scholarly journals Correction for: TGF-β and NF-κB signaling pathway crosstalk potentiates corneal epithelial senescence through an RNA stress response

Aging ◽  
2021 ◽  
pp. 20853-20853
Author(s):  
Zhi-Yuan Li ◽  
Zhao-Li Chen ◽  
Ting Zhang ◽  
Chao Wei ◽  
Wei-Yun Shi
Keyword(s):  
Stress Response ◽  
Signaling Pathway ◽  
Corneal Epithelial ◽  
Pathway Crosstalk

scholarly journals TGF-β and NF-κB signaling pathway crosstalk potentiates corneal epithelial senescence through an RNA stress response

Aging ◽  
2016 ◽  
Vol 8 (10) ◽  
pp. 2337-2354 ◽  
Author(s):  
Zhi-Yuan Li ◽  
Zhao-Li Chen ◽  
Ting Zhang ◽  
Chao Wei ◽  
Wei-Yun Shi
Keyword(s):  
Stress Response ◽  
Signaling Pathway ◽  
Corneal Epithelial ◽  
Pathway Crosstalk

Esculetin protects human corneal epithelial cells from oxidative stress through Nrf-2 signaling pathway

2021 ◽  
Vol 202 ◽  
pp. 108360
Author(s):  
Yingjun Zhang ◽  
Yuanlong An ◽  
Xiangdong He ◽  
Donglei Zhang ◽  
Wei He
Keyword(s):  
Oxidative Stress ◽  
Epithelial Cells ◽  
Signaling Pathway ◽  
Corneal Epithelial Cells ◽  
Corneal Epithelial ◽  
Human Corneal Epithelial Cells

scholarly journals Acupuncture modulates stress response by the mTOR signaling pathway in a rat post-traumatic stress disorder model

2018 ◽  
Vol 8 (1) ◽  
Author(s):  
Ju-Young Oh ◽  
Yu-Kang Kim ◽  
Seung-Nam Kim ◽  
Bombi Lee ◽  
Jae-Hwan Jang ◽  
...  
Keyword(s):  
Stress Response ◽  
Signaling Pathway ◽  
Post Traumatic Stress Disorder ◽  
Traumatic Stress ◽  
Stress Disorder ◽  
Mtor Signaling ◽  
Mtor Signaling Pathway ◽  
Post Traumatic Stress ◽  
Post Traumatic

Oxidative Stress Signaling Pathway of Heme Regulated eIF2α Kinase in mitigating the Severity of β-Thalassemia

Blood ◽  
2008 ◽  
Vol 112 (11) ◽  
pp. 127-127 ◽  
Author(s):  
Rajasekhar NVS Suragani ◽  
Sijin Liu ◽  
Wanting Zhao ◽  
Jane-Jane Chen
Keyword(s):  
Oxidative Stress ◽  
Protein Synthesis ◽  
Stress Response ◽  
Signaling Pathway ◽  
Fetal Liver ◽  
Stress Signaling ◽  
Erythroid Precursors ◽  
Inhibition Of Protein Synthesis ◽  
And Oxidative Stress ◽  
Stress Signaling Pathway

Abstract Maturation of erythroid precursors requires active synthesis of hemoglobin which consists of two pairs of α- and β-globin subunits with each monomer bound to a heme moiety. Heme Regulated Inhibitor (HRI) is the only eIF2αkinase responsible for the balanced synthesis of heme and globin at translational level in erythroid cells. Activation of HRI in heme deficiency leads to phosphorylation of the α-subunit of eukaryotic initiation factor (eIF2α) and inhibition of protein synthesis. HRI is also activated by denatured proteins and oxidative stress. In addition to general inhibition of protein synthesis, phosphorylation of eIF2α (eIF2αP) also leads to the induction of a stress signaling pathway. Activating transcription factor 4 (Atf4) mRNA is preferentially translated amidst global inhibition of protein synthesis. Atf4 activates transcription of stress response proteins, Chop (CCAAT/enhancer binding protein homologous protein-10) and the non-enzymatic cofactor of eIF2α phosphatase (PP1A) Gadd34. These stress response proteins help cells in mitigating the stress. While the role of HRI in translational regulation of non-nucleated reticulocytes is well established, the HRIdependent Atf4 stress signaling pathway of nucleated erythroid precursors is unknown. Sodium arsenite toxicity was used as a model system of oxidative stress to elucidate the HRI signaling pathway in Hri +/+ and −/− E14.5 mouse fetal liver erythroid precursors. In HRI deficiency, erythroid precursors were more sensitive to arsenite toxicity with decreased cell viability and increased apoptosis, by caspase 3 executed intrinsic apoptotic pathway. HRI was activated by autophosphorylation as early as 15 minutes following arsenite treatment. In addition to increased eIF2αP, there was induction of Atf4, Chop and Gadd34 in Hri+/+ fetal liver cells. Importantly, in Hri−/− cells neither the phosphorylation of eIF2α nor the expression of Atf4, Chop and Gadd34 was increased upon arsenite treatment. In addition, we also observed HRI dependent induction of Heme Oxygenase 1 (HO-1) that plays a pivotal role in adaptation to oxidative stress. These results demonstrate that HRI induces a signaling pathway for adaptive gene expression to protect the nucleated erythroid precursors from apoptosis upon oxidative stress. Iron overload, accumulation of unpaired α-globin and oxidative stress are well documented in β-thalassemia. Recently, HRI was discovered to be necessary for the survival of β-thalassemic mice. β-thalassemic mice lacking one copy of HRI (Hri+/− Hbb−/−) also manifest a more severe syndrome of the disease. We have investigated the activation of eIF2αP/Atf4 signaling pathway in Hri+/−Hbb−/− β-thalassemic erythroid cells using eIF2αP phosphatase (Gadd34) inhibitor salubrinal. Treatment of reticulocytes from Hri+/−Hbb−/− mice with salubrinal increased eIF2αP and resulted in inhibition of newly synthesized globin protein synthesis. The decreased globin protein synthesis also resulted in decreased aggregation of the unpaired α-globins. Furthermore, treatment of salubrinal in nucleated fetal liver erythroblasts also increased Chop expression and decreased apoptosis. Thus, activation of the eIF2αP/Atf4 pathway by small chemicals might be a novel pharmaceutical approach to decrease proteotoxicity and apoptosis for the treatment of β-thalassemia.

scholarly journals cGMP signaling pathway is involved in Leyding cell stress response

2007 ◽  
Vol 7 (S1) ◽  
Author(s):  
Silvana Andric ◽  
Natasa Stojkov ◽  
Marija Janjic ◽  
Stanko Stojilkovic ◽  
Tatjana Kostic
Keyword(s):  
Stress Response ◽  
Signaling Pathway ◽  
Cell Stress ◽  
Cgmp Signaling ◽  
Cell Stress Response

scholarly journals Cis‐urocanic acid inhibits SAPK/JNK signaling pathway in UV‐B exposed human corneal epithelial cells in vitro

2011 ◽  
Vol 89 (s248) ◽  
pp. 0-0
Author(s):  
T PAIMELA ◽  
HM JAUHONEN ◽  
A KAUPPINEN ◽  
JK LAIHIA ◽  
L LEINO ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Signaling Pathway ◽  
Urocanic Acid ◽  
Corneal Epithelial Cells ◽  
Jnk Signaling ◽  
Corneal Epithelial ◽  
Human Corneal Epithelial Cells ◽  
Jnk Signaling Pathway

scholarly journals Primary cilia maintain corneal epithelial homeostasis by regulation of the Notch signaling pathway

2016 ◽  
Vol 129 (13) ◽  
pp. e1.2-e1.2
Author(s):  
Laura Grisanti ◽  
Ekaterina Revenkova ◽  
Ronald E. Gordon ◽  
Carlo Iomini
Keyword(s):  
Notch Signaling ◽  
Signaling Pathway ◽  
Primary Cilia ◽  
Notch Signaling Pathway ◽  
Corneal Epithelial ◽  
Epithelial Homeostasis
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