scholarly journals Vamorolone, a dissociative steroidal compound, reduces pro-inflammatory cytokine expression in glioma cells and increases activity and survival in a murine model of cortical tumor

Oncotarget ◽  
2016 ◽  
Vol 8 (6) ◽  
pp. 9366-9374 ◽  
Author(s):  
Elizabeth Wells ◽  
Madhuri Kambhampati ◽  
Jesse M. Damsker ◽  
Heather Gordish-Dressman ◽  
Sridevi Yadavilli ◽  
...  
Keyword(s):  
Murine Model ◽  
Inflammatory Cytokine ◽  
Glioma Cells ◽  
Cytokine Expression ◽  
Steroidal Compound

scholarly journals AB0074 Daily exercise suppresses acute pro-inflammatory cytokine expression systemically and il-1Β locally in a murine model of gout

2018 ◽  
Author(s):  
N.A. Young ◽  
K. Jablonski ◽  
B. Sandoval ◽  
A. Kalyanasundaram ◽  
P. Harb ◽  
...  
Keyword(s):  
Murine Model ◽  
Inflammatory Cytokine ◽  
Cytokine Expression ◽  
Daily Exercise

Porcine circovirus type 3 capsid protein induces NF-κB activation and upregulates pro-inflammatory cytokine expression in HEK-293T cells

2021 ◽  
Author(s):  
Xianhui Liu ◽  
Hanqin Shen ◽  
Xinming Zhang ◽  
Tairun Liang ◽  
Yanfang Ban ◽  
...  
Keyword(s):  
Capsid Protein ◽  
Inflammatory Cytokine ◽  
Porcine Circovirus Type ◽  
Cytokine Expression ◽  
Porcine Circovirus ◽  
Type 3

Abdominal irradiation increases inflammatory cytokine expression and activates NF-κB in rat ileal muscularis layer

2003 ◽  
Vol 285 (3) ◽  
pp. G556-G565 ◽  
Author(s):  
C. Linard ◽  
A. Ropenga ◽  
M. C. Vozenin-Brotons ◽  
A. Chapel ◽  
D. Mathe
Keyword(s):  
Inflammatory Cytokine ◽  
Intestinal Inflammation ◽  
Clinical Symptoms ◽  
Early Stage ◽  
Cytokine Expression ◽  
Mrna Levels ◽  
Activator Protein 1 ◽  
Γ Irradiation ◽  
Control Tissue ◽  
Anti Inflammatory

The small bowel is an important dose-limiting organ in abdominal radiotherapy because irradiation can cause acute enteritis that, in turn, leads to progressively reduced motility and finally, in a later phase, to fibrosis. Because these clinical symptoms may be caused by the early stage of an inflammatory process, we characterized the radiation-induced intestinal inflammation in rats. Abdominal γ-irradiation (10-Gy) induced a cascade of inflammatory events characterized by an early (6 h after exposure) increase in IL-1β, TNF-α, and IL-6 mRNA levels in the rat ileal muscularis layer. IL-8 [a cytokine-induced neutrophil chemoattractant (CINC)] mRNA appeared later (at 3 days). The expression of TGF-β (a profibrotic cytokine) was higher in irradiated than control tissue at day 1, whereas IL-10 (an anti-inflammatory cytokine) expression vanished completely. Despite strong IL-1ra expression, the IL-1ra/IL-1β ratio, which is an indicator of inflammatory balance, was -41% at day 1 in irradiated compared with control tissue. The nuclear transcription factors NF-κB and activator protein-1 (AP-1) govern transcription of these genes, directly or indirectly. Although expression of the subunits of NF-κB (p65, p50) and AP-1 (c- fos, c- jun) did not increase, irradiation caused a rapid and persistent translocation of p65 and p50. An imbalance between proinflammatory and anti-inflammatory mediators may contribute to perpetuating intestinal inflammation, thus making it chronic.

scholarly journals Kefir reduces insulin resistance and inflammatory cytokine expression in an animal model of metabolic syndrome

2016 ◽  
Vol 7 (8) ◽  
pp. 3390-3401 ◽  
Author(s):  
Damiana D. Rosa ◽  
Łukasz M. Grześkowiak ◽  
Célia L. L. F. Ferreira ◽  
Ana Carolina M. Fonseca ◽  
Sandra A. Reis ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Metabolic Syndrome ◽  
Animal Model ◽  
Inflammatory Cytokine ◽  
Fasting Glucose ◽  
Cytokine Expression ◽  
Fasting Insulin ◽  
Insulin Levels ◽  
Reduce Insulin Resistance

Kefir supplementation in rats with induced metabolic syndrome was able to lower fasting glucose, fasting insulin levels, and reduce insulin resistance.

94 Probiotic Saccharomyces boulardii CNCM I-745 Inhibits Hypervirulent Clostridium difficile-Associated Cecal Tissue Damage and Pro-Inflammatory Cytokine Expression in Hamsters

2016 ◽  
Vol 150 (4) ◽  
pp. S23-S24
Author(s):  
Hon Wai Koon ◽  
Diana Hoang-Ngoc Tran ◽  
Xinhua Chen ◽  
Ciaran P. Kelly ◽  
Charalabos Pothoulakis
Keyword(s):  
Clostridium Difficile ◽  
Tissue Damage ◽  
Inflammatory Cytokine ◽  
Saccharomyces Boulardii ◽  
Cytokine Expression
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