scholarly journals Comparative study between ondansetron & palonosetron in prevention of post operative nausea vomiting operated under general anaesthesia: A randomised double blind study

2020 ◽  
Vol 7 (2) ◽  
pp. 245-250
Author(s):  
Manish K Singh ◽  
◽  
Sarvjeet Verma ◽  
Trilok Chand ◽  
◽  
...  
Keyword(s):  
Comparative Study ◽  
General Anaesthesia ◽  
Blind Study ◽  
Double Blind Study ◽  
Double Blind ◽  
Post Operative Nausea

Pharmacological Modulation of Cutaneous Reactivity to Histamine: A Double-Blind Acute Comparative Study between Cetirizine, Terfenadine and Astemizole

1989 ◽  
Vol 17 (1) ◽  
pp. 24-27 ◽  
Author(s):  
L. Ghys ◽  
J.-P. Rihoux
Keyword(s):  
Comparative Study ◽  
Healthy Volunteers ◽  
Inhibitory Effect ◽  
Blind Study ◽  
Double Blind Study ◽  
Single Administration ◽  
Double Blind ◽  
Pharmacological Modulation ◽  
The Difference ◽  
Cutaneous Reactivity

In a double-blind study performed in 81 healthy volunteers, 10 mg cetirizine and 60 mg terfenadine given orally in a single administration significantly inhibited skin reactivity to histamine. Astemizole (10 mg) was completely ineffective. The inhibitory effect of cetirizine was potent and regular whereas 6/28 (21%) volunteers did not respond to terfenadine. The difference observed beween cetirizine and terfenadine might be due to differences in the metabolism of the two drugs after administration: terfenadine is rapidly and extensively metabolized whereas cetirizine is directly active without the need for biotransformation and, indeed is poorly metabolized.

A Double-Blind Comparative Study with Dolo-Neurobion® and its Separate Constituents in the Treatment of Polyneuritis

1974 ◽  
Vol 2 (1) ◽  
pp. 32-35 ◽  
Author(s):  
E Reyes-Armijo
Keyword(s):  
Comparative Study ◽  
The Other ◽  
Blind Study ◽  
Vitamin B ◽  
Double Blind Study ◽  
Double Blind

A double-blind study was carried out with Dolo-Neurobion® and matching tablets containing: the vitamin B combination, and the metamizol component of the preparation. Forty-five patients suffering from polyneuritis were each treated with eight tablets a day for fourteen days. All fifteen patients who received Dolo-Neurobion were free from pain after treatment but this result was not observed in the patients treated with the vitamin combination alone nor with the metamizol component of the preparation. Dolo-Neurobion also proved more successful after the first half of the treatment (one week), the degree of pain being reduced more significantly than with the other two forms of medication.

A Comparative Study Using Propofol Alone Versus Propofol Combined Midazolam for Colonoscopy: Randomized Double-Blind Study

2006 ◽  
Vol 63 (5) ◽  
pp. AB190 ◽  
Author(s):  
Cheol Hee Park ◽  
Jong Hyeok Kim ◽  
Jae One Jung ◽  
Joon Ho Moon ◽  
Woon Geon Shin ◽  
...  
Keyword(s):  
Comparative Study ◽  
Blind Study ◽  
Double Blind Study ◽  
Double Blind

A RANDOMIZED, DOUBLE-BLIND STUDY OF PALONOSETRON COMPARED WITH ONDANSETRON IN PREVENTING POSTOPERATIVE NAUSEA AND VOMITING AFTER MODIFIED RADICAL MASTECTOMY SURGERY.

2021 ◽  
pp. 72-74
Author(s):  
Anusha K ◽  
Sherin bright
Keyword(s):  
Side Effects ◽  
Postoperative Nausea ◽  
Radical Mastectomy ◽  
Postoperative Nausea And Vomiting ◽  
Complete Response ◽  
Nausea And Vomiting ◽  
Blind Study ◽  
Double Blind Study ◽  
Double Blind ◽  
Post Operative Nausea

BACKGROUND : Palonosetron is a new potent 5-hydroxytryptamine 3 antagonist. Although used for chemo induced emesis, data is lacking for PONV. The high incidence of nausea and vomiting after breast surgery is well documented. This study compared the effects of i.v.ondansetron and palonosetron administered at the time of induction for preventing postoperative nausea and vomiting (PONV) in these high-risk patients . The aim was to compare Onda METHODS : nsetron 8 mg and Palonosetron 0.075mg administered intravenously for prevention of post operative nausea and vomiting in patients undergoing modied radical mastectomy 24 hours postoperatively, by a randomised , controlled, double blind study. 70 female non smoking patients scheduled for elective modied radical mastectomy were, allocated randomly into 2 groups . Patients received either Palonosetron 0.075mg (GROUP P ) or ondansetron 8mg ( GROUP O ) intravenously, immediately before induction of general anaesthesia. The occurence of nausea, vomiting, retching, need for rescue antiemetics and side effects were monitored for a period of 24 hours after surgery. The compete response rate and overall PONV for 0 - 24 hours were calculated. The demographic prole of the patients were comparable. The RESULTS : incidence of a complete response (no PONV, no rescue antiemetics ) during 0 - 24 hours in post operative period was signicantly high in GROUP P ( 85.7% vs 62.9%, p=0.02) than GROUP O. The incidence of nausea was signicantly low in GROUP P ( 14.3% vs 37.1%). There was no statistically signicant difference between the 2 groups in vomiting, retching, side effects and need for rescue antiemetics. Thus overall PONV was low in GROUP P (14.3% vs 37.1% p = 0.02 statistically signicant.) We conclude that Palonosetron 0.075mg was more effective for preventing PONV in patients undergoing modied radical mastectomy surgery

Sign in / Sign up

Export Citation Format

Share Document