scholarly journals Characterization of the urinary microbiota of elderly women and the effects of type 2 diabetes and urinary tract infections on the microbiota

Oncotarget ◽  
2017 ◽  
Vol 8 (59) ◽  
pp. 100678-100690 ◽  
Author(s):  
Fengping Liu ◽  
Zongxin Ling ◽  
Yonghong Xiao ◽  
Qing Yang ◽  
Li Zheng ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Urinary Tract ◽  
Urinary Tract Infections ◽  
Elderly Women ◽  
Urinary Microbiota ◽  
Tract Infections

scholarly journals PDB4 Characterization of the Risk for Urinary Tract Infections in US Patients with Type 2 Diabetes Mellitus

2011 ◽  
Vol 14 (7) ◽  
pp. A472
Author(s):  
K. Lento ◽  
Y. Qiu ◽  
A.Z. Fu ◽  
S.S. Engel ◽  
R. Shankar ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Urinary Tract ◽  
Urinary Tract Infections ◽  
Tract Infections

scholarly journals Use of sodium-glucose cotransporter-2 inhibitors and urinary tract infections in type 2 diabetes patients: a systematic review

2019 ◽  
Vol 65 (2) ◽  
pp. 246-252 ◽  
Author(s):  
Izabela Rodrigues Figueiredo ◽  
Sara Cardoso Paes Rose ◽  
Nathália Bandeira Freire ◽  
Marina Stabile Patrocínio ◽  
Natália Pierdoná ◽  
...  
Keyword(s):  
Systematic Review ◽  
Type 2 Diabetes ◽  
Urinary Tract ◽  
Urinary Tract Infections ◽  
Randomized Clinical Trials ◽  
Oral Antidiabetic Agents ◽  
Sodium Glucose Cotransporter ◽  
Increased Risk ◽  
Tract Infections

SUMMARY Sodium-glucose cotransporter-2 inhibitors (SGLT2i) are drugs that act by maintaining glycosuria. Recent studies have shown promising effects of these in the treatment of type 2 diabetes mellitus (DM2). However, there may be an increased risk of developing urinary tract infections (UTIs) in patients treated with these. Our study aims to analyze the association between the risk of UTI in patients treated with SGLT2i. A systematic review of the literature was carried out by randomized clinical trials, totalizing at the end of the selection 23 articles that were statistically evaluated. The incidence of UTI was generally demonstrated in articles and in different subgroups: patients on SGLT2i monotherapy or on combination therapy; according to specific comorbidities of each sample or according to the drug used. They noticed an increase in the chance of UTI in the SGLT2i groups compared to the control groups on placebo or other oral antidiabetic agents. This increased chance was found predominantly with the use of Dapagliflozin, Canagliflozin, and Tofogliflozin, regardless of the dosing. Lastly, stands out that the dimension of UTI chances for DM2 patients who use SGLT2i remains to be more strictly determined.

scholarly journals A clinical prediction rule for urinary tract infections in patients with type 2 diabetes mellitus in primary care

2008 ◽  
Vol 137 (2) ◽  
pp. 166-172 ◽  
Author(s):  
L. M. A. J. VENMANS ◽  
K. J. GORTER ◽  
G. E. H. M. RUTTEN ◽  
F. G. SCHELLEVIS ◽  
A. I. M. HOEPELMAN ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Urinary Tract ◽  
Urinary Tract Infections ◽  
Prediction Rule ◽  
Clinical Prediction Rule ◽  
Receiver Operating Curve ◽  
Tract Infections

SUMMARYWe aimed to develop a prediction rule for urinary tract infections (UTIs) in patients with type 2 diabetes mellitus (DM2). A 12-month prospective cohort study was conducted in patients with DM2 aged ⩾45 years to predict the occurrence of recurrent UTIs in women and lower UTIs in men. Predictors for recurrent UTI in women (n=81, 2%) and lower UTIs in men (n=93, 3%) were age, number of general practitioner (GP) visits, urinary incontinence, cerebrovascular disease or dementia. In women, renal disease was an additional predictor. The optimum corrected area under the receiver-operating curve (AUC) was 0·79 (95% CI 0·74–0·83) for women and 0·75 (95% CI 0·70–0·80) for men. Using a cut-off score of 4, women with a lower risk assignment had a probability of 0·3% for the outcome. For a cut-off score of 6, women with a higher risk assignment had a probability of 5·8%. For men these figures were 0·8 and 7·1 for a cut-off score of 2 and 4, respectively. Simple variables can be used for the risk stratification of patients.

scholarly journals Urinary tract infections in postmenopausal women with type 2 diabetes: clinical correlates and quinolone susceptibility

2017 ◽  
Author(s):  
Martyna Borowczyk ◽  
Anna Chmielarz-Czarnocińska ◽  
Paula Faner ◽  
Andrzej Paciorkowski ◽  
Jan K. Nowak ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Urinary Tract ◽  
Postmenopausal Women ◽  
Urinary Tract Infections ◽  
Clinical Correlates ◽  
Tract Infections

Prediction of complicated urinary tract infections in patients with type 2 diabetes: a questionnaire study in primary care

2007 ◽  
Vol 22 (1) ◽  
pp. 49-54 ◽  
Author(s):  
Leonie M. A. J. Venmans ◽  
Marian Sloof ◽  
Eelko Hak ◽  
Kees J. Gorter ◽  
Guy E. H. M. Rutten
Keyword(s):  
Type 2 Diabetes ◽  
Primary Care ◽  
Urinary Tract ◽  
Urinary Tract Infections ◽  
Questionnaire Study ◽  
Tract Infections

scholarly journals Urinary tract infections in patients with type 2 diabetes mellitus with pharmacological glucosuria

2020 ◽  
Vol 92 (11) ◽  
pp. 106-109
Author(s):  
N. V. Sturov ◽  
S. V. Popov ◽  
N. K. Mamporia ◽  
A. A. Mager
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Urinary Tract ◽  
Urinary Tract Infections ◽  
Renal Tubules ◽  
Sodium Glucose Cotransporter ◽  
Glucose Reabsorption ◽  
Tract Infections

Selective inhibitors of sodium-glucose cotransporter belong to a new class of drugs for the treatment of type 2 diabetes mellitus. The mechanism of their action is based on insulin-independent reduction of glucose reabsorption in the proximal renal tubules, which leads to stimulation of its excretion in the urine and, accordingly, to a decrease in the concentration of glucose in the blood plasma. Drugs of this group demonstrate effectiveness in the treatment of type 2 diabetes, but their use may be associated with an increased frequency of urinary tract infections. Pharmacological glucosuria, which leads to a decrease in the concentration of glucose in the blood, creates the preconditions for the occurrence of urinary tract infections. Urinary tract and genital infections are the most common adverse events associated with the use of sodium-glucose cotransporter inhibitors. In the presented literature review for 20162019, the relationship between urinary tract infections in patients with type 2 diabetes mellitus and therapy with sodium-glucose cotransporter inhibitors was analyzed.

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