scholarly journals Comparative evaluation of effectiveness with cutback incision and without cut back incision technique on healing in patients between 18 to 65 years of age for socket preservation cases: A randomized controlled trial

2021 ◽  
Vol 6 (3) ◽  
pp. 149-156
Author(s):  
Pankti Gangar ◽  
Amit Benjamin ◽  
Nawamee Phadnis ◽  
Chirag Bhatia
Keyword(s):  
Randomized Controlled Trial ◽  
Primary Closure ◽  
Low Cost ◽  
Controlled Trial ◽  
Adult Population ◽  
Socket Preservation ◽  
Randomized Controlled ◽  
Intergroup Comparison ◽  
Group 2 ◽  
Incision Technique

Primary closure is the most important step following tooth extraction. Primary closure using cut back incision technique helps in preserving the bone graft in socket and to preserve it in their desired position. To assess the healing outcome with and without cut back incision technique in adult population for the purpose of socket preservation at baseline, 1 week and 4 weeks. In this single blinded randomized controlled trial forty-two sites were planned for extraction with bone augmentation and were randomly divided. In group 1 sockets were preserved using cutback incision technique and in group 2 sockets were grafted without cutback incision technique. Clinical standardized measurements were used to assess the dimensional alterations of the extraction socket. Various non-parametric tests have been used for comparisons. Intergroup comparison showed statistical higher difference on Pain on VAS (p >0.00 6) and KGW (p 0.039) at 1 week and primary healing showed no significant results at all time intervals. The present finding concluded that use of cutback incision technique enhances primary closure and the socket seal of the extraction site with minimal pain, morbidity and low cost.

scholarly journals Comparison of intrauterine insemination and timed intercourse following controlled ovarian hyperstimulation in unexplained infertility: a randomized controlled trial

2019 ◽  
Vol 8 (3) ◽  
pp. 1035
Author(s):  
Sayanti Paul ◽  
Saumen Mandal ◽  
Arghya Pal ◽  
Sumit Ranjan Pramanik
Keyword(s):  
Randomized Controlled Trial ◽  
Intrauterine Insemination ◽  
Controlled Trial ◽  
Controlled Ovarian Hyperstimulation ◽  
Unexplained Infertility ◽  
Clinical Pregnancy ◽  
Ovarian Hyperstimulation ◽  
Randomized Controlled ◽  
Group 2 ◽  
Group 1

Background: Being a diagnosis of exclusion the treatment options of unexplained infertility are often empiric. There is significant dilemma regarding the superiority of one over another. Despite increasing use of intrauterine insemination (IUI) in adjunct to controlled ovarian hyperstimulation (COH) there is scarcity of randomized controlled trials (RCT) from developing countries. Objective was to compare IUI and timed intercourse (TI) in super ovulated cycles among couples with unexplained infertility over one year.Methods: In this prospective randomized controlled trial total 85 patients were randomly assigned into group 1 (COH with IUI, N= 44) and group 2 (COH with TI, N=41). Patients underwent COH using sequential Clomiphene Citrate and injection human menopausal gonadotrophin followed by IUI in group 1 and timed intercourse in group 2. Either protocol was repeated for three consecutive cycles. Finally, both groups were compared for clinical pregnancy rate, adverse effects and acceptability of the treatment process and outcome. Comparison was done by Student’s unpaired t test for continuous and 2-tailed chi square test for categorical variables.Results: Clinical pregnancy rates following COH/IUI and COH/TI were 13.64% and 19.51% respectively. There was observable difference in the acceptability of the outcome (38.64% in IUI and 56.09% in TI group). All the results including complications and side effect rates were statistically insignificant.Conclusions: Present study failed to show any improvement of pregnancy rates following addition of IUI over TI and it raised the probability that the outcome of the procedure may not be well accepted.

Can Low-Cost Strategies Improve Attendance Rates in Brief Psychological Therapy? Double-Blind Randomized Controlled Trial

2015 ◽  
Vol 71 (12) ◽  
pp. 1139-1152 ◽  
Author(s):  
Jaime Delgadillo ◽  
Omar Moreea ◽  
Elizabeth Murphy ◽  
Shehzad Ali ◽  
Joshua K. Swift
Keyword(s):  
Randomized Controlled Trial ◽  
Low Cost ◽  
Controlled Trial ◽  
Psychological Therapy ◽  
Attendance Rates ◽  
Double Blind ◽  
Randomized Controlled

scholarly journals A live-online mindfulness-based intervention for children living with epilepsy and their families: protocol for a randomized controlled trial of Making Mindfulness Matter©

Trials ◽  
2020 ◽  
Vol 21 (1) ◽  
Author(s):  
Klajdi Puka ◽  
Karen Bax ◽  
Andrea Andrade ◽  
Margo Devries-Rizzo ◽  
Hema Gangam ◽  
...  
Keyword(s):  
Mental Health ◽  
Randomized Controlled Trial ◽  
Family Environment ◽  
Intervention Program ◽  
Local Community ◽  
Mental Health Problems ◽  
Low Cost ◽  
Controlled Trial ◽  
Related Factors ◽  
Randomized Controlled

Abstract Background Epilepsy extends far beyond seizures; up to 80% of children with epilepsy (CWE) may have comorbid cognitive or mental health problems, and up to 50% of parents of CWE are at risk for major depression. Past research has also shown that family environment has a greater influence on children’s and parents’ health-related quality of life (HRQOL) and mental health than epilepsy-related factors. There is a pressing need for low-cost, innovative interventions to improve HRQOL and mental health for CWE and their parents. The aim of this randomized controlled trial (RCT) is to evaluate whether an interactive online mindfulness-based intervention program, Making Mindfulness Matter (M3), can be feasibly implemented and whether it positively affects CWE’s and parents’ HRQOL and mental health (specifically, stress, behavioral, depressive, and anxiety symptoms). Methods This parallel RCT was planned to recruit 100 child-parent dyads to be randomized 1:1 to the 8-week intervention or waitlist control and followed over 20 weeks. The intervention, M3, will be delivered online and separately to parents and children (ages 4–10 years) in groups of 4–8 by non-clinician staff of a local community epilepsy agency. The intervention incorporates mindful awareness, social-emotional learning skills, and positive psychology. It is modeled after the validated school-based MindUP program and adapted for provision online and to include a parent component. Discussion This RCT will determine whether this online mindfulness-based intervention is feasible and effective for CWE and their parents. The proposed intervention may be an ideal vector to significantly improve HRQOL and mental health for CWE and their parents given its low cost and implementation by community epilepsy agencies. Trial registration ClinicalTrials.gov NCT04020484. Registered on July 16, 2019. 

scholarly journals Effects of Water Restriction and Supplementation on Cognitive Performances and Mood among Young Adults in Baoding, China: A Randomized Controlled Trial (RCT)

Nutrients ◽  
2021 ◽  
Vol 13 (10) ◽  
pp. 3645
Author(s):  
Jianfen Zhang ◽  
Guansheng Ma ◽  
Songming Du ◽  
Shufang Liu ◽  
Na Zhang
Keyword(s):  
Randomized Controlled Trial ◽  
Controlled Trial ◽  
Hydration Status ◽  
Water Restriction ◽  
Operation Span ◽  
Randomized Controlled ◽  
Baseline Test ◽  
Group 2 ◽  
Water Supplementation ◽  
Group 1

The brain is approximately 75% water. Therefore, insufficient water intake may affect the cognitive performance of humans. The present study aimed to investigate the effects of water restriction and supplementation on cognitive performances and mood, and the optimum amount of water to alleviate the detrimental effects of dehydration, among young adults. A randomized controlled trial was conducted with 76 young, healthy adults aged 18–23 years old from Baoding, China. After fasting overnight for 12 h, at 8:00 a.m. of day 2, the osmolality of the first morning urine and blood, cognitive performance, and mood were measured as a baseline test. After water restriction for 24 h, at 8:00 a.m. of day 3, the same indexes were measured as a dehydration test. Participants were randomly assigned into four groups: water supplementation group (WS group) 1, 2, or 3 (given 1000, 500, or 200 mL purified water), and the no water supplementation group (NW group). Furthermore, participants were instructed to drink all the water within 10 min. Ninety minutes later, the same measurements were performed as a rehydration test. Compared with the baseline test, participants were all in dehydration and their scores on the portrait memory test, vigor, and self-esteem decreased (34 vs. 27, p < 0.001; 11.8 vs. 9.2, p < 0.001; 7.8 vs. 6.4, p < 0.001). Fatigue and TMD (total mood disturbance) increased (3.6 vs. 4.8, p = 0.004; 95.7 vs. 101.8, p < 0.001) in the dehydration test. Significant interactions between time and volume were found in hydration status, fatigue, vigor, TMD, symbol search test, and operation span test (F = 6.302, p = 0.001; F = 3.118, p = 0.029; F = 2.849, p = 0.043; F = 2.859, p = 0.043; F = 3.463, p = 0.021) when comparing the rehydration and dehydration test. Furthermore, the hydration status was better in WS group 1 compared to WS group 2; the fatigue and TMD scores decreased, and the symbol search test and operation span test scores increased, only in WS group 1 and WS group 2 (p < 0.05). There was no significant difference between them (p > 0.05). Dehydration impaired episodic memory and mood. Water supplementation improved processing speed, working memory, and mood, and 1000 mL was the optimum volume.

scholarly journals A Randomized Controlled Trial of Curcuma longa and Boswellia serrata Extract in Osteoarthritis

2019 ◽  
pp. 51-56
Author(s):  
Rizaldy Taslim Pinzon ◽  
Rosa De Lima Renita Sanyasi ◽  
Esdras Ardi Pramudita ◽  
Septian Dewi Periska
Keyword(s):  
Randomized Controlled Trial ◽  
Curcuma Longa ◽  
Controlled Trial ◽  
Diclofenac Sodium ◽  
Therapeutic Interventions ◽  
Boswellia Serrata ◽  
Randomized Controlled ◽  
Drug Of Choice ◽  
Group 3 ◽  
Group 2

Background: Chronic pain is the major complaint in subjects with osteoarthritis (OA). Non-steroid anti-inflammatory drug (NSAID) is still the drug of choice in Indonesia to treat OA patients. The prolonged consumption of NSAID may lead to many adverse events (AE). Some previous studies showed the extract of Curcuma longa and Boswellia serrata is a promising potential as therapeutic interventions against OA. Objective: This study aimed to evaluate the effectiveness and safety of CB extract to relieve symptoms in patients with OA. Study Design: This was a randomized controlled trial (RCT) in OA patients. The treatment used in this trial were CB extract (350 mg of Curcuma longa and 150 mg Boswellia serrata) and NSAID (400 mg ibuprofen or 50 mg diclofenac sodium). Subjects were randomized to 3 different groups (Group 1: CB extract and NSAID; group 2: CB extract; group 3: NSAID). Each medication was taken two times per day for four weeks. Paracetamol tablet 500 mg gave to each subject as a rescue medication.

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