scholarly journals Effects of Gami-Handayeolso-Tang on Body Fat Reduction in High Fat Diet-Fed Obese Mice

2016 ◽  
Vol 26 (1) ◽  
pp. 13-31 ◽  
Author(s):  
Ha-Il Lee ◽  
Jong-Ha Lee ◽  
Young-Mi Kwon ◽  
Yung-Sun Song
Keyword(s):  
Body Fat ◽  
High Fat Diet ◽  
Obese Mice ◽  
High Fat ◽  
Fat Reduction

scholarly journals Antiobesity Effect of a Novel Herbal Formulation LI85008F in High-Fat Diet-Induced Obese Mice

2021 ◽  
Vol 2021 ◽  
pp. 1-8
Author(s):  
Hak Joo Choi ◽  
Hwa Young Kim ◽  
Kyoung Sik Park
Keyword(s):  
Weight Gain ◽  
Body Fat ◽  
Fat Mass ◽  
High Fat Diet ◽  
Body Weight Gain ◽  
Whole Body ◽  
Body Fat Mass ◽  
Obese Mice ◽  
High Fat ◽  
Herbal Formulation

A variety of natural products have been explored for their antiobesity potential and widely used to develop dietary supplements for the prevention of weight gain from excess body fat. In an attempt to find a natural antiobesity agent, this study was designed to evaluate the antiobesity activity of a novel herbal formulation LI85008F composed of extracts from three medicinal plants in high-fat diet- (HFD-) induced obese mice. After the thirteen-week oral administration of the test materials to mice, the body weight gain, whole-body fat mass, adipose tissue weight, and the expression levels of obesity-related proteins were measured. Our results indicated that LI85008F can suppress body weight gain and lower whole-body fat mass in HFD-induced obese mice. Significant decreases in epididymal and retroperitoneal fat mass were observed in LI85008F-treated groups compared with the HFD-fed control group ( p < 0.05 ). Furthermore, the oral administration of LI85008F caused significant decreases in the expression level of adipogenic (C/EBPα and PPARγ) and lipogenic (ACC) markers and notable increases in the production level of thermogenetic (AMPKα, PGC1α and UCP1) and lipolytic (HSL) proteins. These findings suggest that LI85008F holds great promise for a novel herbal formulation with antiobesity activities, preventing body fat accumulation and altering lipid metabolism.

scholarly journals Obesity is Irreversible Without a Controlled Dietary Regimen in a Murine Model

2019 ◽  
Vol 4 (4) ◽  
pp. 2473011419S0040
Author(s):  
Chris Stauch ◽  
Jesse King ◽  
Morgan Kim ◽  
David Waning ◽  
John Elfar ◽  
...  
Keyword(s):  
Body Fat ◽  
High Intensity ◽  
High Fat Diet ◽  
Exercise Program ◽  
Body Fat Percentage ◽  
Obese Mice ◽  
High Fat ◽  
Fat Percentage ◽  
Mineral Density ◽  
Cardiovascular Training

Category: Diabetes, Hindfoot, Midfoot/Forefoot, obesity Introduction/Purpose: In recent decades, the prevalence of obesity in the United States has increased dramatically. This can be attributed in-part to the high-fat “Western Diet”. Consequentially, the economic burden of obesity to the healthcare system has rapidly increased, accounting for more than 10 percent of all medical spending in America. Furthermore, with regards to orthopedics, obesity has been shown to be a strong risk factor for musculoskeletal pain, injury, and post-operative complications. The purpose of this study was to determine the effects of high intensity cardiovascular training and controlled dietary intake on body weight, body fat percentage (BFP), and bone mineral density (BMD) in obese and non-obese mice. These results will provide a better understanding of how to optimally facilitate weight loss in obese patients. Methods: Following IAUCUC approval, 8 diet-induced obesity (DIO) C57BL/6 mice were obtained along with 6 non-obese C57BL/6 control mice. DIO mice were fed a high-fat diet (60% fat by kcal) ad libitum starting at the age of 6 weeks. Control mice were fed a standard low-fat diet (10% fat by kcal) ad libitum from birth. Starting at the age of 14 weeks, all mice underwent a controlled high intensity cardiovascular training protocol using a treadmill four times per week at 30 minute intervals. This was carried out for seven weeks including a one-week acclimation period. Speed, distance, and time spent running were all constant between groups. Mouse body weights were recorded several times per week throughout the study. Additionally, BFP and BMD were obtained bi-weekly using dual energy X-ray absorptiometry (DEXA) to assess morphophysiological changes longitudinally. Results: Preliminary investigations with a controlled exercise regimen reveal that obese mice, when fed a high-fat diet, continue to gain weight rapidly despite high intensity cardiovascular training whereas control mice maintain their weight. Following the seven-week training period, control mice gained an average of 1.25 g (p=0.41), while DIO mice gained an average of 8.55 g (p<0.001). DIO mice also showed an 8.74% increase in body fat percentage (p=0.002) while control mice showed a 0.51% decrease in body fat percentage (p=0.75). Lastly, BMD was significantly lower in DIO mice compared to controls following the exercise protocol (p<0.05). Conclusion: The results of this study support the hypothesis that a controlled exercise regimen alone is ineffective for facilitating weight loss. In fact, obese mice administered a high-fat diet actually gain weight despite undergoing a rigorous exercise program. Additionally, simple differences in dietary intake have significant effects on body weight, body fat percentage, and bone mineral density. This suggests that while exercise may play a small role in maintaining a normal weight, obesity is irreversible with exercise alone. Obese orthopedic patients should be counseled on dietary modifications before engaging in an exercise program.

Effect of selenium-enriched kiwifruit on body fat reduction and liver protection in hyperlipidaemic mice

2021 ◽  
Vol 12 (5) ◽  
pp. 2044-2057
Author(s):  
Xiaoni Zhang ◽  
Haidong Xia ◽  
Jie Wang ◽  
Ruyue Leng ◽  
Xiaojing Zhou ◽  
...  
Keyword(s):  
Body Fat ◽  
High Fat Diet ◽  
Lipid Lowering ◽  
High Fat ◽  
Liver Protection ◽  
Fat Reduction

This study aimed to investigate the effects and mechanism of selenium-enriched kiwifruit (Se-Kiwi) on lipid-lowering and liver protection in hyperlipidaemic mice induced by consuming a long-term high-fat diet.

scholarly journals Effects of Gami-Cheongpyesagan-Tang on Body Fat in High Fat Diet-Fed Obese Mice

2015 ◽  
Vol 15 (2) ◽  
pp. 75-92 ◽  
Author(s):  
Seon-Oh Keum ◽  
Ha-Il Lee ◽  
Jong-Ha Lee ◽  
Yong-Il Yoon ◽  
Young-Mi Kwon ◽  
...  
Keyword(s):  
Body Fat ◽  
High Fat Diet ◽  
Obese Mice ◽  
High Fat

scholarly journals Green coffee bean extract improves obesity by decreasing body fat in high-fat diet-induced obese mice

2016 ◽  
Vol 9 (7) ◽  
pp. 635-643 ◽  
Author(s):  
Bong-Keun Choi ◽  
Sung-Bum Park ◽  
Dong-Ryung Lee ◽  
Hae Jin Lee ◽  
Ying-Yu Jin ◽  
...  
Keyword(s):  
Body Fat ◽  
High Fat Diet ◽  
Coffee Bean ◽  
Green Coffee ◽  
Obese Mice ◽  
High Fat ◽  
Green Coffee Bean Extract ◽  
Green Coffee Bean

scholarly journals Effects ofBangkibokryeong-tang(Fangjifuling-tang) on the Reduction of Blood Glucose and Body Fat in High Fat Diet Induced Obese Mice

2017 ◽  
Vol 27 (1) ◽  
pp. 1-17
Author(s):  
Hyung-Jin Yoo ◽  
Jong-Ha Lee ◽  
Soo-Kyung Lee ◽  
Yung-Sun Song
Keyword(s):  
Blood Glucose ◽  
Body Fat ◽  
High Fat Diet ◽  
Obese Mice ◽  
High Fat

scholarly journals Cissus quadrangularis Extracts Decreases Body Fat Through Regulation of Fatty acid Synthesis in High-fat Diet-induced Obese Mice

2016 ◽  
Vol 59 (1) ◽  
pp. 49-56 ◽  
Author(s):  
Hae Jin Lee ◽  
Dong-Ryung Lee ◽  
Bong-Keun Choi ◽  
Sung-Bum Park ◽  
Ying-Yu Jin ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Body Fat ◽  
Fatty Acid Synthesis ◽  
High Fat Diet ◽  
Acid Synthesis ◽  
Obese Mice ◽  
High Fat ◽  
Cissus Quadrangularis

Topical Application of Capsaicin Reduces Visceral Adipose Fat by Affecting Adipokine Levels in High-Fat Diet-Induced Obese Mice

Obesity ◽  
2012 ◽  
Author(s):  
Gong-Rak Lee ◽  
Mi Kyung Shin ◽  
Dong-Joon Yoon ◽  
Ah-Ram Kim ◽  
Rina Yu ◽  
...  
Keyword(s):  
Topical Application ◽  
High Fat Diet ◽  
Obese Mice ◽  
High Fat ◽  
Visceral Adipose
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