scholarly journals A direct observation of aqueous humour flow in vivo after implantable collamer lens with a central hole implantation

2021 ◽  
Vol 14 (1) ◽  
pp. 160-162
Author(s):  
Mei-Yan Li ◽  
◽  
Pei-Jun Yao ◽  
Ying-Jun Chen ◽  
Ruo-Yan Wei ◽  
...  
2009 ◽  
Vol 106 (33) ◽  
pp. 13832-13837 ◽  
Author(s):  
S. Hasegawa ◽  
K. Maruyama ◽  
H. Takenaka ◽  
T. Furukawa ◽  
T. Saga

2018 ◽  
Vol 4 (1) ◽  
pp. 225-227
Author(s):  
Thomas Eickner ◽  
Franziska Kopp ◽  
Andreas Brietzke ◽  
Sabine Kischkel ◽  
Stefan Oschatz ◽  
...  

AbstractGlaucoma is the second most common cause of blindness. An increased intraocular pressure is the only treatable symptom of glaucoma. Because patients often exhibit a poor therapy adherence, a drug depot consisting of ELA-NCO and hyaluronic acid with timolol was developed to ensure sustained drug release. This drug depot is formed by in situ polymerisation after injection into the subconjunctival space. To test the in vivo drug release of timolol in serum and aqueous humour, a liquid chromatography mass spectrometry (LCMS) method was developed and tested using spike- and recovery experiments, and on in vivo samples after topical application. Samples of serum and aqueous humour were taken from New Zealand White rabbits. For topical application, a commercially available formulation of timolol was used. This study presents results concerning the recovery of timolol from spiked samples. Serum and aqueous humour samples were spiked with timolol maleate to a final concentration of 50 ng/mL. Subsequently, the samples were extracted and analysed by LCMS. External calibration of the developed method showed high linearity. Recovery experiments showed no loss of timolol. Hence, the extraction method is robust and able to recover the whole amount of timolol from aqueous humour and serum.


2019 ◽  
Vol 2019 ◽  
pp. 1-6 ◽  
Author(s):  
Xun Chen ◽  
Tian Han ◽  
Feng Zhao ◽  
Huamao Miao ◽  
Xiaoying Wang ◽  
...  

Purpose. To investigate disk halo size changes produced by a glare source after surgical insertion of an implantable collamer lens with a central hole (ICL V4c) for myopia correction. Methods. In this prospective study, disk halo size and pupillary light response with a vision monitor were measured preoperatively and at 1 week, 1 month, and 3 months postoperatively. Pupillary light response parameters included contraction amplitude, latency, duration, and velocity; dilation latency, duration, and velocity; and initial, maximum, minimum, and average pupil diameters. Results. Forty-two right eyes of 42 patients were enrolled. Postoperative uncorrected distance visual acuity was better than or equal to 20/20 in all eyes. Compared to preoperative values, disk halo size showed no significant difference at 1 week postoperatively (P>0.05) and then decreased significantly at 1 and 3 months postoperatively (both P<0.001). Contraction amplitude and velocity, as well as dilation velocity, decreased significantly at all postoperative time points (all P<0.001). Disk halo size at 3 months postoperatively was significantly correlated with initial (r = 0.446, P=0.003), maximum (r = 0.483, P=0.001), minimum (r = 0.425, P=0.005), and average pupil diameters (r = 0.474, P=0.002). Conclusions. After ICL V4c implantation, disk halo size was reduced in the short term. Patients with smaller pupil sizes during pupillary response to light experienced smaller halos after ICL V4c implantation.


2009 ◽  
Vol 75 (1) ◽  
pp. 63-66 ◽  
Author(s):  
K. M. Saari ◽  
O. M. Guillén-Monterrubio ◽  
J. Hartikainen ◽  
M. M. Hämäläinen ◽  
K. Taskinen

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