scholarly journals In vitro release of cytotoxic nucleoside analogs from lactide-caprolactone and lactide-glycolide copolymers.

2002 ◽  
Vol 49 (1) ◽  
pp. 205-210 ◽  
Author(s):  
Tomasz Kryczka ◽  
Maciej Bero ◽  
Janusz Kasperczyk ◽  
Piotr Dobrzyński ◽  
Barbara Marciniec ◽  
...  
Keyword(s):  
Ethylene Oxide ◽  
Gamma Radiation ◽  
Local Treatment ◽  
In Vitro Release ◽  
Nucleoside Analogs ◽  
Further Development ◽  
Kinetics Of ◽  
Vitro Release ◽  
Observation Period

The aims of our study were to assess the release of cytotoxic nucleoside analogs 5-fluorouracil and 2-chloro-2'-deoxyadenosine from different lactide-glycolide or lactide-caprolactone biodegradable copolymers and the effects of sterilization on this release. The polymers were sterilized either with ethylene oxide at 37 degrees C, or with gamma radiation (15 kGy, 20 kGy, or 25 kGy). The kinetics of nucleoside release from the copolymers were measured over 50 days. Four copolymers exhibited relatively constant release of nucleosides in micromolar concentrations during the entire observation period. Sterilization with either ethylene oxide or gamma radiation only slightly influenced nucleoside release. Further development of these copolymers as an intracerebral nucleoside delivery system for local treatment of brain tumors is indicated.

Formulation and In Vitro Release Kinetics of Mucoadhesive Blend Gels Containing Matrine for Buccal Administration

2017 ◽  
Vol 19 (1) ◽  
pp. 470-480 ◽  
Author(s):  
Xiaojin Chen ◽  
Jun Yan ◽  
Shuying Yu ◽  
Pingping Wang
Keyword(s):  
Release Kinetics ◽  
In Vitro Release ◽  
Kinetics Of ◽  
Vitro Release

scholarly journals Kinetics of a nucleoside release from lactide-caprolactone and lactide-glycolide polymers in vitro.

2000 ◽  
Vol 47 (1) ◽  
pp. 59-64
Author(s):  
T Kryczka ◽  
P Grieb ◽  
M Bero ◽  
J Kasperczyk ◽  
P Dobrzynski
Keyword(s):  
Formation Rate ◽  
Local Treatment ◽  
Extracellular Fluid ◽  
Brain Extracellular Fluid ◽  
Artificial Cerebrospinal Fluid ◽  
Fluid Formation ◽  
Further Development ◽  
Kinetics Of ◽  
The Brain

We assessed the rate of release of a model nucleoside (adenosine, 5%, w/w) from nine different lactide-glycolide or lactide-caprolactone polymers. The polymer discs were eluted every second day with an artificial cerebrospinal fluid at the elution rate roughly approximating the brain extracellular fluid formation rate. Adenosine in eluate samples was assayed by HPLC. Three polymers exhibited a relatively constant release of adenosine for over four weeks, resulting in micromolar concentrations of nucleoside in the eluate. This points to the necessity of further development of polymers of this types as intracerebral nucleoside delivery systems for local treatment of brain tumors.

scholarly journals Phenobarbital loaded microemulsion: development, kinetic release and quality control

2016 ◽  
Vol 52 (2) ◽  
pp. 251-264 ◽  
Author(s):  
Kayo Alves Figueiredo ◽  
Jamilly Kelly Oliveira Neves ◽  
José Alexsandro da Silva ◽  
Rivelilson Mendes de Freitas ◽  
André Luis Menezes Carvalho
Keyword(s):  
Analytical Method ◽  
In Vitro Release ◽  
Physicochemical Characterization ◽  
Primary Stability ◽  
Isopropyl Myristate ◽  
Microemulsion System ◽  
Transdermal Application ◽  
Kinetics Of ◽  
Vitro Release

ABSTRACT This study aimed to obtain and characterize a microemulsion (ME) containing phenobarbital (PB). The PB was incorporated in the proportion of 5% and 10% in a microemulsion system containing Labrasol(r), ethanol, isopropyl myristate and purified water. The physicochemical characterization was performed and the primary stability of the ME was evaluated. An analytical method was developed using spectrophotometry in UV = 242 nm. The kinetics of the in vitro release (Franz model) of the ME and the emulsion (EM) containing PB was evaluated. The incorporation of PB into ME at concentrations of 5 and 10% did not change pH and resistance to centrifugation. There was an increase in particle size, a decrease of conductivity and a change in the refractive index in relation to placebo ME. The ME remained stable in preliminary stability tests. The analytical method proved to be specific, linear, precise, accurate and robust. Regarding the kinetics of the in vitro release, ME obtained an in vitro release profile greater than the EM containing PB. Thus, the obtained ME has a potential for future transdermal application, being able to compose a drug delivery system for the treatment of epilepsy.

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