scholarly journals ANTIMICROBIAL EFFECT OF OLIGOMERIC COPPER(II) DERIVATIVES OF BIS(PYRIMIDIN-2-YLTHIO)- AND BIS(4,6-DIMETHYLPYRIMIDIN-2-YLTHIO)ALKANES

2016 ◽  
Vol 2 (2) ◽  
pp. 001-017
Author(s):  
Ricardo Soares Mota Silva ◽  
Márcia Cristina de Souza ◽  
Lilian Berlini ◽  
José Roberto Da Silveira Maia ◽  
Renata Diniz ◽  
...  
Keyword(s):  
Gel Permeation Chromatography ◽  
Antimicrobial Effect ◽  
Planar Geometry ◽  
X Ray Diffraction ◽  
Average Molecular Mass ◽  
E Coli ◽  
Pyramidal Geometry ◽  
Square Planar ◽  
Derivatives Of ◽  
Square Pyramidal Geometry

A novel series of copper(II) derivatives of bis(pyrimidin-2-ylthio)- and bis(4,6-dimethylpyrimidin-2-ylthio)alkane of general formula [CuxCly(L)z]n {x = 1, y = 2, z = 1, L = ptm (1), pte (2), dptm (4), dpte (5), dpth (6); x = 2, y = 4, z = 3, L = pth (3) were tested for antimicrobial activity. These complexes were characterized by elemental analysis, infrared spectroscopy (IR) and gel permeation chromatography (GPC). Complex-4, 5 and 6 have the metal at the center of a square planar geometry and in complex-1, 2 and 3 the metal is at the center a square pyramidal geometry. The structure of complex-4, determined by X-ray diffraction analysis, shows this compound as an oligomer with one-dimensional chain in zigzag conformation. The high average molecular mass (Mw) of these copper(II) complexes confirms their oligomeric character. Although the free ligands were inactive agaisnt the microorganisms tested, the copper(II) derivatives showed good antifungal and antibacterial inhibition against C. albicans, C. tropicalis, S. aureus and E. coli, more effective than Nystatin and Norfloxacin.doi: https://doi.org/10.18540/2446941602022016001

scholarly journals Crystal structure of orthorhombic {bis[(pyridin-2-yl)methyl](3,5,5,5-tetrachloropentyl)amine-κ3N,N′,N′′}chloridocopper(II) perchlorate

2015 ◽  
Vol 71 (7) ◽  
pp. 847-851 ◽  
Author(s):  
Katherine A. Bussey ◽  
Annie R. Cavalier ◽  
Jennifer R. Connell ◽  
Margaret E. Mraz ◽  
Kayode D. Oshin ◽  
...  
Keyword(s):  
Crystal Structure ◽  
Title Compound ◽  
Planar Geometry ◽  
Apical Position ◽  
Pyramidal Geometry ◽  
Counter Ion ◽  
Square Planar ◽  
Chloride Ligand ◽  
Square Pyramidal Geometry ◽  
Amine Ligand

In the title compound, [CuCl(C17H19Cl4N3)]ClO4, the CuIIion adopts a distorted square-planar geometry defined by one chloride ligand and the three nitrogen atoms from the bis[(pyridin-2-yl)methyl](3,5,5,5-tetrachloropentyl)amine ligand. The perchlorate counter-ion is disordered over three sets of sites with refined occupancies 0.0634 (17), 0.221 (16) and 0.145 (7). In addition, the hetero-scorpionate arm of the bis[(pyridin-2-yl)methyl](3,5,5,5-tetrachloropentyl)amine ligand is disordered over two sets of sites with refined occupancies 0.839 (2) and 0.161 (2). In the crystal, weak Cu...Cl interactions between symmetry-related molecules create a dimerization with a chloride occupying the apical position of the square-pyramidal geometry typical of many copper(II) chloride hetero-scorpionate complexes.

scholarly journals Synthesis and Characterization of Catecholato Copper(II) Complexes with Sterically Hindered Neutral and Anionic N3 Type Ligands: Tris(3,5-diisopropyl-1-pyrazolyl)methane and Hydrotris(3,5-diisopropyl-1-pyrazolyl)borate

Inorganics ◽  
2020 ◽  
Vol 8 (5) ◽  
pp. 37 ◽  
Author(s):  
Kiyoshi Fujisawa ◽  
Tetsuya Ono ◽  
Moemi Okamura
Keyword(s):  
Planar Geometry ◽  
X Ray ◽  
Pyramidal Geometry ◽  
Square Planar ◽  
Ct Transitions ◽  
Sterically Hindered ◽  
Protonated Ligand ◽  
Square Pyramidal Geometry ◽  
Oxidation State Of Copper

Three catecholato copper(II) complexes, [Cu(catCl4)(L1′)], [Cu(catBr4)(L1′)], and [Cu(catCl4)(L1H)], supported by sterically hindered neutral and anionic N3 type ligands: tris(3,5-diisopropyl-1-pyrazolyl)methane (referred to as L1′) and hydrotris(3,5-diisopropyl-1-pyrazolyl)borate (referred to as L1−), are synthesized and characterized in detail. Their X-ray structures reveal that both [Cu(catCl4)(L1′)] and [Cu(catBr4)(L1′)] complexes have a five-coordinate square-pyramidal geometry and [Cu(catCl4)(L1H)] complex has a four-coordinate square-planar geometry. The L1H is unusual protonated ligand that controls its overall charge. For the three catecholato copper(II) complexes, the oxidation state of copper is divalent, and catechol exists in catecholate as two minus anion. This difference in coordination geometry affects their d-d and CT transitions energy and ESR parameters.

scholarly journals Novel (N4) Macrocyclic Metal Complexes: Synthesis, Characterization, Spectral Studies and Anticancer Activity

2018 ◽  
Vol 5 (1) ◽  
pp. 51-63 ◽  
Author(s):  
Hanaa A. El-Boraey ◽  
Ohyla A. EL-Gammal
Keyword(s):  
Condensation Reaction ◽  
Spectral Studies ◽  
Planar Geometry ◽  
Human Breast ◽  
Nitrogen Ligand ◽  
Pyramidal Geometry ◽  
Square Planar ◽  
Square Pyramidal Geometry ◽  
Mcf 7

Introduction:A new series of mononuclear Fe(II), Co(II), Ni(II), Cu(II) and Pd(II) complexes correspond to tetradentate macrocyclic nitrogen ligandi.e.naphthyl-3,4:10,11-dibenzo,7-methylene,8-methyl,6-phenyl-1,5,9,13-tetraazacyclohexadecane-5,8-diene-2,12-dione metal(II) complexes, have been synthesized by the template condensation reaction.Methods:The complexes have been characterized by elemental analysis, spectral (IR, UV–Vis, and ESR, molar conductivity, and magnetic as well as thermal analysis measurements.Results:On the basis of above studies, an octahedral geometry has been proposed for all complexes except Cu(II) nitrate complex that adopt square pyramidal geometry, and square planar geometry for Pd(II) chloride complex, respectively.Conclusion:The thermal behavior and the kinetic parameters of degradation were determined using Coats-Redfern and Horowitz-Metzger methods. Moreover, thein vitroantitumor activity of the some synthesized complexes against human breast and human hepatocarcinoma cell lines (MCF-7) and (HePG2), respectively has been studied.

Synthesis and crystal structure analyses of tri-substituted guanidine-based copper(II) complexes

2021 ◽  
Vol 76 (3-4) ◽  
pp. 193-199
Author(s):  
Muhammad Said ◽  
Sadia Rehman ◽  
Muhammad Ikram ◽  
Hizbullah Khan ◽  
Carola Schulzke
Keyword(s):  
Crystal Structure ◽  
Solid State ◽  
Molecular Structures ◽  
Hydroxyl Groups ◽  
Synthesis And Crystal Structure ◽  
Pyramidal Geometry ◽  
Tautomeric Forms ◽  
Square Planar ◽  
Nitrogen Donor ◽  
Square Pyramidal Geometry

Abstract Three guanidine-derived tri-substituted ligands viz. N-pivaloyl-N′,N″-bis-(2-methoxyphenyl)guanidine (L1), N-pivaloyl-N′-(2-methoxyphenyl)-N″-phenylguanidine (L2) and N-pivaloyl-N′-(2-methoxyphenyl)-N″-(2-tolyl)guanidine (L3) were reacted with Cu(II) acetate to produce the corresponding complexes. The significance of the substituent on N″ for the resulting molecular structures and their packing in the solid state has been studied with respect to the structural specifics of the corresponding Cu(II) complexes. The key characteristic of the guanidine-based metal complexation with Cu(II) is the formation of an essentially square planar core with an N2O2 donor set. As an exception, in the complex of L1, the substituent’s methoxy moiety also interacts with the Cu(II) center to generate a square-pyramidal geometry. The hydroxyl groups of the imidic acid tautomeric forms of L1–L3, in addition to N″, are also bonded to Cu(II) in all three complexes rather than the nitrogen donor of the guanidine motif.

Synthesis, structural and magnetic properties of macrocyclic aza-amido binuclear copper(II) complexes

1989 ◽  
Vol 67 (4) ◽  
pp. 662-670 ◽  
Author(s):  
Sanat K. Mandal ◽  
Laurence K. Thompson ◽  
Michael J. Newlands ◽  
Amal K. Biswas ◽  
Bibhutosh Adhikary ◽  
...  
Keyword(s):  
Variable Temperature ◽  
Complex Iii ◽  
Azomethine Nitrogen ◽  
X Ray Diffraction ◽  
Binuclear Copper ◽  
Magnetic Studies ◽  
Monoclinic System ◽  
Space Group ◽  
Pyramidal Geometry ◽  
Square Planar

Binuclear, antiferromagnetically coupled, macrocyclic copper(II) complexes, [Cu2(C28H32N4O4)]•H2O (II) and [Cu2(C36H32N4O4)]•CH3CN•H2O (III), involving asymmetric ligands with two deprotonated amide, two azomethine nitrogen, and two phenoxide donors at the binuclear centre, have been synthesized and characterized by single-crystal X-ray diffraction and variable temperature magnetic studies. Complex II crystallizes in the monoclinic system, space group P21/n, with a = 16.4854(9) Å, b = 7.6005(13) Å, c = 21.1617(11) Å, β = 104.090(5)°, Z = 4, Rf = 0.068 for 2062 significant reflections. The two copper(II) centres have square planar N2O2 donor sets with two phenoxide oxygen atoms bridging the copper centres with a copper–copper separation of 2.898(2) Å. A long copper–oxygen (amide) contact (2.808(10) Å) forms a weak dimer association. Complex III crystallizes in the triclinic system, space group [Formula: see text], with a = 8.7771(9) Å, b = 12.3983(16) Å, c = 15.7299(16) Å, α = 85.003(11)°, β = 84.574(8)°, γ = 76.838(10)°, Z = 2, Rf = 0.041 for 2966 significant reflections. The two copper(II) centres have distorted square-pyramidal geometry involving an N2O2 in plane donor set and two phenoxide oxygen bridges with a copper–copper separation of 3.018(1) Å. The fifth coordination site at each copper centre involves an amide oxygen from a neighbouring molecule (Cu(1)—O 2.371(4), Cu(2)—O 2.413(3) Å) in a staggered intermolecular array. Very strong antiferromagnetic exchange is observed in both cases (−2J = 689 ± 7 cm−1 (II), −2J = 816 ± 8 cm−1 (III)). Keywords: macrocycles, binuclear copper(II) complexes.

Synthesis, Characterization and Biological Activity Evaluation of Novel Pd(II) and Pt(II) Complexes with Heterocyclic Hydrazone Ligands

2007 ◽  
Vol 555 ◽  
pp. 423-427 ◽  
Author(s):  
Nenad R. Filipović ◽  
Tamara R. Todorović ◽  
D.M. Sladić ◽  
Irena T. Novaković ◽  
D.A. Jeremić ◽  
...  
Keyword(s):  
Biological Activity ◽  
13C Nmr Spectroscopy ◽  
Chloride Ions ◽  
Planar Geometry ◽  
Moderate Activity ◽  
Coordination Sites ◽  
Ligand Type ◽  
Square Planar ◽  
Derivatives Of ◽  
Hydrazone Ligands

New complexes of Pt(II) with condensation derivatives of ethyl hydrazinoacetate and either 2-acetylpyridine or 2-quinolinecarboxaldehyde, and of Pd(II) with the condensation derivative of ethyl hydrazinoacetate and 2-quinolinecarboxaldehyde were synthesized and characterized by elemental analysis, IR, 1H- and 13C-NMR spectroscopy, and molar conductivity measurements. The complexes have a square planar geometry, ligands binding as bidentates in the neutral form, and the remaining two coordination sites being occupied by chloride ions. Biological activity of new complexes, and of previously synthesized Pd(II), Cd(II), Co(III) and Zn(II) complexes with this ligand type was evaluated by the brine shrimp test. All the complexes showed a moderate activity.

scholarly journals Metal Complexes of π-Expanded Ligand (7): Syntheses, Structures and Properties of Pt(II) Complexes Containing the Isomeric 1- and 2-Alkyliminomethyl Pyrene Ligands

Crystals ◽  
2020 ◽  
Vol 10 (6) ◽  
pp. 476 ◽  
Author(s):  
Xuan-Dien Luong ◽  
Xuan-Truong Nguyen
Keyword(s):  
Molecular Structure ◽  
Planar Geometry ◽  
X Ray Diffraction ◽  
X Ray ◽  
Pt Complex ◽  
Physico Chemical ◽  
Clear Explanation ◽  
Square Planar ◽  
Structures And Properties ◽  
The Relationship

A [O,N] bidentate π-expanded ligand system, (E)-1-(n-octylimino)methylpyren-2-ol (2), was newly synthesized via a six-step synthesis from pyrene. The ligand 2 reacts with [PtCl2(PhCN)2] in chlorobenzene and the presence of a base at reflux for 2 h under the formation of (2(Pt)) complex with a yield of 70%. The molecular structure of (2(Pt)), studied by common spectroscopic methods and X-ray diffraction, shows a square planar geometry with a trans-configuration of the ligands. The molecular structure, absorption spectra, electrochemical properties, and phosphorescence characteristics of the (2(Pt)) complex are discussed, emphasizing the comparison with those of the previously reported Pt complex (1(Pt)) containing the isomeric ligands of 2, (E)-2-(n-octylimino)methylpyren-1-ol. The DFT calculations of the two Pt complexes are carried out and exhibit a clear explanation of the relationship between their physico-chemical characteristics.

Silver-Supporting Diatomite Preparation and Antibacterial Performance Test

2011 ◽  
Vol 694 ◽  
pp. 742-745 ◽  
Author(s):  
Fen E Hu ◽  
Zhi Juan Wang ◽  
Jun Li Li
Keyword(s):  
Performance Test ◽  
Silver Content ◽  
Antimicrobial Effect ◽  
X Ray Diffraction ◽  
E Coli ◽  
Agno3 Solution ◽  
Antibacterial Performance ◽  
Reaction Solution ◽  
Vacuum Heating ◽  
Dipping Time

The silver-supporting diatomite was prepared by the vacuum heating decomposition method with diatomite as the carrier and AgNO3 solution as the reaction solution. Its structure was characterized by X-ray diffraction (XRD). The factors influencing silver content of diatomite have been discussed in prepared silver-supporting diatomite. The results show that when the mass ratio of diatomite to AgNO3 is 10:1, the dipping time of 2 hours and the decomposing temperature of 350°C are suitable to preparing silver-supporting diatomite. XRD analyses show that the Ag loaded on the surface and micropore of the diatomite is nano-silver. The antimicrobial effect of silver-supporting diatomite was investigated against Escherichia coli (E. coli). The results show that the silver-supporting diatomite have obvious inhibiting effect on E. coli and its minimum inhibitory concentration decrease with increase of its silver content. The silver-supporting diatomite with the silver content of 1.46% is suitable to kill E. coli in water.

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