Acinar Cystic Transformation of the Pancreas: A Diagnostic Problem

Acinar cystic transformation (ACT) or acinar cell cystadenoma is a rare benign tumor of the pancreas. Their clinical presentation is nonspecific, thus hampering their detection and frequently leading to misdiagnosis. In this report, we present a case of ACT of the pancreas in a 54-year-old man that was vague abdominal symptoms. A magnetic resonance imaging was shown a well-defined cystic mass located in the head of the pancreas, measuring 57×47×23 mm. Our patient was treated by pancreaticoduodenectomy. In the macroscopic examination of the mass, a multicystic lesion was found in cream-colored pancreatic tissue. Histological and immunohistochemical studies examination revealed a cystic mass containing multiple cysts at varying sizes, lined by epithelial cells without atypia and positive staining of CK7, CK8/18, and CK19. A high index of clinical suspicion is required to diagnose this tumor. The surgical approach is to ensure accurate diagnosis and to avoid complications

Download Full-text

Mesectodermal Leiomyoma of the Ciliary Body: A Unique Variant of Leiomyoma with Myogenic and Neurogenic Histological Features

International Journal of Surgical Pathology ◽

10.1177/10668969211038694 ◽

2021 ◽

pp. 106689692110386

Author(s):

Osamu Inamori ◽

Hideki Fukuoka ◽

Michiko Nagamine ◽

Chie Sotozono ◽

Eiichi Konishi

Keyword(s):

Malignant Melanoma ◽

Ciliary Body ◽

Benign Tumor ◽

Frozen Section ◽

Smooth Muscle Actin ◽

Japanese Woman ◽

Reproductive Age ◽

Positive Staining ◽

Rare Benign Tumor ◽

Slow Growing

Mesectodermal leiomyoma of the ciliary body is a rare benign tumor, showing both neurogenic and myogenic characteristics. This tumor typically shows predilection for women of reproductive age. Because it is almost impossible to clinically distinguish this tumor from malignant melanoma, unnecessary eye enucleations have been unfortunately performed. Herein, we report a case of mesectodermal leiomyoma of the ciliary body in a young Japanese woman. She was referred to our hospital due to a slow-growing mass in her left iris. A malignant tumor could not be clinically ruled out and surgery with intraoperative pathology consultation was performed. Intraoperative frozen section diagnosis was a benign tumor with neurogenic features, and a simple excision of the tumor was performed. Histologically, the tumor was composed of diffuse growth of spindle cells with fibrillary indistinctive cytoplasm. Immunohistochemical examination showed diffuse positive staining of α-smooth muscle actin, h-caldesmon, calponin, and CD56. Scattered tumor cells were weakly positive for desmin. Neither melanocytic markers nor neural markers except for CD56 were positive. We diagnosed this tumor as mesectodermal leiomyoma. Mesectodermal leiomyoma is rare and often misdiagnosed as malignant melanoma. To avoid overtreatment, a correct preoperative diagnosis is essential.

Download Full-text

A Misdiagnosis of a Huge Lung Fibroleiomyomatous Hamartoma in Pleural Cavity

10.21203/rs.3.rs-146998/v1 ◽

2021 ◽

Author(s):

Minghui Liu ◽

Xin Li ◽

Hongbing Zhang ◽

Fan Ren ◽

Ming Dong ◽

...

Keyword(s):

Benign Tumor ◽

Pleural Cavity ◽

Good Prognosis ◽

Positive Staining ◽

Case Presentation ◽

Napsin A ◽

Mediastinal Germ Cell Tumor ◽

S 100 ◽

Rare Benign Tumor ◽

Percutaneous Lung Biopsy

Abstract Backgroud: Lung fibroleiomyomatous hamartoma is an extremely rare benign tumor in lung, it belongs to hamartoma. There were only five patients with solitary pulmonary fibroleiomyomatous hamartoma reported in literatures and our case has the largest size of the tumor from lung.Case presentation: Our case is a 36-year woman with a huge mass in pleural cavity. She was once misdiagnosed mediastinal germ cell tumor with pleural effusion through percutaneous lung biopsy in other hospital. After traditional thoracotomy, a huge size of 22 x 18 x 5.5 cm mass was completely dissected and a diagnosis of pulmonary fibroleiomyomatous hamartoma was given by pathology combined with immunohistochemical staining, which showed the positive staining of SMA, Desmin, CD34, BCL2, TTF1, Napsin A, and CK7, and the negative staining of S-100 and Calretinin. The patient recovered well with 40 months following up without recurrence.Conclusions:In our case, we had reported the largest size of lung fibroleiomyomatous hamartoma. The treatment of fibroleiomyomatous hamartoma is completely resected it and have a good prognosis.

Download Full-text

Adrenal myelolipoma: a case report

BIRDEM Medical Journal ◽

10.3329/birdem.v11i3.55226 ◽

2021 ◽

Vol 11 (3) ◽

pp. 231-234

Author(s):

Mohammad Sowkat Hossain ◽

SM Mahbubul Alam ◽

Sk Md Jaynul Islam ◽

Shamoli Yasmin

Keyword(s):

Benign Tumor ◽

Adrenal Tumor ◽

Clinical Presentation ◽

Hormone Secretion ◽

Final Diagnosis ◽

Fatty Tissue ◽

Adrenal Myelolipoma ◽

Abdominal Symptoms ◽

Adrenocortical Adenomas ◽

Rare Benign Tumor

Myelolipoma is a relatively rare benign tumor of adrenal gland. Most cases are non-functioning and asymptomatic and usually discovered during various diagnostic-imaging procedures performed for other diseases of abdomen. Cases associated with excessive hormone secretion have been reported which may constitute adrenocortical adenomas with associated myelolipomatous components. Histopathological findings are very interesting and the tumor is composed of bone marrow elements with various amounts of fatty tissue. The fat component in myelolipoma can facilitate the diagnosis by radiological examination. Here, we report a case of adrenal myelolipoma and its clinical presentation and evaluation. In this case, initially the patient presented with nonspecific abdominal symptoms. Her adrenal tumor was found incidentally and the final diagnosis was proved by histopathology. BIRDEM Med J 2021; 11(3): 231-234

Download Full-text

Serous microcystic adenoma of the head of the pancreas causing an obstructive jaundice

Vojnosanitetski pregled ◽

10.2298/vsp0811839c ◽

2008 ◽

Vol 65 (11) ◽

pp. 839-842 ◽

Cited By ~ 2

Author(s):

Radoje Colovic ◽

Nikica Grubor ◽

Marjan Micev ◽

Vitomir Rankovic ◽

Slavko Matic ◽

...

Keyword(s):

Obstructive Jaundice ◽

Complete Recovery ◽

Postoperative Recovery ◽

Venous Stasis ◽

Abdominal Symptoms ◽

Microcystic Adenoma ◽

Whipple’S Procedure ◽

Rare Benign Tumor ◽

Distal Pancreas ◽

Head Of The Pancreas

Background. Serous microcystic adenoma is a rare benign tumor of the exocrine pancreas originating from the ductal system and composed of a large number of small cysts covered by cuboid cells, filled with clear serous fluid and separated with fibrocolagenous stroma. Most frequently it appears in women in 7th and 8th decades, in the distal pancreas. It shows a very low malignant potential. In 2/3 of patients symptoms are uncharacteristic and in 1/3 they are absent. When localized within the head of the pancreas it rarely causes an obstructive jaundice. Case report. We presented a 61-year-old female patient who for months had had mild and nonspecific abdominal symptoms developing to progressive obstructive jaundice. At surgery we revealed a rather large policystic mass of the head of the pancreas causing not only obstructive jaundice but also a venous stasis by compression and dislocation of the portomesenteric vein. The tumor was removed with pylorus preserving cephalic duodenopancreatectomy (Whipple's procedure modified by Longmire-Traverso). Histology confirmed serous microcystic adenoma of the pancreas. The postoperative recovery was uneventful and preoperative symptoms disappeared. Conclusion. Although very rare, serous microcystic adenoma might appear within the head of the pancreas and has to be taken into consideration in differential diagnosis of cystic lesions of the head of the pancreas. Very rarely the tumour might cause obstructive jaundice. Surgical resection, which might be demanding, leads to complete recovery.

Download Full-text

An Invasive Hemolymphangioma of the Pancreas in a Young Woman

Combinatorial Chemistry & High Throughput Screening ◽

10.2174/1386207322666190103110747 ◽

2019 ◽

Vol 21 (10) ◽

pp. 798-800 ◽

Cited By ~ 1

Author(s):

Zhijun Zhang ◽

Qinghong Ke ◽

Weiliang Xia ◽

Xiuming Zhang ◽

Yan Shen ◽

...

Keyword(s):

Computed Tomography ◽

Case Report ◽

Young Woman ◽

Benign Tumor ◽

Abdominal Distension ◽

Accurate Diagnosis ◽

Cystic Tumor ◽

Rare Benign Tumor ◽

Radical Surgical Resection

Background: Hemolymphangioma is a rare benign tumor. To the best of our knowledge, there were only 10 reports of this tumor of the pancreas until March 2018. Case Report: Here, we reported a large invasive hemolymphangioma of the pancreas in a young woman with a complaint of abdominal distension and an epigastric mass about 3 weeks. She was found to have a huge multilocular cystic tumor at the neck and body of pancreas on computed tomography. She was eventually diagnosed with hemolymphangioma of the pancreas after operation. After 2 years of follow-up, there was no signs of recurrence. Conclusion: From our case and literature, we can conclude that hemolymphangioma of the pancreas is uncommon benign tumor, and it is hard to make an accurate diagnosis preoperatively. Radical surgical resection should be performed whenever possible. The prognosis of this disease seems good.

Download Full-text

Testicular fibroma: A case report

Archive of oncology ◽

10.2298/aoo1304139s ◽

2013 ◽

Vol 21 (3-4) ◽

pp. 139-140

Author(s):

Sunita Shere ◽

Anjali Kulkarni ◽

Shubhjyoti Pore ◽

Rajan Bindu

Keyword(s):

Case Report ◽

Benign Tumor ◽

Histopathological Diagnosis ◽

Testicular Mass ◽

Rare Benign Tumor ◽

Testicular Malignancy ◽

Slow Growing

Testicular fibroma of gonadal stromal origin is a rare benign tumor of testis, which usually presents as a slow growing testicular mass. Intratesticular fibroma of gonadal stromal origin, with or without minor sex cord elements, must be considered, analogous to similar tumors in ovary, as a benign tumor. Until now, only 25 cases of testicular fibroma have been reported in the literature. We reported a case of testicular fibroma in a 20 years male who presented with painless right testicular enlargement since two years. Ultrasonography (USG) showed heterogeneous mass in right scrotum suggestive of testicular malignancy. Right orchidectomy was done. Histopathological diagnosis was testicular fibroma, which was confirmed by immunohistochemistry.

Download Full-text

Unusual Tissue – Unusual Issue: Pancreatic Heterotopia Presenting as Gastric Outlet Obstruction

Case Reports in Gastroenterology ◽

10.1159/000512427 ◽

2021 ◽

pp. 338-343

Author(s):

Thu L. Nguyen ◽

Shivani Kapur ◽

Stephen C. Schlack-Haerer ◽

Grzegorz T. Gurda ◽

Milan E. Folkers

Keyword(s):

Gastric Outlet Obstruction ◽

Epigastric Pain ◽

Outlet Obstruction ◽

Needle Aspiration ◽

Pancreatic Tissue ◽

Cystic Mass ◽

Pancreatic Heterotopia ◽

History Of

Pancreatic heterotopia (PH) is a common, but typically small (<1 cm), incidental and asymptomatic finding; however, PH should be considered even for large and symptomatic upper gastrointestinal masses. A 27-year-old white woman presented with a 3-week history of burning epigastric pain, nausea, early satiety, and constipation. Physical examination revealed epigastric and right upper quadrant tenderness with normal laboratory workup, but imaging revealed a 5-cm, partly cystic mass arising from the gastric antrum with resulting pyloric stenosis and partial gastric outlet obstruction. Endoscopic ultrasound-guided fine needle aspiration revealed PH – an anomalous pancreatic tissue lying in a nonphysiological site. The patient ultimately underwent a resection and recovered uneventfully, with a complete pathologic examination revealing normal exocrine pancreatic tissue (PH type 2) without malignant transformation. We report a case of heterotopic pancreas manifesting as severe gastric outlet obstruction, in addition to a thorough diagnostic workup and surgical follow-up, in a young adult. Differential diagnoses and features that speak to benignity of a large, symptomatic mass lesion (PH in particular) are discussed.

Download Full-text

Management of Basal Cell Adenoma of Accessory Parotid Gland Through Transoral Approach: Report of a Rare Case With Review

Craniomaxillofacial Trauma & Reconstruction Open ◽

10.1177/24727512211030839 ◽

2021 ◽

Vol 6 ◽

pp. 247275122110308

Author(s):

Charudatta Naik ◽

Sanjay Joshi ◽

Bhupendra Mhatre ◽

Sneha Punamiya

Keyword(s):

Parotid Gland ◽

Basal Cell ◽

Benign Tumor ◽

Transoral Approach ◽

Surgical Approaches ◽

Basal Cell Adenoma ◽

Diagnostic Dilemma ◽

Cell Adenoma ◽

Rare Benign Tumor ◽

Accessory Parotid Gland

Diagnosis of mid-cheek mass has always been a diagnostic dilemma for clinicians. The incidence of the accessory parotid gland (APG) has been well documented in the literature. However, a diverse spectrum of pathologies can arise from this accessory parotid tissue. Basal cell adenoma is a rare benign tumor that predominantly affects the parotid gland. Its occurrence in the accessory parotid gland has been documented in 9 cases till date. Surgical approaches for the management of such APG lesions have been in debate. This report documents a case of Basal Cell Adenoma arising in accessory parotid tissue in a 55-year-old woman who was treated by transoral excision. This paper also reviews previously documented cases of all APG lesions and attempts to elucidate the rationale for selecting an appropriate surgical approach.

Download Full-text

Robotic, totally endoscopic excision of mitral valve papillary fibroelastoma

10.1510/mmcts.2021.045 ◽

2021 ◽

Keyword(s):

Mitral Valve ◽

Aortic Valve ◽

Tricuspid Valve ◽

Benign Tumor ◽

Pulmonary Valve ◽

Papillary Fibroelastoma ◽

Robotic Assisted ◽

Endoscopic Excision ◽

Rare Benign Tumor ◽

Sixth Decade

Papillary fibroelastoma is a rare, benign tumor that affects males more frequently than females and that tends to be diagnosed during the fifth or sixth decade of life. It tends to arise on cardiac valves, with the aortic valve being the most frequent location followed by the mitral valve, the tricuspid valve, and the pulmonary valve. We present the case of a robotic-assisted, totally endoscopic excision of a mitral valve papillary fibroelastoma.

Download Full-text