scholarly journals The interplay between gray matter and white matter neurodegeneration in subjective cognitive decline

Aging ◽  
2021 ◽  
Author(s):  
Nira Cedres ◽  
Patricia Diaz-Galvan ◽  
Lucio Diaz-Flores ◽  
J-Sebastian Muehlboeck ◽  
Yaiza Molina ◽  
...  
Keyword(s):  
White Matter ◽  
Cognitive Decline ◽  
Gray Matter ◽  
Subjective Cognitive Decline

scholarly journals The Interplay Between Gray Matter and White Matter Neurodegeneration in Subjective Cognitive Decline

2020 ◽  
Author(s):  
Nira Cedres ◽  
Patricia Diaz-Galvan ◽  
Lucio Diaz-Flores ◽  
J-Sebastian Muehlboeck ◽  
Yaiza Molina ◽  
...  
Keyword(s):  
White Matter ◽  
Cognitive Decline ◽  
Gray Matter ◽  
Mean Diffusivity ◽  
Occipital Lobe ◽  
Hippocampal Volume ◽  
Subjective Cognitive Decline ◽  
Community Based ◽  
Cortical Thinning ◽  
Behavioral Marker

Abstract AIMS: To investigate the interplay between gray matter (GM) and white matter (WM) neurodegeneration in subjective cognitive decline (SCD), including thickness across the whole cortical mantle, hippocampal volume, and integrity across the whole WM. METHODS: We included 225 cognitively unimpaired individuals from a community-based cohort, of whom 123 endorsed one or more subjective cognitive complaints. GM neurodegeneration was assessed through measures of cortical thickness across the whole mantle and hippocampal volume. WM neurodegeneration was assessed through measures of mean diffusivity (MD) across the whole WM skeleton. Mediation analysis and multiple linear regression were conducted to investigate the interplay between the measures of GM and WM neurodegeneration.RESULTS: A higher number of complaints was associated with reduced hippocampal volume, cortical thinning in several frontal and temporal areas and the insula, and higher MD across the WM skeleton, with a tendency to spare the occipital lobe. SCD-related cortical thinning and increased MD were associated with each other and jointly contributed to the complaints, but the contribution of cortical thinning to SCD was stronger.CONCLUSIONS: Neurodegeneration processes affecting the GM and WM seem to be associated with each other in SCD and include brain areas other than those typically targeted by Alzheimer’s disease (AD). Our findings suggest that SCD may be a sensitive behavioral marker of heterogeneous brain pathologies in individuals recruited from the community.

Altered mismatch response precedes gray matter atrophy in subjective cognitive decline

2021 ◽  
Author(s):  
Chia‐Hsiung Cheng ◽  
Chiung‐Chih Chang ◽  
Yi‐Ping Chao ◽  
Hsinjie Lu ◽  
Shih‐Wei Peng ◽  
...  
Keyword(s):  
Cognitive Decline ◽  
Gray Matter ◽  
Subjective Cognitive Decline ◽  
Gray Matter Atrophy

Associations Between the Subjective Cognitive Decline-Questionnaire’s Scores, Gray Matter Volume, and Amyloid-β Levels

2019 ◽  
Vol 72 (4) ◽  
pp. 1287-1302
Author(s):  
Natalia Valech ◽  
Gonzalo Sánchez-Benavides ◽  
Adrià Tort-Merino ◽  
Nina Coll-Padrós ◽  
Jaume Olives ◽  
...  
Keyword(s):  
Cognitive Decline ◽  
Gray Matter ◽  
Gray Matter Volume ◽  
Amyloid Β ◽  
Subjective Cognitive Decline ◽  
Matter Volume

scholarly journals Disrupted Topologic Efficiency of White Matter Structural Connectome in Individuals with Subjective Cognitive Decline

Radiology ◽  
2018 ◽  
Vol 286 (1) ◽  
pp. 229-238 ◽  
Author(s):  
Ni Shu ◽  
Xiaoni Wang ◽  
Qiuhui Bi ◽  
Tengda Zhao ◽  
Ying Han
Keyword(s):  
White Matter ◽  
Cognitive Decline ◽  
Subjective Cognitive Decline ◽  
Structural Connectome

P1-272: Hybrid Diffusion Imaging (HYDI) of White Matter Changes in Older Adults With Subjective Cognitive Decline (SCD): Assessment of Orientation Dispersion and Axonal Density

2016 ◽  
Vol 12 ◽  
pp. P519-P521
Author(s):  
Sourajit Mitra Mustafi ◽  
Pratik K. Gandhi ◽  
Shannon L. Risacher ◽  
John D. West ◽  
Eileen F. Tallman ◽  
...  
Keyword(s):  
Older Adults ◽  
White Matter ◽  
Cognitive Decline ◽  
Diffusion Imaging ◽  
Subjective Cognitive Decline ◽  
White Matter Changes ◽  
Axonal Density

scholarly journals Is Brain Connectome Research the Future Frontier for Subjective Cognitive Decline? A Systematic Review

2019 ◽  
Author(s):  
Ioulietta Lazarou ◽  
Spiros Nikolopoulos ◽  
Stavros Dimitriadis ◽  
Ioannis Kompatsiaris ◽  
Martha Spylioti ◽  
...  
Keyword(s):  
Systematic Review ◽  
White Matter ◽  
Cognitive Decline ◽  
Brain Network ◽  
Subjective Cognitive Decline ◽  
Research Activity ◽  
Brain Connectome ◽  
Advanced Stages ◽  
Multiple Network ◽  
The Brain

Objective: We performed a systematic literature review on Subjective Cognitive Decline (SCD) in order to examine whether the resemblance of brain connectome and functional connectivity (FC) alterations in SCD with respect to MCI, AD and HC can help us draw conclusions on the progression of SCD to more advanced stages of dementia.Methods: We searched for studies that used any neuroimaging tool to investigate potential differences of brain connectome in SCD with respect to HC, MCI, and AD.Results: Sixteen studies were finally included in the review. Apparent FC connections and disruptions were observed in the white matter, default mode and gray matter networks in SCD with regards to HC, MCI, and AD. Interestingly, more apparent connections in SCD were located over the posterior regions, while an increase of FC over anterior regions was observed as the disease progressed. Conclusions: Elders with SCD present a significant disruption of the brain network, which in most of the cases is worse than HC across multiple network parameters. Significance: The present review provides comprehensive and balanced coverage of a timely target research activity around SCD and the design of network-based biomarkers for the accurate detection of SCD.

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