scholarly journals Association Between Rheumatoid Arthritis and Pulmonary Hypertension: A Clinical Investigation

2021 ◽  
Author(s):  
Nayyereh Saadati ◽  
Bahram Naghibzadeh ◽  
Asma Khalilipour ◽  
Maryam Miri
Keyword(s):  
Rheumatoid Arthritis ◽  
Pulmonary Hypertension ◽  
Left Ventricular Systolic Dysfunction ◽  
Clinical Investigation ◽  
Heart Diseases ◽  
Systolic Dysfunction ◽  
Left Ventricular ◽  
Mitral Insufficiency ◽  
Diastolic Velocity ◽  
Valvular Heart Diseases

Assessment of pulmonary hypertension (PAH) frequency and its association with interstitial lung disease (ILD), left ventricular diastolic dysfunction (LVDD), left ventricular systolic dysfunction (LVSD), and valvular heart diseases (VHD) in adult patients with rheumatoid arthritis (RA). Cross-sectional study. Cardiology and Rheumatology Departments, Ghaem Medical Center, Mashhad University of Medical Sciences, Mashhad, Iran. A total of 40 patients with RA without history or clinical features of cardiac diseases underwent cardiopulmonary and rheumatological assessment, including history taking, physical examination, chest X-ray, chest High-Resolution Computed Tomography (HRCT), and echocardiography. Echocardiographic variables of patients with RA were measured and analyzed. The relationship between rheumatoid arthritis and pulmonary hypertension. The prevalence of PAH was 60% in RA. The tests showed no significant differences in PAH between age and gender groups. The most common valve involvement among patients was tricuspid insufficiency, followed by mitral insufficiency. Grades I and II LVDD were present in 27.5% and 2.5% of patients, respectively. There were significant correlations between systolic velocity (Sm) and ejection fraction, early diastolic velocity and diastolic velocity, as well as Sm and systolic wave velocity. This study revealed a high prevalence of severe LVDD in RA patients with PAH. Early diagnosis and management of cardiovascular risk factors may prevent the development and progression of PAH in RA patients.

Clinical Trials Update

2013 ◽  
Vol 12 (3) ◽  
pp. 118-118
Author(s):  
Fernando Torres
Keyword(s):  
Clinical Trials ◽  
Pulmonary Hypertension ◽  
Left Ventricular Systolic Dysfunction ◽  
Systolic Dysfunction ◽  
Left Ventricular ◽  
Ventricular Systolic Dysfunction ◽  
Ongoing Research

The Clinical Trials Update highlights new and ongoing research trials that are evaluating therapies for PAH. In this issue, Fernando Torres, MD, examines a study on patients with pulmonary hypertension associated with left ventricular systolic dysfunction.

scholarly journals Macrophage Activities in Myocardial Infarction and Heart Failure

2020 ◽  
Vol 2020 ◽  
pp. 1-16 ◽  
Author(s):  
Sophia Esi Duncan ◽  
Shan Gao ◽  
Michael Sarhene ◽  
Joel Wake Coffie ◽  
Deng Linhua ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Heart Failure ◽  
Ventricular Remodeling ◽  
Left Ventricular Systolic Dysfunction ◽  
Heart Diseases ◽  
Systolic Dysfunction ◽  
Left Ventricular ◽  
Hibernating Myocardium ◽  
Clear Understanding ◽  
Myocardial Repair

Heart diseases remain the major cause of death worldwide. Advances in pharmacological and biomedical management have resulted in an increasing proportion of patients surviving acute heart failure (HF). However, many survivors of HF in the early stages end up increasing the disease to chronic HF (CHF). HF is an established frequent complication of myocardial infarction (MI), and numerous influences including persistent myocardial ischemia, shocked myocardium, ventricular remodeling, infarct size, and mechanical impairments, as well as hibernating myocardium trigger the development of left ventricular systolic dysfunction following MI. Macrophage population is active in inflammatory process, yet the clear understanding of the causative roles for these macrophage cells in HF development and progression is actually incomplete. Long ago, it was thought that macrophages are of importance in the heart after MI. Also, though inflammation is as a result of adverse HF in patients, but despite the fact that broad immunosuppression therapeutic target has been used in various clinical trials, no positive results have showed up, but rather, the focus on proinflammatory cytokines has proved more benefits in patients with HF. Therefore, in this review, we discuss the recent findings and new development about macrophage activations in HF, its role in the healthy heart, and some therapeutic targets for myocardial repair. We have a strong believe that there is a need to give maximum attention to cardiac resident macrophages due to the fact that they perform various tasks in wound healing, self-renewal of the heart, and tissue remodeling. Currently, it has been discovered that the study of macrophages goes far beyond its phagocytotic roles. If researchers in future confirm that macrophages play a vital role in the heart, they can be therapeutically targeted for cardiac healing.

scholarly journals AB0182 HEMOGLOBIN RATE AS A PREDICTOR OF SUBCLINICAL LEFT VENTRICULAR SYSTOLIC DYSFUNCTION IN RHEUMATOID ARTHRITIS

2021 ◽  
Vol 80 (Suppl 1) ◽  
pp. 1116.2-1116
Author(s):  
Y. Ben Abderrazek ◽  
R. Dhahri ◽  
W. Lahmar ◽  
M. Slouma ◽  
B. Louzir ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Roc Curve ◽  
Left Ventricular Systolic Dysfunction ◽  
Systolic Dysfunction ◽  
Left Ventricular ◽  
Curve Analysis ◽  
Myocardial Deformation ◽  
Ventricular Systolic Dysfunction ◽  
Roc Curve Analysis ◽  
History Of

Background:The role of rheumatoid arthritis as an ischemic heart disease and heart failure risk factor is well acknowledged even if the physiopathological pathways are still debated. The effect of anemia on myocardial deformation has already been established and a hemoglobin level below 9g/dL was associated with a significantly lower global longitudinal strain (GLS) patients with no history of CVD or chronic inflammatory diseases.[1]Objectives:In the present study, we looked into the effect of anemia and hemoglobin on the myocardial impairement in RA patients.Methods:We conducted a monocentric cross-sectional study between march 2019 and september 2019 on 36 RA patients without any history of cardiovascular disease and non-altered left ventricular ejection fraction in the outpatient population of the rheumatology department of the military hospital of Tunis matched with 36 healthy control subjects. Both groups underwent conventional echocardiography and STE to measure GLS; subclinical left ventricular systolic dysfunction was defined as a GLS > −18%, and a complete blood cell count; anemia was defined as Hemoglobin levels < 12 g/dL for women and < 13 g/dL for men.Results:Myocardial deformation study revealed that rheumatoid arthritis patients had a significantly worse GLS than healthy controls (18.99±2.81% vs 20.42±1.33%; P=.015). We also observed that third of the RA patients had subclinical left ventricular systolic dysfunction.In our report 36% of RA patients were anemic. In our univariate analysis anemia was found to be significantly correlated with GLS (r=−0.368, P=.027) and hemoglobin was found to be the best predictor of subclinical LVSD in our ROC curve analysis (AUC=0.752, 95% CI: 0.577-0.927, P=.02). In our multivariate analysis anemia was the only factor that was independently related to subclinical LVSD (OR: 11.39, 95% CI: 1.57-82.89, P=.016).Figure 1.ROC curve analysis for Hemoglobin as a predictor of subclinical left ventricular systolic dysfunctionConclusion:To our knowledge, this is the first study to look into the relationship between GLS and anemia among RA patients, and now it is safe to say that anemia is yet another added burden on the myocardial function in RA patients that needs to be taken into account when discussing therapeutic action.References:[1]Zhou Q, Shen J, Liu Y, Luo R, Tan B, Li G. Assessment of left ventricular systolic function in patients with iron deficiency anemia by three-dimensional speckle-tracking echocardiography. Anatol J Cardiol. 2017;18(3):194–9.Disclosure of Interests:None declared

Prevalence and Factors Associated with Subclinical Left Ventricular Systolic Dysfunction Evaluated by Mid-Wall Mechanics in Rheumatoid Arthritis

2016 ◽  
Vol 33 (9) ◽  
pp. 1290-1299 ◽  
Author(s):  
Giovanni Cioffi ◽  
Ombretta Viapiana ◽  
Federica Ognibeni ◽  
Elena Fracassi ◽  
Alessandro Giollo ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Left Ventricular Systolic Dysfunction ◽  
Systolic Dysfunction ◽  
Left Ventricular ◽  
Ventricular Systolic Dysfunction ◽  
Factors Associated

scholarly journals Left ventricular systolic dysfunction associated with pulmonary hypertension riociguat trial (LEPHT): rationale and design

2012 ◽  
Vol 14 (8) ◽  
pp. 946-953 ◽  
Author(s):  
Stefano Ghio ◽  
Diana Bonderman ◽  
Stephan B. Felix ◽  
Hossein A. Ghofrani ◽  
Evangelos D. Michelakis ◽  
...  
Keyword(s):  
Pulmonary Hypertension ◽  
Left Ventricular Systolic Dysfunction ◽  
Systolic Dysfunction ◽  
Left Ventricular ◽  
Ventricular Systolic Dysfunction
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