scholarly journals Direct transfer of IL-12 gene into growing Renca tumors.

2000 ◽  
Vol 47 (2) ◽  
pp. 385-391 ◽  
Author(s):  
M Budryk ◽  
U Wilczyńska ◽  
J Szary ◽  
S Szala
Keyword(s):  
Cancer Cells ◽  
Therapeutic Effect ◽  
Reporter Gene ◽  
Plasmid Dna ◽  
Time Span ◽  
Direct Transfer ◽  
Therapeutic Gene ◽  
Naked Dna ◽  
Naked Plasmid ◽  
Naked Plasmid Dna

We investigated the feasibility of transferring naked plasmid DNA containing a therapeutic gene (IL-12) into mice harboring growing Renca tumors. We found that naked DNA transferred into growing Renca and B16(F10) tumors gives higher expression level of reporter gene than complexes of DNA with DDAB/DOPE or DC-Chol/DOPE. Transfer of naked DNA carrying the IL-12 gene into growing Renca tumors causes a distinct therapeutic effect that depends on the time span between inoculation of mice with cancer cells and the beginning of the therapy. Therapy started on day 3 resulted in total cure (100%) of mice.

Electroporation enhances reporter gene expression following delivery of naked plasmid DNA to the lung

2007 ◽  
Vol 9 (5) ◽  
pp. 369-380 ◽  
Author(s):  
Ian A. Pringle ◽  
Gerry McLachlan ◽  
David D. S. Collie ◽  
Stephanie G. Sumner-Jones ◽  
Anna E. Lawton ◽  
...  
Keyword(s):  
Gene Expression ◽  
Reporter Gene ◽  
Plasmid Dna ◽  
Reporter Gene Expression ◽  
Naked Plasmid ◽  
Naked Plasmid Dna

scholarly journals Therapeutic Effect of Intravenous Interferon Gene Delivery with Naked Plasmid DNA in Murine Metastasis Models

2002 ◽  
Vol 6 (6) ◽  
pp. 737-744 ◽  
Author(s):  
Naoki Kobayashi ◽  
Takeshi Kuramoto ◽  
Shi Chen ◽  
Yoshihiko Watanabe ◽  
Yoshinobu Takakura
Keyword(s):  
Gene Delivery ◽  
Therapeutic Effect ◽  
Plasmid Dna ◽  
Metastasis Models ◽  
Naked Plasmid ◽  
Interferon Gene ◽  
Naked Plasmid Dna

In vivo expression and antitumor activity of p53 gene transfer with naked plasmid DNA in an ovarian cancer xenograft model in nude mice

2006 ◽  
Vol 32 (5) ◽  
pp. 449-453 ◽  
Author(s):  
Pierre Collinet ◽  
Rodolphe Vereecque ◽  
Frédéric Sabban ◽  
Denis Vinatier ◽  
Eric Leblanc ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Gene Transfer ◽  
Antitumor Activity ◽  
Nude Mice ◽  
Plasmid Dna ◽  
Xenograft Model ◽  
P53 Gene ◽  
Naked Plasmid ◽  
Naked Plasmid Dna

scholarly journals Rubbing Gastric Serosal Surface Enhances Naked Plasmid DNA Transfer in Rats and Mice

2011 ◽  
Vol 34 (9) ◽  
pp. 1514-1517 ◽  
Author(s):  
Toyoharu Mine ◽  
Hiroki Ishii ◽  
Sayuri Nakajima ◽  
Naoki Yoshikawa ◽  
Hirotaka Miyamoto ◽  
...  
Keyword(s):  
Plasmid Dna ◽  
Dna Transfer ◽  
Serosal Surface ◽  
Naked Plasmid ◽  
Rats And Mice ◽  
Naked Plasmid Dna

scholarly journals Naked plasmid DNA transfer to the porcine liver using rapid injection with large volume

Gene Therapy ◽  
2006 ◽  
Vol 13 (24) ◽  
pp. 1696-1702 ◽  
Author(s):  
H Yoshino ◽  
K Hashizume ◽  
E Kobayashi
Keyword(s):  
Large Volume ◽  
Plasmid Dna ◽  
Dna Transfer ◽  
Porcine Liver ◽  
Rapid Injection ◽  
Naked Plasmid ◽  
Naked Plasmid Dna

scholarly journals Pretreatment with Epidermal Growth Factor Enhances Naked Plasmid DNA Transfer onto Gastric Serosal Surface in Mice

2012 ◽  
Vol 35 (6) ◽  
pp. 903-908 ◽  
Author(s):  
Hirotaka Miyamoto ◽  
Sumie Baba ◽  
Sayuri Nakajima ◽  
Toyoharu Mine ◽  
Naoki Yoshikawa ◽  
...  
Keyword(s):  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Plasmid Dna ◽  
Dna Transfer ◽  
Serosal Surface ◽  
Epidermal Growth ◽  
Naked Plasmid ◽  
Naked Plasmid Dna
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