Comparative Study of Pregnancy Outcome in Day 2 Embryo Transfer versus Day 5 Transfer

Background: This study is cross-sectional, observational and comparative study, at Index Medical College, Hospital & Research Centre, Indore, Madhya Pradesh from July 2017 to July 2019 with sample size 100 placentae. Method: The placenta received was evaluated blinded of maternal pregnancy outcome. The pattern of morphology was evaluated both qualitatively (type of lesion) and quantitatively (number of lesions). Result: In Present study 79% of the deliveries were term deliveries and 21% were preterm deliveries. On placental macroscopy, placenta weight was significantly low among the neonates of preterm deliveries (370.00±60.49) as compared to term deliveries (440.89±55.22). Preterm placenta had higher number of abnormal placental lesion compared to term pregnancies. Conclusion: The uteroplacental insufficiency defined as placental infarct, fibrosis of chorionic villi, thickening of blood vessels, and poor vascularity of chorionic villi. Placental histopathological lesions are strongly associated with maternal under perfusion and uteroplacental insufficiency. These are the reasons for preterm birth. Thus, knowledge of the etiological factor can be use to reduce maternal and neonatal morbidity and mortility. Keywords: Placenta, Term & Preterm.

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Blastocoele re-expansion speed is correlated with pregnancy outcome in frozen embryo transfer cycles

10.26226/morressier.5912d9e8d462b80292386ae1 ◽

2017 ◽

Author(s):

Dong shaonan

Keyword(s):

Pregnancy Outcome ◽

Embryo Transfer ◽

Frozen Embryo Transfer ◽

Expansion Speed

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Pregnancy outcome and cord blood cotinine level: A cross-sectional comparative study between secondhand smokers and non-secondhand smokers

European Journal of Obstetrics & Gynecology and Reproductive Biology ◽

10.1016/j.ejogrb.2017.05.002 ◽

2017 ◽

Vol 214 ◽

pp. 86-90 ◽

Cited By ~ 6

Author(s):

B. Abdullah ◽

B. Muadz ◽

M.N. Norizal ◽

N. Ismail ◽

N.K. Kornain ◽

...

Keyword(s):

Comparative Study ◽

Cord Blood ◽

Pregnancy Outcome ◽

Cross Sectional ◽

Cotinine Level

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Impact of the oxytocin receptor antagonist (ATOSIBAN) administered shortly before embryo transfer on pregnancy outcome after intracytoplasmic sperm injection (ICSI)

Fertility and Sterility ◽

10.1016/j.fertnstert.2016.07.260 ◽

2016 ◽

Vol 106 (3) ◽

pp. e88-e89

Author(s):

S.A. Hebisha ◽

B.A. Aboelazm ◽

H.M. Adel ◽

A.I. Ahmed

Keyword(s):

Receptor Antagonist ◽

Pregnancy Outcome ◽

Embryo Transfer ◽

Intracytoplasmic Sperm Injection ◽

Oxytocin Receptor

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Premature luteinization during controlled ovarian hyperstimulation for in vitro fertilization-embryo transfer has no impact on pregnancy outcome

Fertility and Sterility ◽

10.1016/s0015-0282(16)58693-2 ◽

1996 ◽

Vol 66 (6) ◽

pp. 980-986 ◽

Cited By ~ 52

Author(s):

Glen E. Hofmann ◽

Jane Khoury ◽

Chad A. Johnson ◽

Jennifer Thie ◽

Richard T. Scott

Keyword(s):

In Vitro Fertilization ◽

Pregnancy Outcome ◽

Embryo Transfer ◽

Controlled Ovarian Hyperstimulation ◽

Ovarian Hyperstimulation ◽

Vitro Fertilization ◽

Premature Luteinization

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Effect of the trends of estradiol level on the outcome of in vitro fertilization-embryo transfer with antagonist regimens: a single center retrospective cohort study

10.21203/rs.3.rs-1066884/v1 ◽

2021 ◽

Author(s):

Chun-Xiao Wei ◽

liang zhang ◽

Cong-Hui Pang ◽

Ying-Hua qi ◽

Jian-Wei Zhang

Keyword(s):

In Vitro Fertilization ◽

Pregnancy Rate ◽

Pregnancy Outcome ◽

Embryo Transfer ◽

Ovarian Response ◽

Vitro Fertilization ◽

The Relationship ◽

Estradiol Levels

Abstract BackgroundThe outcome of in vitro fertilization-embryo transfer is often determined according to follicles and estradiol levels following gonadotropin stimulation. However, there is no accurate indicator to predict pregnancy outcome, and it has not been determined how to choose subsequent drugs and dosage based on the ovarian response. This study aimed to make timely adjustments to follow-up medication to improve clinical outcomes based on the potential value of estradiol growth rate. MethodsSerum estradiol levels were measured on the day of gonadotrophin treatment (Gn0), four days later (Gn4), seven days later (Gn7), and on the trigger day (HCG). The ratio was used to determine the increase in estradiol levels. According to the ratio of estradiol increase, the patients were divided into four groups: group A1 (Gn4/Gn0≤6.44), group A2 (6.44˂Gn4/Gn0≤10.62), group A3 (10.62˂Gn4/Gn0 ≤21.33), and group A4 (Gn4/Gn0>21.33); group B1 (Gn7/Gn4≤2.39), group B2 (2.39˂Gn7/Gn4≤3.03), group B3 (3.03˂Gn7/Gn4≤3.84), and group B4 (Gn7/Gn4>3.84). We analyzed and compared the relationship between data in each group and pregnancy outcome. ResultsIn the statistical analysis, the estradiol levels of Gn4 (P = 0.029, P = 0.042), Gn7 (P< 0.001, P = 0.001), and HCG (P< 0.001, P = 0.002), as well as the ratios of Gn4/Gn0 (P = 0.004, P = 0.006), Gn7/Gn4 (P = 0.001, P = 0.002), and HCG/Gn0 (P< 0.001, P< 0.001) both had clinical guiding significance, and the lower one significantly reduced the pregnancy rate. The outcomes were positively linked to groups A (P = 0.040, P = 0.041) and B (P = 0.015, P = 0.017). The logistical regression analysis revealed that group A1 (OR = 0.440 [0.223–0.865]; P = 0.017, OR = 0.368 [0.169–0.804]; P = 0.012) and B1 (OR = 0.261 [0.126–0.541]; P< 0.001, OR = 0.299 [0.142–0.629]; P = 0.001) had opposite influence on outcomes. ConclusionMaintaining a serum estradiol increase ratio at least above 2.39 on Gn7/Gn4 may result in a higher pregnancy rate. When estradiol growth is not ideal, gonadotrophin dosage should be adjusted appropriately to ensure the desired outcome.

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The Effects of Subcutaneous Administration of Granulocyte Colony-Stimulating Factor on Pregnancy Outcome After Assisted Reproductive Technology: Clinical Trial

Avicenna Journal of Medical Biochemistry ◽

10.15171/ajmb.2018.08 ◽

2018 ◽

Vol 6 (2) ◽

pp. 31-36

Author(s):

Marzie Farimani ◽

Narges Mehrabi ◽

Azar Pirdehghan ◽

Maryam Bahmanzadeh

Keyword(s):

Placebo Group ◽

Assisted Reproductive Technology ◽

Pregnancy Outcome ◽

Embryo Transfer ◽

Endometrial Thickness ◽

Subcutaneous Administration ◽

Reproductive Technology ◽

Granulocyte Colony Stimulating Factor ◽

Colony Stimulating Factor ◽

Stimulating Factor

Background: Granulocyte-colony stimulating factor (G-CSF) is an innovative therapy in reproductive medicine. Although its mechanisms of action have remained unknown, G-CSF seems to be effective in the case of recurrent abortion or implantation failure and thin endometrium. Objectives: This study was conducted to investigate whether subcutaneous administration of G-CSF has any effect on pregnancy outcome after assisted reproductive technology (ART). Methods: Fifty women with male infertility factors undergoing ART treatment were enrolled and stimulated with the standard long protocol. The G-CSF group of women received one dose of subcutaneous G-CSF (Filgrastim, 300 µg/1 mL) on the day of embryo transfer and again two days later while the placebo group received normal saline. Results: Seventeen patients had a positive β-human chorionic gonadotropin concentration after embryo transfer (8 and 9 in G-CSF and placebo groups, respectively) although the difference was not statistically significant. In addition, spontaneous abortion occurred in three patients (1 patient in the G-CSF group vs. 2 patients in the placebo group). Conclusion: Overall, although G-CSF failed to affect the endometrial thickness, as well as implantation, or clinical pregnancy rates, a lower prevalence of abortion in G-CSF group may be due to the positive effect of G-CSF administration on the endometrium as compared to the placebo group.

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