scholarly journals Comparing the Effectiveness of Doing Intra-uterine Insemination 36 and 42 Hours after Human Chorionic Gonadotropin (HCG) Injection on Pregnancy Rate: A Randomized Clinical Trial

2020 ◽  
Author(s):  
Mahboubeh Firouz ◽  
Narjes Noori ◽  
Marzieh Ghasemi ◽  
Alireza Dashipour ◽  
Narjes Keikha
Keyword(s):  
Clinical Trial ◽  
Chorionic Gonadotropin ◽  
Human Chorionic Gonadotropin ◽  
Intrauterine Insemination ◽  
Uterine Cavity ◽  
Female Reproductive Tract ◽  
Control Group ◽  
Case Group ◽  
Significant Difference ◽  
Intra Uterine Insemination

Objective: Intrauterine insemination (IUI) is an assisted conception technique that involves the deposition of a processed semen sample in the upper uterine cavity, overcoming natural barriers to sperm ascent in the female reproductive tract. Hence, we compared the results of doing intra-uterine insemination 36 and 42 hours after human chorionic gonadotropin (hCG) hormone injection to achieve clinical and chemical pregnancy rates. Materials and methods: One hundred and sixty infertile women with unexplained infertility participated in this clinical trial. They were divided into two groups: those who underwent IUI 36 hours after hCG injection (control group), and those who underwent IUI 42 hours after hCG injection (case group). Statistical analyses were done using IBM-SPSS 25.0. and Chi-square test were used for data analysis. Results: The percentages of clinical and chemical pregnancies were significantly higher in the 42h group compared to the other group (P = 0.038 vs. P = 0.009, respectively). There was no significant difference regarding frequency of abortion, twin and ectopic pregnancies between the two groups (P > 0.05). Conclusion: Doing IUI 42 hours after hCG injection can significantly increase chances of fertility compared to doing it 36 hours after hCG injection.

scholarly journals The effect of Myo-inositol on sperm parameters and pregnancy rate in oligoasthenospermic men treated with IUI: A randomized clinical trial

2019 ◽  
Author(s):  
Afsane Ghasemi ◽  
Fatemehsadat Amjadi ◽  
Seyedeh Masoumeh Ghazi Mirsaeed ◽  
Robabeh Mohammad Beigi ◽  
Samaneh Ghasemi ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Randomized Clinical Trial ◽  
Sperm Motility ◽  
Potential Role ◽  
Intrauterine Insemination ◽  
Sperm Parameters ◽  
Control Group ◽  
Case Group ◽  
Significant Difference ◽  
Motility Of Sperm

Background: In about 40% of the couples, the cause of infertility problems is attributed to men because of low sperm production and disturbed motility of sperm. Pieces of evidence show that Myo-inositol has a potential role for the treatment of sperm morphology and male fertility. Objectives: This study aimed to determine the effect of Myo-inositol on the sperm parameters and fertility rate in patients with oligoasthenospermia treated by intrauterine insemination (IUI). Materials and Methods: This study was a randomized clinical trial conducted on 37 patients with oligoasthenospermia treated by IUI during 2016-2017. In this study, the patients were randomly divided into two groups of oligoasthenospermia treated with (Case group) and without Myo-inositol (Control group). The case group received 0.5 ml of Myo-inositol with a concentration of 2 mg/ml and incubated at 37°C incubator for 2 hr, but the control group had no interventions. Results: The results of this study showed that although there was no significant difference in sperm parameters including sperm motility and concentration before processing with Myo-inositol in the case group, but there was a significant increase in sperm motility during the treatment with Myo-inositol. The therapeutic effect of this method was confirmed on induction of pregnancy in 18% of the treated patients, in such a way that was about twice greater than those who did not receive the drug. Conclusion: According to the results of this study, the use of Myo-inositol is efficient enough to change sperm parameters to increase the chance of fertility. Key words: Myo-inositol, Pregnancy, Sperm, Motility, Oligoasthenospermic.

scholarly journals Effects of human chorionic gonadotropin intrauterine injection on oocyte retrieval day on assisted reproductive techniques outcomes: An RCT

2021 ◽  
pp. 773-780
Author(s):  
Robabe Hosseinisadat ◽  
Lida Saeed ◽  
Sareh Ashourzadeh ◽  
Sedigheh Safar Heidari ◽  
Victoria Habibzadeh
Keyword(s):  
Chorionic Gonadotropin ◽  
Human Chorionic Gonadotropin ◽  
Oocyte Retrieval ◽  
Pregnancy Rates ◽  
Clinical Pregnancy ◽  
Assisted Reproductive Techniques ◽  
Control Group ◽  
Case Group ◽  
Reproductive Techniques ◽  
Clinical Pregnancy Rates

Background: Several mediators play an important role in implantation. One of these mediators is human chorionic gonadotropin (HCG). Objective: To evaluate the effects of HCG intrauterine injection on the day of oocyte retrieval on the result of assisted reproductive techniques (ART). Materials and Methods: In this randomized clinical trial study, 126 women who were referred to Afzalipour Infertility Center between December 2018 to December 2019 undergoing in vitro fertilization/intracytoplasmic sperm injection cycles were enrolled and assigned to two groups of: a case (n = 62) and a control group (n = 64). The protocols for both groups were the same; except that the case group was injected with the protocols for both groups were the same, except that the case group was injected with 1000 IU of HCG into uterine cavity following the oocyte puncture, while no medication was administered to the control group. The implantation rate, chemical pregnancy, clinical pregnancy, and abortion rates were compared between the two groups. Results: Positive chemical pregnancy was seen in 15 (27.3%) cases of the case group and 14 (25.5%) of the control group. No significant difference was seen in the chemical and clinical pregnancy rates between the groups. The abortion rate was higher in the control group but that was not significant. Conclusion: A 1000 IU of HCG intrauterine injection after oocyte retrieval does not improve implantation, chemical or clinical pregnancy rates in ART cycles. Further studies are needed to clearly understand the role of HCG intrauterine injection in the day of oocyte retrieval in ART outcomes. Key words: Oocyte retrieval, Chorionic gonadotropin, Pregnancy, Assisted reproductive techniques.

scholarly journals The effect of topical endometrial scratching on pregnancy outcome in women with previous failure of intrauterine insemination: A non-randomized clinical trial

2021 ◽  
Author(s):  
Farahnaz Farzaneh ◽  
Farzaneh Khastehfekr
Keyword(s):  
Clinical Trial ◽  
Randomized Clinical Trial ◽  
Intrauterine Insemination ◽  
Control Group ◽  
Case Group ◽  
Male Factor ◽  
Chi Square ◽  
Endometrial Scratching ◽  
Chi Square Test ◽  
Endometrial Scratch

Background: The prevalence of infertility is increasing worldwide and the treatment is one of the important issues. Objective: This study aimed to evaluate the effect of local endometrial scratching on pregnancy outcomes in women with previous failure of intrauterine insemination. Materials and Methods: This non-randomized clinical trial study was performed on 336 women referred to the infertility clinic of Ali ebn-e Abitaleb Hospital of Zahedan (between May and November 2019). Women were divided into two groups: endometrial scratch as case and a control group. In the case group (n = 173), endometrial scratching was performed on days 8–9 of the menstrual cycle in addition to routine infertility treatments, while in the control group (n = 163), only routine treatment was performed. Chi-square test was used to compare the frequency of male factor severity and the percentage of successful pregnancies between both groups and was used to investigate the effect of male factor on the fertility rate in each group (moderate male factor and mild male factor). Results: The mean age of the women was 28.4 ± 5.2 yr. The success rate of pregnancy in the case group was 12.3% and in the control group 11%, which were not statistically significant (p = 0.697). Conclusion: Overall, the results of this study showed that endometrial scratching had no effect on the pregnancy rate. Key words: Infertility, Endometrial, Scratch, Insemination.

scholarly journals Comparison of the Effectiveness of Chelleh Daghi Herbal Ointment and Piroxicam Gel on Ankle Sprains

2020 ◽  
Vol 23 (4) ◽  
pp. 450-461
Author(s):  
Alireza Amani ◽  
◽  
Ali Kamali ◽  
Bahman Sadeghi ◽  
Ali Reza Sistani ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Statistical Tests ◽  
Joint Inflammation ◽  
Ankle Injuries ◽  
Control Group ◽  
Case Group ◽  
Therapeutic Effects ◽  
Ankle Sprains ◽  
Significant Difference ◽  
The Mean

Background and Aim: Ankle injuries are among the most common musculoskeletal injuries in sports, accounting for 10% to 15% of all injuries. Since controlling pain and inflammation in ankle sprains is one of the main goals of treatment, we decided to compare the therapeutic effects of Cheleh daghi Herbal ointment with a common therapeutic gel such as piroxicam. Methods & Materials: This study was performed as a double-blinded clinical trial for 6 months from January 2019 to August 2019. After referral, all patients completed the consent form, and the patientchr('39')s details and study variables were recorded by the evaluator in the research form. To measure joint inflammation, we measured the ankle with a meter tape in the ankle area (cm) and recorded. A goniometer was also used to measure the degree of ankle movements. The symptoms of ankle ecchymosis were also checked by physical examination and observation and recorded in the checklist. Statistical analysis was performed in SPSS V. 18 using statistical tests (the Mann-Whitney U test, the Chi-square, and the independent t-test). Ethical Considerations: The Research Ethics Committee of Arak University of Medical Sciences approved the study (Code: IR.ARAKMU.REC.1396.55) and registered by the Clinical Trial (Code: IRCT2017071720258N53). Results: The Mean±SD age in the control group was 34.2±8.6 years, and in the case group was 35.4±8.9 years. There was no statistically significant difference according to the Mann-Whitney U test (P<0.05). Also, the Mean±SD height in the control group was 1.7±0.12 m and in the case group was 1.72±0.11 m. The results also showed a statistically significant difference between the two groups studied before and after the intervention regarding the mean indicators of pain, swelling, and inflammation around the joints (P<0.05). Conclusion: The results of our study showed that Cheleh daghi Herbal ointment for 3 weeks could be more effective in reducing local pain and inflammation than piroxicam gel treatment.

scholarly journals Effectiveness of Letrozole and Human Chorionic Gonadotropin Injection in Ovulation Induction: A Cohort Study

2021 ◽  
Author(s):  
Peter Chukwudi Udealor ◽  
Eric Ezenwa Asimadu ◽  
Emeka Iloghalu
Keyword(s):  
Cohort Study ◽  
Chorionic Gonadotropin ◽  
Human Chorionic Gonadotropin ◽  
Ovulation Induction ◽  
Intrauterine Insemination ◽  
Statistical Significance ◽  
Pregnancy Rates ◽  
Significant Difference ◽  
Ovulation Stimulation ◽  
Group A

Introduction: Ovulation stimulation followed by timed intercourse or Intrauterine Insemination (IUI) is widely used for treatment of anovulatory infertility. Aim: To compare the effectiveness of Letrozole (LE) alone versus LE and human chorionic gonadotropin injection in ovulation induction and pregnancy rates in women undergoing ovulation induction/follicular tracking in Enugu, Nigeria. Materials and Methods: The longitudinal cohort study was carried out in University of Nigeria Teaching Hospital and Livingston Specialist Gynaecological Hospital in Enugu, Nigeria. Study population were women coming for ovulation stimulation/follicular tracking. Ovulation was confirmed by ultrasound evidence of ovulation with a progesterone level of greater or equal to 25 nmol/L on day 21, positive pregnancy test/ultrasound detection of a gestational sac. Patients were consecutively assigned to group A or B. Group A received LE only for the induction while group B received 10000 IU of human chorionic gonadotropin injection in addition to LE. A total of 5 mg of LE was given daily from day 3 to day 7. The primary outcome measured was the number of ruptured/crenated follicles on either arm while the secondary outcomes were the number of Luteinised Unruptured Follicles (LUF) and pregnancy rates. The Statistical analysis was performed using the Statistical Package for the Social Sciences version 21.0 software (SPSS Inc., Chicago, IL, United States). Results: A total of 50 women were in each arm of the study. There was no significant difference in age and parity between the two arms. There was no significance difference between the period of infertility and the number of the previous cycles of ovulation stimulation. (p=0.444 and 0.526, respectively). Ovulation was significantly associated with HCG injection (p=0.001). However, there was no statistical significance between both arms regarding the number of LUF (p=0.216). HCG injection was significantly associated with pregnancy. Subjects who took HCG injection were over two times more likely to become pregnant than those without HCG injection (OR=2.488, 95% CI for OR=1.057-5.857, p=0.037). Conclusion: This study showed that both the ovulation rate and pregnancy rate are significantly improved when human chorionic gonadotrophin injection is given after ovarian stimulation.

scholarly journals Comparison of 3-port with standard 4-port laparoscopic cholecystectomy: A clinical trial

2020 ◽  
pp. 52-57
Keyword(s):  
Clinical Trial ◽  
Laparoscopic Cholecystectomy ◽  
Gallstone Disease ◽  
Control Group ◽  
P Value ◽  
Case Group ◽  
Double Blind ◽  
Laparoscopic Cholecystectomy Group ◽  
Significant Difference ◽  
Duration Of Surgery

Introduction: Since the laparoscopic cholecystectomy was introduced first in 1990, the 4-port laparoscopic cholecystectomy was the gold standard. The 4-port (lateral) is used to hold gallbladder fundus and observe Calot's triangle. It is discussed that the 4-port technique is not required in many patients. Therefore, this study aimed to make a comparison between 3-port and 4-port laparoscopic cholecystectomy methods in the treatment of gallstone disease. Methods: A double-blind clinical trial was performed on patients admitted to Imam Reza Hospital, Birjand, Iran. The patients with gallstone disease (n=60) were randomly assigned into the case (3-port) and control (4-port) groups using balanced block randomization and underwent 3- or 4-port laparoscopic cholecystectomy. Postoperative pain was measured by a visual analog scale four h after surgery. The amount of pain-killer, duration of surgery, as well as length of stay and scars were measured in this study. Data were analyzed statistically in SPSS software (version 18) through the Chi-square test and t-test. A p-value less than 0.05 was considered statistically significant. Results: The groups were compared in terms of demographic characteristics. There were 24 females (80%) and 6 males (20%) in the control group and 25 females (83.4%) and 5 males (16.7%) in the case group (P=0.739). Moreover, the mean ages of the control and case groups were 59.823±7.8 and 61.10±4.7, respectively, and there was no significant difference between the groups in this regard (P=0.348). Furthermore, length of operation (P=0.001) and analgesic consumption (P=0.001) in the 3-port laparoscopic cholecystectomy group were lower than those in the 4-port group; however, the hospital stay (P=0.896) was the same in both groups. Conclusions: The 3-port laparoscopic cholecystectomy is a safe, reliable, and cost-effective method in patients who underwent laparoscopic cholecystectomy.

scholarly journals Effects of Atorvastatin in Patients with Acute Spinal Cord Injury

2017 ◽  
Vol 11 (6) ◽  
pp. 903-907 ◽  
Author(s):  
Javad Aghazadeh ◽  
Parviz Samadi Motlagh ◽  
Firooz Salehpour ◽  
Ali Meshkini ◽  
Majid Fatehi ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Surgical Therapy ◽  
Acute Spinal Cord Injury ◽  
Control Group ◽  
Case Group ◽  
Significant Difference ◽  
Cord Injury

<sec><title>Study Design</title><p>Clinical trial study.</p></sec><sec><title>Purpose</title><p>The aim of this study was to evaluate the effect of atorvastatin on sensory and motor function in patients with acute spinal cord injury.</p></sec><sec><title>Overview of Literature</title><p>The prevalence and incidence of traumatic spinal cord injury are increasing. Statins are well established for use in hypercholesterolemia as well as during anti-inflammatory events.</p></sec><sec><title>Methods</title><p>This clinical trial study included 60 patients with acute spinal cord injury. These were randomly divided into two groups: the case group which received atorvastatin and also underwent surgical therapy and the control group which only underwent surgical therapy.</p></sec><sec><title>Results</title><p>The severity of spinal cord lesions was evaluated based on the Frankel grade at three periods; this showed no significant difference between the two groups. Comparisons of the levels of pain between the groups based on a Visual Analog Scale system showed no significant difference at the three periods.</p></sec><sec><title>Conclusions</title><p>We observed no improvement at the 3- and 6-month follow-up in patients who were administered atorvastatin. However, a comparison of the two groups based on pain severity demonstrated a significant difference, suggesting that atorvastatin had a positive effect on patients with spinal cord injury.</p></sec>

scholarly journals Comparative study of albumin 5% solution with Ringer’s lactate for substitute blood loss of intraoperation on the integrity of the patient’s coagulation system, renal function and electrolytes after surgery; a double-blind clinical trial study

2020 ◽  
Vol 9 (3) ◽  
pp. e24-e24
Author(s):  
Hossein Madinah ◽  
Gholamreza Shabaniyan ◽  
Mehdi Hadadzadeh
Keyword(s):  
Clinical Trial ◽  
Coagulation System ◽  
Control Group ◽  
Case Group ◽  
Coagulation Disorder ◽  
Double Blind ◽  
Sodium Potassium ◽  
Intraoperative Bleeding ◽  
Significant Difference ◽  
Ringer’S Lactate

Introduction: The type of fluid replace sufficient volume loss during surgery is crucial for normal renal functioning. Objectives: The aim of this study was to compare the effect of albumin 5% infusion versus Ringer’s lactate solution on substitution of intraoperative bleeding on the status of the patient’s hemodynamic and coagulation system after surgery. Patients and Methods: This clinical trial study was performed on 80 patients with nonemergency surgery with the possibility of intraoperative bleeding. Bleeding replacement was performed in the control group with Ringer’s lactate serum and in the case group was replaced with 5% albumin. Patients’ coagulation status (prothrombin time [PT] and relative thromboplastin time and international normalized ratio; INR), electrolyte concentrations (sodium, potassium, and calcium), renal activity tests (serum urea and creatinine) were performed before and at 6, 12, and 24 hours after anesthesia. Results: The results of the study showed no significant difference between the two groups regarding renal parameters, electrolytes (sodium, potassium and calcium) in all stages of the study. Additionally, PT and partial thromboplastin time (PPT) at 6, 12, and 24 hours postoperation in albumin receiving group was less than that of the Ringer’s lactate group (P <0.01). Additionally, 12 and 24 hours after operation, the INR was significantly less in the albumin group compared to Ringer’s lactate serum receiver (P<0.05). Conclusion: This study showed that the administration of albumin solution in comparison with Ringer’s lactate for replacement of intraoperative bleeding reduces the risk of bleeding after surgery due to less coagulation disorder.

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