scholarly journals The diagnostic role of microRNA-34a in breast cancer: a systematic review and meta-analysis

Oncotarget ◽  
2017 ◽  
Vol 8 (14) ◽  
pp. 23177-23187 ◽  
Author(s):  
Saber Imani ◽  
Xianqin Zhang ◽  
Hossein Hosseinifard ◽  
Shangyi Fu ◽  
Junjiang Fu
Keyword(s):  
Breast Cancer ◽  
Systematic Review ◽  
Meta Analysis ◽  
Diagnostic Role

scholarly journals Diagnostic role of 18F-FDG PET/MRI in the TNM staging of breast cancer: a systematic review and meta-analysis

2021 ◽  
Vol 10 (4) ◽  
pp. 50-50
Author(s):  
Xing-Ru Lu ◽  
Meng-Meng Qu ◽  
Ya-Nan Zhai ◽  
Wen Feng ◽  
Ya Gao ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Systematic Review ◽  
Fdg Pet ◽  
Meta Analysis ◽  
Tnm Staging ◽  
Diagnostic Role ◽  
18F Fdg

Diagnostic Role of Long Non-Coding RNAs in Breast Cancer: a Systematic Review and Meta-Analysis

2021 ◽  
Vol 67 (03/2021) ◽  
Author(s):  
Xiaojiao Gao ◽  
Jianhao Xu ◽  
Fang Cao ◽  
Fang Chen ◽  
Ting Chen ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Systematic Review ◽  
Meta Analysis ◽  
Diagnostic Role ◽  
Non Coding Rnas

scholarly journals Correction: Diagnostic role of 18F-FDG PET/MRI in patients with gynecological malignancies of the pelvis: A systematic review and meta-analysis

PLoS ONE ◽  
2018 ◽  
Vol 13 (8) ◽  
pp. e0202314 ◽  
Author(s):  
Ji Nie ◽  
Jing Zhang ◽  
Jinsheng Gao ◽  
Linghong Guo ◽  
Hui Zhou ◽  
...  
Keyword(s):  
Systematic Review ◽  
Fdg Pet ◽  
Meta Analysis ◽  
Gynecological Malignancies ◽  
Diagnostic Role ◽  
18F Fdg

The role of LHRH agonists in ovarian function preservation in premenopausal women undergoing chemotherapy for early stage breast cancer: A systematic review and meta-analysis.

2015 ◽  
Vol 33 (15_suppl) ◽  
pp. 1050-1050
Author(s):  
Rodrigo Ramella Munhoz ◽  
Allan Andresson Lima Pereira ◽  
Andre Deeke Sasse ◽  
Paulo Marcelo Hoff ◽  
Tiffany A. Traina ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Systematic Review ◽  
Ovarian Function ◽  
Early Stage ◽  
Meta Analysis ◽  
Premenopausal Women ◽  
Early Stage Breast Cancer ◽  
Lhrh Agonists ◽  
Function Preservation

scholarly journals The diagnostic role of DNA methylation in sporadic endometrial cancer: a systematic review and meta-analysis

Oncotarget ◽  
2017 ◽  
Vol 9 (9) ◽  
pp. 8642-8652 ◽  
Author(s):  
Yu Fan ◽  
Yu Wang ◽  
Shaozhi Fu ◽  
Linglin Yang ◽  
Sheng Lin ◽  
...  
Keyword(s):  
Systematic Review ◽  
Dna Methylation ◽  
Endometrial Cancer ◽  
Meta Analysis ◽  
Diagnostic Role

Diagnostic role of postmortem CK-MB in cardiac death: a systematic review and meta-analysis

2020 ◽  
Vol 16 (2) ◽  
pp. 287-294
Author(s):  
Chengyang Xu ◽  
Tianyi Zhang ◽  
Baoli Zhu ◽  
Zhipeng Cao
Keyword(s):  
Systematic Review ◽  
Cardiac Death ◽  
Meta Analysis ◽  
Diagnostic Role

scholarly journals Clinical Method Applied to Focused Ultrasound: The Case of Wells’ Score and Echocardiography in the Emergency Department: A Systematic Review and a Meta-Analysis

Medicina ◽  
2021 ◽  
Vol 57 (8) ◽  
pp. 766
Author(s):  
Lorenzo Falsetti ◽  
Vincenzo Zaccone ◽  
Alberto M. Marra ◽  
Nicola Tarquinio ◽  
Giovanna Viticchi ◽  
...  
Keyword(s):  
Systematic Review ◽  
Pulmonary Embolism ◽  
High Risk ◽  
Right Ventricle ◽  
Meta Analysis ◽  
Diagnostic Role ◽  
Wells Score ◽  
Risk Patients ◽  
Low Sensitivity

Background and Objectives: bedside cardiac ultrasound is a widely adopted method in Emergency Departments (ED) for extending physical examination and refining clinical diagnosis. However, in the setting of hemodynamically-stable pulmonary embolism, the diagnostic role of echocardiography is still the subject of debate. In light of its high specificity and low sensitivity, some authors suggest that echocardiographic signs of right ventricle overload could be used to rule-in pulmonary embolism. In this study, we aimed to clarify the diagnostic role of echocardiographic signs of right ventricle overload in the setting of hemodynamically-stable pulmonary embolism in the ED. Materials and Methods: we performed a systematic review of literature in PubMed, Web of Science and Cochrane databases, considering the echocardiographic signs for the diagnosis of pulmonary embolism in the ED. Studies considering unstable or shocked patients were excluded. Papers enrolling hemodynamically stable subjects were selected. We performed a diagnostic test accuracy meta-analysis for each sign, and then performed a critical evaluation according to pretest probability, assessed with Wells’ score for pulmonary embolism. Results: 10 studies were finally included. We observed a good specificity and a low sensitivity of each echocardiographic sign of right ventricle overload. However, once stratified by the Wells’ score, the post-test probability only increased among high-risk patients. Conclusions: signs of echocardiographic right ventricle overload should not be used to modify the clinical behavior in low- and intermediate- risk patients according to Wells’ score classification. Among high-risk patients, however, echocardiographic signs could help a physician in detecting patients with the highest probability of pulmonary embolism, necessitating a confirmation by computed tomography with pulmonary angiography. However, a focused cardiac and thoracic ultrasound investigation is useful for the differential diagnosis of dyspnea and chest pain in the ED.

scholarly journals Clinical Theragnostic Relationship between Drug-Resistance Specific miRNA Expressions, Chemotherapeutic Resistance, and Sensitivity in Breast Cancer: A Systematic Review and Meta-Analysis

Cells ◽  
2019 ◽  
Vol 8 (10) ◽  
pp. 1250 ◽  
Author(s):  
Jayaraj ◽  
Nayagam ◽  
Kar ◽  
Sathyakumar ◽  
Mohammed ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Systematic Review ◽  
Drug Targets ◽  
Meta Analysis ◽  
Treatment Options ◽  
Rank Correlation ◽  
P Value ◽  
Bibliographic Search ◽  
Trim And Fill

Awareness of breast cancer has been increasing due to early detection, but the advanced disease has limited treatment options. There has been growing evidence on the role of miRNAs involved in regulating the resistance in several cancers. We performed a comprehensive systematic review and meta-analysis on the role of miRNAs in influencing the chemoresistance and sensitivity of breast cancer. A bibliographic search was performed in PubMed and Science Direct based on the search strategy, and studies published until December 2018 were retrieved. The eligible studies were included based on the selection criteria, and a detailed systematic review and meta-analysis were performed based on PRISMA guidelines. A random-effects model was utilised to evaluate the combined effect size of the obtained hazard ratio and 95% confidence intervals from the eligible studies. Publication bias was assessed with Cochran’s Q test, I2 statistic, Orwin and Classic fail-safe N test, Begg and Mazumdar rank correlation test, Duval and Tweedie trim and fill calculation and the Egger’s bias indicator. A total of 4584 potential studies were screened. Of these, 85 articles were eligible for our systematic review and meta-analysis. In the 85 studies, 188 different miRNAs were studied, of which 96 were upregulated, 87 were downregulated and 5 were not involved in regulation. Overall, 24 drugs were used for treatment, with doxorubicin being prominently reported in 15 studies followed by Paclitaxel in 11 studies, and 5 drugs were used in combinations. We found only two significant HR values from the studies (miR-125b and miR-4443) and our meta-analysis results yielded a combined HR value of 0.748 with a 95% confidence interval of 0.508–1.100; p-value of 0.140. In conclusion, our results suggest there are different miRNAs involved in the regulation of chemoresistance through diverse drug genetic targets. These biomarkers play a crucial role in guiding the effective diagnostic and prognostic efficiency of breast cancer. The screening of miRNAs as a theragnostic biomarker must be brought into regular practice for all diseases. We anticipate that our study serves as a reference in framing future studies and clinical trials for utilising miRNAs and their respective drug targets.

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