Prediction of complicated urinary tract infections in patients with type 2 diabetes: a questionnaire study in primary care

SUMMARY Sodium-glucose cotransporter-2 inhibitors (SGLT2i) are drugs that act by maintaining glycosuria. Recent studies have shown promising effects of these in the treatment of type 2 diabetes mellitus (DM2). However, there may be an increased risk of developing urinary tract infections (UTIs) in patients treated with these. Our study aims to analyze the association between the risk of UTI in patients treated with SGLT2i. A systematic review of the literature was carried out by randomized clinical trials, totalizing at the end of the selection 23 articles that were statistically evaluated. The incidence of UTI was generally demonstrated in articles and in different subgroups: patients on SGLT2i monotherapy or on combination therapy; according to specific comorbidities of each sample or according to the drug used. They noticed an increase in the chance of UTI in the SGLT2i groups compared to the control groups on placebo or other oral antidiabetic agents. This increased chance was found predominantly with the use of Dapagliflozin, Canagliflozin, and Tofogliflozin, regardless of the dosing. Lastly, stands out that the dimension of UTI chances for DM2 patients who use SGLT2i remains to be more strictly determined.

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A clinical prediction rule for urinary tract infections in patients with type 2 diabetes mellitus in primary care: Erratum

Epidemiology and Infection ◽

10.1017/s0950268808001210 ◽

2008 ◽

Vol 137 (2) ◽

pp. 173-173

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Primary Care ◽

Type 2 Diabetes Mellitus ◽

Urinary Tract ◽

Prediction Rule ◽

Clinical Prediction Rule ◽

Clinical Prediction ◽

Tract Infections

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PDB4 Characterization of the Risk for Urinary Tract Infections in US Patients with Type 2 Diabetes Mellitus

Value in Health ◽

10.1016/j.jval.2011.08.1307 ◽

2011 ◽

Vol 14 (7) ◽

pp. A472

Author(s):

K. Lento ◽

Y. Qiu ◽

A.Z. Fu ◽

S.S. Engel ◽

R. Shankar ◽

...

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Urinary Tract ◽

Urinary Tract Infections ◽

Tract Infections

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A clinical prediction rule for urinary tract infections in patients with type 2 diabetes mellitus in primary care

Epidemiology and Infection ◽

10.1017/s0950268808001015 ◽

2008 ◽

Vol 137 (2) ◽

pp. 166-172 ◽

Cited By ~ 3

Author(s):

L. M. A. J. VENMANS ◽

K. J. GORTER ◽

G. E. H. M. RUTTEN ◽

F. G. SCHELLEVIS ◽

A. I. M. HOEPELMAN ◽

...

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Urinary Tract ◽

Urinary Tract Infections ◽

Prediction Rule ◽

Clinical Prediction Rule ◽

Receiver Operating Curve ◽

Tract Infections

SUMMARYWe aimed to develop a prediction rule for urinary tract infections (UTIs) in patients with type 2 diabetes mellitus (DM2). A 12-month prospective cohort study was conducted in patients with DM2 aged ⩾45 years to predict the occurrence of recurrent UTIs in women and lower UTIs in men. Predictors for recurrent UTI in women (n=81, 2%) and lower UTIs in men (n=93, 3%) were age, number of general practitioner (GP) visits, urinary incontinence, cerebrovascular disease or dementia. In women, renal disease was an additional predictor. The optimum corrected area under the receiver-operating curve (AUC) was 0·79 (95% CI 0·74–0·83) for women and 0·75 (95% CI 0·70–0·80) for men. Using a cut-off score of 4, women with a lower risk assignment had a probability of 0·3% for the outcome. For a cut-off score of 6, women with a higher risk assignment had a probability of 5·8%. For men these figures were 0·8 and 7·1 for a cut-off score of 2 and 4, respectively. Simple variables can be used for the risk stratification of patients.

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