scholarly journals Key features of phenylephrine administration against the background of If-current blockade on rat cardiovascular indicators in postnatal ontogenesis

2021 ◽  
Vol 79 (1) ◽  
pp. 58-59
Author(s):  
R.E. Dementyeva ◽  
T.M. Shibaeva ◽  
A.M. Kuryaeva ◽  
I.A. Kaminsky
Keyword(s):  
Nervous System ◽  
Autonomic Nervous System ◽  
Rat Heart ◽  
Heart Rhythm ◽  
Postnatal Ontogenesis ◽  
Adrenergic Regulation ◽  
Autonomic Nervous ◽  
If Current ◽  
Key Features

The results of the studying expand views on the mechanisms of regulatory influences of the sympathetic part of the autonomic nervous system on the chronotropic function of the rat heart in postnatal ontogenesis, the results of experiments indicate the determining value of currents activated during hyperpolarization (If) in the adrenergic regulation of heart rhythm.

scholarly journals The nature of the course of the retention period in adolescents after orthodontic treatment depending on the state of the autonomic nervous system

2012 ◽  
Vol 93 (4) ◽  
pp. 651-653
Author(s):  
D R Singatullina ◽  
N Kh Khamitova
Keyword(s):  
Nervous System ◽  
Autonomic Nervous System ◽  
Orthodontic Treatment ◽  
Heart Rhythm ◽  
The State ◽  
Autonomic Reactivity ◽  
Autonomic Tone ◽  
Retention Period ◽  
Autonomic Nervous ◽  
Complete Adaptation

Aim. To study the condition of the autonomic nervous system in groups of adolescents in the period of retention after active orthodontic treatment with non-removable equipment. Methods. Examined were 100 adolescents aged 13-17 years in the period of retention after active orthodontic treatment. The baseline autonomic tone was assessed according to the combined table of sympathetic and parasympathetic reactions (Wayne A., 1981) in the modification of N.A. Belokon’ et al. (1986) for children and adolescents, taken into account were the heart rate, respiratory rate, systolic and diastolic blood pressure. In order to evaluate the adaptation of the organism used was a mathematical analysis of the heart rhythm (cardiointervalography), determined was the mode (Mo), the amplitude of the mode (AMo), and the variational span (ΔX). Results. Revealed were two groups of patients with different variants of the course of retention: favorable course without recurrence (53%) and unfavorable course with recurrences (47%). In the group of patients with recurrences cardiointervalography most frequently showed a asympaticotonic (41.7%) or hypersympaticotonic (58.3%) type of autonomic reactivity. In all patients of the group with recurrences noted was a disturbance of the adaptation processes. The state of adaptation is regarded as unsatisfactory in 72.6% of cases, as the complete adaptation failure - in 27.4%. Conclusion. A recurrence during the period of retention after active orthodontic treatment occurs significantly more frequently in the group of patients with high constraint and overload of the autonomic reactivity, with a mismatch of cardiac rhythm management processes, with a reduction of the adaptive capacity of the organism to the level of complete failure of adaptation; patients who have expressed sympathicotonia, are at risk for destructive periodontal disease and require special attention during the retention period.

scholarly journals INFLUENCE OF VEGETATIVE REGULATION OF HEART RHYTHM ON THE MANIFESTATION OF PHYSICAL PERFORMANCE OF QUALIFIED ATHLETES (І MESSAGE)

2020 ◽  
Author(s):  
Olena Lysenko ◽  
Svitlana Fedorchuk ◽  
Valerii Vinogradov
Keyword(s):  
Physical Activity ◽  
Heart Rate ◽  
Nervous System ◽  
Autonomic Nervous System ◽  
Physical Performance ◽  
Heart Rhythm ◽  
Respiratory Response ◽  
Cardiorespiratory System ◽  
Autonomic Nervous ◽  
Level Of Activity

Introduction. To assess the characteristics of the body’s adaptation of skilled athletes to strenuous exercise, it is most important to define how the manifestation of physical performance of athletes depend on the autonomic regulation of physiological functions of the body. Aim is to study the dependence of the autonomic regulation of heart rate on the manifestation of physical performance of qualified athletes and the reaction of the cardiorespiratory system under conditions of physical activity of different nature. Materials and methods. Determination of physical performance of qualified athletes and the reaction of the cardiorespiratory system (CRS) to test physical activity (ergospirometric complex "Oxycon Pro", treadmill LE-200 C), mathematical analysis of heart rhythm variability, mathematical and statistical methods. Results. The predominance in the regulation of heart rate activity of the parasympathetic division of the autonomic nervous system helps athletes achieve a higher level of physical performance both in terms of physical activity with a predominance of aerobic processes in energy supply and in terms of maximum realization of aerobic capacity. Increased activity of the parasympathetic division of the autonomic nervous system is combined with a reduced level of VE, which indicates the efficiency of the reaction of cattle under physical conditions, mainly aerobic (low and medium power). With increasing intensity of physical activity (starting from the threshold of aerobic metabolism), the increased level of activity of the parasympathetic division of the autonomic nervous system will increase the level of pulmonary ventilation, which characterizes the most effective response of CRS Conclusions. The higher level of activity of the parasympathetic division of the autonomic emergency in the regulation of heart rate contributed to the formation of a more economical pattern of respiratory response due to higher VT and lower fT, which under intense physical work allowed to achieve higher levels of VE and aerobic potential of the athlete. With increasing activity of the sympathetic channel of heart rate regulation, there was a decrease in the efficiency of the respiratory response. Thus, the required operating level VE was formed due to the smaller value of VT at a high level

scholarly journals HEART RATE TURBULENCE INDICATORS IN CLINICAL PRACTICE

2021 ◽  
Vol 14 (5) ◽  
pp. 62-67
Author(s):  
GRIGORIY A. FADEEV ◽  
◽  
NIKOLAY A. TSIBULKIN ◽  
OLGA YU. MIKHOPAROVA ◽  
GRIGORIY G. BATYRSHIN ◽  
...  
Keyword(s):  
Heart Rate ◽  
Nervous System ◽  
Autonomic Nervous System ◽  
Sinus Rhythm ◽  
Cardiac Rhythm ◽  
Heart Rhythm ◽  
Holter Monitoring ◽  
Left Ventricular ◽  
Heart Rate Turbulence ◽  
Autonomic Nervous

Background. Heart disease is the leading cause of death in developed countries. Approximately half of these fatalities are due to sudden cardiac death. Electrocardiogram recording from the body surface allows stratification of patients according to the risk of cardiac arrest without the use of invasive methods. Arrhythmias, particularly ventricular extrasystole, can affect the sinus rhythm pattern. The change in sinus rhythm that occurs after an extrasystole is defined as heart rate turbulence. This phenomenon is not pathological, but some variants are associated with a risk of fatal arrhythmias. Aim. To analyze the indices and clinical significance of cardiac rhythm turbulence according to Holter monitoring in patients with various cardiological abnormalities at the hospital profile department. Material and methods. The study included 54 patients who were routinely treated in a cardiac hospital. Cardiac rhythm turbulence indices were obtained by Holter monitoring. Patients in severe and moderately severe clinical condition were not included in the study. Concomitant and past somatic diseases affecting the state of heart and cardiovascular system were considered. Results and discussion. Deviations in heart rhythm turbulence indices can be detected both in life- threatening arrhythmias and in benign extrasystoles. They are associated with the influence of the autonomic nervous system, but probably have different mechanisms. Deviations of heart rhythm turbulence indices were associated with left ventricular myocardial hypertrophy of concentric remodeling type and with an increased number of low-risk ventricular extrasystoles. To identify patients with arrhythmias of different risk, various threshold values of cardiac rhythm turbulence indices can be used. Conclusion. Factors likely to affect the indices of cardiac rhythm turbulence such as left ventricular myocardial remodeling and hypertrophy were revealed, as well as changes in autonomic nervous system regulatory function, including those associated with the constitutional features of the patient.

scholarly journals The Role of the Autonomic Nervous System on Cardiac Rhythm during the Evolution of Diabetes Mellitus Using Heart Rate Variability as a Biomarker

2019 ◽  
Vol 2019 ◽  
pp. 1-10 ◽  
Author(s):  
Alondra Albarado-Ibañez ◽  
Rosa Elena Arroyo-Carmona ◽  
Rommel Sánchez-Hernández ◽  
Geovanni Ramos-Ortiz ◽  
Alejandro Frank ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Heart Rate ◽  
Heart Rate Variability ◽  
Nervous System ◽  
Autonomic Nervous System ◽  
Early Diagnosis ◽  
Negative Symptoms ◽  
Heart Rhythm ◽  
Autonomic Nervous ◽  
Cardiovascular Morbidity And Mortality

Heart rate variability (HRV) is highly influenced by the Autonomic Nervous System (ANS). Several illnesses have been associated with changes in the ANS, thus altering the pattern of HRV. However, the variability of the heart rhythm is originated within the Sinus Atrial Node (SAN) which has its own variability. Still, although both oscillators produce HRV, the influence of the SAN on HRV has not yet been exhaustively studied. On the other hand, the complications of diabetes mellitus (DM), for instance, nephropathy, retinopathy, and neuropathy, increase cardiovascular morbidity and mortality. Traditionally, these complications are diagnosed only when the patient is already suffering from the negative symptoms these complications implicate. Consequently, it is of paramount importance to develop new techniques for early diagnosis prior to any deterioration on healthy patients. HRV has been proved to be a valuable, noninvasive clinical evidence for evaluating diseases and even for describing aging and behavior. In this study, several ECGs were recorded and their RR and PP intervals were analyzed to detect the interpotential interval (ii) of the SAN. Additionally, HRV reduction was quantified to identify alterations in the nervous system within the nodal tissue via measuring the SD1/SD2 ratio in a Poincaré plot. With 15 years of DM development, the data showed an age-dependent increase in HRV due to the axon retraction of ANS neurons from its effectors. In addition, these alterations modify the heart rhythm-producing fatal arrhythmias. Therefore, it is possible to avoid the consequences of DM identifying alterations in SAN previous to its symptomatic appearance. This could be used as an early diagnosis indicator.

scholarly journals Fractals disruption as the footprint of subthreshold depressive symptoms on the heart rate

2021 ◽  
Author(s):  
Piergiorgio mandarano ◽  
Paolo Ossola ◽  
Maria Carsillo ◽  
Pierluca Marazzi ◽  
Stefano Rozzi ◽  
...  
Keyword(s):  
Heart Rate ◽  
Nervous System ◽  
Depressive Symptoms ◽  
Autonomic Nervous System ◽  
Healthy Subjects ◽  
Smoking Habit ◽  
Heart Rhythm ◽  
Low Frequencies ◽  
Autonomic Nervous ◽  
Diagnostic Threshold

Psychopathology, and in particular depression, is a cardiovascular risk factor independent from co-occurring pathology. This link is traced back to the mind-heart-body connection, whose underlying mechanisms are, to date, not completely known. It is clear, however, that the autonomic nervous system plays a leading role in the mediation between the parts of that connection. Therefore, to study psychopathology in relation to the heart, it is necessary to observe the autonomic nervous system, whose gold standard of evaluation is the study of heart rate variability (HRV). Two short-term HRV recordings (5 min - supine and sitting) were analysed in 77 healthy subjects. Here we adopted a three-fold approach to evaluate HRV: a set of scores belonging to the time domain (SDNN, pNN50, RMSSD); the frequency analyses that gauges three main components (high, low, and very low frequencies) and a new set of complexity nonlinear parameters. The PHQ-9 scale was used to detect depressive symptoms. Depressive symptoms were associated only with a parameter from the non-linear approach and specifically the long-term fluctuations of fractal dimensions (DFA-α2). This association remained significant even after controlling for age, gender, BMI, arterial hypertension, anti-hypertensive drugs, dyslipidaemia, and smoking habit. Moreover, the DFA-α2 was not affected by the baroreflex (postural change), unlike other autonomic markers. In conclusion, fractal analysis of HRV (DFA-α2) allows to predict depressive symptoms below diagnostic threshold in healthy subjects regardless of their health status. DFA-α2 may be then considered as an imprint of subclinical depression on the heart rhythm.

scholarly journals Features of autonomic regulation in cholelithiasis before and after cholecystectomy

2018 ◽  
pp. 60-64
Author(s):  
A. D. Bagmet ◽  
A. P. Ruban ◽  
V. N. Egorov ◽  
T. V. Tayutina
Keyword(s):  
Quality Of Life ◽  
Nervous System ◽  
Autonomic Nervous System ◽  
Mathematical Analysis ◽  
Sympathetic Activity ◽  
Heart Rhythm ◽  
Autonomic Regulation ◽  
Autonomic Nervous ◽  
Before And After

It is appropriate and necessary to examine the functional state of the autonomic nervous system and the quality of life in patients with cholelithiasis using the mathematical analysis of the heart rhythm at the present-day level. Materials and methods: 136 patients (115 women and 21 men) were examined, of which 70 patients after cholecystectomy with cholelithiasis and 66 patients with cholelithiasis. Fractional chromatic minute-type duodenal intubation with an analysis of the biochemical and microscopic composition of the bile was used to assess the biliary system condition. The examination of the autonomic nervous system was carried out by determining the heart rhythm using the cardiointervalography method with further mathematical analysis of the structure and variational pulsometry. Changes in the autonomic status in patients with cholelithiasis before and after cholecystectomy differ in general patterns: adaptive possibilities decrease and sympathetic activity of the autonomic regulation increases. An increase in the lithogenicity of bile, which positively correlates with the level of sympathicotonia, is characteristic for patients with cholelithiasis before and after cholecystectomy. The autonomic regulation in patients with cholelithiasis after cholecystectomy improves, however, the high bile lithogenicity persists. 

scholarly journals The prevalence of neurocirculatory astheniaamong adolescents and young men of military age with bradyarrhythmia based on the results of screening diagnostics

2018 ◽  
Vol 9 (4) ◽  
pp. 73-80
Author(s):  
Inna A. Klubkova ◽  
Marina V. Avdeeva ◽  
Larisa V. Shcheglova ◽  
Dina R. Kiryanova ◽  
Marina Yu. Erina
Keyword(s):  
Nervous System ◽  
Autonomic Nervous System ◽  
Functional State ◽  
Sinus Bradycardia ◽  
Cardiac Activity ◽  
Young Men ◽  
Heart Rhythm ◽  
Severe Form ◽  
Compensatory Mechanisms ◽  
Autonomic Nervous

The article presents the results of clinical and instrumental examination of adolescents and young men of military age with bradyarrhythmia. The study involved 2067 people (mean age19,7 ± 2,7 years), subject to conscription (from 17 to 27 years) and potential conscripts (16-year-olds). According to the results of the screening ECG, bradyarrhythmia (sinus bradycardia, sinus bradyarrhythmia, rhythm and conduction disorders) was diagnosed in 630 adolescents and young men of military age. We studied the functional status of the autonomic nervous system on the device “Cardiometry-MT” (Russia). The functional state of the autonomic nervous system was studied on the basis of cardiointervalography and correlation rhythmography. Evaluation of the functional state of the autonomic nervous system was carried out according to three parameters: the type of vegetative regulation of the heart rhythm (normotonic, vagotonic, sympathicotonic); reactivity of the sympathetic and parasympathetic parts of the autonomic nervous system (normal reactivity, hyperreactivity, low reactivity, and paradoxical reactions); nature of vegetative maintenance of cardiac activity (normal vegetative maintenance of cardiac activity, vegetative maintenance with adaptation, vegetative maintenance with disadaptation). According to the results of respiratory samples from 81,9% of adolescents and young men of military age with bradyarrhythmia diagnosed neurocirculatory asthenia, of whom 63,6% – light, while 18,3% – severe degree. With a mild form of neurocirculatory asthenia, compensatory mechanisms are connected, so vegetative homeostasis is not generally disturbed and the heart rhythm responds adequately to the effect of physiological stimuli. Severe form of neurocirculatory asthenia is characte rized by disadaptation of vegetative maintenance of cardiac activity. Such patients need regular follow-up because they are at risk for developing cardiovascular diseases.

Fibromyalgia beyond reductionism. Heart rhythm fractal analysis to assess autonomic nervous system resilience

2015 ◽  
Vol 45 (2) ◽  
pp. 151-157 ◽  
Author(s):  
C Lerma ◽  
L-A Martinez-Martinez ◽  
N Ruiz ◽  
A Vargas ◽  
O Infante ◽  
...  
Keyword(s):  
Nervous System ◽  
Autonomic Nervous System ◽  
Fractal Analysis ◽  
Heart Rhythm ◽  
Autonomic Nervous ◽  
System Resilience

scholarly journals Correlation between adipocytokine profile and heart rate variability in patients with obesity

2020 ◽  
Vol 37 (3) ◽  
pp. 12-17
Author(s):  
S. G. Shulkina ◽  
E. N. Smirnova ◽  
E. A. Laurent ◽  
N. Yu. Kolomeets ◽  
V. V. Konovalov ◽  
...  
Keyword(s):  
Heart Rate ◽  
Heart Rate Variability ◽  
Nervous System ◽  
Uric Acid ◽  
Autonomic Nervous System ◽  
Spectral Characteristics ◽  
Heart Rhythm ◽  
Control Group ◽  
Autonomic Nervous ◽  
Group 2

Objective. The high prevalence of obesity in employable population dictates the necessity for preclinical diagnosis of diseases associated with it, including the study of the autonomic regulation of heart rhythm. The objective was to study the correlations between the adipocytokine profile and heart rate variability in patients with obesity. Materials and methods. 300 persons were examined, the average age was 46.2 6.4 years; Group 1 was metabolically unhealthy obesity phenotype (MUHOP) 90 patients; group 2 was obesity without metabolic disorders [Ob(+)MD(-)] (MHOP) 50 persons; the control group consisted of 100 healthy respondents. We studied the following indices: blood serum adipocytokines: leptin, insulin, resistin, adiponectin. Heart rate variability was studied using Poly-Spectrum Rhythm 2012 computer electrocardiograph. Results. In the course of the study, decrease in the total heart rate variability and reactivity of the parasympathetic part of the autonomic nervous system in patients from MUHOP group was found, while there were no differences with the control in the MHOP group. It was established that a decrease in the parasympathetic effect on the regulation of heart rhythm is associated with the presence of abdominal obesity, insulin resistance, and an increase in the level of TG, glucose, resistin, and uric acid. Conclusions. The received relationships between indicators of carbohydrate and lipid metabolism, the level of uric acid and adipocytokines with temporal and spectral characteristics of the autonomic nervous system confirm their contribution to the development of autonomic dysfunction in obese persons.

scholarly journals Heart rate variabilit y during epileptic seizures as a factor in the development of sudden unexpected death in epilepsy (literat ure review)

2019 ◽  
Vol 14 (2) ◽  
pp. 18-22
Author(s):  
A. V. Monakhova ◽  
A. Yu. Yakshina ◽  
E. D. Belousova
Keyword(s):  
Heart Rate ◽  
Nervous System ◽  
Autonomic Nervous System ◽  
Significant Proportion ◽  
Heart Rhythm ◽  
Epileptic Seizures ◽  
Epileptic Activity ◽  
Sudden Unexpected Death ◽  
Unexpected Death ◽  
Autonomic Nervous

Sudden unexpected death in epilepsy (SUDEP) is the most common cause of death in patients with epilepsy and occurs at least 20 times more often in patients with fore mentioned condition compared with healthy people. During epileptic seizures, a significant proportion of patients develop heart rate variability and respiratory depression. It is assumed that these cardiorespiratory complications are the most probable risk factor for the development of SUDEP. Asystole and ventricular fibrillation, developing immediately after the seizure, are the most significant arrhythmias in the pathophysiology of SUDEP. Discoordination of the autonomic nervous system activity in connection with the involvement of autonomous control centers in epileptic activity leads to the emerging cardiopulmonary pathology. In patients with long-term resistant epilepsy, chronic dysfunction of the autonomic nervous system is formed and, as a consequence, a greater predisposition to the disturbances of heart rhythm. A detailed study of cardiac disorders during epileptic seizures will provide the key for understanding the risks of developing SUDEP and developing some approaches to its prevention.

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