Mesectodermal Leiomyoma of the Ciliary Body: A Unique Variant of Leiomyoma with Myogenic and Neurogenic Histological Features

2021 ◽  
pp. 106689692110386
Author(s):  
Osamu Inamori ◽  
Hideki Fukuoka ◽  
Michiko Nagamine ◽  
Chie Sotozono ◽  
Eiichi Konishi
Keyword(s):  
Malignant Melanoma ◽  
Ciliary Body ◽  
Benign Tumor ◽  
Frozen Section ◽  
Smooth Muscle Actin ◽  
Japanese Woman ◽  
Reproductive Age ◽  
Positive Staining ◽  
Rare Benign Tumor ◽  
Slow Growing

Mesectodermal leiomyoma of the ciliary body is a rare benign tumor, showing both neurogenic and myogenic characteristics. This tumor typically shows predilection for women of reproductive age. Because it is almost impossible to clinically distinguish this tumor from malignant melanoma, unnecessary eye enucleations have been unfortunately performed. Herein, we report a case of mesectodermal leiomyoma of the ciliary body in a young Japanese woman. She was referred to our hospital due to a slow-growing mass in her left iris. A malignant tumor could not be clinically ruled out and surgery with intraoperative pathology consultation was performed. Intraoperative frozen section diagnosis was a benign tumor with neurogenic features, and a simple excision of the tumor was performed. Histologically, the tumor was composed of diffuse growth of spindle cells with fibrillary indistinctive cytoplasm. Immunohistochemical examination showed diffuse positive staining of α-smooth muscle actin, h-caldesmon, calponin, and CD56. Scattered tumor cells were weakly positive for desmin. Neither melanocytic markers nor neural markers except for CD56 were positive. We diagnosed this tumor as mesectodermal leiomyoma. Mesectodermal leiomyoma is rare and often misdiagnosed as malignant melanoma. To avoid overtreatment, a correct preoperative diagnosis is essential.

Testicular fibroma: A case report

2013 ◽  
Vol 21 (3-4) ◽  
pp. 139-140
Author(s):  
Sunita Shere ◽  
Anjali Kulkarni ◽  
Shubhjyoti Pore ◽  
Rajan Bindu
Keyword(s):  
Case Report ◽  
Benign Tumor ◽  
Histopathological Diagnosis ◽  
Testicular Mass ◽  
Rare Benign Tumor ◽  
Testicular Malignancy ◽  
Slow Growing

Testicular fibroma of gonadal stromal origin is a rare benign tumor of testis, which usually presents as a slow growing testicular mass. Intratesticular fibroma of gonadal stromal origin, with or without minor sex cord elements, must be considered, analogous to similar tumors in ovary, as a benign tumor. Until now, only 25 cases of testicular fibroma have been reported in the literature. We reported a case of testicular fibroma in a 20 years male who presented with painless right testicular enlargement since two years. Ultrasonography (USG) showed heterogeneous mass in right scrotum suggestive of testicular malignancy. Right orchidectomy was done. Histopathological diagnosis was testicular fibroma, which was confirmed by immunohistochemistry.

scholarly journals Renal Hemangioblastoma with Mixed Mullerian tumor of endometrium: A tale of two rare primary tumors

2020 ◽  
Author(s):  
Aparna Setia ◽  
Devender Kumar ◽  
Lovenish Bains ◽  
Pallavi Sharma ◽  
Anjali Tempe ◽  
...  
Keyword(s):  
Endometrial Cancer ◽  
Renal Mass ◽  
Benign Tumor ◽  
Frozen Section ◽  
Rare Entity ◽  
Primary Tumors ◽  
Rare Benign Tumor ◽  
Mixed Müllerian Tumor ◽  
Mixed Mullerian Tumor ◽  
Mullerian Tumor

Abstract Introduction: Renal hemangioblastoma (RH) is a very rare benign tumor. Hemangioblastoma most commonly occur in the central nervous system (CNS) and only few cases of RH have been reported as they occur most commonly as asymptomatic masses found incidentally. Mixed Mullerian Tumor (MMT) of the uterus is a rarer and aggressive form of uterine malignancy. The detection of two primary rare tumors incidentally is a rare entity. Case presentation: A 50 years female presented with abnormal uterine bleeding which on endometrial sampling was diagnosed as a rare variety of endometrial cancer i.e., MMT or uterine carcinosarcoma. On preoperative imaging, a renal mass was also detected which was highly vascular and was mimicking Renal Cell Carcinoma (RCC). Fine needle aspiration cytology (FNAC) was done from the renal mass to differentiate between RCC and metastasis but it showed only blood cells. Patient underwent staging laparotomy for endometrial cancer and frozen section examination of the renal mass which was inconclusive with few atypical cells and thus patient underwent radical nephrectomy too. Histopathological examination revealed it to be a RH which is a very rare benign tumor. Discussion: RH is a rare benign tumor which doesn’t require any treatment in majority of the patients. Only 26 cases of RH outside the CNS have been reported till date. MMT is a rare aggressive uterine tumor with an incidence of 1-2 % of all uterine neoplasms, which metastasizes early and thus early identification and treatment is the key. RH needs to be differentiated from RCC to avoid over treatment. Morphological findings are similar in both, preoperative FNAC, PET scan and intraoperative frozen section can be utilized to differentiate in between two in well circumcised tumors and in high suspicion. Occurrence of renal mass as an incidental finding in the preoperative work up of uterine malignancy directed us to the differentials of metastasis or another histologically distinct primary tumor. The presence of two rare primary tumors i.e., RH and MMT in the same patient which are unrelated is a rare entity.

scholarly journals Renal Hemangioblastoma with Mixed Mullerian tumor of endometrium: A tale of two rare primary tumors

2020 ◽  
Author(s):  
Aparna Setia ◽  
Devender Kumar ◽  
Lovenish Bains ◽  
Pallavi Sharma ◽  
Anjali Tempe ◽  
...  
Keyword(s):  
Endometrial Cancer ◽  
Renal Mass ◽  
Benign Tumor ◽  
Frozen Section ◽  
Rare Entity ◽  
Primary Tumors ◽  
Rare Benign Tumor ◽  
Mixed Müllerian Tumor ◽  
Mixed Mullerian Tumor ◽  
Mullerian Tumor

Abstract Introduction Renal hemangioblastoma (RH) is a very rare benign tumor. Hemangioblastoma most commonly occur in the central nervous system (CNS) and only few cases of RH have been reported in literature. They occur most commonly as asymptomatic masses found incidentally. Mixed Mullerian Tumor (MMT) of the uterus is a rarer and aggressive form of uterine malignancy. The detection of two primary rare tumors incidentally is a rare entity. Case presentation A 50 years female patient presented with abnormal uterine bleeding which on endometrial sampling was diagnosed as a rare variety of endometrial cancer i.e., MMT or uterine carcinosarcoma. On preoperative Magnetic resonance imaging (MRI), a renal mass was also detected which was highly vascular and was mimicking Renal Cell Carcinoma (RCC). Fine needle aspiration cytology (FNAC) was done from the renal mass to differentiate between RCC and metastasis but it showed only blood cells. Patient underwent staging laparotomy for endometrial cancer and frozen section examination of the renal mass. Frozen section report was inconclusive with few atypical cells and thus patient underwent radical nephrectomy too. Histopathological examination revealed it to be a RH which is a very rare benign tumor. Discussion Only 14 cases of RH outside the CNS have been reported till date. Occurrence of renal mass as an incidental finding in the preoperative work up of uterine malignancy directed us to the differentials of metastasis or another histologically distinct primary tumor. RH may mimic RCC radiologically. To correctly diagnose RH is important because sporadic RH does not require further treatment and the prognosis is much better than that of RCC. MMT which compromise 1-2% of all uterine neoplasms have higher chance of metastasis than endometroid variety. Conclusion Renal hemangioblastoma is a rare benign tumor which doesn’t require any treatment in majority of the patients. Mixed Mullerian tumor is a rare aggressive uterine tumor which metastasizes early, henceforth early identification and treatment is the key. RH needs to be differentiated from RCC to avoid over treatment. Morphological findings are similar in both, preoperative FNAC, PET scan and intraoperative frozen section can be utilized to differentiate in between two in well circumcised tumors and in high suspicion. The presence of two rare primary tumors i.e., RH and MMT in the same patient which are unrelated is a rare entity.

scholarly journals A Misdiagnosis of a Huge Lung Fibroleiomyomatous Hamartoma in Pleural Cavity

2021 ◽  
Author(s):  
Minghui Liu ◽  
Xin Li ◽  
Hongbing Zhang ◽  
Fan Ren ◽  
Ming Dong ◽  
...  
Keyword(s):  
Benign Tumor ◽  
Pleural Cavity ◽  
Good Prognosis ◽  
Positive Staining ◽  
Case Presentation ◽  
Napsin A ◽  
Mediastinal Germ Cell Tumor ◽  
S 100 ◽  
Rare Benign Tumor ◽  
Percutaneous Lung Biopsy

Abstract Backgroud: Lung fibroleiomyomatous hamartoma is an extremely rare benign tumor in lung, it belongs to hamartoma. There were only five patients with solitary pulmonary fibroleiomyomatous hamartoma reported in literatures and our case has the largest size of the tumor from lung.Case presentation: Our case is a 36-year woman with a huge mass in pleural cavity. She was once misdiagnosed mediastinal germ cell tumor with pleural effusion through percutaneous lung biopsy in other hospital. After traditional thoracotomy, a huge size of 22 x 18 x 5.5 cm mass was completely dissected and a diagnosis of pulmonary fibroleiomyomatous hamartoma was given by pathology combined with immunohistochemical staining, which showed the positive staining of SMA, Desmin, CD34, BCL2, TTF1, Napsin A, and CK7, and the negative staining of S-100 and Calretinin. The patient recovered well with 40 months following up without recurrence.Conclusions:In our case, we had reported the largest size of lung fibroleiomyomatous hamartoma. The treatment of fibroleiomyomatous hamartoma is completely resected it and have a good prognosis.

Corpora amylacea in gastrointestinal leiomyomas: a clinical, light microscopic, ultrastructural and immunohistochemical study with comparison to hyaline globules

2013 ◽  
Vol 66 (11) ◽  
pp. 951-955 ◽  
Author(s):  
Jaclyn Frances Hechtman ◽  
Ronald E Gordon ◽  
Russell B McBride ◽  
Noam Harpaz
Keyword(s):  
Smooth Muscle ◽  
Alcian Blue ◽  
Frozen Section ◽  
Smooth Muscle Actin ◽  
Periodic Acid ◽  
Consecutive Series ◽  
Positive Staining ◽  
Corpora Amylacea ◽  
Small Intestinal ◽  
Hyaline Globules

ContextCorpora amylacea (CA) are inclusions with starch-like composition that occur in various conditions. We have observed CA in gastrointestinal leiomyomas (GILM) and hypothesised that they differ from intracytoplasmic hyaline globules (HG) of GILM. We aimed to investigate the anatomical distribution, prevalence, staining characteristics and ultrastructural features of CA and compare them with HG of GILM.DesignSlides from a consecutive series of resected GILM and bland spindle cell tumours were examined for CA and HG. Special stains, electron microscopy and elemental analysis were performed on select leiomyomas.ResultsCA occurred in 13/35 GILM (37%) from the following sites: oesophagus (4/8), stomach (5/7) including one frozen section, small intestine (1/2) and large intestine (3/18), but were not identified in 19 gastrointestinal stromal tumours (12 gastric, 7 small intestinal; p=0.0019), five schwannomas (three gastric, two small intestinal; p=0.154) and 35 non-GILM (p=0.0001). The densities of CA ranged from one per 4–200 mm2. CA stained intensely with periodic acid Schiff after diastase predigestion (PASD), Alcian blue and ubiquitin, and faintly in peripheral zones for desmin and smooth muscle actin. Ultrastructurally, CA consisted of an electron-dense outer layer and a fibrillar core with scattered particle matter. HG were present in all leiomyomas, but showed variable staining for PASD, negative staining for Alcian blue and ubiquitin, and positive staining for smooth muscle markers.ConclusionsCA are a distinctive histological feature of approximately one third of GILM with different composition to HG. These differences may represent divergent degenerative processes or different stages of a single degenerative process over time.

scholarly journals Slow-growing amelanotic malignant melanoma of the esophagus with long survival: a case report and review of the literature

2017 ◽  
Vol 05 (11) ◽  
pp. E1076-E1080 ◽  
Author(s):  
Yutaka Hirayama ◽  
Tajika Masahiro ◽  
Tsutomu Tanaka ◽  
Makoto Ishihara ◽  
Sachiyo Ohnishi ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Malignant Melanoma ◽  
Gastric Tube ◽  
Submucosal Tumor ◽  
Japanese Woman ◽  
Review Of The Literature ◽  
Thoracoscopic Resection ◽  
Amelanotic Malignant Melanoma ◽  
Old Japanese ◽  
Slow Growing

Abstract Background and study aims We report a case of amelanotic malignant melanoma of the esophagus (AMME), an exceedingly rare disease. A 77-year-old Japanese woman presented to our hospital with features suggestive of a middle esophageal submucosal tumor, which was diagnosed pathologically as AMME. The patient underwent thoracoscopic resection of the esophagus and laparoscopic gastric tube reconstruction. Three years after surgery, computed tomography showed no recurrence. Generally, the prognosis of malignant melanoma of the esophagus is very poor. However, our patient had no recurrence, and is alive 3 years after surgery and 5 years after the tumor was first detected.

scholarly journals Acinar Cystic Transformation of the Pancreas: A Diagnostic Problem

2020 ◽  
Author(s):  
Mehmet Yildirim ◽  
Asuman Argon ◽  
Sedat Tan ◽  
Ahmet Cekic
Keyword(s):  
Benign Tumor ◽  
Pancreatic Tissue ◽  
Cystic Mass ◽  
Positive Staining ◽  
Abdominal Symptoms ◽  
Rare Benign Tumor ◽  
Head Of The Pancreas ◽  
Immunohistochemical Studies ◽  
Multiple Cysts ◽  
Macroscopic Examination

Acinar cystic transformation (ACT) or acinar cell cystadenoma is a rare benign tumor of the pancreas. Their clinical presentation is nonspecific, thus hampering their detection and frequently leading to misdiagnosis. In this report, we present a case of ACT of the pancreas in a 54-year-old man that was vague abdominal symptoms. A magnetic resonance imaging was shown a well-defined cystic mass located in the head of the pancreas, measuring 57×47×23 mm. Our patient was treated by pancreaticoduodenectomy. In the macroscopic examination of the mass, a multicystic lesion was found in cream-colored pancreatic tissue. Histological and immunohistochemical studies examination revealed a cystic mass containing multiple cysts at varying sizes, lined by epithelial cells without atypia and positive staining of CK7, CK8/18, and CK19. A high index of clinical suspicion is required to diagnose this tumor. The surgical approach is to ensure accurate diagnosis and to avoid complications

Uterine Hemangioma: A Rare Pathologic Entity

2012 ◽  
Vol 136 (5) ◽  
pp. 567-571 ◽  
Author(s):  
Wan-Yi Chou ◽  
Hui-Wen Chang
Keyword(s):  
Benign Tumor ◽  
Reproductive Age ◽  
Hereditary Diseases ◽  
Adenomatoid Tumor ◽  
Vaginal Examination ◽  
Total Hysterectomy ◽  
Reproductive Age Women ◽  
Rare Benign Tumor ◽  
Uterine Curettage ◽  
Physical Changes

Uterine hemangioma is a rare benign tumor usually presenting with menorrhagia or pregnancy-associated complications. Although the current literature identifies fewer than 50 cases, we in our institution identified 5 similar cases among 3700 patients undergoing total hysterectomy from January 2006 to December 2010. Adenomyosis was the most common preoperative diagnosis among our patients. Vaginal examination, uterine curettage specimens, ultrasonography, and hysterography are usually uninformative, and the definitive diagnosis relies on the final histologic examination. The differential diagnosis includes adenomatoid tumor, lymphangioma, and arteriovenous malformation. Uterine hemangiomas are classified into congenital and acquired. The former is believed to be associated with some hereditary diseases, while the latter is associated with both physical changes and hormone alteration, especially high estrogen level. The best treatment for hemangiomas is unclear. However, it is very important to obtain an accurate diagnosis to prevent overtreatment among reproductive-age women. The prognosis is excellent after hysterectomy.

Actin and α-tubulin immuno-EM labelings reveal differences in intra versus interphotoreceptor matrix

1990 ◽  
Vol 48 (3) ◽  
pp. 466-467
Author(s):  
Matti Järvilehto ◽  
Riitta Harjula
Keyword(s):  
Compound Eye ◽  
Frozen Section ◽  
Smooth Muscle Actin ◽  
Photoreceptor Cells ◽  
Immune Serum ◽  
Cell Organelles ◽  
Calliphora Erythrocephala ◽  
Optical Axes ◽  
Interphotoreceptor Matrix ◽  
Similar Kind

The photoreceptor cells in the compound eyes of higher diptera are clustered in groups (ommatidia) of eight receptor cells. The cells from six adjacent ommatidia are organized into optical units, neuro-ommatia sharing the same visual field. In those ommatidia the optical axes of the photopigment containing structures (rhabdomeres) are parallel. The rhabdomeres of the photoreceptor cells are separated from each other by an interstitial i.e innerommatidial space (IOS). In the photoreceptor cell body, besides of the normal cell organelles, a cellular matrix is a structurally apparent component. Similar kind of reticular formation is also found in the IOS containing some unidentified filamentary substance, of which composition and functional significance for optical properties of vision is the aim of this report.The prefixed (2% PA + 0.2% GA in 0.1-n phosphate buffer, pH 7.4, for 1h), frozen section blocks of the compound eye of the blowfly (Calliphora erythrocephala) were prepared by immuno-cryo-techniques. The ultrathin cryosections were incubated with antibodies of monoclonal α-tubulin and polyclonal smooth muscle actin. Control labelings of excess of antigen, non-immune serum and non-present antibody were perforated.

Clinical and sonological features in endometriomas in women of reproductive age

2016 ◽  
pp. 85-89
Author(s):  
О. Shapoval ◽  
Keyword(s):  
Endometrial Hyperplasia ◽  
Benign Tumor ◽  
Pain Syndrome ◽  
Reproductive Age ◽  
Control Group ◽  
Women Of Reproductive Age ◽  
Ovarian Endometriosis ◽  
Gynecological Examination ◽  
Different Characteristics ◽  
Ovarian Endometriomas

The objective: to study the prevalence of ovarian endometriosis in women of reproductive age, the features of clinical and ultrasound picture of endometriosis. Patients and methods. The study involved 22 patients with endometriomas, the control group – 50 women gynecological and somatically healthy. Results. The incidence of ovarian endometriomas in the structure of benign tumor-like formations of ovaries is 0.62%. In 72.73% of ovarian endometriomas occur on a background of concomitant gynecological pathology. Clinically, in 77.27% of cases there is a pain syndrome, in 59.09% – algomenorrhea, in 13.64% – infertility; 18.18% of cases endometriomas remain «dumb» and proceed with the erased clinical picture. Sonologically in patients with endometriomas adenomyosis, endometrial hyperplasia, changes in the contralateral ovary are determined. Conclusion. Without additional methods of diagnostic gynecological examination may identify the 3 cm tumor-like formation of the ovary with different characteristics, which does not allow to differentiate endometrioma from inflammation, functional and ovarian tumors. Ultrasound can diagnose pathological ovarian formation of 1 cm, detailing the nature of the cyst. Key words: endometriosis, reproductive age, retrospective analysis, ultrasound.

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