scholarly journals Efficacy of autologous platelet rich fibrin matrix in the management of non-healing ulcers

2019 ◽  
Vol 5 (4) ◽  
pp. 686
Author(s):  
Prachi V. Gole ◽  
Naziya Muhammed ◽  
Siddhi R. Patadia
Keyword(s):  
Therapeutic Option ◽  
Venous Blood ◽  
Middle Layer ◽  
Complete Healing ◽  
Duration Of Treatment ◽  
Platelet Rich Fibrin ◽  
Average Percentage ◽  
Fibrin Matrix ◽  
Plain Tube ◽  
Healing Wounds

<p class="abstract"><strong>Background:</strong> Non healing ulcers have a worldwide prevalence of 1.9%-13.1% with lower extremity being the commonest site. They are difficult to manage for the physician and frustrating for the patient due longer duration of treatment, cost, unsatisfactory outcomes and impairment caused due to them. Standard conventional management may fail at times and hence growth factors derived from platelets have been tried in the management of these ulcers. The purpose of our study was to evaluate the efficacy of platelet rich fibrin matrix (PRFM) in treatment of these ulcers.</p><p class="abstract"><strong>Methods:</strong> Twelve patients with fifteen non-healing ulcers more than 3 months duration were included in the study. 10cc of venous blood was withdrawn in plain tube without anti-coagulants and centrifuged at 1500 rpm for 14 minutes as early as possible as per advanced PRF protocol. Middle layer of PRFM was applied to the clean ulcer followed by a secondary dressing. All patients received PRFM sittings every 7-10 days or till ulcer healed. Baseline photographs and measurements of length, breadth and depth were taken to calculate the area of ulcer at every sitting.<strong></strong></p><p class="abstract"><strong>Results:</strong> The average percentage reduction in area and volume of the ulcer was 95.84% and 98.18% respectively at the end of six sittings. Twelve out of fifteen ulcers showed complete healing by 6 weeks, while three ulcers showed significant improvement but did not heal completely. The procedure was safe, well tolerated without any side effects.</p><p class="abstract"><strong>Conclusions:</strong> Platelet rich fibrin matrix is a novel modality and an ideal, safe, affordable therapeutic option for non-healing wounds of varied causes.</p>

scholarly journals Treatment of diabetic neuropathy induced non healing foot ulcer using merisistm supercellplatelet rich fibrin matrix: a clinical study

2021 ◽  
Vol 6 (10) ◽  
Keyword(s):  
Point Of Care ◽  
Foot Ulcer ◽  
Complete Healing ◽  
Foot Ulcers ◽  
Diabetic Patients ◽  
Diabetic Mellitus ◽  
Platelet Rich Fibrin ◽  
Quick Recovery ◽  
Fibrin Matrix ◽  
Effective Treatment Modality

Objective: Non healing foot ulcers are a major debilitating condition in diabetic patients which leads to limb amputation.In this study we discuss the use ofMERISISTM Supercell plus Platelet Rich Fibrin Matrix (PRFM) kitfor point of care treatments towards limb salvation. Method: We selected diabetic mellitus patients havingDiabetic foot ulcer (DFU) grade 1 or higher. Use of MERISISTM Supercell plus PRFM is a biological matrix of extracellular matrix (ECM) protein plus growth factors derived from peripheral blood to treat the DFU 45 days over. Result: Following treatment the patients showed quick recovery and complete healing of the ulcers. Conclusion: Supercellplus PRFM therapy promotes wound healing in patients suffering from chronic non-healing diabetes foot ulcers. Supercells plus PRFM dressing is a safe and effective treatment modality to promote wound contraction in patients suffering from non-healing diabetic foot ulcers.

Obsidian ASG® Autologous Platelet-Rich Fibrin Matrix and Colorectal Anastomotic Healing: A Preliminary Study

2021 ◽  
Vol 39 ◽  
Author(s):  
Andreas Shamiyeh ◽  
◽  
Bettina Klugsberger ◽  
Carina Aigner ◽  
Wolfgang Schimetta ◽  
...  
Keyword(s):  
Anastomotic Leakage ◽  
Anastomotic Leak ◽  
Colorectal Resection ◽  
Rectal Resection ◽  
Leak Rate ◽  
Anastomotic Healing ◽  
Platelet Rich Fibrin ◽  
Anastomotic Leak Rate ◽  
Fibrin Matrix ◽  
Autologous Platelet

Introduction: Anastomotic leakage (AL) following colorectal resection is a devastating complication affecting morbidity, mortality, and quality of life of patients in the long term. Different tissue sealants and biologic glues were tested showing conflicting results regarding their influence on anastomotic healing and leak prevention. Application of autologous platelet-rich fibrin (Vivostat A/S, Alleroed, Denmark), which acts as a source of angiogenic growth factors and cytokines, showed promising results in an in-vivo porcine model. Herein, we present the first human study of stapled colorectal anastomoses supplemented with an autologous-derived platelet-rich fibrin matrix (Obsidian ASG®, Rivolution GmbH, Rosenheim, Germany and Vivostat A/S, Alleroed, Denmark). Materials and Methods: A retrospective analysis of prospectively accumulated data was performed in two colorectal centers (Linz, Vienna) on patients undergoing left-sided colorectal or coloanal stapled anastomosis between October 2018 and December 2019. The Obsidian ASG® Matrix was applied to the rectal stump, and after closure with the circular stapling device, at the circumference of anastomosis in every single case. Anastomoses were supplemented with intra- and extra-anastomotic application (IAA—intra-anastomotic application developed by Rivolution GmbH, Rosenheim, Germany) of Obsidian ASG® Matrix. The primary endpoints were incidence of perioperative complications and anastomotic leak rate. Results: Two-hundred-sixty-one (138 female) patients underwent left-sided colonic (n=177) or rectal resection (n=84). In 253 (96.9%) cases, a laparoscopic or robotic-assisted approach was used. There were no complications attributable to the intraoperative application of the Obsidian ASG® Matrix. All intraoperative leak tests were negative. Overall, anastomotic leak rate accounted for 2.3% (6/261). AL following colonic and rectal resection was seen in 2.3% (4/177) and 2.4% (2/84), respectively. Complication and leak rate was similar in the two participating centers. Postoperative fever and elevated CRP levels were significantly correlated to AL. There was no significant risk factor for AL on multivariate analysis. Conclusion: Application of an autologous-derived platelet-rich fibrin matrix (Obsidian ASG®) at anastomotic site following colorectal resection is safe and associated with a low rate of anastomotic leakage.

scholarly journals Adjunctive Hyperbaric Oxygen Therapy in Refractory Crohn’s Disease: An Observational Study

2021 ◽  
Vol 2021 ◽  
pp. 1-8
Author(s):  
Marley R. Feitosa ◽  
Rogério S. Parra ◽  
Vanessa F. Machado ◽  
Gustavo N. Vilar ◽  
Jussara C. Aquino ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Hyperbaric Oxygen ◽  
Hyperbaric Oxygen Therapy ◽  
Oxygen Therapy ◽  
Optimal Number ◽  
Complete Healing ◽  
Duration Of Treatment ◽  
Treatment Regimens ◽  
Incomplete Healing

Background and Aims. Patients may experience complications of Crohn’s disease (CD) even when treated with optimal medical therapy strategies. Previous data have shown the efficacy of hyperbaric oxygen therapy (HBOT) in the management of complicated CD. However, there is no consensus regarding the optimal number of sessions or duration of treatment regimens. The aim of the present study was to investigate the efficacy of HBOT in CD patients who were refractory to conventional medical management. Methods. This study included patients who underwent HBOT for the treatment of the following complications: perianal fistulizing Crohn’s disease (pCD), enterocutaneous fistulas (ECF), or pyoderma gangrenosum (PG). Complete healing was defined as the closure of external orifice and the absence of active draining (in pCD), complete wound healing (in PG), and granulation or complete wound epithelialization with no enteric draining (in ECF). The persistence of draining and the absence of wound granulation were defined as incomplete healing. Results. Forty patients were included. The mean CD duration was 10.6 ± 5.8 years. pCD comprised most of the included patients (25/62.5%), followed by ECF ( n = 13 / 32.5 % ) and PG ( n = 6 / 15 % ). In two patients (5%), a combination of ECF and PG was diagnosed, and in one patient (2.5%), all three complications were observed. A total of 32 patients (82.5%) had complete healing. Patients with PG had the highest healing rates (100%), followed by those with ECF (84.6%) and pCD (80%). Conclusions. Adjunctive HBO was associated with significant healing rates for CD-associated complications such as pCD, ECF, and PG.

scholarly journals A CLINICAL STUDY ON THE ROLE OF ERANDA KSHARA IN STHAULYA (OBESITY)

2015 ◽  
Author(s):  
*Borse Vilas Pundlikrao ◽  
Bhaskare Sunil A ◽  
Pawar Kiran Bhikaji ◽  
Meshram Dnyaneshwar Sudhakar
Keyword(s):  
Clinical Study ◽  
Waist Circumference ◽  
Duration Of Treatment ◽  
Average Percentage ◽  
Waist Hip Ratio ◽  
Arm Circumference ◽  
Laboratory Investigations ◽  
Basic Concepts

There are so many basic concepts in Ayurveda; Dhatvagni mandya is one of them. The whole phenomenon of disease cannot be completed without Dosha-Dushya Siddhant. They play important role in the pathology of disease. Obesity is one of them, which affect the health as well as life span. Sthaulya is one of the disease which is known to mankind since Vedic era, has been dealt in great details in Ayurvedic texts. The sign, symptoms and etiological factor of Sthaulya show very much resemblance with obesity. Worldwide Obesity is emerging health problem. It is a metabolic disorder which has affected every corner of world. In present study 30 patients of Sthaulya were selected from OPD and IPD of M.A. Podar hospital, Mumbai. These patients were undergone throw laboratory investigations. They were treated with Eranda Kshara with Ghrita bharjit Hingu given orally, duration of treatment was two months and follow up was done with parameters like Height, weight, BMI, Mid arm circumference, Waist circumference, Waist Hip ratio and symptoms of Sthaulya. It was observed that Atikshuda and Atitrushna reduce significantly. It shows relief in weight, BMI, Waist Circumference, Mid Arm Circumference and Waist Hip ratio. There was no significant change in hematological as well as Urine investigations. Average percentage of relief was 60.72%. 

scholarly journals Interdisciplinary Approach to a Tooth with Open Apex and Persistent Sinus

2015 ◽  
Vol 2015 ◽  
pp. 1-4 ◽  
Author(s):  
Anoop N. Das ◽  
Krishnamohan Geetha ◽  
Ajay Varghese Kurian ◽  
Radhakrishnan Nair ◽  
K. Nandakumar
Keyword(s):  
Surgical Treatment ◽  
Root Development ◽  
Tricalcium Phosphate ◽  
Surgical Intervention ◽  
Interdisciplinary Approach ◽  
Complete Healing ◽  
Traumatic Injuries ◽  
Platelet Rich Fibrin

Traumatic injuries in childhood may disrupt root development leading to a tooth with open apex. Apexification procedures in such cases aim at root end closure after reasonable period of time. In some chronic cases, complete healing of the periapical area does not occur resulting in development of a nonhealing sinus. Failure of nonsurgical approach in such cases needs surgical intervention permitting thorough periapical curettage. In the present case, apexification procedure with MTA achieved root end closure but failed to heal the sinus for which surgical treatment was completed with thorough periapical curettage and application of platelet rich fibrin (PRF) and a combination ofβ-tricalcium phosphate and hydroxyapatite resulted in healing.

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