Comparison of the Effectiveness of Chelleh Daghi Herbal Ointment and Piroxicam Gel on Ankle Sprains

Background and Aim: Ankle injuries are among the most common musculoskeletal injuries in sports, accounting for 10% to 15% of all injuries. Since controlling pain and inflammation in ankle sprains is one of the main goals of treatment, we decided to compare the therapeutic effects of Cheleh daghi Herbal ointment with a common therapeutic gel such as piroxicam. Methods & Materials: This study was performed as a double-blinded clinical trial for 6 months from January 2019 to August 2019. After referral, all patients completed the consent form, and the patientchr('39')s details and study variables were recorded by the evaluator in the research form. To measure joint inflammation, we measured the ankle with a meter tape in the ankle area (cm) and recorded. A goniometer was also used to measure the degree of ankle movements. The symptoms of ankle ecchymosis were also checked by physical examination and observation and recorded in the checklist. Statistical analysis was performed in SPSS V. 18 using statistical tests (the Mann-Whitney U test, the Chi-square, and the independent t-test). Ethical Considerations: The Research Ethics Committee of Arak University of Medical Sciences approved the study (Code: IR.ARAKMU.REC.1396.55) and registered by the Clinical Trial (Code: IRCT2017071720258N53). Results: The Mean±SD age in the control group was 34.2±8.6 years, and in the case group was 35.4±8.9 years. There was no statistically significant difference according to the Mann-Whitney U test (P<0.05). Also, the Mean±SD height in the control group was 1.7±0.12 m and in the case group was 1.72±0.11 m. The results also showed a statistically significant difference between the two groups studied before and after the intervention regarding the mean indicators of pain, swelling, and inflammation around the joints (P<0.05). Conclusion: The results of our study showed that Cheleh daghi Herbal ointment for 3 weeks could be more effective in reducing local pain and inflammation than piroxicam gel treatment.

Download Full-text

Comparison of the Effectiveness of Nursing Consultation and Guided Imagery-Based Training on Stress and Anxiety in Angiography Candidates: A Clinical Trial

Medical - Surgical Nursing Journal ◽

10.5812/msnj.111967 ◽

2020 ◽

Vol 9 (3) ◽

Author(s):

Malihe Nikfarjam ◽

Mohammadreza Firouzkouhi ◽

Hossein Shahdadi ◽

Abdolghani Abdollahimohammad

Keyword(s):

Clinical Trial ◽

Coronary Angiography ◽

Guided Imagery ◽

Statistical Tests ◽

Analysis Of Covariance ◽

Control Group ◽

Audio File ◽

Positive Effects ◽

Significant Difference ◽

The Mean

Background: Despite the use of various pharmacological and non-pharmacological methods for reducing stress among patients, one of the most important nursing challenges is how to control anxiety and stress in patients undergoing coronary angiography. Objectives: The present study aimed to compare the effectiveness of nursing consultation and guided imagery-based training on the level of stress and anxiety in patients undergoing coronary angiography. Methods: The participants in this clinical trial included 60 angiography candidates, admitted to the coronary care unit (CCU) of Ali-Ibn Abi-Taleb Hospital in Zahedan, southeast of Iran, in 2019. The participants were selected using convenience sampling and randomly assigned to three groups: nursing consultation, guided imagery, and control groups. The instruments used to collect the data included a demographic information form and the Depression, Anxiety, and Stress scale (DASS-21). The questionnaires were completed by the participants in all three groups on the day of hospitalization and one hour before angiography. A guided imagery audio file was played one day before angiography for each participant in the nursing consultation group for a maximum of two hours. On the other hand, the guided imagery group, besides receiving routine care, listened to the same audio file for 30 - 45 minutes. However, the participants in the control group only received routine hospital training. The collected data were analyzed in SPSS version 25, using statistical tests, such as analysis of variance (ANOVA), Tukey’s post hoc test, analysis of covariance (ANCOVA), paired samples t-test, Fisher’s exact test, and chi-square test at a significance level of less than 0.05 (P < 0.05). Results: After controlling for the significant effect of pretest scores, the results of ANCOVA test showed significant differences between the two intervention groups in terms of the mean scores of anxiety and stress after the intervention (P < 0.001). Also, the mean scores of anxiety and stress decreased in the guided imagery and nursing consultation groups as compared to the control group. However, the two interventions were not significantly different in reducing anxiety and stress among patients undergoing coronary angiography (P = 1). Conclusions: In this study, nursing consultation and guided imagery interventions led to a reduction in the stress and anxiety of patients undergoing angiography. Although the two interventions showed no significant difference in terms of effectiveness, they had positive effects on the mental health of angiography candidates. Therefore, these techniques can be employed by nurses, depending on their ease of use and conditions, to reduce stress and anxiety among angiography candidates.

Download Full-text

Association of interleukin-17A rs2275913 polymorphism with rheumatoid arthritis susceptibility in Sudanese population

SAGE Open Medicine ◽

10.1177/20503121211020207 ◽

2021 ◽

Vol 9 ◽

pp. 205031212110202

Author(s):

Rgda Mohamed Osman ◽

Mounkaila Noma ◽

Abdallah Elssir Ahmed ◽

Hanadi Abdelbagi ◽

Rihab Ali Omer ◽

...

Keyword(s):

Rheumatoid Arthritis ◽

Confidence Interval ◽

Statistical Tests ◽

Demographic Data ◽

Control Group ◽

P Value ◽

Case Group ◽

Molecular Technique ◽

Interleukin 17A ◽

Significant Difference

Objectives: Rheumatoid arthritis is a chronic inflammatory autoimmune disease. This study aimed to determine the association of interleukin-17A-197G/A polymorphism with rheumatoid arthritis in Sudanese patients. Methods: A case–control study was conducted between March and December 2018. Clinical and demographic data of the study participants were collected and analyzed. Polymerase chain reaction restriction fragment length polymorphism molecular technique was done to investigate interleukin-17A-197G/A polymorphisms. All statistical tests were considered statistically significant when p < 0.05. Results: The study population included 266 participants aged between 1 and 85 years, with an average of 40 years, classified into 85 (31.2%) cases (mean age 48.5 ± 11.3 years), and 181 (68.8%) controls (mean age 35.3 ± 15.9 years). The interleukin-17A homozygote AA genotype was more frequent among the control group compared to the case group; 95 (52.5%) and 7 (8.2%), respectively. The homozygote GG and the heterozygote AG genotypes were proportionally not different among the cases and control groups; 13 (54.2%) and 11 (45.8%), and 65 (46.4%) and 75 (53.6%), respectively. According to the distribution of interleukin-17A genotypes, a statistically significant difference was observed among cases with the interleukin-17A AA and AG genotypes, p values 0.001 and 0.004, respectively. For the association interleukin-17A genotypes and family history a negatively significant association was reported (95% confidence interval, –0.219, p value = 0.001). There was also a negatively significant association of interleukin-17A genotypes and anti-cyclic citrullinated peptide (95% confidence interval, −0.141, p value = 0.002). Conclusion: This study is the first study in Sudan established the association between interleukin-17A-197G/A (rs2275913) polymorphisms and susceptibly to rheumatoid arthritis. These findings appeal for further research in Sudan to investigate the exact role of IL-17A in immunopathology and disease severity among Sudanese rheumatoid arthritis

Download Full-text

Compare the effect of aromatherapy using lavender and Damask rose essential oils on the level of anxiety and severity of pain following C-section: A double-blinded randomized clinical trial

Journal of Complementary and Integrative Medicine ◽

10.1515/jcim-2019-0141 ◽

2020 ◽

Vol 17 (3) ◽

Author(s):

Ali Abbasijahromi ◽

Hamed Hojati ◽

Saeid Nikooei ◽

Hossein Kargar Jahromi ◽

Hamid Reza Dowlatkhah ◽

...

Keyword(s):

Clinical Trial ◽

Essential Oil ◽

Essential Oils ◽

Randomized Clinical Trial ◽

Control Group ◽

Content Type ◽

Gate Control Theory ◽

Significant Difference ◽

The Mean ◽

Damask Rose

AbstractBackgroundAnxiety is the most common psychological reaction in women during labor. Similar to numerous other surgeries, postoperative pain is also reported following cesarean section (C-section). According to the (Gate) Control Theory, there is a relationship between pain and psychological problems such as anxiety. Accordingly, the present study aimed to compare the effect of aromatherapy using lavender and Damask rose essential oils on the level of anxiety and severity of pain following C-section.MethodsThis triple-group randomized clinical trial was performed on 90 mothers who visited Motahari Hospital of Jahrom, Iran, for C-section in 2017. The incidence and severity of pain and anxiety were measured and recorded for all three groups prior to intervention. The intervention groups underwent aromatherapy with lavender and Damask rose essential oils. Patients were asked to inhale cotton balls, separately stained with three drops of each essential oil at a distance of 10 cm for 30 mins. The severity of pain and anxiety was measured using the visual analogue scale (VAS) and the Spielberger State-Trait Anxiety Inventory (STAI) 5 min after the specified process, respectively. The control group underwent aromatherapy in a similar fashion with normal saline. Finally, data were analyzed using descriptive statistical indices and ANOVA and Kruskal–Wallis tests in SPSS 21.ResultsThere was no significant difference between the three groups in the mean severity of pain and anxiety before the intervention (p>0.05). The mean severity of pain and overt anxiety in the lavender and Damask rose aromatherapy groups was significantly different than the control group after the intervention (p<0.001). In addition, no significant difference was observed between the overt and overall anxiety levels of the two intervention groups after the intervention (p>0.05).ConclusionsThe findings suggested that inhalation aromatherapy can reduce the severity of overt anxiety and pain after C-section, with Damask rose essential oil showing a larger effect than lavender.

Download Full-text

Comparison of Salivary Alpha-Amylase, Sialic Acid, and pH in Pregnant and Nonpregnant Subjects

European Journal of General Dentistry ◽

10.1055/s-0041-1732771 ◽

2021 ◽

Author(s):

Masoomeh Shirzaiy ◽

Zohreh Dalirsani

Keyword(s):

Sialic Acid ◽

Pregnant Women ◽

First Trimester ◽

Control Group ◽

Case Group ◽

Third Trimester ◽

The Third ◽

Significant Difference ◽

Salivary Ph ◽

The Mean

Abstract Objectives During pregnancy, systemic physiological alterations lead to some changes in the oral cavity, which could prepare the mouth environment for oral and dental problems. This study was aimed to investigate salivary α-amylase, sialic acid levels, and pH levels in pregnant and nonpregnant females. Materials and Methods In this analytical, case–control study, unstimulated saliva samples were collected with spiting method from 35 pregnant women (case group) and 35 nonpregnant women (control group) and transferred to the laboratory to assess salivary α-amylase, sialic acid, and pH levels. Data were analyzed by SPSS (version: 19) software through statistical methods of independent t-test and analysis of variance. Results The mean sialic acid levels were 2.285 ± 1.230 mg/dL in pregnant and 2.744 ± 1.326 in nonpregnant women without any significant difference (p = 0.138). The mean salivary α-amylase concentrations were 2.461 ± 1.869 U/L and 2.439 ± 2.058 U/L, respectively, in pregnant and nonpregnant women, with no significant difference (p = 0.963).The mean salivary pH in nonpregnant women was significantly more than that in pregnant women (7.845 ± 0.430 and 6.868 ± 0.413, respectively) (p < 0.001). Also, the mean salivary pH levels in pregnant women were 7.474 ± 0.420 in the first trimester, 6.868 ± 0.413 in the second trimester, and 6.568 ± 0.387 in the third trimester, which were significantly different (p < 0.001). Conclusion Salivary sialic acid and α-amylase levels among pregnant women were no different from those of other subjects. During pregnancy, the salivary pH significantly reduced, and the mean salivary pH during pregnancy had a decreasing trend from the first trimester to the third trimester.

Download Full-text

The effect of delivery ball and warm shower on the childbirth experience of nulliparous women: A randomized controlled clinical trial

10.21203/rs.3.rs-903099/v1 ◽

2021 ◽

Author(s):

parvaneh sharifipour ◽

Masoomeh Kheirkhah ◽

Mojgan Rajati ◽

hamid haghani

Keyword(s):

Clinical Trial ◽

Pregnant Women ◽

Control Group ◽

Controlled Clinical Trial ◽

Control Groups ◽

Childbirth Experience ◽

Nulliparous Women ◽

Significant Difference ◽

The Mean ◽

And Control

Abstract Background Childbirth is a unique experience that affects women’s life. Therefore, this study was performed to determine the effect of delivery ball and warm shower on the childbirth experience of primiparous women. Methods This study is a clinical trial that was carried out on primiparous pregnant women referred to Motazedi Hospital in Kermanshah, Iran. Sampling was done by continuous method and pregnant women were divided into three groups of delivery ball-warm shower (n = 33), delivery ball (n = 33) and control (n = 33). Exercise with ball at the dilation of 4 cm was similar in the two groups of delivery ball-warm shower and delivery ball, but the first group also used warm shower at the dilatation of 7 cm. The control group only received the routine delivery care. Demographic information form consisting of pregnancy history and information about the mother and infant were completed and the childbirth experience questionnaire (CEQ) were completed by the women two hours after the childbirth. Results There was a statistically significant difference in the mean score of childbirth experience after the intervention between the two groups of delivery ball-warm shower and control (P = 0.001), and also between the delivery ball and control groups (P = 0.001). There was a statistically significant difference in the mean scores of professional support between the two groups of delivery ball-warm shower and control (P = 0.02) and also between the delivery ball and control groups (p = 0.02). There was a statistically significant difference in the mean scores of participation between the two groups of delivery ball-warm shower and control (P = 0.003) and also between the delivery ball and control groups (P = 0.01). There was also a statistically significant difference in the mean scores of sense of security between the two groups of delivery ball-warm shower and control (P = 0.01). Conclusion Delivery ball and warm shower were effective interventions to create a positive childbirth experience. This method was more effective than using delivery ball alone in childbirth experience. To achieve a positive experience of childbirth in mothers, the use of both intervention (delivery ball and warm shower) is recommended.

Download Full-text

Templating of Syndesmotic Ankle Lesions by Use of 3D Analysis in Weightbearing and Nonweightbearing CT

Foot & Ankle International ◽

10.1177/1071100718791834 ◽

2018 ◽

Vol 39 (12) ◽

pp. 1487-1496 ◽

Cited By ~ 15

Author(s):

Arne Burssens ◽

Hannes Vermue ◽

Alexej Barg ◽

Nicola Krähenbühl ◽

Jan Victor ◽

...

Keyword(s):

External Rotation ◽

Imaging Techniques ◽

Ankle Injuries ◽

Control Group ◽

3D Analysis ◽

Anatomical Landmarks ◽

Distal Fibula ◽

Fracture Group ◽

Significant Difference ◽

The Mean

Background: Diagnosis and operative treatment of syndesmotic ankle injuries remain challenging due to the limitations of 2-dimensional imaging. The aim of this study was therefore to develop a reproducible method to quantify the displacement of a syndesmotic lesion based on 3-dimensional computed imaging techniques. Methods: Eighteen patients with a unilateral syndesmotic lesion were included. Bilateral imaging was performed with weightbearing cone-beam computed tomography (CT) in case of a high ankle sprain (n = 12) and by nonweightbearing CT in case of a fracture-associated syndesmotic lesion (n = 6). The healthy ankle was used as a template after being mirrored and superimposed on the contralateral ankle. The following anatomical landmarks of the distal fibula were computed: the most lateral aspect of the lateral malleolus and the anterior and posterior tubercle. The change in position of these landmarks relative to the stationary, healthy fibula was used to quantify the syndesmotic lesion. A control group of 7 studies was used. Results: The main clinical relevant findings demonstrated a statistically significant difference between the mean mediolateral diastasis of both the sprained (mean [SD], 1.6 [1.0] mm) and the fracture group (mean [SD], 1.7 [0.6] mm) compared to the control group ( P < .001). The mean external rotation was statistically different when comparing the sprained (mean [SD], 4.7 [2.7] degrees) and the fracture group (mean [SD], 7.0 [7.1] degrees) to the control group ( P < .05). Conclusion: This study evaluated an effective method for quantifying a unilateral syndesmotic lesion of the ankle. Applications in clinical practice could improve diagnostic accuracy and potentially aid in preoperative planning by determining which correction needs to be achieved to have the fibula correctly reduced in the syndesmosis. Level of Evidence: Level III, retrospective comparative study.

Download Full-text

Evaluation of Oxidative Stress in Patients with Fracture Admitted to Khatam Al-Anbia Hospital in Zahedan

Annals of Military and Health Sciences Research ◽

10.5812/amh.108052 ◽

2020 ◽

Vol 18 (3) ◽

Author(s):

Mansour Karajibani ◽

Farzaneh Montazerifar ◽

Faezeh Kazemi ◽

Ali Reza Dashipour

Keyword(s):

Oxidative Stress ◽

Antioxidant Activities ◽

Control Group ◽

Case Group ◽

Cross Sectional ◽

Stress Markers ◽

Significant Difference ◽

Before And After ◽

Markers Of Oxidative Stress ◽

The Mean

Background: Caused by an imbalance in the body’s oxidant and antioxidant status, oxidative stress can give rise to tissue damage and exacerbation of many diseases. Objectives: This study investigated the oxidative stress markers in patients with fractures and healthy subjects. Methods: In a cross-sectional case-control study, 40 patients with fractures admitted to an orthopedic ward and 40 healthy, non-fractured patients were selected using convenience sampling. Serum was analyzed for oxidant and antioxidant activities based on standard methods. P < 0.05 was considered statistically significant. Results: There was a significant difference in mean TAC between the case (748.2 ± 302.83 μmol/L) and control (984.90 ± 207.02 μmol/L) groups (P = 0.003). The mean MDA was 16.61 ± 4.16 µmol/L in the case group and 18.45 ± 5.43 µmol/L in the control group (P = 0.09). The mean SOD was 63.41 ± 16.67 U/g Hb in the case group and 58.54 ± 21.83 U/g Hb in the control group (P = 0.2). There was no significant difference between the two groups in terms of BMI and other variables. Conclusions: A significant difference existed in TAC between the two groups, which indicated increased oxidative stress in patients. However, oxidative stress could occur before and after undergoing fractures. The results suggested a slight, but not significant, difference between the two groups in the SOD and MDA scores. More conclusive results are required to determine the enzymatic and non-enzymatic markers of oxidative stress in larger sample sizes and during different stages of treatment.

Download Full-text

Vitamin D and Parathyroid Hormone Status in Female Garment Workers: A Case-Control Study in Bangladesh

BioMed Research International ◽

10.1155/2017/4105375 ◽

2017 ◽

Vol 2017 ◽

pp. 1-7 ◽

Cited By ~ 4

Author(s):

Shakil Mahmood ◽

Matiur Rahman ◽

Subrata Kumar Biswas ◽

Shaikh Nazmus Saqueeb ◽

Shiblee Zaman ◽

...

Keyword(s):

Vitamin D ◽

Vitamin D Deficiency ◽

Serum Vitamin ◽

Control Group ◽

Case Group ◽

Serum Vitamin D ◽

Garment Workers ◽

Significant Difference ◽

The Status ◽

The Mean

Despite the abundant sunlight, vitamin D deficiency is prevalent in South Asian countries including Bangladesh. Information on vitamin D level is insufficient in adults particularly in female garment workers in Bangladesh. This study was designed to evaluate the status of vitamin D, parathormone (PTH), calcium, and alkaline phosphatase (ALP) among the female garment workers in Bangladesh. Blood samples were collected from female garment workers (n=40, case group) and general female workers (n=40, control group) in Dhaka. Serum vitamin D, PTH, calcium, and ALP were measured by chemiluminescence microparticle immunoassay. The mean level of vitamin D was significantly (p<0.001) lower in case (14.2±2.6 ng/mL) than in the control (22.4±2.4 ng/mL) group. No significant difference was found at mean of PTH and calcium between case (33.9±17.2 pg/mL;9.1±0.6 mg/dL, resp.) and control (35.9±16.3 pg/mL;9.3±0.6 mg/dL, resp.) group. The mean ALP in case (117.2±14.4 U/L) group was significantly (p<0.001) higher than the control group (80.5±30.6 U/L). Overall, PTH level did not show significant correlation with vitamin D. However, calcium and ALP levels showed a significant positive (p<0.05) and negative (p<0.001) correlation with vitamin D, respectively. This study indicates a high prevalence of vitamin D deficiency in the female garment workers in Bangladesh.

Download Full-text

Effect of lavender aromatherapy on well-being among hemodialysis patients: A randomized clinical trial

Pharmaceutical and Biomedical Research ◽

10.18502/pbr.v4i2.215 ◽

2018 ◽

Author(s):

Masoumeh Bagheri Nesami ◽

Seyed Afshin Shorofi ◽

Attieh Nikkhah ◽

Hossein Roohi Moghaddam ◽

Ali Mahdavi

Keyword(s):

Clinical Trial ◽

Randomized Clinical Trial ◽

Well Being ◽

Underlying Disease ◽

Hemodialysis Patients ◽

Control Group ◽

Significant Difference ◽

The Mean ◽

And Control ◽

Experimental Group

In spite of the improvement of dialysis techniques, hemodialysis patients still experience debilitation. Impaired functioning, well-being, and quality of life are among the factors that are of a great concern in these patients. The current study aimed to examine the effects of lavender essential oil on well-being among hemodialysis patients. This randomized clinical trial was conducted on 30 hemodialysis patients. For each patient in the experimental group, five cotton balls were prepared using two drops of lavender essence diluted with sweet almond oil. Lavender was used at five concentrations of 10%, 20%, 30%, 40%, and 50%, administered through pinning the soaked cotton ball on the patients' collar on the first, second, third, fourth, and fifth weeks of the intervention, respectively. The patients were asked to breathe normally for 20 min. On the other hand, the control group received only routine nursing care. The perceived sense of well-being was measured in both groups at the end of each week using a visual analog scale. The mean ages of patients were obtained as 58.9 ± 14.31 and 53.03 ± 15.84 years for the experimental and control groups, respectively. Hypertension was reported to be the most common underlying disease in both groups. The results showed a significant difference in the mean level of well-being in the experimental group in the fourth and fifth weeks of the intervention, compared to that before the intervention. Inhalation aromatherapy with 40% and 50% lavender essence had a positive effect on the perceived sense of well-being in hemodialysis patients. However, lower concentrations of 10%, 20%, and 30% did not exert a comparable effect.

Download Full-text

Effectiveness of Counseling for Infertile Couples on Women's Emotional Disturbance: A Randomized Clinical Trial

Revista Brasileira de Ginecologia e Obstetrícia / RBGO Gynecology and Obstetrics ◽

10.1055/s-0041-1736305 ◽

2021 ◽

Vol 43 (11) ◽

pp. 826-833

Author(s):

Tayebeh Mokhtari Sorkhani ◽

Atefeh Ahmadi ◽

Moghaddameh Mirzaee ◽

Victoria Habibzadeh ◽

Katayoun Alidousti

Keyword(s):

Clinical Trial ◽

Randomized Clinical Trial ◽

Emotional Disturbance ◽

Intervention Group ◽

T Test ◽

Control Group ◽

Infertile Women ◽

Primary Infertility ◽

Significant Difference ◽

The Mean

Abstract Objective The psychosocial burden of infertility among couples can be one of the most important reasons for women's emotional disturbance. The goal of the present study was to investigate the effect of counseling on different emotional aspects of infertile women. Methods The present randomized clinical trial was performed on 60 couples with primary infertility who were referred for treatment for the first time and did not receive psychiatric or psychological treatment. Samples were allocated to an intervention group (30 couples) and a control group (30 couples) by simple randomization. The intervention group received infertility counseling for 6 45-minute sessions twice a week, and the control group received routine care. The Screening on Distress in Fertility Treatment (SCREENIVF) questionnaire was completed before and after the intervention. Samples were collected from November to December 2016 for 3 months. For the data analysis, we used the Statistical Package for the Social Sciences (IBM SPSS Statistics for Windows, IBM Corp., Armonk, NY, United States) software, version 19.0, and the paired t-test, the independent t-test, the Mann-Whitney test, the Wilcoxon test, and the Chi-squared test. Results The mean age of the participants was 33.39 ± 5.67 years. All studied couples had primary infertility and no children. The mean duration of the couples' infertility was 3 years. There was a significant difference regarding depression (1.55 ± 1.92; p < 0.0001), social support (15.73 ± 3.41; p < 0.0001), and cognitions regarding domains of fertility problems (26.48 ± 3.05; p = 0.001) between the 2 groups after the intervention, but there was no significant difference regarding anxiety (25.03 ± 3.09; p = 0.35). Conclusion The findings showed that infertility counseling did not affect the total score of infertile women' emotional status, but improved the domains of it except, anxiety.

Download Full-text