The Role of Presepsin, C-Reactive Protein and Procalcitonin as a Marker of Therapy Response and Prognosis for Late Onset Neonatal Sepsis in Preterm Neonates

INTRODUCTION C-reactive protein (CRP) is the most common diagnostic marker of infection. OBJECTIVE Objectives of this study were to determine the serum CRP level in neonates with sepsis and establish the influence of gestational age (GA) on the CRP level in the first few weeks after birth. METHOD Diagnosis of neonatal sepsis was established by the presence of clinical signs of sepsis, isolation of the causative agent of sepsis and abnormal hematological parameters. All neonates were divided into two groups: early onset sepsis (EOS) and late onset sepsis (LOS). According to GA all neonates were divided into three groups: <32 GA, 32-36 GA and ?37 GA. Serum CRP was measured 0-72 h after the onset of signs and symptoms of infection. RESULTS This study included all neonates with sepsis at our Institute during 2003. EOS was diagnosed in 130 neonates (mean age was 33 weeks; range 27-41 weeks) and 33 infants (mean age 29 weeks; range 27-38 weeks). We defined a relevant CRP response as a concentration of >10 mg/l for term and near term neonates and >5 mg/l for preterm neonates. The maximum concentrations of CRP were reached 48 hr after the first symptoms of neonatal sepsis. CONCLUSION CRP levels are proportional with increasing GA and body weight in EOS. The effects of gestational age do not influence CRP levels in LOS. Maturation changes in the immune system are the most likely explanation for this and partly the organisms responsible for an infection may be different at different gestational ages and also in EOS and LOS. There is no correlation with serum CRP levels and with the severity of the disease and bad prognosis in EOS.

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C-reactive protein and interleukin-6 responses for differentiating fungal and bacterial aetiology in late-onset neonatal sepsis

Mycoses ◽

10.1111/j.1439-0507.2009.01802.x ◽

2011 ◽

Vol 54 (3) ◽

pp. 212-216 ◽

Cited By ~ 11

Author(s):

Suna Serife Oguz ◽

Erden Sipahi ◽

Ugur Dilmen

Keyword(s):

Interleukin 6 ◽

Neonatal Sepsis ◽

Late Onset ◽

C Reactive Protein ◽

Reactive Protein ◽

Bacterial Aetiology

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The Role of the Procalcitonin in Diagnosis of Neonatal Sepsis and Correlation Between Procalcitonin and C-Reactive Protein in these Patients

Pakistan Journal of Biological Sciences ◽

10.3923/pjbs.2008.1785.1790 ◽

2008 ◽

Vol 11 (14) ◽

pp. 1785-1790 ◽

Cited By ~ 11

Author(s):

K. Sakha ◽

M.B. Husseini ◽

N. Seyyedsadr

Keyword(s):

Neonatal Sepsis ◽

C Reactive Protein ◽

Reactive Protein

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Diagnostic Value of Urine sTREM-1 and Urine C-reactive Protein for Infants with Late Onset Neonatal Sepsis

Journal of Pediatric Infectious Diseases ◽

10.1055/s-0039-3400468 ◽

2019 ◽

Vol 15 (02) ◽

pp. 072-078

Author(s):

Senem Alkan Ozdemir ◽

Ruya Colak ◽

Ezgi Yangin Ergon ◽

Sebnem Calkavur

Keyword(s):

Neonatal Sepsis ◽

Predictive Value ◽

Late Onset ◽

Diagnostic Value ◽

C Reactive Protein ◽

Reactive Protein ◽

Late Onset Sepsis ◽

Noninvasive Markers ◽

Serum Crp ◽

Sepsis Detection

Abstract Objective Noninvasive markers have been increasingly used as a diagnostic marker for sepsis detection and monitoring of the disease. The aim of this observational, prospective pilot study was to investigate the diagnostic performance of urinary soluble triggering receptor expressed on myeloid cells (sTREM-1) and urine C-reactive protein (CRP) levels in the late onset neonatal sepsis and to compare them with serum CRP levels. Materials and Methods Sixty-six infants with clinical sepsis were included. Urine sTREM-1 and urine CRP were collected at the diagnosis of late-onset sepsis. All laboratory investigations were also noted from the infants. Results There were no significant differences between characteristics of the infants. Culture-positive neonates had significantly higher urine sTREM-1 than culture-negative neonates (p < 0.001). Using a cut-off point for urine sTREM-1 of 129 pg/mL, the sensitivity was 0.63, the specificity was 0.84, positive predictive value was 0.80, negative predictive value was 0.70. Urine sTREM-1 and urine CRP were recollected on the seventh day of sepsis treatment and it was found that the levels of sTREM-1 and CRP decreased. Conclusion This is the first study in the literature which evaluates the place of urine sTREM-1 and urine CRP in the diagnosis of neonatal sepsis. Urine sTREM-1 and urine CRP may be useful in the diagnosis of sepsis and in evaluating the effect of antibiotic treatment.

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