vol 8 (8) ◽  
pp. 1244 ◽  
Author(s):  
Celine C. Berthier ◽  
Lam C. Tsoi ◽  
Tamra J. Reed ◽  
Jasmine N. Stannard ◽  
Emily M. Myers ◽  
...  
Keyword(s):  
Disease Activity ◽  
Lupus Erythematosus ◽  
Cutaneous Lupus Erythematosus ◽  
Discoid Lupus Erythematosus ◽  
Type I ◽  
Systemic Involvement ◽  
Ifn Γ ◽  
Therapeutic Decision Making ◽  
Cutaneous Lupus

Cutaneous lupus erythematosus (CLE) is a common manifestation of systemic lupus erythematosus (SLE), and CLE can also develop without systemic involvement. CLE can be difficult to treat and negatively contributes to quality of life. Despite the importance of CLE, our knowledge of what differentiates cutaneous lupus subtypes is limited. Here, we utilized a large cohort of 90 CLE lesional biopsies to compare discoid lupus erythematosus (DLE) and subacute cutaneous lupus (SCLE) in patients with and without associated SLE in order to discern the drivers of disease activity and possibly uncover better treatment targets. Overall, we found that DLE and SCLE share many differentially expressed genes (DEG) reflecting type I interferon (IFN) signaling and repression of EGFR pathways. No differences between CLE only and SLE-associated CLE lesions were found. Of note, DLE uniquely expresses an IFN-γ node. Unbiased cluster analysis of the DEGs identified two groups separated by neutrophilic vs. monocytic signatures that did not sort the patients based on clinical phenotype or disease activity. This suggests that unbiased analysis of the pathobiology of CLE lesions may be important for personalized medicine and targeted therapeutic decision making.

scholarly journals Sustained Drug Free Remission of Lupus Panniculitis with Methotrexate: A Report From Nepal

2018 ◽  
Vol 56 (214) ◽  
pp. 963-966
Author(s):  
Binit Vaidya ◽  
Rikesh Baral ◽  
Hritu Baral ◽  
Shweta Nakarmi
Keyword(s):  
Lupus Erythematosus ◽  
Common Variant ◽  
Discoid Lupus Erythematosus ◽  
Skin Atrophy ◽  
Cutaneous Manifestations ◽  
Lupus Panniculitis ◽  
Systemic Manifestations ◽  
Drug Free ◽  
Cutaneous Lupus

Cutaneous manifestations are second most common presenting feature of lupus. Discoid lupus erythematosus is the most common variant amongst all; lupus panniculitis being described in only 2-5% of cases. Most cases of cutaneous lupus are associated with autoantibodies and either precede or follow the systemic manifestations of lupus. There is no proven treatment for cutaneous manifestations of lupus including lupus panniculitis. Available non-randomized studies show efficacy of hydroxychoroquine in most cases, whereas methotrexate and other immunosuppressant are used in relapsing cases. We describe a case of lupus panniculitis presenting as an isolated manifestation of lupus with negative autoantibody titers which responded well to methotrexate. We observed that lesions went into drug-free remission in 1year and did not recur on 1year follow-up. There was no residual skin atrophy or scarring. Drug-free remission in isolated cases of lupus panniculitis variant could be possible with timely intervention in the absence of autoantibodies

scholarly journals Atypical and Rare Forms of Cutaneous Lupus Erythematosus: The Importance of the Diagnosis for the Best Management of Patients

Dermatology ◽  
2021 ◽  
pp. 1-10
Author(s):  
Astrid Herzum ◽  
Giulia Gasparini ◽  
Emanuele Cozzani ◽  
Martina Burlando ◽  
Aurora Parodi
Keyword(s):  
General Practitioner ◽  
Autoimmune Disease ◽  
Lupus Erythematosus ◽  
Cutaneous Lupus Erythematosus ◽  
Cutaneous Manifestations ◽  
Skin Manifestation ◽  
Systemic Involvement ◽  
Best Management ◽  
Wide Range ◽  
Cutaneous Lupus

Lupus erythematosus (LE) is an autoimmune disease with a wide range of clinical and cutaneous manifestations. Along with the well-known typical cutaneous manifestations of LE, some cutaneous manifestations are rarer, but still characteristic, enabling the dermatologist and the general practitioner who know them to suspect cutaneous LE (CLE) and investigate a possible underlying systemic involvement. Indeed, not infrequently a skin manifestation is the first presentation of systemic LE (SLE), and &#x3e;75% of SLE patients show signs of skin disease during the course of the illness. Especially, SLE involvement occurs in cases of acute CLE, while it is uncommon in subacute CLE and rare in chronic CLE. This review aims to concentrate especially on atypical cutaneous manifestations of LE to enable the clinician to diagnose even the rarest forms of CLE.

scholarly journals Ocular Complications in Cutaneous Lupus Erythematosus: A Systematic Review with a Meta-Analysis of Reported Cases

2015 ◽  
Vol 2015 ◽  
pp. 1-8 ◽  
Author(s):  
L. Arrico ◽  
A. Abbouda ◽  
I. Abicca ◽  
R. Malagola
Keyword(s):  
Lupus Erythematosus ◽  
Meta Analysis ◽  
Correct Diagnosis ◽  
Cutaneous Lupus Erythematosus ◽  
Discoid Lupus Erythematosus ◽  
Systemic Lupus ◽  
Ocular Complications ◽  
Ocular Symptoms ◽  
Inflammatory Syndrome ◽  
Cutaneous Lupus

Ocular complications associated with cutaneous lupus erythematosus (CLE) are less studied compared with those ones associated with systemic lupus erythematosus (SLE). The main ocular sites involved in patients affected by discoid lupus erythematosus (DLE) are eyelids followed by orbit and periorbit, the least being cornea. The most common complications are blepharitis usually affecting the lower lid and associated with some type of lid lesion such as plaque or erythematosus patches and madarosis. Few cases with LE profundus (LEP) and ocular complications are reported, but they are associated with orbital inflammatory syndrome and severe complications. The main treatment prescribed is hydroxychloroquine with a dose of 200 mg twice a day for 6 to 8 weeks. Corticosteroids are also used. Intervals between the correct diagnosis and the beginning of the ocular symptoms are commonly delayed. Ophthalmologist should be aware of the ocular manifestation of this autoimmune disease.

Evaluation of the Incidence of Discoid Lupus Erythematosus in Patients with Systemic Lupus Erythematosus and Its Relationship to Disease Activity

2014 ◽  
Vol 18 (5) ◽  
pp. 316-319 ◽  
Author(s):  
Massoud Saghafi ◽  
Kamila Hashemzadeh ◽  
Sima Sedighi ◽  
Mohammad Javad Yazdanpanah ◽  
Zahra Rezaieyazdi ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Disease Activity ◽  
Lupus Erythematosus ◽  
Activity Index ◽  
Systemic Disease ◽  
Severe Disease ◽  
Discoid Lupus Erythematosus ◽  
Systemic Lupus ◽  
Cross Sectional ◽  
Cutaneous Manifestations

Background: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with wide clinical features ranging from cutaneous manifestations to systemic disease. Skin is one of the most commonly affected organs in SLE. Objective: To determine whether there is any correlation between discoid lupus erythematosus (DLE) and the severity of SLE. Methods: In a prospective cross-sectional study, 60 consecutive patients with newly diagnosed SLE were enrolled. Skin biopsy was performed to establish the diagnosis of DLE. Disease activity was determined by the Systemic Lupus Erythematosus Disease Activity Index 2000 (SLEDAI-2K). A SLEDAI-2K score ≥ 10 was considered active and severe disease. Results: Eleven SLE patients (9 females and 2 males) had DLE (18.3%) and 49 patients (46 females and 3 males) had SLE without DLE (81.7%). The mean age of patients with DLE was 30.18 ± 11.07 years and in patients without it was 28.4 ± 10.26 years ( p = .6). Three of 11 patients with DLE (27.3%) and 14 of 49 patients without DLE (28.6%) had a SLEDAI-2K score ≥ 10 ( p = 1). Conclusion: The presence of DLE in our patients with SLE was not associated with less severe disease.

scholarly journals Management and obstetric prognosis of pregnancy with isolated cutaneous lupus

2020 ◽  
Vol 11 (e) ◽  
pp. e129.1-e129.4
Author(s):  
Aida Oulehri ◽  
Hanane Baybay ◽  
Soukaina Chhiti
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Cutaneous Lupus Erythematosus ◽  
Fetal Loss ◽  
Insufficient Data ◽  
Systemic Lupus ◽  
Fetal Outcomes ◽  
Systemic Involvement ◽  
Increased Risk ◽  
Cutaneous Lupus

It is well known that pregnancy in a woman with systemic lupus erythematosus (SLE) is associated with an increased risk of adverse maternal and fetal outcomes. But what about the risk in patients with isolated cutaneous lupus erythematosus (CLE) during pregnancy? There are insufficient data on clinical obstetrical and neonatal outcomes in women with CLE and very few studies have been published concerning the obstetric prognosis in the various types of cutaneous lupus. We report the case of a 24-year-old woman with no known pathological history, who presented with a severe and inaugural flare-up of a typical acute lupus erythematosus (ACLE) without systemic involvement which was complicated by a fetal loss.

scholarly journals Discoid lupus erythematosus leading to squamous cell carcinoma: a case report

2017 ◽  
Vol 3 (3) ◽  
pp. 456
Author(s):  
Dadapeer H. J. ◽  
Anupama Y. G. ◽  
Sushma D. M.
Keyword(s):  
Squamous Cell Carcinoma ◽  
Case Report ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Hair Loss ◽  
Lupus Erythematosus ◽  
Discoid Lupus Erythematosus ◽  
Chronic Form ◽  
Short Period ◽  
Cutaneous Lupus

<p><span>Discoid lupus erythematosus (DLE) is the most common chronic form of cutaneous lupus. It is characterised by persistent scaly, disk-like plaques on scalp, face and ears that may cause pigmentary changes, scarring and hair loss. </span><span class="apple-converted-space"><span>Squamous cell carcinoma can</span></span><span> rarely arise within a longstanding DLE plaque<span class="apple-converted-space"> </span>in the skin. It presents as an enlarging warty<span class="apple-converted-space"> </span>growth or ulcer. We report a case of squamous cell carcinoma which developed on lesion of discoid lupus erythematosus within a short period of time.</span></p>

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