scholarly journals The G-protein-coupled bile acid receptor Gpbar1 (TGR5) protects against renal inflammation and renal cancer cell proliferation and migration through antagonizing NF-κB and STAT3 signaling pathways

Oncotarget ◽  
2017 ◽  
Vol 8 (33) ◽  
pp. 54378-54387 ◽  
Author(s):  
Jia Su ◽  
Qiqi Zhang ◽  
Hui Qi ◽  
Linlin Wu ◽  
Yuanqiang Li ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Bile Acid ◽  
Cancer Cell Proliferation ◽  
Stat3 Signaling ◽  
Cell Proliferation And Migration ◽  
Renal Cancer Cell ◽  
Bile Acid Receptor ◽  
And Migration ◽  
G Protein Coupled ◽  
Proliferation And Migration

Scutellarin inhibits human renal cancer cell proliferation and migration via upregulation of PTEN

2018 ◽  
Vol 107 ◽  
pp. 1505-1513 ◽  
Author(s):  
Wenting Deng ◽  
Wei Han ◽  
Tao Fan ◽  
Xiaoku Wang ◽  
Zhao Cheng ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Cancer Cell ◽  
Renal Cancer ◽  
Cancer Cell Proliferation ◽  
Cell Proliferation And Migration ◽  
Renal Cancer Cell ◽  
And Migration ◽  
Proliferation And Migration

ARFGAP3 an androgen target gene promotes prostate cancer cell proliferation and migration.

2020 ◽  
Author(s):  
Lungwani Muungo
Keyword(s):  
Cell Proliferation ◽  
Cancer Cell ◽  
Cell Biology ◽  
Adaptor Protein ◽  
Cancer Cell Proliferation ◽  
Lncap Cells ◽  
Gtpase Activating Protein ◽  
Cell Proliferation And Migration ◽  
And Migration ◽  
Proliferation And Migration

ADP ribosylation factor GTPase-activating protein 3 (ARFGAP3) is a GTPase-activating protein that associates with the Golgiapparatus and regulates the vesicular trafficking pathway. In the present study, we examined the contribution of ARFGAP3 toprostate cancer cell biology. We showed that ARFGAP3 expression was induced by 100 nM of dihydrotestosterone (DHT) atboth the mRNA and protein levels in androgen-sensitive LNCaP cells. We generated stable transfectants of LNCaP cells withFLAG-tagged ARFGAP3 or a control empty vector and showed that ARFGAP3 overexpression promoted cell proliferation andmigration compared with control cells. We found that ARFGAP3 interacted with paxillin, a focal adhesion adaptor protein thatis important for cell mobility and migration. Small interfering RNA (siRNA)-mediated knockdown of ARFGAP3 showed thatARFGAP3 siRNA markedly reduced LNCaP cell growth. Androgen receptor (AR)-dependent transactivation activity on prostatespecificantigen (PSA) enhancer was synergistically promoted by exogenous ARFGAP3 and paxillin expression, as shown byluciferase assay in LNCaP cells. Thus, our results suggest that ARFGAP3 is a novel androgen-regulated gene that can promoteprostate cancer cell proliferation and migration in collaboration with paxillin.

scholarly journals Exopolysaccharides from aCodonopsis pilosulaendophyte activate macrophages and inhibit cancer cell proliferation and migration

2018 ◽  
Vol 9 (5) ◽  
pp. 630-639 ◽  
Author(s):  
Min Chen ◽  
Yuanyuan Li ◽  
Zhu Liu ◽  
Yajun Qu ◽  
Huajie Zhang ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Cancer Cell ◽  
Cancer Cell Proliferation ◽  
Cell Proliferation And Migration ◽  
And Migration ◽  
Proliferation And Migration

scholarly journals Mir-483 inhibits colon cancer cell proliferation and migration by targeting TRAF1

2018 ◽  
Vol 34 (9) ◽  
pp. 479-486 ◽  
Author(s):  
Zi-Yu Niu ◽  
Wen-Li Li ◽  
Da-Lei Jiang ◽  
Yan-Song Li ◽  
Xiang-Jun Xie
Keyword(s):  
Colon Cancer ◽  
Cell Proliferation ◽  
Cancer Cell ◽  
Colon Cancer Cell ◽  
Cancer Cell Proliferation ◽  
Cell Proliferation And Migration ◽  
And Migration ◽  
Proliferation And Migration

ARHGEF39 promotes gastric cancer cell proliferation and migration via Akt signaling pathway

2017 ◽  
Vol 440 (1-2) ◽  
pp. 33-42 ◽  
Author(s):  
Haixiao Wang ◽  
Miaomiao Li ◽  
Xiaobao Tao ◽  
Yan Qian ◽  
Linfang Chen ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cell Proliferation ◽  
Gastric Cancer Cell ◽  
Akt Signaling ◽  
Cancer Cell Proliferation ◽  
Akt Signaling Pathway ◽  
Cell Proliferation And Migration ◽  
Gastric Cancer Cell Proliferation ◽  
And Migration ◽  
Proliferation And Migration

scholarly journals hYSK1 promotes cancer cell proliferation and migration through negative regulation of p16INK4a under hypoxic conditions

Oncotarget ◽  
2017 ◽  
Vol 8 (51) ◽  
pp. 89072-89085 ◽  
Author(s):  
Mee-Hyun Lee ◽  
Zigang Dong ◽  
Young-Joon Surh ◽  
Bu Young Choi
Keyword(s):  
Cell Proliferation ◽  
Cancer Cell ◽  
Negative Regulation ◽  
Cancer Cell Proliferation ◽  
Hypoxic Conditions ◽  
Cell Proliferation And Migration ◽  
And Migration ◽  
Proliferation And Migration
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