scholarly journals Effects ofBangkibokryeong-tang(Fangjifuling-tang) on the Reduction of Blood Glucose and Body Fat in High Fat Diet Induced Obese Mice

2017 ◽  
Vol 27 (1) ◽  
pp. 1-17
Author(s):  
Hyung-Jin Yoo ◽  
Jong-Ha Lee ◽  
Soo-Kyung Lee ◽  
Yung-Sun Song
Keyword(s):  
Blood Glucose ◽  
Body Fat ◽  
High Fat Diet ◽  
Obese Mice ◽  
High Fat

scholarly journals Antiobesity Effect of a Novel Herbal Formulation LI85008F in High-Fat Diet-Induced Obese Mice

2021 ◽  
Vol 2021 ◽  
pp. 1-8
Author(s):  
Hak Joo Choi ◽  
Hwa Young Kim ◽  
Kyoung Sik Park
Keyword(s):  
Weight Gain ◽  
Body Fat ◽  
Fat Mass ◽  
High Fat Diet ◽  
Body Weight Gain ◽  
Whole Body ◽  
Body Fat Mass ◽  
Obese Mice ◽  
High Fat ◽  
Herbal Formulation

A variety of natural products have been explored for their antiobesity potential and widely used to develop dietary supplements for the prevention of weight gain from excess body fat. In an attempt to find a natural antiobesity agent, this study was designed to evaluate the antiobesity activity of a novel herbal formulation LI85008F composed of extracts from three medicinal plants in high-fat diet- (HFD-) induced obese mice. After the thirteen-week oral administration of the test materials to mice, the body weight gain, whole-body fat mass, adipose tissue weight, and the expression levels of obesity-related proteins were measured. Our results indicated that LI85008F can suppress body weight gain and lower whole-body fat mass in HFD-induced obese mice. Significant decreases in epididymal and retroperitoneal fat mass were observed in LI85008F-treated groups compared with the HFD-fed control group ( p < 0.05 ). Furthermore, the oral administration of LI85008F caused significant decreases in the expression level of adipogenic (C/EBPα and PPARγ) and lipogenic (ACC) markers and notable increases in the production level of thermogenetic (AMPKα, PGC1α and UCP1) and lipolytic (HSL) proteins. These findings suggest that LI85008F holds great promise for a novel herbal formulation with antiobesity activities, preventing body fat accumulation and altering lipid metabolism.

scholarly journals Obesity is Irreversible Without a Controlled Dietary Regimen in a Murine Model

2019 ◽  
Vol 4 (4) ◽  
pp. 2473011419S0040
Author(s):  
Chris Stauch ◽  
Jesse King ◽  
Morgan Kim ◽  
David Waning ◽  
John Elfar ◽  
...  
Keyword(s):  
Body Fat ◽  
High Intensity ◽  
High Fat Diet ◽  
Exercise Program ◽  
Body Fat Percentage ◽  
Obese Mice ◽  
High Fat ◽  
Fat Percentage ◽  
Mineral Density ◽  
Cardiovascular Training

Category: Diabetes, Hindfoot, Midfoot/Forefoot, obesity Introduction/Purpose: In recent decades, the prevalence of obesity in the United States has increased dramatically. This can be attributed in-part to the high-fat “Western Diet”. Consequentially, the economic burden of obesity to the healthcare system has rapidly increased, accounting for more than 10 percent of all medical spending in America. Furthermore, with regards to orthopedics, obesity has been shown to be a strong risk factor for musculoskeletal pain, injury, and post-operative complications. The purpose of this study was to determine the effects of high intensity cardiovascular training and controlled dietary intake on body weight, body fat percentage (BFP), and bone mineral density (BMD) in obese and non-obese mice. These results will provide a better understanding of how to optimally facilitate weight loss in obese patients. Methods: Following IAUCUC approval, 8 diet-induced obesity (DIO) C57BL/6 mice were obtained along with 6 non-obese C57BL/6 control mice. DIO mice were fed a high-fat diet (60% fat by kcal) ad libitum starting at the age of 6 weeks. Control mice were fed a standard low-fat diet (10% fat by kcal) ad libitum from birth. Starting at the age of 14 weeks, all mice underwent a controlled high intensity cardiovascular training protocol using a treadmill four times per week at 30 minute intervals. This was carried out for seven weeks including a one-week acclimation period. Speed, distance, and time spent running were all constant between groups. Mouse body weights were recorded several times per week throughout the study. Additionally, BFP and BMD were obtained bi-weekly using dual energy X-ray absorptiometry (DEXA) to assess morphophysiological changes longitudinally. Results: Preliminary investigations with a controlled exercise regimen reveal that obese mice, when fed a high-fat diet, continue to gain weight rapidly despite high intensity cardiovascular training whereas control mice maintain their weight. Following the seven-week training period, control mice gained an average of 1.25 g (p=0.41), while DIO mice gained an average of 8.55 g (p<0.001). DIO mice also showed an 8.74% increase in body fat percentage (p=0.002) while control mice showed a 0.51% decrease in body fat percentage (p=0.75). Lastly, BMD was significantly lower in DIO mice compared to controls following the exercise protocol (p<0.05). Conclusion: The results of this study support the hypothesis that a controlled exercise regimen alone is ineffective for facilitating weight loss. In fact, obese mice administered a high-fat diet actually gain weight despite undergoing a rigorous exercise program. Additionally, simple differences in dietary intake have significant effects on body weight, body fat percentage, and bone mineral density. This suggests that while exercise may play a small role in maintaining a normal weight, obesity is irreversible with exercise alone. Obese orthopedic patients should be counseled on dietary modifications before engaging in an exercise program.

scholarly journals Effects of Omega-3 Fatty Acids on Insulin Resistance in an Ovariectomized Mouse Model of Diet-Induced Obesity Treated with Chemotherapy

2020 ◽  
Vol 4 (Supplement_2) ◽  
pp. 345-345
Author(s):  
Kate Ormiston ◽  
Zihan Zhang ◽  
Kelly Murphy ◽  
A Courtney DeVries ◽  
Maryam Lustberg ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Body Weight ◽  
Blood Glucose ◽  
Body Fat ◽  
High Fat Diet ◽  
Serum Insulin ◽  
Model Assessment ◽  
Omega 3 ◽  
High Fat ◽  
Body Weights

Abstract Objectives Our objective was to examine effects of dietary enrichment of eicosapentaenoic acid + docosahexaenoic acid (EPA + DHA) on high fat diet-induced insulin resistance during chemotherapy. Methods Adult, female C57Bl/6 mice (n = 48) were assigned to 1 of 3 diets; low-fat diet (LF; 10% kcals fat), high-fat diet (HF; 45% kcals fat), or HF diet with omega-3 s (HF n-3; 2% kcals EPA + DHA) for 7 weeks. Mice received vehicle or chemotherapy injections (doxorubicin + cyclophosphamide), by tail vein at week 4 and 6. Food intake and body weights were recorded. Fasted blood glucose and serum insulin were measured weekly.  Homeostatic model assessment of insulin resistance (HOMA-IR) was calculated. Body composition was measured using Echo MRI. Data were analyzed using ANOVA; p &lt; 0.05 was considered significant. Results Total kilocalories significantly differed by group (p &lt; 0.001); HF and HF n-3 groups consumed more than the LF group (p &lt; 0.001, p &lt; 0.0001; respectively). Obesity was induced prior to first injection with body weights being significantly different (p &lt; 0.01); the LF group weighed less than the HF n-3 group (p &lt; 0.01), and there was a similar trend between LF and HF groups (p = 0.0519). Body weights at sacrifice significantly differed (p &lt; 0.0001); chemotherapy mice weighed less than vehicle (p &lt; 0.0001). Percent body fat at sacrifice significantly differed (p &lt; 0.0001); chemotherapy mice had less fat than vehicle (p &lt; 0.0001), and the LF group had less fat than HF  (p &lt; 0.01) and HF n-3 group (p &lt; 0.01). Blood glucose significantly differed at sacrifice (p &lt; 0.01); chemotherapy mice had lower glucose than vehicle (p &lt; 0.05) and HF group had higher glucose than LF group (p &lt; 0.01). HOMA-IR scores at sacrifice significantly differed (p &lt; 0.05); chemotherapy mice had lower scores than vehicle  (p &lt; 0.05) and mice on the LF and HF n-3 diets had lower scores than the HF diet (p &lt; 0.01; p &lt; 0.05 respectively). Conclusions Chemotherapy lowered body weight and body fat in mice, potentially contributing to decreases in blood glucose and insulin resistance. EPA + DHA enrichment of a HF diet reduced insulin resistance in mice comparable to a LF diet group. This occurred in both chemotherapy and vehicle treated mice, despite LF diet-fed mice having lower body weight and adiposity. Underlying mechanisms are being investigated. Funding Sources NIH #5R01CA18994.

scholarly journals Supplementation of Non-Dairy Creamer-Enriched High-Fat Diet with D-Allulose Ameliorated Blood Glucose and Body Fat Accumulation in C57BL/6J Mice

2019 ◽  
Vol 9 (13) ◽  
pp. 2750 ◽  
Author(s):  
Ga Young Do ◽  
Eun-Young Kwon ◽  
Yun Jin Kim ◽  
Youngji Han ◽  
Seong-Bo Kim ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Lipid Metabolism ◽  
Blood Glucose ◽  
Body Fat ◽  
High Fat Diet ◽  
Fasting Blood Glucose ◽  
Control Group ◽  
High Fat ◽  
Food Component ◽  
Fat Accumulation

D-allulose, which has 70% of the sweet taste of sucrose but nearly no calories, has been reported to inhibit the absorption of lipids and suppress body weight gain in obese mice. Fats in non-dairy creamer consist of highly saturated fatty acids, which can cause various lipid disorders when consumed over a long period. We investigated whether D-allulose supplementation alleviates the effects of a non-dairy creamer-enriched high-fat diet on lipid metabolism. High-fat diets enriched with non-dairy creamer were administered to C57BL/6J mice with or without D-allulose supplementation for eight weeks by the pair-feeding design. Lipid metabolic markers were compared between the non-dairy creamer control group (NDC) and non-dairy creamer allulose group (NDCA). Body, adipose tissue, and liver weights, and fasting blood glucose levels, were significantly lower in the NDCA group than in the NDC group. Fecal fatty acid and triglyceride levels were significantly higher in the NDCA group than in the NDC group. Supplementing a non-dairy creamer-enriched high-fat diet with D-allulose improved overall lipid metabolism, including the plasma and hepatic lipid profiles, hepatic and adipose tissue morphology, and plasma inflammatory adipokine levels in mice. These results suggest that D-allulose can be used as a functional food component for preventing body fat accumulation from a high-fat diet that includes hydrogenated plant fats.

scholarly journals Effects of Gami-Handayeolso-Tang on Body Fat Reduction in High Fat Diet-Fed Obese Mice

2016 ◽  
Vol 26 (1) ◽  
pp. 13-31 ◽  
Author(s):  
Ha-Il Lee ◽  
Jong-Ha Lee ◽  
Young-Mi Kwon ◽  
Yung-Sun Song
Keyword(s):  
Body Fat ◽  
High Fat Diet ◽  
Obese Mice ◽  
High Fat ◽  
Fat Reduction

scholarly journals Effects of Gami-Cheongpyesagan-Tang on Body Fat in High Fat Diet-Fed Obese Mice

2015 ◽  
Vol 15 (2) ◽  
pp. 75-92 ◽  
Author(s):  
Seon-Oh Keum ◽  
Ha-Il Lee ◽  
Jong-Ha Lee ◽  
Yong-Il Yoon ◽  
Young-Mi Kwon ◽  
...  
Keyword(s):  
Body Fat ◽  
High Fat Diet ◽  
Obese Mice ◽  
High Fat
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